Cited by 50Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis

Chen, Yongdui, Li, Siqi, Su, Liling, Sheng, Jinghao, Lv, Wen, Chen, Guangdi, Xu, Zhengping·2015·Journal of Neurology

Abstract

The purpose of this meta-analysis was to investigate the association between progranulin polymorphism rs5848 and risk of the neurodegenerative diseases frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Published literature from PubMed and other databases were retrieved, and 16 case-control studies were identified as eligible: 5 on FTLD (1,439 cases, 4,461 controls), 5 on AD (2,502 cases, 2,162 controls), 3 on PD (1,605 cases, 1,591 controls), and 3 on ALS (663 cases, 811 controls). The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. We found that rs5848 was associated with an increased risk of neurodegenerative diseases in the homozygous (TT vs. CC: OR, 1.24; 95% CI, 1.10-1.39; P < 0.001) and recessive models (TT vs. CC + CT: OR, 1.23; 95% CI, 1.10-1.37; P < 0.001). Stratified analyses showed associations of rs5848 with increased risk of AD and PD in the homozygous and recessive models. Our data indicate that rs5848 is associated with risk of AD and PD, suggesting important roles of progranulin in neurodegenerative processes.

Integrity signals

Registry

Crossref · 10.1007/s00415-014-7630-2

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Progranulin polymorphism is linked to higher PD risk.

    “Progranulin polymorphism is associated with increased PD risk but the mechanism is not clear143.”

    From Microglia in neurodegeneration (2018) · cites this paper as [143]

  • Progranulin polymorphism is also associated with late-onset AD.

    “Progranulin polymorphism is also linked to late-onset AD143.”

    From Microglia in neurodegeneration (2018) · cites this paper as [143]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chen, Y., Li, S., Su, L., Sheng, J., Lv, W., Chen, G., & Xu, Z.
Affiliations
  • Zhejiang University (CN)
  • Sir Run Run Shaw Hospital (CN)
Corresponding author
  • Chen, Guangdi
  • Xu, Zhengping
Venue
Journal of Neurology
Published
2015-01-13
Volume
262
Issue
4
Pages
814-822
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
OpenAlex
W2062305803
Cited by
50
References
39
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 4
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
progranulin, genetic polymorphism, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, genetic risk
MeSH terms
Progranulins, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Humans, Parkinson Disease, Polymorphism, Single Nucleotide, Intercellular Signaling Peptides and Proteins, Frontotemporal Lobar Degeneration

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review