Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the rotterdam criteria

Jamil, Avin S.; Alalaf, Shahla K.; Al-Tawil, Namir G.; Al-Shawaf, Talha

doi:10.1007/s00404-015-3889-5

Cited by 73Ovarian function and disordersEndometriosis Research and TreatmentGenetic and Kidney Cyst Diseases

Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the rotterdam criteria

Jamil, Avin S., Alalaf, Shahla K., Al-Tawil, Namir G., Al-Shawaf, Talha·2016·Archives of Gynecology and Obstetrics

DOI 10.1007/s00404-015-3889-5

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Abstract

Purpose Polycystic Ovary Syndrome (PCOS) is the most common endocrine disturbances in women and is divided into different phenotypes. The aim of study is to compare the clinical and hormonal parameters among the four phenotypes of PCOS based on the Rotterdam criteria and with control group.Methods Women with PCOS (n = 263) confirmed based on the Rotterdam criteria and 263 women with no evidence of PCOS were recruited as controls using observational case-control study. Evaluation of clinical and hormonal parameters, and differences in anti-Mullerian hormone (AMH) were compared between four phenotypes of PCOS and controls.Results Women with phenotype A (olig-anovulation (O) + hyperandrogenism (H) + polycystic ovary morphology (P)) had significantly larger waist than phenotype D (O + P) and higher body mass index than phenotype C (H + P). The LH/FSH ratio was significantly higher in phenotype A than phenotype D and controls along with significantly higher serum total testosterone levels in phenotype A compared to the phenotype B (O + H), C, D, and controls. AMH was significantly higher with phenotype A, C, and D than in women phenotype B and controls.Conclusions The highest AMH levels were found in phenotype A. Phenotype B similar to controls had significantly low AMH compared to other three PCOS phenotypes. Women in the phenotypes D and controls showed significantly lower levels of LH/FSH ratio, total testosterone, and free androgen index, and higher levels of FSH and SHBG compared with phenotype A (P < 0.001). In logistic regression analysis, AMH and LH were predictors for PCOS.

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Women with phenotype C had intermediate values for BMI and testosterone serum levels compared with phenotype A.
“They found that women with phenotype C had intermediate values for BMI and testosterone serum levels compared with phenotype A.”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Jamil et al., 2016

Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
(2004) · The Lancet · doi:10.1016/s0140-6736(03)15268-3 · Cited by 12,717 · see citing works
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715 · see citing works
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219 · see citing works
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132 · see citing works
Collegium antropologicum
(2020) · Collegium Antropologicum · doi:10.5671/ca · Cited by 1,329 · see citing works
Ultrasound assessment of the polycystic ovary: international consensus definitions
Balen, A. H., Laven, J. S. E., Tan, S.-L., & Dewailly, D. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg044 · Cited by 1,015 · see citing works
Hirsutism: Implications, etiology, and management
Hatch, R., Rosenfield, R. L., Kim, M. H., & Tredway, D. R. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90746-8 · Cited by 1,013 · see citing works
Antimüllerian hormone serum levels: a putative marker for ovarian aging
de Vet, A., Laven, J. S. E., de Jong, F. H., Themmen, A. P. N., & Fauser, B. C. J. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02993-4 · Cited by 886 · see citing works
Elevated serum level of anti-Mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest
Pigny, P., Merlen, E., Robert, Y., Cortet-Rudelli, C., Decanter, C., Jonard, S., & Dewailly, D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030727 · Cited by 709 · see citing works
Anti-Mullerian Hormone Serum Concentrations in Normoovulatory and Anovulatory Women of Reproductive Age
Laven, J. S. E., Mulders, A. G. M. G. J., Visser, J. A., Themmen, A. P. N., de Jong, F. H., & Fauser, B. C. J. M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030932 · Cited by 519 · see citing works
Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome
Pasquali, R., Gambineri, A., & Pagotto, U. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00990.x · Cited by 359 · see citing works
