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Cited by 80Vestibular and auditory disordersSpaceflight effects on biologyMultisensory perception and integration

Vestibular animal models: contributions to understanding physiology and disease

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Straka, Hans, Zwergal, Andreas, Cullen, Kathleen E.·2016·Journal of Neurology
DOI 10.1007/s00415-015-7909-yPMC PMC4833800
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Abstract

Our knowledge of the vestibular sensory system, its functional significance for gaze and posture stabilization, and its capability to ensure accurate spatial orientation perception and spatial navigation has greatly benefitted from experimental approaches using a variety of vertebrate species. This review summarizes the attempts to establish the roles of semicircular canal and otolith endorgans in these functions followed by an overview of the most relevant fields of vestibular research including major findings that have advanced our understanding of how this system exerts its influence on reflexive and cognitive challenges encountered during daily life. In particular, we highlight the contributions of different animal models and the advantage of using a comparative research approach. Cross-species comparisons have established that the morpho-physiological properties underlying vestibular signal processing are evolutionarily inherent, thereby disclosing general principles. Based on the documented success of this approach, we suggest that future research employing a balanced spectrum of standard animal models such as fish/frog, mouse and primate will optimize our progress in understanding vestibular processing in health and disease. Moreover, we propose that this should be further supplemented by research employing more "exotic" species that offer unique experimental access and/or have specific vestibular adaptations due to unusual locomotor capabilities or lifestyles. Taken together this strategy will expedite our understanding of the basic principles underlying vestibular computations to reveal relevant translational aspects. Accordingly, studies employing animal models are indispensible and even mandatory for the development of new treatments, medication and technical aids (implants) for patients with vestibular pathologies.

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  • The vestibular system provides a "sense of position" encoded in egocentric frames of reference anchored to the invariant direction of the gravity field and provides the sensory basis for inertial navigation.

    “the vestibular system, that provides a “sense of position” encoded in egocentric frames of reference anchored to the invariant direction of the gravity field and that also provide the sensory basis for inertial navigation”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [116]

    The Principles of mechanotransduction section says otolith organs detect changes in body position relative to gravity, and the Introduction identifies vestibular sensing as important for orientation and navigation. Higher level processing and perception links vestibular self-motion information to spatial navigation. Our copy does not establish the more specific claim that position is encoded in egocentric frames anchored to gravity or that the system provides the sensory basis for inertial navigation; no page numbers were supplied. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Some sensory systems and neural networks involved in egocentric navigation in teleost fish are shared with other vertebrates and seem to correspond to an ancestral design well-conserved in different vertebrate radiations.

    “Some of these systems are shared with other vertebrates and seem to correspond to an ancestral design well-conserved in the different vertebrate radiations.”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [116]

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Cited by

Sorted by citations

Authors
Straka, H., Zwergal, A., & Cullen, K. E.
Affiliations
  • Deutsches Schwindel- und Gleichgewichtszentrum (DE)
  • McGill University (CA)
Corresponding author
Straka, Hans
ORCID
Venue
Journal of Neurology
Publisher
Springer Science and Business Media LLC
Published
2016-04
Volume
263
Issue
S1
Pages
10-23
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
DOI
10.1007/s00415-015-7909-y
PMC
PMC4833800
OpenAlex
W2338703472
Cited by
80
References
4
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 14 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 1
FWCI
0.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neurology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • German Federal Ministry of Education and Research (01 EO 0901)
  • Institute of Neurosciences, Mental Health and Addiction
  • Office of Extramural Research, National Institutes of Health (DC002390)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
vestibular system, animal models, semicircular canals, otolith organs, vestibular signal processing, gaze stabilization, postural control, spatial orientation, spatial navigation, comparative physiology, vestibular disorders, vestibular implant, mouse model, nonhuman primate model, introduced species
MeSH terms
Animals, Disease Models, Animal, Humans, Motion Perception, Posture, Reflex, Vestibulo-Ocular, Vestibule, Labyrinth, Vestibular Diseases, Mechanotransduction, Cellular

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