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Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential
Abstract
Stroke, a global disease with a high disability rate, has limited options for functional rehabilitation and results in an adverse impact on patients' lives. In recent years, mesenchymal stem cells (MSCs) have become a new focus of treatment owing to their potential for neuroregeneration. MSCs have demonstrated therapeutic efficacy capable of cell migration, angiogenesis, immunomodulation, neuroprotection and neural circuit reconstruction. The paracrine action of MSCs can also exert neurotrophic effects and improve the functional recovery. This review shows the transplantation protocol for MSCs, discusses the potential therapeutic mechanisms, and summarizes clinical trials on MSCs for treating ischemic stroke. The current proofs show that MSC therapy for ischemic stroke is safe and feasible. The timing and optimal dose of MSC administration are the main challenges in its clinical use. Although still under research, MSC therapy has the potential to be a new therapeutic approach for neurological recovery from ischemic stroke in the future.
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“A growing body of research has illuminated the therapeutic potential of EVs derived from a diverse array of cell types [207, 208]. This includes MSCs [209–211], iPSCs [212], brain-derived NSCs [213], embryonic stem cells (ESCs) [214], and dendritic cells (DC) [215].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [210]
Citations
Cites
1 retracted
Hou, K., Li, G., Zhao, J., Xu, B., Zhang, Y., Yu, J., & Xu, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1725-8 · Cited by 93
Self-citationRetractedDominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., Pell, C. L., Johnstone, B. H., Considine, R. V., & March, K. L. (2004) · Circulation · doi:10.1161/01.cir.0000121425.42966.f1 · Cited by 2,269
Self-citationHorwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,071
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,503
Research works printed but not linked: 1
- Song M, Mohamad O, Gu X, Wei L, Yu SP (2013) Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice. Cell Transplant 22(11):2001–2015. https://doi.org/10.3727/096368912x657909 · DOI
Cited by
Sorted by citations
Items 101–129 of 129
Tang, X., Zheng, N., Gong, Z., You, Y., Lin, Q., Zhuang, Y., Wu, J., Wang, Y., Huang, H., Chen, F., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3552856/v1
Mesenchymal Stem Cell Therapy for Ischemic Stroke in Animal Model: A Systematic Review
Aulia, M. A., Lestari, K., Faried, A., Sartika, C. R., Wijaya, A., Adam, A., Gunawan, H., Haifa, R., Naura, N. F. F., & Pongajow, B. Y. C. (2023) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v15i6.2460
(2023) · Research Square · doi:10.21203/rs.3.rs-3552856/v2
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons
Zhao, E., Wang, D., Jing, L., Zhao, Z., Huang, S., Xie, L., Hu, S., Liang, H., & Chen, Y. (2023) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2024.2303014
Primak, A. L., Никитична, С. М., Станиславович, Д. С., Va, T., & Karagyaur, M. N. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202412403283
Neurological diseases and pathophysiology
Sonkaya, R., & Malikov, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00017-2
Gubskiy, I. L., Namestnikova, D. D., Cherkashova, E. A., Gumin, I. S., Kurilo, V. V., Chekhonin, V. P., & Yarygin, K. N. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-025-06366-2
Cell Therapy for Cerebral Stroke
Liem, N. T., & Nguyen, Q. T. (2025) · Springer eBooks · doi:10.1007/978-981-96-1261-1_12
Konovalov, S. V., Мороз, В. М., Yoltukhovskii, M. V., Stelmashchuk, A., Deryabina, О. G., & Арнольдович, К. В. (2023) · Neurophysiology · doi:10.1007/s11062-025-09952-2
Konovalov, S. V. (2024) · Bulletin Of Medical And Biological Research · doi:10.63341/bmbr/4.2024.08
Nsumbu, D., Rolland, T. J., Tajlil, A., Ahmed, D., Young, R. F., Palka, B., & Weil, B. R. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110744
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22607404
Yabuno, S., Yasuhara, T., Nagase, T., Kawauchi, S., Sugahara, C., Okazaki, Y., Hosomoto, K., Sasada, S., Sasaki, T., Tajiri, N., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26563663
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22607398
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22607392
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22607395
Huang, H., Zhang, J., Lin, J., & Shi, S. (2024) · Figshare · doi:10.6084/m9.figshare.26673978
Tang, H., Zhang, X., Hao, X., Dou, H., Zou, C., Zhou, Y., Li, B., Yue, H., Wang, D., Wang, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22607401
Review of Selected Contemporary Treatments for Ischemic Stroke
Conteh, G. K. (2021) · Scholarly Research In Progress · doi:10.64057/001c.142548
Zeng, H., Yu, X., Zheng, Z., WANG, Z., Dong, W., & Gan, J. (2026) · Scientific Reports · doi:10.1038/s41598-026-40104-6
Wei, L., Ren, H., Lin, Y., Sun, J., Nie, S., Gao, X., & Huang, Y. (2026) · Cell & Bioscience · doi:10.1186/s13578-026-01551-w
Huang, T. (n.d.) · Institutional Repositories DataBase (IRDB) · doi:10.15083/0002011542
Yuge, L., Nakagawa, K., Tanaka, E., & Kawahara, Y. (2026) · Stem Cells and Development · doi:10.1177/15473287261436291
Wang, Y.-X., Zhao, Y.-B., Zhang, Z.-Y., Liu, T. F., Yang, Z.-A., Liu, H.-Y., & Li, Y. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111061
Takamiya, S., Morii, Y., Osanai, T., Ohashi, K., Ogasawara, K., Houkin, K., & Fujimura, M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0349756
Biomaterial platforms for enhanced stem cell therapy in ischemic stroke
Sun, Z., Zhao, J., Li, J., Ma, X., Wang, Z., Wang, Y., Li, Y., Bai, Y., Wei, D., & Jiang, W. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124427
Self-citationPathological mechanisms and interventions during the recovery phase of ischemic stroke
Zhu, L.-H., Wang, S.-R., Zhong, C.-J., Huang, Z., & Liu, J.-Y. (2026) · Discover Medicine · doi:10.1007/s44337-026-00671-z
Self-citationPost-stroke spasticity: advances in network mechanisms and therapeutics
Yao, W., Yuanbin, Y. A. N. G., Wang, Z., Yi, L., Daneva, D., Fang, Z., Gan, K., & Lin, Z. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1868901
Metadata
- Authors
- Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J.
- Affiliations
- Capital Medical University (CN)
- Corresponding author
- Zhao, Jizong
- Venue
- Journal of Neurology
- Published
- 2020-08-06
- Volume
- 268
- Issue
- 11
- Pages
- 4095-4107
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W3047476089
- Cited by
- 128
- References
- 171
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 32 · 2023: 31 · 2022: 15 · 2021: 17 · 2020: 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- mesenchymal stem cells, ischemic stroke, cell transplantation, nerve regeneration, angiogenesis, immunomodulation, neuroprotection, paracrine signaling, neurotrophic factors, functional recovery, timing of transplantation, clinical trials
- MeSH terms
- Ischemic Stroke, Brain Ischemia, Humans, Stroke, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells
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