Anti-Müllerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels
Piouka, A., Farmakiotis, D., Katsikis, I., Μacut, D., Gerou, S., & Panidis, D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90684.2008 · Cited by 316 · see citing works
Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters
Carmina, E., Chu, M. C., Longo, R. A., Rini, G. B., & Lobo, R. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2279 · Cited by 274 · see citing works
Restoration of Reproductive Potential by Lifestyle Modification in Obese Polycystic Ovary Syndrome: Role of Insulin Sensitivity and Luteinizing Hormone
Huber-Buchholz, M.-M. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1470 · Cited by 269 · see citing works
Relationship between serum müllerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women
Cook, C. L., Siow, Y., Brenner, A. G., & Fallat, M. E. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02944-2 · Cited by 266 · see citing works
Characterizing Discrete Subsets of Polycystic Ovary Syndrome as Defined by the Rotterdam Criteria: The Impact of Weight on Phenotype and Metabolic Features
Welt, C. K., Gudmundsson, J., Arason, G., Adams, J., Pálsdottir, H. S., Gudlaugsdottir, G. J., Ingadóttir, G., & Crowley, W. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1327 · Cited by 260 · see citing works
Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome
Barber, T. M., Wass, J. A. H., McCarthy, M. I., & Franks, S. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02764.x · Cited by 254 · see citing works
Anti-Müllerian hormone and ovarian dysfunction
Broekmans, F. J., Visser, J. A., Laven, J. S. E., Broer, S. L., Themmen, A. P. N., & Fauser, B. C. J. M. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.002 · Cited by 221 · see citing works
Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria
Juran, R., Syrop, C. H., Davis, W. A., Voorhis, B. J. V., & Dokras, A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.032 · Cited by 214 · see citing works
Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes
Guastella, E., Longo, R. A., & Carmina, E. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.02.014 · Cited by 205 · see citing works
Oligoanovulation with Polycystic Ovaries But Not Overt Hyperandrogenism
Dewailly, D., Catteau-Jonard, S., Reyss, A.-C., Leroy, M., & Pigny, P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1054 · Cited by 198 · see citing works
Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet
Carmina, E. (2003) · Human Reproduction · doi:10.1093/humrep/deg440 · Cited by 196 · see citing works
Recruitment and development of the follicle; the roles of the transforming growth factor-β superfamily
Findlay, J. K., Drummond, A. E., Dyson, M., Baillie, A. J., Robertson, D. M., & Ethier, J.-F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00053-9 · Cited by 173 · see citing works
Clinical characteristics of polycystic ovary syndrome in Indian women
Ramanand, S., Ghongane, B. B., Ramanand, J. B., Patwardhan, M., Ghanghas, R. R., & Jain, S. (2013) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.107858 · Cited by 142 · see citing works
Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin
van Hooff, M. H. A., Voorhorst, F. J., Kaptein, M. B. H., Hirasing, R. A., Koppenaal, C., & Schoemaker, J. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00584-7 · Cited by 141 · see citing works
Should obese women with polycystic ovary syndrome receive treatment for infertility?
Balen, A. H., Dresner, M., SCOTT, E. M., & Drife, J. (2006) · BMJ · doi:10.1136/bmj.332.7539.434 · Cited by 127 · see citing works
Androgens Augment the Mitogenic Effects of Oocyte-Secreted Factors and Growth Differentiation Factor 9 on Porcine Granulosa Cells1
Hickey, T. E., Marrocco, D. L., Amato, F., Ritter, L. J., Norman, R. J., Gilchrist, R. B., & Armstrong, D. T. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.039362 · Cited by 123 · see citing works
Investigation of Hirsutism: Testosterone is Not Enough
Carter, G. D., Holland, S., Alaghband-Zadeh, J., Rayman, G. A., Dorrington-Ward, P., & Wise, P. H. (1983) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328302000502 · Cited by 122 · see citing works
Endocrine and metabolic differences among phenotypic expressions of polycystic ovary syndrome according to the 2003 Rotterdam consensus criteria
Kauffman, R. P., Baker, T. E., Baker, V. M., DiMarino, P., & Castracane, V. D. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.01.037 · Cited by 111 · see citing works
