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Cited by 233Amyotrophic Lateral Sclerosis ResearchAmyloidosis: Diagnosis, Treatment, OutcomesHereditary Neurological Disorders

Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

Wang, Ming-Dong, Little, Julian, Gomes, James, Cashman, Neil R., Krewski, Daniel·2017·NeuroToxicology
DOI 10.1016/j.neuro.2016.06.015
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Abstract

Although amyotrophic lateral sclerosis (ALS) was identified as a neurological condition 150 years ago, risk factors related to the onset and progression of ALS remain largely unknown. Monogenic mutations in over 30 genes are associated with about 10% of ALS cases. The age at onset of ALS and disease types has been found to influence ALS progression. The present study was designed to identify additional putative risk factors associated with the onset and progression of ALS using systematic review and meta-analysis of observational studies. Risk factors that may be associated with ALS include: 1) genetic mutations, including the intermediate CAG repeat expansion in ATXN2; 2) previous exposure to heavy metals such as lead and mercury; 3) previous exposure to organic chemicals, such as pesticides and solvents; 4) history of electric shock; 5) history of physical trauma/injury (including head trauma/injury); 6) smoking (a weak risk factor for ALS in women); and 6) other risk factors, such as participating in professional sports, lower body mass index, lower educational attainment, or occupations requiring repetitive/strenuous work, military service, exposure to Beta-N-methylamino-l-alanin and viral infections. Risk factors that may be associated with ALS progression rate include: 1) nutritional status, including vitamin D deficiency; 2) comorbidities; 3) ethnicity and genetic factors; 4) lack of supportive care; and 4) smoking. The extent to which these associations may be causal is discussed, with further research recommended to strengthen the evidence on which determinations of causality may be based.

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Research works printed but not linked: 2

  1. Berg, 2011, Smoking, alcohol consumption and the risk of amyotrophic lateral sclerosis: a population-based study, Neurology, 76, A115
  2. Wang, 2008, Prospective studies on smoking and risk off amyotrophic lateral sclerosis, Neurology, 70, A190

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Authors
Wang, M.-D., Little, J., Gomes, J., Cashman, N. R., & Krewski, D.
Affiliations
  • University of Ottawa (CA)
  • University of British Columbia (CA)
ORCID
Venue
NeuroToxicology
Publisher
Elsevier BV
Published
2017-07
Volume
61
Pages
101-130
ISSN
0161-813X (ISSN-L)
DOI
10.1016/j.neuro.2016.06.015
OpenAlex
W2474295863
Semantic Scholar
0e430eadc608f581e1ad6228c57d93f444885b97
Cited by
233
References
326
Citations by year
2026: 19 · 2025: 24 · 2024: 22 · 2023: 36 · 2022: 28 · 2021: 31 · 2020: 25 · 2019: 17 · 2018: 14 · 2017: 12 · 2016: 4
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroToxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Public Health Agency of Canada
Topics
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords
amyotrophic lateral sclerosis, risk factors, disease onset, disease progression, CAG repeat expansion, ATN2, heavy metal exposure, lead, mercury, pesticide exposure, solvents, electric shock, head trauma, smoking, sports participation, body mass index, educational attainment, occupational exposure, BMAA, vitamin D deficiency, comorbidities, ethnicity, military service, supportive care
MeSH terms
Amyotrophic Lateral Sclerosis, Environmental Exposure, Humans, Mutation, Nerve Tissue Proteins, Nutritional Status, Pesticides, Risk Factors, Vitamin D Deficiency, Databases, Bibliographic, Age of Onset, Disease Progression

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