Stromal myofibroblasts are drivers of invasive cancer growth

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works

Understanding Adipocyte Differentiation

Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,358 · see citing works

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works

Endothelial/Pericyte Interactions

Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048 · see citing works

Formation and function of the myofibroblast during tissue repair

Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658 · see citing works

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 3× · see citing works

Randomized Trial of Laparoscopic-Assisted Resection of Colorectal Carcinoma: 3-Year Results of the UK MRC CLASICC Trial Group

Jayne, D. G., Guillou, P. J., Thorpe, H. C., Quirke, P., Copeland, J., Smith, A., Heath, R. M., & Brown, J. M. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.7758 · Cited by 1,500 · see citing works

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works

Pathological features of rectal cancer after preoperative radiochemotherapy

Dworak, O., Keilholz, L., & Hoffmann, A. (1997) · International Journal of Colorectal Disease · doi:10.1007/s003840050072 · Cited by 1,346 · see citing works

Molecular characterization of the tumor microenvironment in breast cancer

Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299 · see citing works

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Radisky, D. C., Levy, D. D., Littlepage, L. E., Liu, H., Nelson, C. M., Fata, J. E., Leake, D., Godden, E. L., Albertson, D. G., Angela Nieto, M., et al. (2005) · Nature · doi:10.1038/nature03688 · Cited by 1,284 · see citing works

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

Basset, P., Bellocq, J., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M., Rio, M., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,125 · see citing works

Role of tissue stroma in cancer cell invasion

De Wever, O., & Mareel, M. (2003) · The Journal of Pathology · doi:10.1002/path.1398 · Cited by 1,042 · see citing works

Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents

Studeny, M., Marini, F. C., Dembinski, J. L., Zompetta, C., Cabreira-Hansen, M. D. G., Bekele, B. N., Champlin, R. E., & Andreeff, M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh299 · Cited by 841 · see citing works

The tumour microenvironment as a target for chemoprevention

Albini, A., & Sporn, M. B. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2067 · Cited by 823 · see citing works

Host cyclooxygenase-2 modulates carcinoma growth

Williams, C. S., Tsujii, M., Reese, J., Dey, S. K., & DuBois, R. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9621 · Cited by 672 · see citing works

THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure

Brown, R. D., Ambler, S. K., Mitchell, M. D., & Long, C. S. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095802 · Cited by 643 · see citing works

Smad3 as a mediator of the fibrotic response

Flanders, K. C. (2004) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2004.00377.x · Cited by 610 · see citing works

Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

Svegliati, S., Santillo, M., Bevilacqua, F., Luchetti, M. M., Spadoni, T., Mancini, M., Fraticelli, P., Sambo, P., Funaro, A., Kazlauskas, A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052955 · Cited by 581 · see citing works

Contraction of Granulation Tissue in vitro: Similarity to Smooth Muscle

Majno, G., Gabbiani, G., Hirschel, B. J., Ryan, G. B., & Statkov, P. R. (1971) · Science · doi:10.1126/science.173.3996.548 · Cited by 567 · see citing works

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

Desmoulière, A., Guyot, C., & Gabbiani, G. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041802ad · Cited by 551 · see citing works

Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts

Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530 · see citing works

Radiation and the microenvironment – tumorigenesis and therapy

Barcellos‐Hoff, M. H., Park, C., & Wright, E. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1735 · Cited by 513 · see citing works

Predicting Complications following Expander/Implant Breast Reconstruction: An Outcomes Analysis Based on Preoperative Clinical Risk

McCarthy, C. M., Mehrara, B. J., Riedel, E., Davidge, K. M., Hinson, A., Disa, J. J., Cordeiro, P. G., & Pusic, A. L. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31817151c4 · Cited by 474 · see citing works

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

Pietras, K., Pahler, J. C., Bergers, G., & Hanahan, D. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050019 · Cited by 452 · see citing works

Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma

Koukourakis, M. I., Giatromanolaki, A. N., Harris, A. L., & Sivridis, E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3260 · Cited by 440 · see citing works

Peritumoral Fibroblast SPARC Expression and Patient Outcome With Resectable Pancreatic Adenocarcinoma

Infante, J. R., Matsubayashi, H., Sato, N., Tonascia, J., Klein, A. P., Riall, T. S., Yeo, C. J., Iacobuzio–Donahue, C. A., & Goggins, M. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.8824 · Cited by 403 · see citing works

Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac

De Wever, O., Nguyen, Q., Van Hoorde, L., Bracke, M., Bruyneel, E., Gespach, C., & Mareel, M. (2004) · The FASEB Journal · doi:10.1096/fj.03-1110fje · Cited by 402 · cited 5× · see citing works

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

Ohuchida, K., Mizumoto, K., Murakami, M., Qian, L.-W., Sato, N., Nagai, E., Matsumoto, K., Nakamura, T., & Tanaka, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2464 · Cited by 385 · see citing works

Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis

Desmoulière, A., Darby, I. A., & Gabbiani, G. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000101911.53973.90 · Cited by 364 · see citing works

Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

辻野, 督., Seshimo, I., Yamamoto, H., Ngan, C. Y., Ezumi, K., Takemasa, I., Ikeda, M., Sekimoto, M., Matsuura∥, N., & Monden, M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2191 · Cited by 352 · see citing works

Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?

Radisky, D. C., Kenny, P. A., & Bissell, M. J. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21186 · Cited by 342 · see citing works

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

Yang, G., Rosen, D. G., Zhang, Z., Bast, R. C., Mills, G. B., Colacino, J. A., Mercado-Uribe, I., & Liu, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605752103 · Cited by 341 · see citing works

Inhibition of Fibrocyte Differentiation by Serum Amyloid P 1

Pilling, D., Buckley, C., Salmon, M., & Gomer, R. (2003) · Journal of Immunology · doi:10.4049/jimmunol.171.10.5537 · Cited by 331 · see citing works

Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis

Hill, R., Song, Y., Cardiff, R. D., & Van Dyke, T. (2005) · Cell · doi:10.1016/j.cell.2005.09.030 · Cited by 324 · see citing works

Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases

Patócs, A., Zhang, L., Xu, Y., Weber, F., Caldés, T., Mutter, G. L., Platzer, P., & Eng, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071825 · Cited by 297 · see citing works

VEGF‐null cells require PDGFR α signaling‐mediated stromal fibroblast recruitment for tumorigenesis

Dong, J., Grunstein, J., Tejada, M. L., Peale, F., Frantz, G. D., Liang, W., Bai, W., Yu, L., Kowalski, J., Liang, X., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600289 · Cited by 294 · see citing works

Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction

Ishii, G., Sangai, T., Oda, T., Aoyagi, Y., Hasebe, T., Kanomata, N., Endoh, Y., Okumura, C., Okuhara, Y., Magae, J., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01544-4 · Cited by 281 · see citing works

Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium

Ao, M., Franco, O. E., Park, D., Raman, D., Williams, K., & Hayward, S. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3946 · Cited by 276 · see citing works

Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

Lewis, M. P., Lygoe, K. A., Nystrom, M. L., Anderson, W., Speight, P. M., Marshall, J. F., & Thomas, G. J. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601611 · Cited by 261 · see citing works

Matrix metalloproteases in aberrant fibrotic tissue remodeling

Pardo, A., & Selman, M. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-012tk · Cited by 260 · see citing works

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells

Nazareth, M. R., Broderick, L., Simpson-Abelson, M. R., Kelleher, R. J., Yokota, S. J., & Bankert, R. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5552 · Cited by 259 · see citing works

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts

Amatangelo, M. D., Bassi, D. E., Klein-Szanto, A. J. P., & Cukierman, E. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62991-4 · Cited by 248 · see citing works

Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice

Czochra, P., Klopcic, B. R. S., Meyer, E., Herkel, J., Garcia-Lazaro, J. F., Thieringer, F. R., Schirmacher, P., Biesterfeld, S., Galle, P. R., Lohse, A. W., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.04.010 · Cited by 244 · see citing works

Foxf1andFoxf2control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production

Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B. R., Miura, N., & Carlsson, P. (2006) · Development · doi:10.1242/dev.02252 · Cited by 240 · see citing works

Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β

Stuelten, C. H., Byfield, S. D., Arany, P. R., Karpova, T., Stetler‐Stevenson, W. G., & Roberts, A. B. (2005) · Journal of Cell Science · doi:10.1242/jcs.02334 · Cited by 236 · see citing works

Suppression of Tumor Development and Metastasis Formation in Mice Lacking the S100A4(mts1) Gene

Grum-Schwensen, B., Klingelhöfer, J., Berg, C. H., El-Naaman, C., Grigorian, M., Lukanidin, E. M., & Ambartsumian, N. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4510 · Cited by 235 · see citing works

Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

Wever, O. D., Pauwels, P., Craene, B. D., Sabbah, M., Emami, S., Redeuilh, G., Gespach, C. P., Bracke, M., & Berx, G. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0464-1 · Cited by 229 · see citing works

Epithelial Cells and Their Neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer

Powell, D. W., Adegboyega, P. A., Mari, J. F. D., & Mifflin, R. C. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00075.2005 · Cited by 222 · see citing works

TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

Caraci, F., Gili, E., Calafiore, M., Failla, M., LAROSA, C., Crimi, N., Sortino, M. A., Nicoletti, F., Copani, A., & Vancheri, C. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.02.001 · Cited by 203 · see citing works

A Secreted Form of ADAM9 Promotes Carcinoma Invasion through Tumor-Stromal Interactions

Mazzocca, A., Coppari, R., Franco, R. D., Cho, J., Libermann, T. A., Pinzani, M., & Toker, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4449 · Cited by 191 · see citing works

Stromelysin-3 Is a Potent Negative Regulator of Adipogenesis Participating to Cancer Cell-Adipocyte Interaction/Crosstalk at the Tumor Invasive Front

Andarawewa, K. L., Motrescu, E. R., Chenard, M., Gansmüller, A., Stoll, I., Tomasetto, C., & Rio, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1231 · Cited by 184 · see citing works

Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis

Li, X., Molina‐Molina, M., Abdul‐Hafez, A., Uhal, V., Xaubet, A., & Uhal, B. D. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00009.2008 · Cited by 182 · see citing works

Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis

Kang, H., Lee, C. G., Homer, R., & Elias, J. A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061273 · Cited by 176 · see citing works

Fibrotic disorders in the eye: Targets of gene therapy

Saika, S., Yamanaka, O., Sumioka, T., Miyamoto, T., Miyazaki, K.-I., Okada, Y., Kitano, A., Shirai, K., Tanaka, S., & Ikeda, K. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.12.002 · Cited by 174 · see citing works

Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

Christian, S., Winkler, R., Helfrich, I., Boos, A. M., Besemfelder, E., Schadendorf, D., & Augustin, H. G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070623 · Cited by 169 · see citing works

Integrin α11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

Zhu, C., Popova, S. N., Brown, E. R., Baršytė-Lovejoy, D., Navab, R., Shih, W., Li, M., Lu, M. W., Jurišica, I., Penn, L. Z., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703040104 · Cited by 163 · see citing works

Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy

Micke, P., & Östman, A. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.6.1217 · Cited by 162 · see citing works

Cancer-Derived Lysophosphatidic Acid Stimulates Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells

Jeon, E. S., Moon, H. J., Lee, M. J., Song, H. Y., Kim, Y. M., Cho, M., Suh, D. S., Yoon, M., Chang, C. L., Jung, J. S., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0742 · Cited by 161 · see citing works

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding

Wever, O. D., Westbroek, W., Verloes, A., Bloemen, N., Bracke, M., Gespach, C. P., Bruyneel, E. A., & Mareel, M. M. K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01322 · Cited by 160 · see citing works

Functional Modulation of Crohn’s Disease Myofibroblasts by Anti-Tumor Necrosis Factor Antibodies

Sabatino, A. D., Pender, S. L. F., Jackson, C. L., Prothero, J. D., Gordon, J. N., Picariello, L., Rovedatti, L., Docena, G. H., Monteleone, G., Rampton, D. S., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.069 · Cited by 159 · see citing works

Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer

Joesting, M. S., Perrin, S., Elenbaas, B., Fawell, S. E., Rubin, J. S., Franco, O. E., Hayward, S. W., Cunha, G. R., & Marker, P. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0824 · Cited by 159 · see citing works

Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways.

Satyamoorthy, K., Li, G., Vaidya, B., Patel, D., & Herlyn, M. (2001) · PubMed · Cited by 159 · see citing works

Gene Expression Profiling of Tumor–Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts

Sato, N., Maehara, N., & Goggins, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0677 · Cited by 158 · see citing works

Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: Induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation

Kellermann, M. G., Sobral, L. M., da Silva, S. D., et al. (2007) · Oral Oncology · doi:10.1016/j.oraloncology.2007.07.001 · Cited by 154 · see citing works

Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture

Qian, A., Meals, R. A., Rajfer, J., & González-Cadavid, N. F. (2004) · Urology · doi:10.1016/j.urology.2004.04.006 · Cited by 151 · see citing works