Clinical characteristics, metabolic features, and phenotype of Chinese women with polycystic ovary syndrome: a large-scale case–control study
Zhang, H. Y., Guo, C. X., Zhu, F. F., Qu, P. P., Lin, W. J., & Xiong, J. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2568-z · Cited by 94 · see citing works
Serum anti-mullerian hormone levels in the main phenotypes of polycystic ovary syndrome
Şahmay, S., Atakul, N., Öncül, M., Tüten, A., Mathyk, B. A., & Seyisoğlu, H. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.05.019 · Cited by 83 · see citing works
A case–control observational study of insulin resistance and metabolic syndrome among the four phenotypes of polycystic ovary syndrome based on Rotterdam criteria
Jamil, A. S., Alalaf, S., Al-Tawil, N. G., & Al‐Shawaf, T. (2015) · Reproductive Health · doi:10.1186/1742-4755-12-7 · Cited by 80 · see citing works
Self-citation
Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome
Woo, H., Kim, K. H., Rhee, E., Park, H., & Lee, M. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0055 · Cited by 78 · see citing works
Anthropometric, clinical, and metabolic comparisons of the four Rotterdam PCOS phenotypes: A prospective study of PCOS women
Kar, S. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.121422 · Cited by 74 · see citing works
Polycystic ovary syndrome and anti‐Müllerian hormone: role of insulin resistance, androgens, obesity and gonadotrophins
Cassar, S., Teede, H. J., Moran, L., Joham, A. E., Harrison, C. L., Strauss, B. J., & Stepto, N. K. (2014) · Clinical Endocrinology · doi:10.1111/cen.12557 · Cited by 73 · see citing works
Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria
Yilmaz, M., İsaoğlu, Ü., Delibaş, İ. B., & Kadanalı, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2010.01478.x · Cited by 71 · see citing works
Characteristics of different phenotypes of polycystic ovary syndrome in a Bulgarian population
Pehlivanov, B. K., & Orbetzova, M. M. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701536246 · Cited by 70 · see citing works
Polycystic ovaries, as defined by the 2003 Rotterdam consensus criteria, are found to be very common in young healthy women
Duijkers, I. J. M., & Klipping, C. (2010) · Gynecological Endocrinology · doi:10.3109/09513590903247824 · Cited by 66 · see citing works
Polycystic ovaries, as defined by the 2003 Rotterdam consensus criteria, are found to be very common in young healthy women
Duijkers, I. J. M., & Klipping, C. (2009) · Gynecological Endocrinology · doi:10.1080/09513590903247824 · Cited by 60 · see citing works
The prevalence of metabolic syndrome and insulin resistance according to the phenotypic subgroups of polycystic ovary syndrome in a representative sample of Iranian females.
Mehrabian, F., Khani, B., Kelishadi, R., & Kermani, N. (2011) · Europe PMC (PubMed Central) · Cited by 60 · see citing works
Anthropometric and Biochemical Characteristics of Polycystic Ovarian Syndrome in South Indian Women Using AES-2006 Criteria
Thathapudi, S., Kodati, V., Erukkambattu, J., Katragadda, A., Addepally, U., & Hasan, Q. A. (2014) · Intern J Endocrinol Metab · doi:10.5812/ijem.12470 · Cited by 53 · see citing works
Acanthosis nigricans in obese patients: Presentations and implications for prevention of atherosclerotic vascular disease
Katz, A. S., Goff, D. C., & Feldman, S. R. (2000) · Dermatology Online Journal · doi:10.5070/d36fj340w2 · Cited by 43 · see citing works
Anti-Mullerian hormone and insulin resistance in classic phenotype lean PCOS
Çağlar, G. S., Kahyaoğlu, İ., Pabuçcu, R., Demırtaş, S., & Şeker, R. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-013-2833-9 · Cited by 42 · see citing works
Influence of sociocultural factors on the ovulatory status of polycystic ovary syndrome
Fede, G. D., Mansueto, P., Longo, R. A., Rini, G., & Carmina, E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.161 · Cited by 35 · see citing works
Endocrine and metabolic characteristics of polycystic ovary syndrome in Chinese women with different phenotypes
Xu, X., Shi, Y., Cui, Y., Ma, J., Che, L., & Chen, Z. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04194.x · Cited by 33 · see citing works
Polycystic Ovary Syndrome
Pereira-Eshraghi, C., & Vuguin, P. M. (2024) · Pediatrics in Review · doi:10.1542/pir.2023-006036 · Cited by 32 · see citing works
Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in the Croatian population.
