CoChat
Sign Up
Cited by 721Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchDeep Brain Stimulation and Movement Disorders

Risk of dementia in Parkinson’s disease: A community-based, prospective study

Aarsland, D., Andersen, K., Larsen, J.P., Lolk, A., Nielsen, H., Kragh–Sørensen, P.·2001·Neurology
DOI 10.1212/wnl.56.6.730
Open this paper in CoChat — free account

Abstract

Objective To calculate the incidence of and determine possible risk factors for dementia in PD. Background Dementia has important clinical consequences for patients with PD and their caregivers, but the incidence is unknown. Methods A population-based cohort of nondemented patients with PD (n = 171) from the county of Rogaland, Norway, was assessed at baseline and 4.2 years later with a comprehensive evaluation of motor, cognitive, and neuropsychiatric symptoms. The diagnosis of dementia was made according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised (DSM-III-R) criteria, based on interview of the patient and a caregiver, cognitive rating scales, and neuropsychologic tests. A representative sample of 3,062 nondemented elderly subjects without PD served as control group. Results Forty-three patients with PD were demented at follow-up evaluation, equivalent to an incidence rate of 95.3 per 1,000 person-years (95% CI, 68.2 to 122.0). The risk for the development of dementia in patients with PD relative to the control subjects after adjusting for age, sex, and education was 5.9 (95% CI, 3.9 to 9.1). Predictive factors at baseline for dementia in PD in addition to age were Hoehn & Yahr score >2 (OR, 3.4; 95% CI, 1.3 to 8.6) and Mini-Mental State Examination score Conclusions Patients with PD have an almost sixfold increased risk for becoming demented compared with subjects without PD.

Integrity signals

Registry

Crossref · 10.1212/wnl.56.6.730

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Patients with Parkinson's disease have an elevated risk of dementia.

    “Patients with Parkinson’s disease have an elevated risk of dementia;44 anticholinergic antiparkinson drugs have previously been associated with greater cognitive decline.45”

    From Anticholinergic drugs and risk of dementia: case-control study (2018) · cites this paper as [44]

Cites

Flagged first, then by citations

Research works printed but not linked: 32

  1. 10.1001/archneur.1997.00550150024011 · DOI
  2. 10.1212/WNL.54.8.1596 · DOI
  3. 10.1001/archneur.1995.00540310069018 · DOI
  4. Jellinger K. Neuropathological correlates of mental dysfunction in Parkinson’s disease: an update. In: Wolters EC Scheltens P Berendse HW eds. Mental dysfunction in parkinson’s disease II. Current issues in neurodegenerative diseases volume 11. Utrecht: Academic Pharmaceutical Productions 1999:82–105.
  5. 10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z · DOI
  6. 10.1002/mds.870100503 · DOI
  7. Larsen JP, Dupont E, Tandberg E. The clinical diagnosis of Parkinson’s disease: proposal of diagnostic subgroups classified at different levels of confidence. Acta Neurol Scand . 1994; 84: 242–251.
  8. 10.1016/0167-4943(82)90031-0 · DOI
  9. 10.1001/archneur.1996.00550060082020 · DOI
  10. 10.1001/archneur.1978.00500300038006 · DOI
  11. Spreen O Strauss E. A compendium of neuropsychological tests. New York: Oxford University Press 1991: 39–41.
  12. Andersen K, Lolk A, Nielsen H, et al. Prevalence of very mild to severe dementia in Denmark. Acta Neurol Scand . 1997; 96: 82–87.
  13. 10.1192/bjp.149.6.698 · DOI · Paper page
  14. 10.1212/WNL.34.7.939 · DOI · Paper page
  15. 10.1136/jnnp.64.2.178 · DOI
  16. 10.1212/WNL.43.9.1690 · DOI
  17. Portin R, Rinne UK. Predictive factors for cognitive deterioration and dementia in Parkinson’s disease. Adv Neurol . 1986; 45: 413–416.
  18. Read N, Dunn E, Mindham R, et al. A comparison of dementia and survival outcome between tremor dominant and bradykinetic-rigid Parkinson’s disease on extended follow-up. Parkinsonism Rel Dis . 1999; 5 (suppl 2): 32.
  19. 10.1212/WNL.40.8.1222 · DOI
  20. 10.1136/jnnp.57.10.1203 · DOI
  21. 10.1136/jnnp.58.1.51 · DOI
  22. 10.1136/jnnp.55.5.377 · DOI
  23. 10.1001/archneur.55.5.674 · DOI
  24. Piccirilli M, D’Alessandro P, Finali G, et al. Early frontal impairment as a predictor of dementia in Parkinson’s disease. Neurology . 1997; 48: 546–547.
  25. 10.1212/WNL.45.9.1691 · DOI
  26. 10.1001/archneur.1997.00550140025008 · DOI
  27. 10.1097/00002093-199307020-00002 · DOI
  28. 10.1001/archneur.1993.00540020018011 · DOI
  29. 10.1007/s004010050843 · DOI
  30. 10.1212/WNL.54.10.1916 · DOI
  31. 10.1001/archneur.55.7.969 · DOI
  32. 10.1212/WNL.47.5.1113 · DOI · Paper page

Cited by

Sorted by citations

Authors
Aarsland, D., Andersen, K., Larsen, J. P., Lolk, A., Nielsen, H., & Kragh–Sørensen, P.
Affiliations
  • Odense University Hospital (DK)
  • From the Section of Geriatric Psychiatry (Dr. Aarsland), Rogaland Psychiatric Hospital, and the Department of Neurology (Dr. Larsen), Central Hospital of Rogaland, Stavanger, Norway; and the Departments of Psychiatry (Drs. Andersen, Lolk, and Kragh-Sørensen) and Neurology (Dr. Nielsen), Odense University Hospital, Odense, Denmark.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-03-27
Volume
56
Issue
6
Pages
730-736
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.56.6.730
OpenAlex
W1989070599
Cited by
721
References
4
Citations by year
2026: 15 · 2025: 35 · 2024: 31 · 2023: 27 · 2022: 22 · 2021: 25 · 2020: 20 · 2019: 20 · 2018: 32 · 2017: 23 · 2016: 20 · 2015: 42 · 2014: 34 · 2013: 43 · 2012: 36
FWCI
14.57
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, dementia, dementia incidence, risk factors, Mini-Mental State Examination, cognitive impairment, neuropsychiatric symptoms
MeSH terms
Aged, Dementia, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Norway, Parkinson Disease, Prospective Studies, Random Allocation, Risk

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review