The effect of surgical wounding on tumour development

Hofer, S. O. P., Molema, G., Hermens, R., Wanebo, H. J., Reichner, J. S., & Hoekstra, H. J. (1999) · European Journal of Surgical Oncology · doi:10.1053/ejso.1998.0634 · Cited by 149 · see citing works

There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions

Chauhan, H. A., Abraham, A., Phillips, J. R. A., Pringle, J. H., Walker, R. A., & Jones, J. L. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.4.271 · Cited by 148 · see citing works

A human prostatic stromal myofibroblast cell line WPMY-1: a model for stromalepithelial interactions in prostatic neoplasia

Webber, M. M. (1999) · Carcinogenesis · doi:10.1093/carcin/20.7.1185 · Cited by 143 · see citing works

Predicting Risk of Radiation-Induced Lung Injury

Madani, I., Ruyck, K. D., Goeminne, H., et al. (2007) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318145b2c6 · Cited by 137 · see citing works

Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-β1) increase invasion rate of tumor cells: a population study

Casey, T. M., Eneman, J., Crocker, A., White, J., Tessitore, J., Stanley, M., Harlow, S., Bunn, J. Y., Weaver, D., Muss, H., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9684-7 · Cited by 127 · see citing works

Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species

Cat, B., Stuhlmann, D., Steinbrenner, H., Alili, L., Holtkötter, O., Sies, H., & Brenneisen, P. (2006) · Journal of Cell Science · doi:10.1242/jcs.03011 · Cited by 122 · see citing works

Shedding of Syndecan-1 by Stromal Fibroblasts Stimulates Human Breast Cancer Cell Proliferation via FGF2 Activation

Su, G., Blaine, S. A., Qiao, D., & Friedl, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611739200 · Cited by 120 · see citing works

Does ionizing radiation stimulate cancer invasion and metastasis?

Madani, I., Neve, W. D., & Mareel, M. (2008) · PubMed · doi:10.1684/bdc.2008.0598 · Cited by 120 · see citing works

In vivo and in vitro invasiveness of a rat colon‐cancer cell line maintaining E‐cadherin expression: An enhancing role of tumor‐associated myofibroblasts

Dimanche‐Boitrel, M., Vakaet, L. C., Pujuguet, P., Chauffert, B., Martin, M. S., Hammann, A., Roy, F. M. V., Mareel, M. M. K., & Martin, F. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560410 · Cited by 119 · see citing works

Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis

Koyama, H., Kobayashi, N., Harada, M., Takeoka, M., Kawai, Y., Sano, K., Fujimori, M., Amano, J., Ohhashi, T., Kannagi, R., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070360 · Cited by 115 · see citing works

Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma

Aishima, S., Nishihara, Y., Iguchi, T., et al. (2008) · Modern Pathology · doi:10.1038/modpathol.3800985 · Cited by 110 · see citing works

Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors.

Mallat, A., Préaux, A.-M., Gal, C. S., Raufaste, D., Gallois, C., Brenner, D. A., Bradham, C. A., Maclouf, J., Iourgenko, V., Fouassier, L., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119103 · Cited by 105 · see citing works

Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression

Vozenin, M., Milliat, F., Sabourin, J. C., et al. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04601-1 · Cited by 105 · see citing works

IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal

Wynes, M. W., Frankel, S. K., & Riches, D. W. H. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0504288 · Cited by 105 · see citing works

Breast Cancer Recurrence following Prosthetic, Postmastectomy Reconstruction: Incidence, Detection, and Treatment

McCarthy, C. M., Pusic, A. L., Sclafani, L. M., et al. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000298316.74743.dd · Cited by 97 · see citing works

Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing α‐smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling

Huet, E., Vallée, B., Szul, D., Verrecchia, F., Mourah, S., Jester, J. V., Hoang-Xuan, T., Ménashi, S., & GaMson, E. E. (2007) · The FASEB Journal · doi:10.1096/fj.07-8748com · Cited by 93 · see citing works

Stroma-Derived Matrix Metalloproteinase (MMP)-2 Promotes Membrane Type 1-MMP–Dependent Tumor Growth in Mice

Taniwaki, K., Fukamachi, H., Komori, K., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4761 · Cited by 91 · see citing works

In vivo Imaging of the Systemic Recruitment of Fibroblasts to the Angiogenic Rim of Ovarian Carcinoma Tumors

Granot, D., Addadi, Y., Kalchenko, V., Harmelin, A., Kunz‐Schughart, L. A., & Neeman, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0684 · Cited by 90 · see citing works

