Cited by 437Sports Performance and TrainingCardiovascular and exercise physiologyMuscle Physiology and Disorders

The DOI matches its Crossref record; 228 of the 229 references it cites were found in a registry or an index.

New fundamental resistance exercise determinants of molecular and cellular muscle adaptations

Open access

Toigo, Marco, Boutellier, Urs·2006·European Journal of Applied Physiology

Open this paper in CoChat — free account Open PDF

Abstract

Abstract Physical activity relies on muscular force. In adult skeletal muscle, force results from the contraction of postmitotic, multinucleated myofibres of different contractile and metabolic properties. Myofibres can adapt to (patho-)physiological conditions of altered functional demand by radial growth, longitudinal growth, and regulation of fibre type functional gene modules. The adaptation's specificity depends on the distinct molecular and cellular events triggered by unique combinations of conditional cues. In order to derive effective and tailored exercise prescriptions, it must be determined (1) which mechano-biological condition leads to what molecular/cellular response, and (2) how this molecular/cellular response relates to the structural, contractile, and metabolic adaptation. It follows that a thorough mechano-biological description of the loading condition is imperative. Unfortunately, the definition of (resistance) exercise conditions in the past and present literature is insufficient. It is classically limited to load magnitude, number of repetitions and sets, rest in-between sets, number of interventions/week, and training period. In this review, we show why the current description is insufficient, and identify new determinants of quantitative and/or qualitative effects on skeletal muscle with respect to resistance exercise in healthy, adult humans. These new mandatory determinants comprise the fractional and temporal distribution of the contraction modes per repetition, duration of one repetition, rest in-between repetitions, time under tension, muscular failure, range of motion, recovery time, and anatomical definition. We strongly recommend to standardise the design and description of all future resistance exercise investigations by using the herein proposed set of 13 mechano-biological determinants (classical and new ones).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00421-006-0238-1

Cites

228 of 228 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Vivanco, I., & Sawyers, C. L. (2002) · Nature reviews. Cancer · doi:10.1038/nrc839 · Cited by 6,155
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,296
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546

Show all 229 references

Research works printed but not linked: 2

Bowtell J, Park DM, Smith K, Cuthbertson DJR, Waddell T, Rennie MJ (2003) Stimulation of human quadriceps protein synthesis after strenous exercise: no effects of varying intensity between 60 and 90% of one repetition maximum (1RM). J Physiol (Lond) 547P:P16
Schiaffino S, Bormioli SP, Aloisi M (1979) Fibre branching and formation of new fibres during compensatory muscle hypertrophy. In: Mauro A (ed) Muscle regeneration. Raven, New York, pp 177–188

