Cited by 129Mesenchymal stem cell researchStroke Rehabilitation and RecoveryAcute Ischemic Stroke Management

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Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential

Li, Junsheng, Zhang, Qian, Wang, Wen, Lin, Fa, Wang, Shuo, Zhao, Jizong·2021·Journal of Neurology

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Abstract

Stroke, a global disease with a high disability rate, has limited options for functional rehabilitation and results in an adverse impact on patients' lives. In recent years, mesenchymal stem cells (MSCs) have become a new focus of treatment owing to their potential for neuroregeneration. MSCs have demonstrated therapeutic efficacy capable of cell migration, angiogenesis, immunomodulation, neuroprotection and neural circuit reconstruction. The paracrine action of MSCs can also exert neurotrophic effects and improve the functional recovery. This review shows the transplantation protocol for MSCs, discusses the potential therapeutic mechanisms, and summarizes clinical trials on MSCs for treating ischemic stroke. The current proofs show that MSC therapy for ischemic stroke is safe and feasible. The timing and optimal dose of MSC administration are the main challenges in its clinical use. Although still under research, MSC therapy has the potential to be a new therapeutic approach for neurological recovery from ischemic stroke in the future.

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Authors: Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J.
Affiliations: Capital Medical University (CN)
Corresponding author: Zhao, Jizong
ORCID: Li, Junsheng
Zhang, Qian
Wang, Wen
Lin, Fa
Wang, Shuo
Zhao, Jizong
Venue: Journal of Neurology
Publisher: Springer Science and Business Media LLC
Published: 2020-08-06
Volume: 268
Issue: 11
Pages: 4095-4107
ISSN: 0012-1037 (ISSN-L)
0340-5354
1432-1459
DOI: 10.1007/s00415-020-10138-5
OpenAlex: W3047476089
Cited by: 128
References: 171
Citations by year: 2026: 12 · 2025: 18 · 2024: 32 · 2023: 31 · 2022: 15 · 2021: 17 · 2020: 3
FWCI: 2.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: mesenchymal stem cells, ischemic stroke, cell transplantation, nerve regeneration, angiogenesis, immunomodulation, neuroprotection, paracrine signaling, neurotrophic factors, functional recovery, timing of transplantation, clinical trials
MeSH terms: Ischemic Stroke, Brain Ischemia, Humans, Stroke, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential

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