Roles of Myofibroblasts in Prostaglandin E2–Stimulated Intestinal Epithelial Proliferation and Angiogenesis

Shao, J., Sheng, G. G., Mifflin, R. C., Powell, D. W., & Sheng, H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2606 · Cited by 89 · see citing works

Differential impact of TGF-β and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion

Denys, H. G., Derycke, L., Hendrix, A., Westbroek, W., Gheldof, A., Narine, K., Pauwels, P., Gespach, C. P., Bracke, M., & Wever, O. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.068 · Cited by 88 · see citing works

SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

Fu, K., Corbley, M. J., Sun, L., Friedman, J. E., Shan, F., Papadatos, J. L., Costa, D. E., Lutterodt, F., Sweigard, H., Bowes, S., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158030 · Cited by 85 · see citing works

Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients

Manetti, M., Neumann, E., Milia, A. F., Tarner, I. H., Bechi, P., Matucci‐Cerinic, M., Ibba‐Manneschi, L., & Müller‐Ladner, U. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22940 · Cited by 82 · see citing works

Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation

Beppu, H., Mwizerwa, O., Beppu, Y., Dattwyler, M. P., Lauwers, G. Y., Bloch, K. D., & Goldstein, A. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210720 · Cited by 80 · see citing works

Tenascin-W Is a Novel Marker for Activated Tumor Stroma in Low-grade Human Breast Cancer and Influences Cell Behavior

Degen, M., Brellier, F., Kain, R., Ruiz, C. F., Terracciano, L., Orend, G., & Chiquet‐Ehrismann, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0666 · Cited by 77 · see citing works

Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect

Milyavsky, M., Shats, I., Cholostoy, A., Brosh, R., Buganim, Y., Weisz, L., Kogan, I., Cohen, M., Shatz, M., Madar, S., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.022 · Cited by 76 · see citing works

Regulation of HGF and SDF-1 expression by oral fibroblasts – Implications for invasion of oral cancer

Daly, A. J., McIlreavey, L., & Irwin, C. R. (2007) · Oral Oncology · doi:10.1016/j.oraloncology.2007.08.012 · Cited by 75 · see citing works

Colorectal Adenocarcinoma in Cirrhotic Patients

Gervaz, P., Pak‐art, R., Nivatvongs, S., et al. (2003) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(03)00117-0 · Cited by 73 · see citing works

Transforming Growth Factor-β Signaling in Prostate Stromal Cells Supports Prostate Carcinoma Growth by Up-regulating Stromal Genes Related to Tissue Remodeling

Verona, E. V., ELKAHLOUN, A. G., Yang, J., Bandyopadhyay, A. M., Yeh, I., & Sun, L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0444 · Cited by 71 · see citing works

Hic-5 Promotes the Hypertrophic Scar Myofibroblast Phenotype by Regulating the TGF-β1 Autocrine Loop

Dabiri, G., Tumbarello, D. A., Turner, C. E., & Water, L. V. D. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.90 · Cited by 71 · see citing works

CD34+ Fibrocytes: Morphology, Histogenesis and Function

Barth, P. J., & Westhoff, C. C. (2007) · Current Stem Cell Research & Therapy · doi:10.2174/157488807781696249 · Cited by 71 · see citing works

Evasion of myofibroblasts from immune surveillance: A mechanism for tissue fibrosis

Wallach‐Dayan, S. B., Golan‐Gerstl, R., & Breuer, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705582104 · Cited by 70 · see citing works

Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients

Sabatino, A. D., Ciccocioppo, R., Benazzato, L., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01927.x · Cited by 70 · see citing works

High Invasive Melanoma Cells Induce Matrix Metalloproteinase-1 Synthesis in Fibroblasts by Interleukin-1α and Basic Fibroblast Growth Factor-Mediated Mechanisms

Löffek, S., Zigrino, P., Angel, P. E., et al. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23629.x · Cited by 67 · see citing works

Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes

El-Asrar, A. M. A., Struyf, S., Damme, J. V., et al. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.134346 · Cited by 67 · see citing works

Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.