Sorted by citations

The mechanisms of muscle hypertrophy and their application to resistance training
Schoenfeld, B. J. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e840f3 · Cited by 1,214
Dose–Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis
Borde, R., Hortobágyi, T., & Granacher, U. (2015) · Sports Medicine · doi:10.1007/s40279-015-0385-9 · Cited by 737
Potential Mechanisms for a Role of Metabolic Stress in Hypertrophic Adaptations to Resistance Training
Schoenfeld, B. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0017-1 · Cited by 538
Chronic Adaptations to Eccentric Training: A Systematic Review
Douglas, J. M., Pearson, S. N., Ross, A., & McGuigan, M. R. (2016) · Sports Medicine · doi:10.1007/s40279-016-0628-4 · Cited by 385
Effects and dose–response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis
Lesinski, M., Prieske, O., & Granacher, U. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095497 · Cited by 364
Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review
Herold, F., Törpel, A., Schega, L., & Müller, N. G. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0217-2 · Cited by 349
Eccentric Exercise: Physiological Characteristics and Acute Responses
Douglas, J. M., Pearson, S. N., Ross, A., & McGuigan, M. R. (2016) · Sports Medicine · doi:10.1007/s40279-016-0624-8 · Cited by 312
Osteosarcopenic obesity: the role of bone, muscle, and fat on health
Ormsbee, M. J., Prado, C. M., Ilich, J. Z., Purcell, S., Siervo, M., Folsom, A., & Panton, L. (2014) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-014-0146-x · Cited by 257
“Additionally, resistance exercise improves muscle strength and quality through a variety of different mechanisms that include satellite cell recruitment [96] and stimulation of the mammalian target of rapamycin (mTOR) pathway (which regulates skeletal muscle growth) [96].”
Does Exercise-Induced Muscle Damage Play a Role in Skeletal Muscle Hypertrophy?
Schoenfeld, B. J. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31824f207e · Cited by 258
Untitled work
Spiering (2008) · doi:10.2165/00007256-200838070-00001 · Cited by 227
Maximal intended velocity training induces greater gains in bench press performance than deliberately slower half‐velocity training
González‐Badillo, J. J., Rodríguez‐Rosell, D., Sánchez‐Medina, L., Gorostiaga, E. M., & Pareja‐Blanco, F. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.905987 · Cited by 243
Effect of Exercise Training on Bone Mineral Density in Post-menopausal Women: A Systematic Review and Meta-Analysis of Intervention Studies
Shojaa, M., von Stengel, S., Schoene, D., Kohl, M., Barone, G., Bragonzoni, L., Dallolio, L., Marini, S., MURPHY, M. H., Stephenson, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00652 · Cited by 233
Effect of Movement Velocity during Resistance Training on Neuromuscular Performance
Pareja-Blanco, F., Rodríguez-Rosell, D., Sánchez-Medina, L., Gorostiaga, E., & González-Badillo, J. (2014) · International Journal of Sports Medicine · doi:10.1055/s-0033-1363985 · Cited by 218
Strength training in soccer with a specific focus on highly trained players
Silva, J. R., Nassis, G. P., & Rebelo, A. (2015) · Sports Medicine - Open · doi:10.1186/s40798-015-0006-z · Cited by 269
Flywheel resistance training calls for greater eccentric muscle activation than weight training
Norrbrand, L., Pozzo, M., & Tesch, P. A. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1575-7 · Cited by 212
The effect of training volume and intensity on improvements in muscular strength and size in resistance-trained men
Mangine, G. T., Hoffman, J. R., Gonzalez, A. M., Townsend, J. R., Wells, A. J., Jajtner, A. R., Beyer, K. S., Boone, C. H., Miramonti, A. A., Wang, R., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12472 · Cited by 204
Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
Evans, P. L., McMillin, S. L., Weyrauch, L. A., & Witczak, C. A. (2019) · Nutrients · doi:10.3390/nu11102432 · Cited by 190
Effects of strength training with eccentric overload on muscle adaptation in male athletes
Friedmann‐Bette, B., Bauer, T., Kinscherf, R., Vorwald, S., Klute, K., Bischoff, D., Müller, H., Weber, M. D., Metz, J., Kauczor, H., et al. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1292-2 · Cited by 185
Training practices and ergogenic aids used by male bodybuilders
Hackett, D. A., Johnson, N. A., & Chow, C.-M. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318271272a · Cited by 163
Neuromuscular electrical stimulation training induces atypical adaptations of the human skeletal muscle phenotype: a functional and proteomic analysis