Baldani, D. P., Škrgatić, L., Šimunić, V., Zlopaša, G., Čanić, T., & Trgovčić, I. (2013) · PubMed · Cited by 25 · see citing works

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Criteria, Prevalence, and Phenotypes of Polycystic Ovary Syndrome
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Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives
Khan, M. J., Ullah, A., & Basit, S. (2019) · The Application of Clinical Genetics · doi:10.2147/tacg.s200341 · Cited by 363 · see citing works
Criteria, phenotypes and prevalence of polycystic ovary syndrome
Belenkaia, L. V., Лазарева, Л. М., Walker, W., Lizneva, D., & Сутурина, Л. В. (2019) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.19.04404-6 · Cited by 133 · see citing works
Serum AMH levels and insulin resistance in women with PCOS
Şahmay, S., Mathyk, B. A., Sofiyeva, N., Atakul, N., Azemi, A., & Erel, C. T. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.03.007 · Cited by 93 · see citing works
Consecutive lynestrenol and cross-sex hormone treatment in biological female adolescents with gender dysphoria: a retrospective analysis
Tack, L. J. W., Craen, M., Dhondt, K., Bossche, H. V., Laridaen, J., & Cools, M. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0067-9 · Cited by 86 · see citing works
Anti-Müllerian hormone and polycystic ovary syndrome
Bhide, P., & Homburg, R. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.03.004 · Cited by 77 · see citing works
Polycystic Ovarian Syndrome: A Complex Disease with a Genetics Approach
Nautiyal, H., Imam, S. S., Alshehri, S., Ghoneim, M. M., Afzal, M., Alzarea, S. I., Güven, E., Al-Abbasi, F. A., & Kazmi, I. A. (2022) · Biomedicines · doi:10.3390/biomedicines10030540 · Cited by 68 · see citing works
Cardio-Metabolic Disease and Polycystic Ovarian Syndrome (PCOS): A Narrative Review
Sangaraju, S. L., Yepez, D., Grandes, X. A., Manjunatha, R. T., & Habib, S. (2022) · Cureus · doi:10.7759/cureus.25076 · Cited by 71 · see citing works
Anti-müllerian hormone as a diagnostic biomarker for polycystic ovary syndrome and polycystic ovarian morphology: a systematic review and meta-analysis
van der Ham, K., Laven, J. S. E., Tay, C. T., Mousa, A., Teede, H. J., & Louwers, Y. V. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.05.163 · Cited by 79 · see citing works
Antimüllerian hormone to determine polycystic ovarian morphology
de Loos, A. D., Hund, M., Buck, K., Meun, C., Sillman, J., & Laven, J. S. E. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.05.094 · Cited by 59 · see citing works
Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review
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Polak, A. M., Adamska, A., Krentowska, A., Łebkowska, A., Hryniewicka, J., Adamski, M., & Kowalska, I. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030732 · Cited by 48 · see citing works
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Szkodziak, P. R., Szkodziak, F., Trzeciak, K., Woźniak, S., Mlynarczyk, M., & Paszkowski, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-26718-2 · Cited by 25 · see citing works
Determining the age group-based cut-off values of serum anti-Mullerian hormone concentrations to diagnose polycystic ovary syndrome
Timur, H. T., Çımrın, D., Doruk, Ö. G., & Doğan, E. (2023) · Current Medical Research and Opinion · doi:10.1080/03007995.2023.2204768 · Cited by 15 · see citing works
A cross-sectional comparison of clinical and endocrine parameters among phenotypes of polycystic ovarian syndrome in iranian population
Amini, P., Samani, R. O., Hosseini, R., Ahmadi, J., & Maroufizadeh, S. (2018) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2018.07.005 · Cited by 15 · see citing works
Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome
Selçuk, S., Özkaya, E., Eser, A., Kuyucu, M., KUTLU, H. T., Devranoğlu, B., Sofuoğlu, K., & Dayıcıoğlu, V. (2016) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.90094 · Cited by 12 · see citing works
Polycystic ovary syndrome phenotype does not have impact on oocyte morphology
Uk, A., Decanter, C., Grysole, C., Keller, L., Behal, H., Silva, M. S. B., Dewailly, D., Robin, G., & Barbotin, A. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00874-2 · Cited by 12 · see citing works
Cardio-metabolic risk in Rotterdam clinical phenotypes of PCOS
Mitra, S., Saharia, G. K., & Jena, S. K. (2023) · Annales d Endocrinologie · doi:10.1016/j.ando.2023.06.001 · Cited by 11 · see citing works
Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes
Eftekhar, M., Mirhashemi, E. S., & Tabibnejad, N. (2018) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12707 · Cited by 10 · see citing works
Comparison of body mass index, anti-müllerian hormone and insulin resistance parameters among different phenotypes of polycystic ovary syndrome
Gürsu, T., Eraslan, A., & Angun, B. (2022) · Gynecology and Obstetrics Clinical Medicine · doi:10.1016/j.gocm.2022.10.002 · Cited by 10 · see citing works
Salivary and serum androgens with anti-Müllerian hormone measurement for the diagnosis of polycystic ovary syndrome
Sathyapalan, T., Al‐Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Keevil, B. G., & Atkin, S. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22176-1 · Cited by 10 · see citing works
Assessment the Correlations of Hormones,Lipid Profiles, Oxidative Stress, and Zinc Concentration in Iraqi Women with Polycystic Ovary Syndrome
Shenta, A. A., Saud, K., & Al-Shawi, A. A. A. (2020) · Reports of Biochemistry and Molecular Biology · doi:10.29252/rbmb.9.3.270 · Cited by 9 · see citing works
Does insulin resistance increase thyroid volume in patients with polycystic ovary syndrome?
Şahin, M., Demircioğlu, D., Oğuz, A., Tüzün, D., Sarıca, M. A., İnanç, E., & Gül, K. (2016) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000225 · Cited by 9 · see citing works
Advantages of Serum Anti-Müllerian Hormone as a Marker for Polycystic Ovarian Syndrome
Shi, X., Peng, D., Liu, Y., Miao, X., Ye, H., & Zhang, J. (2018) · Laboratory Medicine · doi:10.1093/labmed/lmy068 · Cited by 8 · see citing works
New insights into the relationship of antimüllerian hormone with polycystic ovary syndrome and its diagnostic accuracy: an updated and extended meta-analysis using a marginal beta-binomial model
Barghi, M., Heidari, Z., Haghighatdoost, F., Feizi, A., & Hashemipour, M. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2024.10.004 · Cited by 9 · see citing works
The Role of the AMH, SHBG, Free Androgen Index and LH/FSH Ratio in the Diagnosis of Polycystic Ovary Syndrome in Adolescent
Büyükyılmaz, G., Koca, S. B., Adıgüzel, K. T., Boyraz, M., & Gürbüz, F. (2023) · Turkish Journal of Pediatric Disease · doi:10.12956/tchd.1347807 · Cited by 7 · see citing works
Correlation of phenotypes of polycystic ovarian syndrome with anti-Müllerian hormone levels
Santhiya, R., Habeebullah, S., & Ghose, S. (2021) · Sahel Medical Journal · doi:10.4103/smj.smj_50_20 · Cited by 6 · see citing works
Body Composition and Characterization of Skinfold Thicknesses from Polycystic Ovary Syndrome Phenotypes. A Preliminar Case-Control Study
Sánchez-Ferrer, M. L., Sánchez, E. D. L. C., Árense-Gonzalo, J. J., Prieto‐Sánchez, M. T., Bernabeu-González, I., Carmona‐Barnosi, A., Mendiola, J., & Torres-Cantero, A. M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18062977 · Cited by 6 · see citing works
