The DOI matches its Crossref record; 228 of the 229 references it cites were found in a registry or an index.
New fundamental resistance exercise determinants of molecular and cellular muscle adaptations
Open accessAbstract
Abstract Physical activity relies on muscular force. In adult skeletal muscle, force results from the contraction of postmitotic, multinucleated myofibres of different contractile and metabolic properties. Myofibres can adapt to (patho-)physiological conditions of altered functional demand by radial growth, longitudinal growth, and regulation of fibre type functional gene modules. The adaptation's specificity depends on the distinct molecular and cellular events triggered by unique combinations of conditional cues. In order to derive effective and tailored exercise prescriptions, it must be determined (1) which mechano-biological condition leads to what molecular/cellular response, and (2) how this molecular/cellular response relates to the structural, contractile, and metabolic adaptation. It follows that a thorough mechano-biological description of the loading condition is imperative. Unfortunately, the definition of (resistance) exercise conditions in the past and present literature is insufficient. It is classically limited to load magnitude, number of repetitions and sets, rest in-between sets, number of interventions/week, and training period. In this review, we show why the current description is insufficient, and identify new determinants of quantitative and/or qualitative effects on skeletal muscle with respect to resistance exercise in healthy, adult humans. These new mandatory determinants comprise the fractional and temporal distribution of the contraction modes per repetition, duration of one repetition, rest in-between repetitions, time under tension, muscular failure, range of motion, recovery time, and anatomical definition. We strongly recommend to standardise the design and description of all future resistance exercise investigations by using the herein proposed set of 13 mechano-biological determinants (classical and new ones).
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“This can also be said for muscle mass, as the active tension required to induce hypertrophy or prevent atrophy is very likely to vary as it is subordinate to the complex “response matrix” of the respective subject (Toigo and Boutellier, 2006).”
From Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review (2017) · cites this paper as Toigo and Boutellier, 2006
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The mechanisms of muscle hypertrophy and their application to resistance training
Schoenfeld, B. J. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e840f3 · Cited by 1,214
Borde, R., Hortobágyi, T., & Granacher, U. (2015) · Sports Medicine · doi:10.1007/s40279-015-0385-9 · Cited by 737
Schoenfeld, B. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0017-1 · Cited by 538
Chronic Adaptations to Eccentric Training: A Systematic Review
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Metadata
- Authors
- Toigo, M., & Boutellier, U.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Toigo, Marco
- Venue
- European Journal of Applied Physiology
- Published
- 2006-07-15
- Volume
- 97
- Issue
- 6
- Pages
- 643-663
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W1981567469
- Cited by
- 437
- References
- 229
- Citations by year
- 2026: 12 · 2025: 22 · 2024: 18 · 2023: 35 · 2022: 49 · 2021: 35 · 2020: 47 · 2019: 25 · 2018: 37 · 2017: 26 · 2016: 20 · 2015: 31 · 2014: 14 · 2013: 18 · 2012: 12
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- resistance training, skeletal muscle adaptation, exercise prescription, time under tension, muscular failure, range of motion
- MeSH terms
- Adaptation, Physiological, Animals, Humans, Models, Biological, Signal Transduction, Exercise, Muscle, Skeletal, Muscle Cells, Satellite Cells, Skeletal Muscle, Cell Enlargement
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