Gondin, J., Brocca, L., Bellinzona, E., D’Antona, G., Maffiuletti, N. A., Miotti, D., Pellegrino, M. A., & Bottinelli, R. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00914.2010 · Cited by 162
Evaluation of resistance training to improve muscular strength and body composition in cancer patients undergoing neoadjuvant and adjuvant therapy: a meta-analysis
Padilha, C. S., Marinello, P. C., Galvão, D. A., Newton, R. U., Borges, F. H., Frajacomo, F., & Deminice, R. (2017) · Journal of Cancer Survivorship · doi:10.1007/s11764-016-0592-x · Cited by 149
Effects of dynamic resistance exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis with special emphasis on exercise parameters
Shojaa, M., von Stengel, S., Kohl, M., Schoene, D., & KEMMLER, W. K. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05441-w · Cited by 143
Proximal muscle rehabilitation is effective for patellofemoral pain: a systematic review with meta-analysis
Lack, S. D., Barton, C. J., Sohan, O., Crossley, K. M., & Morrissey, D. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-094723 · Cited by 152
Mechanisms Behind Blood Flow–Restricted Training and its Effect Toward Muscle Growth
Hwang, P. S., & Willoughby, D. S. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002384 · Cited by 140
Physiotherapy Exercise After Fast-Track Total Hip and Knee Arthroplasty: Time for Reconsideration?
Bandholm, T., & Kehlet, H. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.02.014 · Cited by 139
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise–Induced Muscle Protein Anabolism
Reidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128
The effects of short versus long inter‐set rest intervals in resistance training on measures of muscle hypertrophy: A systematic review
Grgić, J., Lazinica, B., Mikulić, P., Krieger, J. W., & Schoenfeld, B. J. (2017) · European Journal of Sport Science · doi:10.1080/17461391.2017.1340524 · Cited by 125
Effects of the Nordic Hamstring exercise on sprint capacity in male football players: a randomized controlled trial
Ishøi, L., Hölmich, P., Aagaard, P., Thorborg, K., Bandholm, T., & Serner, A. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2017.1409609 · Cited by 118
The Use of Nonsteroidal Anti-Inflammatory Drugs for Exercise-Induced Muscle Damage
Schoenfeld, B. J. (2012) · Sports Medicine · doi:10.1007/bf03262309 · Cited by 117
Assessment of Neuromuscular Function After Different Strength Training Protocols Using Tensiomyography
Símola, R. Á. D. P., Harms, N., Raeder, C., Kellmann, M., Meyer, T., Pfeiffer, M., & Ferrauti, A. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000768 · Cited by 115
If exercise is medicine, why don’t we know the dose? An overview of systematic reviews assessing reporting quality of exercise interventions in health and disease
Hansford, H. J., Wewege, M. A., Cashin, A. G., Hagstrom, A. D., Clifford, B. K., McAuley, J. H., & Jones, M. D. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-104977 · Cited by 116
Early Progressive Strength Training to Enhance Recovery After Fast‐Track Total Knee Arthroplasty: A Randomized Controlled Trial
Jakobsen, T. L., Kehlet, H., Husted, H., Petersen, J., & Bandholm, T. (2014) · Arthritis Care & Research · doi:10.1002/acr.22405 · Cited by 106
Muscle weakness in the elderly: role of sarcopenia, dynapenia, and possibilities for rehabilitation
Seene, T., & Kaasik, P. (2012) · European Review of Aging and Physical Activity · doi:10.1007/s11556-012-0102-8 · Cited by 111
Implementing Flywheel (Isoinertial) Exercise in Strength Training: Current Evidence, Practical Recommendations, and Future Directions
Beato, M., & Iacono, A. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00569 · Cited by 101
Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes
Saatmann, N., Zaharia, O., Loenneke, J. P., Roden, M., & Pesta, D. H. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.11.010 · Cited by 112
Imbalances in the Development of Muscle and Tendon as Risk Factor for Tendinopathies in Youth Athletes: A Review of Current Evidence and Concepts of Prevention
Mersmann, F., Böhm, S., & Arampatzis, A. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00987 · Cited by 99
A systematic review on the effects of resistance and plyometric training on physical fitness in youth- What do comparative studies tell us?
Peitz, M., Behringer, M., & Granacher, U. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205525 · Cited by 115
Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy
Gonzalez, A. M., Hoffman, J. R., Stout, J. R., Fukuda, D. H., & Willoughby, D. S. (2015) · Sports Medicine · doi:10.1007/s40279-015-0450-4 · Cited by 97
Toward a New Paradigm in Resistance Training by Means of Velocity Monitoring: A Critical and Challenging Narrative
González‐Badillo, J. J., Sánchez‐Medina, L., Ribas‐Serna, J., & Rodríguez‐Rosell, D. (2022) · Sports Medicine - Open · doi:10.1186/s40798-022-00513-z · Cited by 91
How to manage patellofemoral pain – Understanding the multifactorial nature and treatment options
Lack, S. D., Neal, B. S., Silva, D. D. O., & Barton, C. J. (2018) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2018.04.010 · Cited by 89
How can we implement exercise therapy for patellofemoral pain if we don’t know what was prescribed? A systematic review
Holden, S., Rathleff, M. S., Jensen, M. B., & Barton, C. J. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097547 · Cited by 88
Eccentric strengthening effect of hip-adductor training with elastic bands in soccer players: a randomised controlled trial
Jensen, J., Hölmich, P., Bandholm, T., Zebis, M. K., Andersen, L. L., & Thorborg, K. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091095 · Cited by 85
The biomechanics of running in athletes with previous hamstring injury: A case‐control study
Daly, C., Persson, U. M., Twycross-Lewis, R., WOLEDGE, R. C., & Morrissey, D. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12464 · Cited by 80
Eccentric Exercise in Patients with Chronic Health Conditions: A Systematic Review
Roig, M., Shadgan, B., & Reid, W. D. (2008) · Physiotherapy Canada · doi:10.3138/physio.60.2.146 · Cited by 80
Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement applied to patients with preoperative functional limitations. A single-blinded randomised controlled trial
Mikkelsen, L. R., Mechlenburg, I., Søballé, K., Jørgensen, L. B., Mikkelsen, S. S., Bandholm, T., & Petersen, A. K. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.09.025 · Cited by 76
Physical Activity and Sarcopenia
Pillard, F., Laoudj‐Chenivesse, D., Carnac, G., Mercier, J. G., RAMI, J., Rivière, D., & Rolland, Y. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.009 · Cited by 79
Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
Richter, C., Braunstein, B., Winnard, A., Nasser, M., & Weber, T. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00583 · Cited by 75
Perspective of Dose and Response for Individualized Physical Exercise and Training Prescription
Gronwald, T., Törpel, A., Herold, F., & Budde, H. (2020) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk5030048 · Cited by 73
Postexercise hypertrophic adaptations: A reexamination of the hormone hypothesis and its applicability to resistance training program design
Schoenfeld, B. J. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828ddd53 · Cited by 74
Physiotherapist-led treatment for young to middle-aged active adults with hip-related pain: consensus recommendations from the International Hip-related Pain Research Network, Zurich 2018
Kemp, J. L., Risberg, M. A., Mosler, A., Harris‐Hayes, M., Serner, A., Moksnes, H., Bloom, N. J., Crossley, K. M., Gojanovic, B., Hunt, M. A., et al. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101458 · Cited by 72
The effects of detraining and retraining periods on fat-mass and fat-free mass in elite male soccer players
Suarez-Arrones, L. J., Lara-Lopez, P., Maldonado, R. A., Torreño, N., Lora, M. D. H., Nakamura, F. Y., Salvo, V. D., & Méndez-Villanueva, A. (2019) · PeerJ · doi:10.7717/peerj.7466 · Cited by 68
Muscle Architectural and Functional Adaptations Following 12-Weeks of Stretching in Adolescent Female Athletes
Panidi, I., Bogdanis, G. C., Terzis, G. D., Donti, A., Konrad, A., Gaspari, V., & Donti, Ο. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.701338 · Cited by 69
Stimuli for Adaptations in Muscle Length and the Length Range of Active Force Exertion—A Narrative Review
Kruse, A., Rivares, C., Weide, G., Tilp, M., & Jaspers, R. T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.742034 · Cited by 79
THE SIZE PRINCIPLE AND A CRITICAL ANALYSIS OF THE UNSUBSTANTIATED HEAVIER-IS-BETTER RECOMMENDATION FOR RESISTANCE TRAINING
Carpinelli, R. N. (2008) · Cited by 67
The Effects of Eccentric Training on Biceps Femoris Architecture and Strength: A Systematic Review With Meta-Analysis
Gérard, R., Gojon, L., Decleve, P., & Van Cant, J. (2020) · Journal of Athletic Training · doi:10.4085/1062-6050-194-19 · Cited by 64