McAlhany, S. J., Ressler, S. J., Larsen, M., et al. (2003) · PubMed · Cited by 66 · see citing works

In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma

Micke, P., Kappert, K., Ohshima, M., Sundquist, C., Scheidl, S. J., Lindahl, P., Heldin, C., Botling, J., Pontén, F., & Östman, A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700714 · Cited by 63 · see citing works

A gene expression signature that distinguishes desmoid tumours from nodular fasciitis

Bacac, M., Migliavacca, E., Stehle, J., McKee, T., Delorenzi, M., Coindre, J., Guillou, L., & Stamenkovic, I. (2006) · The Journal of Pathology · doi:10.1002/path.1915 · Cited by 63 · see citing works

NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts

Watson, M. R., Wallace, K., Gieling, R. G., Manas, D., Jaffray, E., Hay, R. T., Mann, D. A., & Oakley, F. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.019 · Cited by 63 · see citing works

Platelet-Derived Growth Factor-BB Controls Epithelial Tumor Phenotype by Differential Growth Factor Regulation in Stromal Cells

Lederle, W., Stark, H., Skobe, M., Fusenig, N. E., & Mueller, M. M. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060120 · Cited by 62 · see citing works

Directionally Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-Compartment Premalignant Prostate Tumors

Jin, C., Wang, F., Wu, X., Yu, C., Luo, Y., & McKeehan, W. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3752 · Cited by 59 · see citing works

Surgical trauma and peritoneal recurrence of colorectal carcinoma

Oosterling, S. J., van der Bij, G. J., van Egmond, M., & van der Sijp, J. R. M. (2004) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2004.10.005 · Cited by 58 · see citing works

IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration.

Yoshifuku, K., Matsune, S., Ohori, J., et al. (2007) · PubMed · Cited by 56 · see citing works

Mastectomy With Immediate Expander-Implant Reconstruction, Adjuvant Chemotherapy, and Radiation for Stage II–III Breast Cancer: Treatment Intervals and Clinical Outcomes

Wright, J. L., Cordeiro, P. G., Ben‐Porat, L., et al. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.05.032 · Cited by 54 · see citing works

Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species

Direkze, N. C., Jeffery, R. E., Hodivala‐Dilke, K., Hunt, T., Playford, R. J., Elia, G., Poulsom, R., Wright, N. A., & Alison, M. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3202 · Cited by 52 · see citing works

Identification of Transforming Growth Factor β1–Driven Genetic Programs of Acute Lung Fibrosis

Pulichino, A.-M., Wang, I., Caron, A., Mortimer, J. R., Auger, A., Boie, Y., Elias, J. A., Kartono, A., Xu, L., Menetski, J. P., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0186oc · Cited by 51 · see citing works

Pancreatic stellate cells: Molecular mechanism of pancreatic fibrosis

Shimizu, K. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05296.x · Cited by 47 · see citing works

Myofibroblastoma of the breast revisited: An etiologic association with androgens?

Morgan, M. B., & Pitha, J. V. (1998) · Human Pathology · doi:10.1016/s0046-8177(98)90114-9 · Cited by 45 · see citing works

Cadherin-11 is Expressed in Detrusor Smooth Muscle Cells and Myofibroblasts of Normal Human Bladder

Kuijpers, K. A. J., Heesakkers, J. P. F. A., Jansen, C. F. J., & Schalken, J. A. (2007) · European Urology · doi:10.1016/j.eururo.2007.01.052 · Cited by 44 · see citing works

Bone marrow and tumour stroma: an intimate relationship

Direkze, N. C., & Alison, M. R. (2006) · Hematological Oncology · doi:10.1002/hon.788 · Cited by 40 · see citing works

Cell cultures from bronchial subepithelial myofibroblasts enhance eosinophil survival in vitro

Zhang, S., Mohammed, Q., Burbidge, A., Morland, C., & Roche, W. R. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09091839 · Cited by 40 · see citing works

Unusual interleukin-4 and -13 signaling in human normal and tumor lung fibroblasts

Doucet, C., Jasmin, C., & Azzarone, B. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203933 · Cited by 36 · see citing works

Smooth muscle cell differentiation in mammary stromo‐epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells

Tommaso, L. D., Pasquinelli, G., & Damiani, S. (2003) · Histopathology · doi:10.1046/j.1365-2559.2003.01607.x · Cited by 33 · see citing works

Epigenetic regulation of hepatic stellate cell activation

Mann, D. A., & Mann, J. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05295.x · Cited by 32 · see citing works

Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation

Willhauck, M. J., Mirancea, N., Vosseler, S., Pavesio, A., Boukamp, P., Mueller, M. M., Fusenig, N. E., & Stark, H.-J. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl188 · Cited by 32 · see citing works

Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy.