Anti-Müllerian Hormone Levels Across Phenotypes in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis
Carvalho, P. B., Maffazioli, G. D. N., Simões, R. S., Macchione, R. F., de Medeiros, S. F., Soares, J. M., Baracat, E. C., & Maciel, G. A. R. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf199 · Cited by 4 · see citing works
Relationship between serum Prostate Specific Antigen (PSA) in women with polycystic ovary syndrome and some reproductive hormones in Kirkuk city
Rifatt, M. G., & Rahim, S. M. (2023) · Tikrit Journal of Pure Science · doi:10.25130/tjps.v22i11.911 · Cited by 4 · see citing works
Anti-Müllerian hormone as a diagnostic marker of polycystic ovary syndrome: a systematic review with meta-analysis
Gomes, M. D. O., Gomes, J. D. O., ANANIAS, L. F., Lombardi, L. A., Silva, F. S., & Espíndula, A. P. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.01.044 · Cited by 4 · see citing works
Distribution of polycystic ovary syndrome (PCOS) phenotypes in Iranian women: a cross-sectional study
Kheirollahi, A., Hamidi, H., & Vatannejad, A. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07202-6 · Cited by 4 · see citing works
Impact of Hypocaloric Dietary Intervention on Phenotypic Presentations of Polycystic Ovary Syndrome (PCOS)
Carter, F. E., Jarrett, B. Y., Oldfield, A. L., Brink, H. V., Kim, J. Y., & Lujan, M. E. (2025) · Nutrients · doi:10.3390/nu17132223 · Cited by 3 · see citing works
An observational analysis of blood and urine testosterone in diagnosis of polycystic ovarian syndrome
Fernanda, M. A. H. F., Sa’adi, A., & Sudjarwo (2023) · Pharmacy Education · doi:10.46542/pe.2023.234.259263 · Cited by 3 · see citing works
Effect of Junk Food on Hormonal and Metabolic Manifestations in Polycystic Ovarian Syndrome Phenotypes: A Case–Control Study of Kashmiri Population
Nisa, K. U., Tarfeen, N., Mir, S. A., Khurshid, Z., Ahmad, M. B., Wani, S., Bhat, H., & Ganai, B. A. (2023) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-023-01169-6 · Cited by 3 · see citing works
The Combination of Diosgenin, Vitamin D, and α-Lactalbumin Normalizes the Menstrual Cycle in Women with PCOS of Phenotype D: A Pilot Clinical Study
Russo, M., Porcaro, G., Aragona, C., Bilotta, G., Liberto, M. D., & Unfer, V. (2025) · Nutrients · doi:10.3390/nu17233695 · Cited by 2 · see citing works
Age- and BMI-stratified assessment of serum anti-Müllerian hormone as a biomarker for polycystic ovary syndrome diagnosis in Chinese women
You, Y., Guo, Z., Hong, X., Li, X., Chen, S., Meng, X., Shang, X., Cheng, X., Liu, M., Zhao, F. Y., et al. (2026) · BMC Endocrine Disorders · doi:10.1186/s12902-025-02136-3 · Cited by 2 · see citing works
Multiomics in polycystic ovarian syndrome
Jabeen, F., Ahmad, R., Rasool, S., Ali, A., & Ganie, S. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23971-7.00010-9 · Cited by 2 · see citing works
Association of Serum Anti-Mullerian Hormone and Free Testosterone with Different Phenotypes of Polycystic Ovary Syndrome
Falh, Z. G., Saleh, B. O. M., & Al-Naddawi, A. M. (2024) · Reports of Biochemistry and Molecular Biology · doi:10.61186/rbmb.13.1.106 · Cited by 2 · see citing works
Insulin resistance and dysglycaemia in polycystic ovary syndrome patients
Dere, K. A. L., Prisca, D. A., Menin, M. M., Coulibaly, D., & Tiahou, G. G. (2021) · International Journal of Clinical Biochemistry and Research · doi:10.18231/j.ijcbr.2020.101 · Cited by 2 · see citing works
Serum Chemerin Levels in Polish Women with PCOS-Phenotype D
Kuliczkowska-Płaksej, J., Halupczok-Żyła, J., Gojny, Ł., Zembska, A., Zimoch, A., Skrzypiec‐Spring, M., Bolanowski, M., & Jawiarczyk-Przybyłowska, A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15020772 · Cited by 1 · see citing works