The Use of Specialized Training Techniques to Maximize Muscle Hypertrophy
Schoenfeld, B. J. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3182221ec2 · Cited by 63
Effects of Two Different Resistance-Training Programs on Mean Tennis-Serve Velocity in Adolescents
Behringer, M., Neuerburg, S., Matthews, M., & Mester, J. (2013) · Pediatric Exercise Science · doi:10.1123/pes.25.3.370 · Cited by 67
REPORT-PFP: a consensus from the International Patellofemoral Research Network to improve REPORTing of quantitative PatelloFemoral Pain studies
Barton, C. J., Silva, D. D. O., Morton, S., Collins, N. J., Rathleff, M. S., Vicenzino, B., van Middelkoop, M., Crossley, K. M., Callaghan, M. J., Selfe, J., et al. (2021) · British Journal of Sports Medicine · doi:10.1136/bjsports-2020-103700 · Cited by 68
Improving function in people with hip-related pain: a systematic review and meta-analysis of physiotherapist-led interventions for hip-related pain
Kemp, J. L., Mosler, A., Hart, H. F., Bizzini, M., Chang, S., Scholes, M. J., Semciw, A. I., & Crossley, K. M. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101690 · Cited by 66
Neuromuscular Fatigue and Physiological Responses After Five Dynamic Squat Exercise Protocols
Raeder, C., Wiewelhove, T., Westphal-Martinez, M. P., Fernández-Fernández, J., Símola, R. Á. D. P., Kellmann, M., Meyer, T., Pfeiffer, M., & Ferrauti, A. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001181 · Cited by 59
Effort Index as a Novel Variable for Monitoring the Level of Effort During Resistance Exercises
Rodríguez‐Rosell, D., Yáñez‐García, J. M., Torres‐Torrelo, J., Mora‐Custodio, R., Marques, M. C., & González‐Badillo, J. J. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002629 · Cited by 67
CURRENT CONCEPTS OF MUSCLE AND TENDON ADAPTATION TO STRENGTH AND CONDITIONING.
Brumitt, J., & Cuddeford, T. J. (2015) · PubMed Central · Cited by 60
Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women
Santiago, L. Â. M., Neto, L. G. L., Pereira, G. B., Leite, R. D., Mostarda, C. T., Brito-Monzani, J. D. O., Sousa, W. R., Pinheiro, A. J. M. R., & Navarro, F. (2018) · Journal of Aging Research · doi:10.1155/2018/1467025 · Cited by 56
IMPROVING THE REPORTING OF THERAPEUTIC EXERCISE INTERVENTIONS IN REHABILITATION RESEARCH.
Page, P., Hoogenboom, B., & Voight, M. L. (2017) · Europe PMC (PubMed Central) · Cited by 55
EVIDENCE!BASED RESISTANCE TRAINING RECOMMENDATIONS FOR MUSCULAR HYPERTROPHY
Fisher, J. P., & Steele, J. (2013) · Southampton Solent University Digital Library · Cited by 53
Balance Training Does Not Alter Reliance on Visual Information during Static Stance in Those with Chronic Ankle Instability: A Systematic Review with Meta-Analysis
Song, K., Rhodes, E. L., & Wikstrom, E. A. (2017) · Sports Medicine · doi:10.1007/s40279-017-0850-8 · Cited by 58
Feasibility of Progressive Strength Training Implemented in the Acute Ward after Hip Fracture Surgery
Kronborg, L., Bandholm, T., Palm, H., Kehlet, H., & Kristensen, M. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093332 · Cited by 52
Comparison of three modes of aerobic exercise combined with resistance training on the pain and function of patients with knee osteoarthritis: A randomized controlled trial
Kabiri, S., Halabchi, F., Angoorani, H., & Yekaninejad, M. S. (2018) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2018.04.001 · Cited by 52
Effects of load and training modes on physiological and metabolic responses in resistance exercise
Buitrago, S., Wirtz, N., Yue, Z., Kleinöder, H., & Mester, J. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2249-9 · Cited by 51
Acute sensory and motor response to 45-s heavy isometric holds for the plantar flexors in patients with Achilles tendinopathy
O’Neill, S., Radia, J., Bird, K., Rathleff, M. S., Bandholm, T., Jørgensen, M. G., & Thorborg, K. (2018) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-018-5050-z · Cited by 51
Unsupervised Isometric Exercise versus Wait-and-See for Lateral Elbow Tendinopathy
Vuvan, V., Vicenzino, B., Mellor, R., Heales, L., & Coombes, B. K. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002128 · Cited by 50
The majority are not performing home-exercises correctly two weeks after their initial instruction—an assessor-blinded study
Faber, M., Andersen, M. H., Sevel, C. T., Thorborg, K., Bandholm, T., & Rathleff, M. S. (2015) · PeerJ · doi:10.7717/peerj.1102 · Cited by 50
Resistance training does not induce uniform adaptations to quadriceps
