Skin as an endocrine organ: implications for its function
Open accessAbstract
Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range of stressors. A flurry of recent findings has established the skin as an important peripheral (neuro)endocrine organ that is tightly networked to central stress axes. This capability is contributing to the maintenance of body homeostasis, and in this way could be harnessed for therapeutic strategies.
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Higher elements of the HPA axis are functional within the pilosebaceous unit and help maintain its immune privilege.
“The higher elements of the HPA axis are functional within the pilosebaceous unit and provide another important element maintaining the immune privilege of this site [131, 133, 171, 183].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [133]
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- Authors
- Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R.
- Affiliations
- University of Tennessee Health Science Center (US)
- SIU Medicine (US)
- University of Lübeck (DE)
- San Francisco VA Medical Center (US)
- University of Bradford (GB)
- Corresponding author
- Slominski, Andrzej
- Venue
- Drug Discovery Today Disease Mechanisms
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 5
- Issue
- 2
- Pages
- e137-e144
- ISSN
- 1740-6765 (ISSN-L)
- PMC
- PMC2658605
- OpenAlex
- W2013175456
- Cited by
- 116
- References
- 62
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 10 · 2012: 19
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug Discovery Today Disease Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049932, R01AR052190, R01AR047079)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- stress response, body homeostasis, treatment options
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