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Cited by 634Vestibular and auditory disordersMultisensory perception and integrationMotor Control and Adaptation

The vestibular system: multimodal integration and encoding of self-motion for motor control

Open access
Cullen, Kathleen E.·2012·Trends in Neurosciences
DOI 10.1016/j.tins.2011.12.001PMC PMC4000483
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Abstract

Understanding how sensory pathways transmit information under natural conditions remains a major goal in neuroscience. The vestibular system plays a vital role in everyday life, contributing to a wide range of functions from reflexes to the highest levels of voluntary behavior. Recent experiments establishing that vestibular (self-motion) processing is inherently multimodal also provide insight into a set of interrelated questions. What neural code is used to represent sensory information in vestibular pathways? How do the interactions between the organism and the environment shape encoding? How is self-motion information processing adjusted to meet the needs of specific tasks? This review highlights progress that has recently been made towards understanding how the brain encodes and processes self-motion to ensure accurate motor control.

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Crossref · 10.1016/j.tins.2011.12.001

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  • Any discrepancy between expected and reafferent signals represents a sensory conflict that potentially could be provocative.

    “Any discrepancy between the expected and reafferent signals represents a sensory conflict that potentially could be provocative (Brooks and Cullen 2009, 2013; Cullen 2012; Cullen et al. 2009; Saab and Willis 2001; Serra et al. 1998).”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Cullen 2012

    In “Balance and the computation of self-motion” (page unavailable), the paper says vestibular reafference is selectively suppressed when neck-proprioceptor activation matches the motor-generated expectation. This supports a distinction between expected and mismatched feedback, but the paper does not say that a discrepancy is a potentially provocative sensory conflict. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Both the hippocampus and vestibular cortex might play a role in forming the internal model.

    “Both the hippocampus and vestibular cortex might play a role in forming internal model.”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [8]

    The Summary section on navigation says the hippocampal formation combines vestibular and other information to encode self-motion. The motor-behavior section discusses an internal model of active head motion, but places its proposed effect at the vestibular nuclei; the copy does not say that either the hippocampus or vestibular cortex helps form that model. Page numbers are unavailable in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Brain regions involved in space orientation and motion perception, including the hippocampus and vestibular cortex, are areas where the internal model is stored.

    “Several lines of evidence suggest that brain regions involved in space orientation and motion perception (hippocampus and vestibular cortex) are areas where internal model stores [7,8].”

    From Motion Sickness: Current Knowledge and Recent Advance. (2016) · cites this paper as [8]

    The navigation section says hippocampal head-direction cells combine vestibular and other information to estimate heading direction. The section on active head movement discusses an internal model used to suppress sensory responses at the vestibular nuclei, but does not say that the model is stored in the hippocampus or vestibular cortex. Page numbers were not available in our copy. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Recent work by Cullen and colleagues has shown an important relationship between corollary discharge signals and reafferent signals associated with the resulting movement of the head or body.

    “Recent work by Cullen and colleagues on the cerebellar and vestibular mechanisms related to the control and appreciation of head and body movements has shown the important relationship between corollary discharge signals and reafferent signals associated with the resulting movement of the head or body.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Cullen 2012

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Authors
Cullen, K. E.
Affiliations
McGill University (CA)
Corresponding author
Cullen, Kathleen E.
ORCID
Cullen, Kathleen E.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2012-03
Volume
35
Issue
3
Pages
185-196
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2011.12.001
PMC
PMC4000483
OpenAlex
W2041756956
Cited by
630
References
116
Citations by year
2026: 45 · 2025: 60 · 2024: 46 · 2023: 54 · 2022: 53 · 2021: 50 · 2020: 55 · 2019: 54 · 2018: 39 · 2017: 49 · 2016: 43 · 2015: 34 · 2014: 25 · 2013: 19 · 2012: 4
FWCI
2.44
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Canadian Institutes of Health Research
  • National Institute on Deafness and Other Communication Disorders (DC-002390, R01DC002390)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
vestibular system, self-motion perception, multimodal integration, neural coding, vestibular pathways, motor control, sensory integration, vestibular processing
MeSH terms
Animals, Postural Balance, Fixation, Ocular, Humans, Motion, Motion Perception, Movement, Neural Pathways, Neurons, Orientation, Proprioception, Reflex, Vestibulo-Ocular, Vestibule, Labyrinth, Vestibular Nuclei, Vision, Ocular, Linear Models, Head Movements

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