Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

Moisse, Katie; Volkening, Kathryn; Leystra-Lantz, Cheryl; Welch, Ian; Hill, Tracy; Strong, Michael J.

doi:10.1016/j.brainres.2008.10.021

Cited by 210Amyotrophic Lateral Sclerosis ResearchNerve injury and regenerationHereditary Neurological Disorders

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

Moisse, Katie, Volkening, Kathryn, Leystra-Lantz, Cheryl, Welch, Ian, Hill, Tracy, Strong, Michael J.·2009·Brain Research

DOI 10.1016/j.brainres.2008.10.021

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Abstract

We have performed sciatic axotomies in adult C57BL/6 mice and observed TDP-43 and progranulin (PGRN) expression patterns over 28 days. TDP-43 expression was markedly upregulated in axotomized motor neurons, with prominent cytosolic immunoreactivity becoming maximal by post-injury day 7 and returning to baseline levels by post-injury day 28. Increased TDP-43 expression was confirmed by western blot. TDP-43 mRNA expression was also increased. This was inversely correlated with neuronal PGRN expression which was clearly reduced by day 7 with a return to baseline by post-injury day 28. In contrast, microglial PGRN expression was dramatically increased, and correlated with the inflammatory response to axotomy. Cytosolic TDP-43 colocalized with Staufen and TIA-1, markers for RNA transport and stress granules respectively. We did not observe colocalization of TDP-43 or PGRN with degradative granules (P-bodies) or activated caspase 3. These results indicate that TDP-43 expression is altered in response to neuronal injury and that normal expression is restored following recovery. These findings suggest that the upregulation of TDP-43 expression with prominent cytosolic localization in motor neurons injured by degenerative processes such as ALS may actually represent an appropriate response to neuronal injury.

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TDP-43 is an RNA-binding protein that regulates RNA metabolism, including mRNA splicing, stability, and transport; after acute traumatic injury in animal models, TDP-43 expression is upregulated and TDP-43 relocates from the neuronal nucleus to accumulate in the neuronal cytoplasm.
“TDP-43 is an RNA-binding protein that regulates RNA metabolism, including mRNA splicing, stability, and transport [167]. After acute traumatic injury in animal models, TDP-43 expression is upregulated and TDP-43 relocates from the neuronal nucleus to accumulate in the neuronal cytoplasm [134, 135]”
From The neuropathology of sport (2014) · cites this paper as [135]

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Authors: Moisse, K., Volkening, K., Leystra-Lantz, C., Welch, I., Hill, T., & Strong, M. J.
Affiliations: Western University (CA)
Robarts Research Institute (CA)
Corresponding author: Strong, Michael J.
ORCID: Volkening, Kathryn
Hill, Tracy
Strong, Michael J.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2009-01
Volume: 1249
Pages: 202-211
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2008.10.021
OpenAlex: W2045602910
Cited by: 210
References: 42
Citations by year: 2026: 1 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 13 · 2020: 9 · 2019: 8 · 2018: 14 · 2017: 18 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 18 · 2012: 20
FWCI: 14.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords: TDP-43, progranulin, axotomy, motor neurons, neuronal injury, microglia, neuroinflammation, stress granules, RNA transport, Staufen, TIA-1, P-bodies, amyotrophic lateral sclerosis, sciatic nerve injury, injury recovery
MeSH terms: Progranulins, Granulins, Analysis of Variance, Animals, Cytosol, DNA-Binding Proteins, Female, Immunohistochemistry, Mice, Inbred C57BL, Motor Neurons, RNA, Messenger, Sciatic Nerve, Spinal Cord, Up-Regulation, RNA-Binding Proteins, Microglia, Microscopy, Confocal, Axotomy, Intercellular Signaling Peptides and Proteins, Mice, Caspase 3

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Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

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