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The effect of age of onset of PD on risk of dementia
Abstract
Background Dementia occurs in the majority of patients with Parkinson's disease (PD). Late onset of PD has been reported to be associated with a higher risk for dementia. However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age. Methods Two community-based studies of PD in New York (n=281) and Rogaland county, Norway (n=227) and two population-based groups of healthy elderly from New York (n=180) and Odense, Denmark (n=2414) were followed prospectively for 3-4 years and assessed for dementia according to DSM-IIIR. All PD and control cases underwent neurological examination and were followed with neurological and neuropsychological assessments. We used Cox proportional hazards regression based on three different time scales to explore the effect of AAO of PD on risk of dementia, adjusting for age at baseline and other demographic and clinical variables. Findings In both PD groups and in the pooled analyses, there was a significant effect of age at baseline assessment on the time to develop dementia, but there was no effect of AAO independent of age itself. Consistent with these results, there was no increased relative effect of age on the time to develop dementia in PD cases compared with controls. Interpretation This study shows that it is the general effect of age, rather than AAO that is associated with incident dementia in subjects with PD.
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“Age itself rather than age at onset of PD has been associated with incident dementia in PD (Aarsland et al. 2007)”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Aarsland et al. 2007
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Metadata
- Authors
- Aarsland, D., Kvaløy, J. T., Andersen, K., Larsen, J. P., Tang, M. X., Lolk, A., Kragh-Sørensen, P., & Marder, K.
- Affiliations
- Stavanger University Hospital (NO)
- Odense University Hospital (DK)
- Columbia University (US)
- Corresponding author
- Aarsland, D.
- Venue
- Journal of Neurology
- Published
- 2007-01
- Volume
- 254
- Issue
- 1
- Pages
- 38-45
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2080300725
- Cited by
- 162
- References
- 49
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 10
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Funders
- National Institutes of Health (5r35ag010963-04)
- National Institute on Aging (P01AG007232, AG 07232, AG10963)
- National Center for Research Resources (RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Parkinson's disease, dementia, age of onset, dementia risk, age as confounder, incident dementia, Parkinson's disease dementia, neuropsychological assessment
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Female, Humans, Male, Neuropsychological Tests, Parkinson Disease, Risk, Time Factors, Cohort Studies, Proportional Hazards Models, Survival Analysis, Age of Onset
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