Darnton, S. J., Allen, S. M., Edwards, C. W., et al. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.1.51 · Cited by 32 · see citing works

Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice.

Epperly, M. W., Franicola, D., Zhang, X., et al. (2007) · PubMed · Cited by 25 · see citing works

A case of nodular pseudoangiomatous stromal hyperplasia (pash)

Okoshi, K., Ogawa, H., Suwa, H., et al. (2006) · Breast Cancer · doi:10.2325/jbcs.13.349 · Cited by 24 · see citing works

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma

Smith, R. A., Lea, R. A., Weinstein, S. R., & Griffiths, L. R. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.03.019 · Cited by 20 · see citing works

Surgical Trauma, Minimal Residual Disease and Locoregional Cancer Recurrence

Ceelen, W. P., Morris, S., Paraskeva, P., et al. (2007) · Springer eBooks · doi:10.1007/978-0-387-48993-3_4 · Cited by 18 · see citing works

Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18‐year‐old girl

Žúbor, P., Kajo, K., Dussan, C. A., et al. (2006) · Apmis · doi:10.1111/j.1600-0463.2006.apm_207.x · Cited by 17 · see citing works

CD34+ fibrocytes are preserved in most invasive lobular carcinomas of the breast

Ebrahimsade, S., Westhoff, C. C., & Barth, P. J. (2007) · Pathology - Research and Practice · doi:10.1016/j.prp.2007.05.009 · Cited by 15 · see citing works

Influence of preoperative core biopsies on uPA/PAI-1 expression in breast cancer tissue

Haas, S., Park, T., Hahne, J. C., et al. (2008) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-007-0563-8 · Cited by 14 · see citing works

A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum

Mynbaev, O. A., Dollé, L., & Bracke, M. (2006) · Surgical Endoscopy · doi:10.1007/s00464-006-9009-7 · Cited by 14 · see citing works

Long-term Expression of Fibrogenic Cytokines in Radiation-Induced Damage to the Internal Anal Sphincter

Gervaz, Hennig, Buechler, et al. (2003) · Swiss Surgery · doi:10.1024/1023-9332.9.4.193 · Cited by 12 · see citing works

The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts

Purkerson, J. M., Smith, R. S., Pollock, S. J., & Phipps, R. P. (2005) · European Journal of Immunology · doi:10.1002/eji.200526219 · Cited by 12 · see citing works

Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas

Nakayama, H., Enzan, H., Miyazaki, E., et al. (2004) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.017137 · Cited by 3 · see citing works

The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334 · see citing works

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003 · see citing works

Recent Developments in Myofibroblast Biology

Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.004 · Cited by 1,193 · see citing works

Targeting TGF-β Signaling in Cancer

Colak, S., & ten Dijke, P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2016.11.008 · Cited by 1,003 · see citing works

Fibroblasts and myofibroblasts in wound healing

Desmouliere, A., Darby, I. A., Laverdet, B., & Bonté, F. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s50046 · Cited by 1,039 · see citing works

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Liu, T., Han, C., Wang, S., Fang, P., Ma, Z., Xu, L., & Yin, R. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0770-1 · Cited by 860 · see citing works

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Shiga, K., Hara, M., Nagasaki, T., Sato, T., Takahashi, H., & Takeyama, H. (2015) · Cancers · doi:10.3390/cancers7040902 · Cited by 774 · see citing works

The myofibroblast matrix: implications for tissue repair and fibrosis

Klingberg, F., Hinz, B., & White, E. S. (2013) · The Journal of Pathology · doi:10.1002/path.4104 · Cited by 776 · see citing works

Metabolites and the Tumour Microenvironment: From Cellular Mechanisms to Systemic Metabolism

Elia, I., & Haigis, M. C. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00317-z · Cited by 651 · see citing works

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

Cox, T. R., Bird, D., Baker, A.-M., Barker, H. E., Ho, M. W.-Y., Lang, G., & Erler, J. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2233 · Cited by 571 · see citing works

A history of exploring cancer in context

Maman, S., & Witz, I. P. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0006-7 · Cited by 502 · see citing works

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

Karagiannis, G. S., Poutahidis, T., Erdman, S. E., Kirsch, R., Riddell, R. H., & Diamandis, E. P. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0307 · Cited by 507 · see citing works

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

Hinz, B. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0017-1 · Cited by 373 · see citing works

