Cognitive impairment in chronic obstructive pulmonary disease
Abstract
Some analogy exists between cognitive impairment in hypoxemic patients with chronic obstructive pulmonary disease (COPD) and Alzheimer's disease (AD). We purposed to verify whether the analogy extends to the cerebral perfusion pattern. Ten normal subjects, 15 COPD patients with and 18 without hypoxemia, and 15 patients with mild AD matched for age and educational level underwent brain perfusion single photon emission computed tomography (SPECT) and neuropsychological assessment. Normal subjects and non hypoxemic COPD patients had comparable perfusion patterns. The average perfusion decreased from non hypoxemic to hypoxemic COPD and, then, to AD patients. Hypoperfusion of associative areas was the hallmark of AD, whereas the average perfusion of anterior cortical and subcortical regions did not distinguish AD and hypoxemic COPD patients. Both COPD groups scored higher than AD patients (p </= 0.01) in 13 cognitive tests but below the normal in selected tests of verbal attainment, attention and deductive thinking. Perfusion of anterior cortical and subcortical regions of the dominant hemisphere was directly correlated with the number of correctly performed neuropsychologic tests. In conclusion, anterior cerebral hypoperfusion and selected neuropsychological dysfunctions characterized hypoxemic COPD patients and could herald frontal-type cognitive decline with the worsening of the hypoxemia.
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Although NIV can produce significant clinical improvement in COPD people, they often reject it or use it incorrectly, resulting in worse clinical outcomes and healthcare costs.
“Although NIV can produce a significant clinical improvement in COPD people, they often reject it or use it incorrectly, resulting in worse clinical outcomes and healthcare costs.”
From Promoting Acceptance and Adherence to Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. (2022) · cites this paper as [24]
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“Clinical experience suggests that patients with cognitive deficits [12, 28, 29] or psychological problems, such as anxiety and depression, are less likely to accept and comply with NIV regimes; however, there has been little research on this.”
Background
- Authors
- Antonelli Incalzi, R., Marra, C., Giordano, A., Calcagni, M. L., Cappa, A., Basso, S., Pagliari, G., & Fuso, L.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Fuso, Leonello
- Venue
- Journal of Neurology
- Published
- 2003-03-01
- Volume
- 250
- Issue
- 3
- Pages
- 325-332
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W148117931
- Cited by
- 172
- References
- 34
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 14 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 9
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- chronic obstructive pulmonary disease, cognitive impairment, hypoxemia, Alzheimer's disease, cerebral perfusion, cerebral hypoperfusion, frontal lobe dysfunction, neuropsychological assessment, single photon emission computed tomography, attention, verbal memory
- MeSH terms
- Aged, Alzheimer Disease, Hypoxia, Brain, Cerebrovascular Circulation, Cognition, Female, Humans, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon, Pulmonary Disease, Chronic Obstructive
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