Pentraxin 3 levels in polycystic ovary syndrome: a meta-analysis
Fard, R. M., Nadi, M., Mansouri, Z., Kazemzadeh, R., Radmehr, V., Hosseinpour, M., Sakhavarz, T., & Bahreiny, S. S. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02091-0 · Cited by 1 · see citing works
Differences in clinical characteristics and cardiovascular disease risk prediction among Chinese women with polycystic ovary syndrome phenotypes: a cross-sectional study
Gong, Z., Li, D., Li, X., Tian, J., Guo, J., Zhao, Y., Lu, Y., Gao, S., & Li, M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1753316 · Cited by 1 · see citing works
Decoding the association of polycystic ovary syndrome with metabolic-associated fatty liver: insights into CK18 and LC3II/ATG7/P62 autophagy axis and adjunct therapeutics of metformin and levothyroxine
Hamad, S. M., Seiwan, A. N., Hashem, M. H., Mohamed, D. I., Bassyouni, L. A., El-Waseef, D. A. E.-D. A., Ezzat, S. F., El-Kharashi, O. A., El-Kareem, H. F. A., Alzahrani, H. A., et al. (2026) · RSC Medicinal Chemistry · doi:10.1039/d5md00819k · Cited by 1 · see citing works
Hormonal and metabolic features of the androgenic phenotypes of polycystic ovary syndrome and non-classic adrenal hyperplasia with various polymorphic variants in the CYP17A1 gene
Константинович, К. Е., Андреевна, М. Е., & Osinovskaya, N. S. (2020) · Journal of obstetrics and women s diseases · doi:10.17816/jowd69127-36 · Cited by 1 · see citing works
The Correlation between Sex Hormone-Binding Globulin and Clinical Characteristics According to Anti-Müllerian Hormone in Women with Regular Menstrual Cycles: A Prospective Study
Keum, J., Kim, Y. J., Choi, S. K., Lee, W. M., & Bae, J. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14030274 · Cited by 1 · see citing works
Hormonal profile and characteristics of polychistic ovarium syndrome among Madurese tribe, Indonesia
Zainiyah, Z., Susanti, E., & Haris, M. (2020) · International Journal of Public Health Science (IJPHS) · doi:10.11591/ijphs.v9i4.20408 · Cited by 1 · see citing works
IVF efficiency in different phenotypes of polycystic ovary syndrome
Nikolayenkov, I. P., Kazymova, O. E., Sudakov, D. S., & Dymarskaya, Y. R. (2021) · Journal of obstetrics and women s diseases · doi:10.17816/jowd61933 · Cited by 1 · see citing works
Polycystic Ovary Syndrome Phenotypes and Infertility Treatment
Badovinac, A. R., & Severinski, N. S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.101994 · Cited by 1 · see citing works
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Uk, A., Decanter, C., Grysole, C., Keller, L., Behal, H., Silva, M. S. B., Dewailly, D., Robin, G., & Barbotin, A. (2021) · Research Square · doi:10.21203/rs.3.rs-720791/v1 · Cited by 1 · see citing works
Analyzing the biochemical, clinical, and hormonal characteristics of patients with polycystic ovary syndrome
GÜRBÜZ, T., & Tosun, Ş. A. (2021) · Journal of Experimental and Clinical Medicine · doi:10.52142/omujecm.38.4.15
Polycystic ovary syndrome phenotypes
Khan, U. I., & Farid, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87932-3.00011-6
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Polat, S., & Erginay, O. N. (2024) · Türk Kadın Sağlığı ve Neonatoloji Dergisi · doi:10.46969/ezh.1482404
Role of Inhibin B and Ratio of Luteinizing: Follicle-Stimulating Hormones in Phenotyping Polycystic Ovarian Syndrome
Falh, Z. G., Saleh, B. O. M., Al-Naddawi, A. M., & Mohammed, G. (2024) · Journal of the Faculty of Medicine Baghdad · doi:10.32007/jfacmedbaghdad.6642418
Antimullerian Hormone Levels by Phenotypes in Polycystic Ovary Syndrome: A Systematic Review and Meta-AnalysisPreprint
