The value of urocortin and Ca-125 in the diagnosis of endometrioma
Abstract
Purposes In this study, we sought to establish the value of a new molecule, urocortin (Ucn), in the diagnosis of endometrioma and compare with Ca-125 to identify superiority of urocortin.Methods Of the patients operated on at our hospital with the initial diagnosis of adnexal mass, 88 patients whose pathology results were endometrioma and benign ovarian cyst were included in the study. As a result of the pathological examination, the patients were assessed in two groups. Group 1 consisted of 42 cases of endometrioma and Group 2 included 46 cases of benign ovarian cyst (control group). The serum Ucn and CA 125 levels of patients were measured from the blood samples drawn prior to the operation.Results While the serum Ucn level was 4.8 ± 1.00 ng/ml in the endometrioma group, it was 4.5 ± 1.03 ng/ml in the control group (P = 0.21). The difference was statistically not meaningful. On the other hand, mean serum Ca-125 level was 43.8 U/l (11.7-251) in the endometrioma group, it was 16.5 U/l (4.3-121.1) in the control group. The difference was statistically meaningful (P = 0.001). When the cut-off point for Serum Ca-125 level was taken as 21.38, sensitivity and specificity levels were found to be 88.1 and 63%. When the cut-off point for Ucn was taken as 4.16, sensitivity was 76.2%, and specificity 45.7%.Conclusion Ucn was not found to be efficient in distinguishing endometrioma from other benign ovarian cysts or to be superior to CA125 in the diagnosis of endometrioma.
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Combinations of CA-125 with urocortin, chlamydia antibody, CD23, and inflammatory cytokines did not provide sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.
“CA-125 has been measured simultaneously with urocortin [34], chlamydia antibody [35], CD23 [39], and inflammatory cytokines [32]. However, none of these combinations provided a sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [34]
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- Authors
- Tokmak, A., Ugur, M., Tonguc, E., Var, T., Moraloğlu, O., & Ozaksit, G.
- Affiliations
- Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi (TR)
- Corresponding author
- Tonguc, Esra
- ORCID
- Tokmak, Aytekin
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2010-05-18
- Volume
- 283
- Issue
- 5
- Pages
- 1075-1079
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2041670026
- Cited by
- 21
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- urocortin, CA125, endometrioma, benign ovarian cysts, adnexal mass, serum biomarkers, sensitivity and specificity, differential diagnosis
- MeSH terms
- Adult, Endometriosis, Female, Humans, Middle Aged, ROC Curve, CA-125 Antigen, Urocortins, Young Adult
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