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Cited by 19Urticaria and Related ConditionsMast cells and histamineDermatology and Skin Diseases

The expression of serotonin transporter protein in the skin of patients with chronic spontaneous urticaria and its relation with depression and anxiety

Zabolinejad, Naghmeh, Molkara, Sara, Bakhshodeh, Behnoosh, Ghaffari-Nazari, Haniyeh, Khoshkhui, Maryam·2019·Archives of Dermatological Research
DOI 10.1007/s00403-019-01969-y
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Abstract

Studies have indicated a possible role for serotonin transporter protein (SERT) in the pathophysiology of inflammatory skin disorders. This study was aimed to determine the expression of SERT in the skin of patients with chronic spontaneous urticaria (CSU) and its relation to depression and anxiety. In this case-control study, 30 CSU patients and 30 healthy controls were evaluated with skin biopsies to evaluate the expression of the SERT protein based on histopathologic findings. Beck depression and anxiety inventories were used to investigate depression and anxiety in the case group. Data were analyzed by SPSS software. P values < 0.05 were considered significant. The case group showed significantly higher percentage of stained cells (P < 0.0001) and intensity of SERT expression (P < 0.0001) compared with the control group. The patients with uncontrolled CSU showed significantly higher percentage (P < 0.002) and intensity (P < 0.006) of SERT expression, compared with those with controlled CSU. The intensity of SERT expression in CSU patients had no significant correlation with the severity of depression, but was significantly correlated with the severity of anxiety (r = 0.555; P = 0.001). The percentage of stained cells was significantly correlated with the severities of depression (r = - 0.433; P = 0.017) and anxiety (r = 0.528; P = 0.003). The SERT expression in patients with CSU was higher compared with controls, which can demonstrate the role of serotonin in the pathogenesis of this disease. This higher SERT expression is correlated with the severity of the disease.

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Crossref · 10.1007/s00403-019-01969-y

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Authors
Zabolinejad, N., Molkara, S., Bakhshodeh, B., Ghaffari-Nazari, H., & Khoshkhui, M.
Affiliations
Mashhad University of Medical Sciences (IR)
Corresponding author
Khoshkhui, Maryam
ORCID
Venue
Archives of Dermatological Research
Publisher
Springer Science and Business Media LLC
Published
2019-09-13
Volume
311
Issue
10
Pages
825-831
ISSN
  • 0003-9187 (ISSN-L)
  • 0340-3696
  • 1432-069X
DOI
10.1007/s00403-019-01969-y
OpenAlex
W2974867948
Cited by
19
References
51
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 2
FWCI
1.90
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Archives of Dermatological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Mashhad University of Medical Sciences (951756)
Topics
  • Health Sciences › Medicine › Rheumatology › Urticaria and Related Conditions
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
serotonin transporter, chronic spontaneous urticaria, depression, anxiety, skin histopathology, serotonin, disease severity, urticaria pathogenesis
MeSH terms
Chronic Urticaria, Adult, Anxiety, Biopsy, Depression, Female, Humans, Male, Middle Aged, Personality Inventory, Serotonin, Severity of Illness Index, Skin, Case-Control Studies, Serotonin Plasma Membrane Transport Proteins, Young Adult, Healthy Volunteers

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