Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis
Abstract
The purpose of this meta-analysis was to investigate the association between progranulin polymorphism rs5848 and risk of the neurodegenerative diseases frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Published literature from PubMed and other databases were retrieved, and 16 case-control studies were identified as eligible: 5 on FTLD (1,439 cases, 4,461 controls), 5 on AD (2,502 cases, 2,162 controls), 3 on PD (1,605 cases, 1,591 controls), and 3 on ALS (663 cases, 811 controls). The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. We found that rs5848 was associated with an increased risk of neurodegenerative diseases in the homozygous (TT vs. CC: OR, 1.24; 95% CI, 1.10-1.39; P < 0.001) and recessive models (TT vs. CC + CT: OR, 1.23; 95% CI, 1.10-1.37; P < 0.001). Stratified analyses showed associations of rs5848 with increased risk of AD and PD in the homozygous and recessive models. Our data indicate that rs5848 is associated with risk of AD and PD, suggesting important roles of progranulin in neurodegenerative processes.
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Progranulin polymorphism is linked to higher PD risk.
“Progranulin polymorphism is associated with increased PD risk but the mechanism is not clear143.”
From Microglia in neurodegeneration (2018) · cites this paper as [143]
Progranulin polymorphism is also associated with late-onset AD.
“Progranulin polymorphism is also linked to late-onset AD143.”
From Microglia in neurodegeneration (2018) · cites this paper as [143]
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Microglia in neurodegeneration
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- Authors
- Chen, Y., Li, S., Su, L., Sheng, J., Lv, W., Chen, G., & Xu, Z.
- Affiliations
- Zhejiang University (CN)
- Sir Run Run Shaw Hospital (CN)
- Corresponding author
- Chen, Guangdi
- Xu, Zhengping
- Venue
- Journal of Neurology
- Published
- 2015-01-13
- Volume
- 262
- Issue
- 4
- Pages
- 814-822
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2062305803
- Cited by
- 50
- References
- 39
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 4
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- progranulin, genetic polymorphism, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, genetic risk
- MeSH terms
- Progranulins, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Humans, Parkinson Disease, Polymorphism, Single Nucleotide, Intercellular Signaling Peptides and Proteins, Frontotemporal Lobar Degeneration
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