TGF-beta in CAF-mediated tumor growth and metastasis

Calon, A., Tauriello, D. V. F., & Batlle, E. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.008 · Cited by 342 · see citing works

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320 · see citing works

Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs

Gok Yavuz, B., Gunaydin, G., Gedik, M. E., Kosemehmetoglu, K., Karakoc, D., Ozgur, F., & Guc, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-39553-z · Cited by 292 · see citing works

Mechanisms of pathological scarring: Role of myofibroblasts and current developments

Sarrazy, V., Billet, F., Micallef, L., Coulomb, B., & Desmoulière, A. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00708.x · Cited by 288 · see citing works

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

Arina, A., Idel, C., Hyjek, E. M., Alegre, M.-L., Wang, Y., Bindokas, V. P., Weichselbaum, R. R., & Schreiber, H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600363113 · Cited by 238 · see citing works

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts

Avery, D., Govindaraju, P., Jacob, M., Todd, L., Monslow, J., & Puré, E. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.003 · Cited by 206 · see citing works

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

Hanley, C. J., Mellone, M., Ford, K., Thirdborough, S. M., Mellows, T., Frampton, S. J., Smith, D. M., Harden, E., Szyndralewiez, C., Bullock, M., et al. (2018) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djx121 · Cited by 195 · see citing works

Contribution of adipose tissue to development of cancer

Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188 · see citing works

Fibroblasts in Omentum Activated by Tumor Cells Promote Ovarian Cancer Growth, Adhesion and Invasiveness

Cai, J., Tang, H., Xu, L., Wang, X., Yang, C., Ruan, S., Guo, J., Hu, S., & Wang, Z. (2012) · Carcinogenesis · doi:10.1093/carcin/bgr230 · Cited by 173 · see citing works

Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression

Bhome, R., Goh, R. W., Bullock, M. D., Pillar, N., Thirdborough, S. M., Mellone, M., Mirnezami, R., Galea, D., Veselkov, K., Gu, Q., et al. (2017) · Aging · doi:10.18632/aging.101355 · Cited by 155 · see citing works

The Emerging Roles of Extracellular Vesicles As Communication Vehicles within the Tumor Microenvironment and Beyond

Sullivan, R., Maresh, G., Zhang, X., Salomon, C., Hooper, J., Margolin, D., & Li, L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00194 · Cited by 112 · see citing works

Hospicells (ascites-derived stromal cells) promote tumorigenicity and angiogenesis

Pasquet, M., Golzio, M., Mery, E., Rafii, A., Benabbou, N., Mirshahi, P., Hennebelle, I., Bourin, P., Allal, B., Teissie, J., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.24886 · Cited by 82 · see citing works

Mesenchymal stromal cells as cancer promoters

Antoon, R., Overdevest, N., Saleh, A. H., & Keating, A. (2024) · Oncogene · doi:10.1038/s41388-024-03183-1 · Cited by 75 · see citing works

Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis

Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works

Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma

Chen, R., Pan, S., Ottenhof, N. A., de Wilde, R. F., Wolfgang, C. L., Lane, Z., Post, J., Bronner, M. P., Willmann, J. K., Maitra, A., et al. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20842 · Cited by 62 · see citing works

Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance

Li, Z., Chan, K., Qi, Y., Lu, L., Ning, F., Wu, M., Wang, H., Wang, Y., Cai, S., & Du, J. (2018) · Cancer Research and Treatment · doi:10.4143/crt.2017.356 · Cited by 43 · see citing works

Non-uniform swelling properties of the corneal stroma

Lee, D. C., & WILSON, G. S. (1981) · Current Eye Research · doi:10.3109/02713688109019986 · Cited by 73 · see citing works

Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

Ansorge, M., Sapudom, J., Chkolnikov, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05912-x · Cited by 25 · see citing works

Myofibroblast progeny in wound biology and wound healing studies

Monika, P., Waiker, P. V., Chandraprabha, M. N., Rangarajan, A., & Murthy, K. N. C. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12937 · Cited by 88 · see citing works

Cancer-associated fibroblasts: A key target to snatch victory from defeat in therapy resistance associated with the pancreatic cancer stroma

Luo, W., & Zhang, T. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216279 · Cited by 25 · see citing works

Abstract P4-04-26: Down-regulation of p16INK4a inhibits miR-146b-5p and modulates IL-6 in breast stromal fibroblasts

Al‐Ansari, M. M., & Aboussekhra, A. (2015) · Cancer Research · doi:10.1158/1538-7445.sabcs14-p4-04-26