Carvalho, P. B., Maffazioli, G. D. N., Simões, R. S., Macchione, R. F., de Medeiros, S. F., Soares, J. M., Baracat, E. C., & Maciel, G. A. R. (2025) · medRxiv · doi:10.1101/2025.01.25.25321110
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Maitra, C., & Maitra, A. (2025) · Cureus · doi:10.7759/cureus.82355
Expression of Hypoxia-Inducible Factor 1a (HIF-1a), Regulatory T Cells (Treg) and T Helper 17 Cells (Th17) in PCOS Phenotype D Patients from Polish Population
Kuliczkowska-Płaksej, J., Szymczak, D., Halupczok-Żyła, J., Strzelec, M., Podsiadły, A., Słoka, N. K., Bolanowski, M., Stachowska, B., Zdrojowy-Wełna, A., & Jawiarczyk-Przybyłowska, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073108
Anti-Müllerian Hormone in Polycystic Ovary Syndrome: Towards a Specific Diagnostic Threshold in the Tunisian Population
Chiboub, M., Braham, M., Gharbi, R., Bennour, M., Chakroun, N. F., Hamdoun, M., Feki, M., Jemel, M., & Kammoun, I. (2026) · AACE Endocrinology and Diabetes · doi:10.1016/j.aed.2026.04.017
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The Role of Anti-Müllerian Hormone in the Characterization of the Different Polycystic Ovary Syndrome Phenotypes
Romualdi, D., Florio, C. D., Tagliaferri, V., Cicco, S. D., Gagliano, D., Immediata, V., Lanzone, A., & Guido, M. (2015) · Reproductive Sciences · doi:10.1177/1933719115611751 · Cited by 29 · see citing works
Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in the Croatian population [Osobine različitih policističnih jajnika u Hrvatskoj dijagnosticiranih po Rotterdamskim kriterijima]
Pavičić Baldani, D., Škrgatić, L., Šimunić, V., Zlopaša, G., Čanić, T., & Trgovčić, I. (2013) · Repository of the Medical Faculty of the University of Zagreb (University of Zagreb)
Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in the Croatian population.
Baldani, D. P., Škrgatić, L., Šimunić, V., Zlopaša, G., Čanić, T., & Trgovčić, I. (2013) · PubMed · Cited by 25 · see citing works
Comparison of Anti-müllerian Hormone (AMH) and Hormonal Assays for Phenotypic Classification of Polycystic Ovary Syndrome
Özay, A. C., Özay, Ö. E., & Gülekli, B. (2020) · Ginekologia Polska · doi:10.5603/gp.a2020.0122 · Cited by 16 · see citing works
Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria
Yilmaz, M., İsaoğlu, Ü., Delibaş, İ. B., & Kadanalı, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2010.01478.x · Cited by 71 · see citing works

Authors: Jamil, A. S., Alalaf, S. K., Al-Tawil, N. G., & Al-Shawaf, T.
Affiliations: Hawler Medical University (IQ)
Corresponding author: Jamil, Avin S.
ORCID: Alalaf, Shahla K.
Al-Tawil, Namir G.
Venue: Archives of Gynecology and Obstetrics
Publisher: Springer Science and Business Media LLC
Published: 2015-09-25
Volume: 293
Issue: 2
Pages: 447-456
ISSN: 0003-9128 (ISSN-L)
0932-0067
1432-0711
DOI: 10.1007/s00404-015-3889-5
OpenAlex: W1702870999
Cited by: 73
References: 49
Citations by year: 2026: 8 · 2025: 8 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7
FWCI: 5.70
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Gynecology and Obstetrics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, PCOS phenotypes, Rotterdam criteria, anti-Müllerian hormone, LH/FSH ratio, total testosterone, free androgen index, sex hormone-binding globulin, oligoanovulation, hyperandrogenism, body mass index, waist circumference
MeSH terms: Adolescent, Adult, Anovulation, Female, Humans, Ovary, Phenotype, Polycystic Ovary Syndrome, Body Mass Index, Case-Control Studies, Hyperandrogenism, Anti-Mullerian Hormone, Young Adult

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Comparison of clinical and hormonal characteristics among four phenotypes of polycystic ovary syndrome based on the rotterdam criteria

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