The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front
Open accessAbstract
Reduction of epithelial cell-cell adhesion via the transcriptional repression of cadherins in combination with the acquisition of mesenchymal properties are key determinants of epithelial-mesenchymal transition (EMT). EMT is associated with early stages of carcinogenesis, cancer invasion and recurrence. Furthermore, the tumor stroma dictates EMT through intensive bidirectional communication. The pathological analysis of EMT signatures is critically, especially to determine the presence of cancer cells at the resection margins of a tumor. When diffusion barriers disappear, EMT markers may be detected in sera from cancer patients. The detection of EMT signatures is not only important for diagnosis but can also be exploited to enhance classical chemotherapy treatments. In conclusion, further detailed understanding of the contextual cues and molecular mediators that control EMT will be required in order to develop diagnostic tools and small molecule inhibitors with potential clinical implications.
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Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121
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The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
Direct regulation of TWIST by HIF-1α promotes metastasis
Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345
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“We previously demonstrated that tenascin C and SF/HGF produced by myoWbroblasts provide convergent pro-invasive signaling to colon cancer cells (De Wever et al. 2004; Denys et al. 2008).”
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Cited by
Stromal myofibroblasts are drivers of invasive cancer growth
De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722
Self-citationKaragiannis, G. S., Poutahidis, T., Erdman, S. E., Kirsch, R., Riddell, R. H., & Diamandis, E. P. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0307 · Cited by 507
Activation of fibroblasts in cancer stroma
Räsänen, K., & Vaheri, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.032 · Cited by 499
Martin, F. T., Dwyer, R. M., Kelly, J., Khan, S., Murphy, J. M., Curran, C., Miller, N., Hennessy, E., Dockery, P., Barry, F. P., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0734-1 · Cited by 290
Vaquero, J., Guedj, N., Clapéron, A., Nguyen Ho-Bouldoires, T. H., Paradis, V., & Fouassier, L. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.09.010 · Cited by 154
Metadata
- Authors
- De Wever, O., Pauwels, P., De Craene, B., Sabbah, M., Emami, S., Redeuilh, G., Gespach, C., Bracke, M., & Berx, G.
- Venue
- Histochemistry and Cell Biology
- Published
- 2008-07-22
- Volume
- 130
- Issue
- 3
- Pages
- 481-94
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W2117962623
- Cited by
- 229
- References
- 7
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- De Wever, O., Pauwels, P., De Craene, B., Sabbah, M., Emami, S., Redeuilh, G., Gespach, C., Bracke, M., & Berx, G. (2008). Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-008-0464-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
