Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson's disease
Abstract
Neuropsychiatric symptoms (NPS) of Parkinson's disease (PD) are of growing diagnostic and therapeutic importance. Data on their prevalence and characteristics have been primarily derived from highly selective clinical populations. We have conducted a national study in the outpatient care sector to provide a fuller characterization of the frequency of dementia, depression, and other NPS in PD outpatients. We also examined associations with biosocial and neurological variables. A nationwide representative sample of 1,449 PD outpatients was examined with a standardized clinical interview. PD severity was rated with the Hoehn and Yahr (HY) scale and the Unified Parkinson's Disease Rating Scale. Depression was measured with the Montgomery-Asberg Depression Rating Scale. Cognitive impairment and dementia were assessed with the Mini-Mental State Exam and according to diagnostic criteria. Logistic regression analyses were used to investigate associations. At least one NPS occurred in 71% of all patients with PD. The estimated prevalences (ranges) by age group and HY-stage were: depression, 25% (13.2-47.9%), dementia, 29% (12.2-59.4%), and psychotic syndromes, 12.7% (3.1-40.9%). Other frequent complications were sleep disturbances (49%) and anxiety (20%). Depression was associated with gender but not with age. Dementia was associated with age. The rates and comorbidity of depression and dementia were driven by PD severity. NPS were highly prevalent in our comprehensive patient sample,…
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Over two-thirds of Parkinson's disease (PD) patients experience comorbid neuropsychiatric symptoms.
“Over two-thirds of Parkinson's disease (PD) patients experience comorbid neuropsychiatric symptoms”
From Remote delivery of psychological interventions for Parkinson's disease. (2018) · cites this paper as Riedel et al., 2010
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- Authors
- Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., Heuser, I., Oertel, W., Reichmann, H., Riederer, P., Trenkwalder, C., Dodel, R., & Wittchen, H.-U.
- Affiliations
- Technische Universität Dresden (DE)
- University of Bonn (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Technical University of Munich (DE)
- Brookhaven National Laboratory (US)
- Charité – Universitätsmedizin Berlin (DE)
- Philipps University of Marburg (DE)
- University Hospital Carl Gustav Carus (DE)
- University of Würzburg (DE)
- Paracelsus Elena Klinik Kassel (DE)
- ORCID
- Venue
- Journal of Neurology
- Published
- 2010-02-06
- Volume
- 257
- Issue
- 7
- Pages
- 1073-1082
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W1999630261
- Cited by
- 256
- References
- 41
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 48 · 2019: 9 · 2018: 14 · 2017: 19 · 2016: 15 · 2015: 12 · 2014: 22 · 2013: 19 · 2012: 11
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, neuropsychiatric symptoms, dementia, depression, psychosis, sleep disorders, anxiety, disease severity, prevalence, Hoehn and Yahr stage, outpatients, comorbidities
- MeSH terms
- Aged, Mental Disorders, Dementia, Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Outpatients, Parkinson Disease, Comorbidity, Prevalence, Age Distribution, Disease Progression
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