Mangine, G. T., Redd, M. J., Gonzalez, A. M., Townsend, J. R., Wells, A. J., Jajtner, A. R., Beyer, K. S., Boone, C. H., Monica, M. B. L., Stout, J. R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198304 · Cited by 49
Strengthening the Brain—Is Resistance Training with Blood Flow Restriction an Effective Strategy for Cognitive Improvement?
Törpel, A., Herold, F., Hamacher, D., Müller, N. G., & Schega, L. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100337 · Cited by 49
Greater Electromyographic Responses Do Not Imply Greater Motor Unit Recruitment and ‘Hypertrophic Potential’ Cannot Be Inferred
Vigotsky, A. D., Beardsley, C., Contreras, B. M., Steele, J., Ogborn, D. I., & Phillips, S. M. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001249 · Cited by 48
Content reporting of exercise interventions in rotator cuff disease trials: results from application of the Consensus on Exercise Reporting Template (CERT)
Major, D. H., Røe, Y., Grotle, M., Jessup, R. L., Farmer, C., Småstuen, M. C., & Buchbinder, R. (2019) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2019-000656 · Cited by 50
A Discussion on Different Approaches for Prescribing Physical Interventions – Four Roads Lead to Rome, but Which One Should We Choose?
Herold, F., Törpel, A., Hamacher, D., Budde, H., & Gronwald, T. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030055 · Cited by 48
Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo
Frese, S., Ruebner, M., Suhr, F., Konou, T. M., Tappe, K. A., Toigo, M., Jung, H. H., Henke, C., Steigleder, R., Strissel, P. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132099 · Cited by 48
Self-citation
The effect of isometric exercise on pain in individuals with plantar fasciopathy: A randomized crossover trial
Riel, H., Vicenzino, B., Jensen, M. B., Olesen, J. L., Holden, S., & Rathleff, M. S. (2018) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13296 · Cited by 47
Self-dosed and pre-determined progressive heavy-slow resistance training have similar effects in people with plantar fasciopathy: a randomised trial
Riel, H., Jensen, M. B., Olesen, J. L., Vicenzino, B., & Rathleff, M. S. (2019) · Journal of physiotherapy · doi:10.1016/j.jphys.2019.05.011 · Cited by 47
Electromyographical and Perceptual Responses to Different Resistance Intensities in a Squat Protocol: Does Performing Sets to Failure With Light Loads Produce the Same Activity?
Looney, D. P., Kraemer, W. J., Joseph, M. F., Comstock, B. A., Denegar, C. R., Flanagan, S. D., Newton, R. U., Szivak, T. K., DuPont, W. H., Hooper, D. R., et al. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001109 · Cited by 46
Exercise for posterior tibial tendon dysfunction: a systematic review of randomised clinical trials and clinical guidelines
Ross, M. H., Smith, M. D., Mellor, R., & Vicenzino, B. (2018) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2018-000430 · Cited by 46
The Role of Fiber Types in Muscle Hypertrophy
Ogborn, D. I., & Schoenfeld, B. J. (2014) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000030 · Cited by 45
Effects of 10 Months of Speed, Functional, and Traditional Strength Training on Strength, Linear Sprint, Change of Direction, and Jump Performance in Trained Adolescent Soccer Players
Keiner, M., Kadlubowski, B., Sander, A., Hartmann, H., & Wirth, K. (2022) · Journal of Strength & Conditioning Research · doi:10.1519/jsc.0000000000003807 · Cited by 44
Physiology of Stretch-Mediated Hypertrophy and Strength Increases: A Narrative Review
Warneke, K., Lohmann, L. H., Lima, C. D., Hollander, K., Konrad, A., Zech, A., Nakamura, M., WIRTH, K. J., Keiner, M., & Behm, D. G. (2023) · Sports Medicine · doi:10.1007/s40279-023-01898-x · Cited by 51
New exercise-integrated technology can monitor the dosage and quality of exercise performed against an elastic resistance band by adolescents with patellofemoral pain: an observational study
Rathleff, M. S., Bandholm, T., McGirr, K., Ibsen, S., Sørensen, A. S., & Thorborg, K. (2016) · Journal of physiotherapy · doi:10.1016/j.jphys.2016.05.016 · Cited by 44
A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise
Cornish, S. M., Bugera, E. M., Duhamel, T. A., Peeler, J. D., & Anderson, J. E. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04337-1 · Cited by 43
Circuit resistance training in sedentary women: body composition and serum cytokine levels
Ferreira, F. C., de Medeiros, A. I., Nicioli, C., Nunes, J. E. D., Shiguemoto, G. E., Prestes, J., Verzola, R. M. M., Baldissera, V., & Perez, S. E. D. A. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-136 · Cited by 44
Explosive Resistance Training Increases Rate of Force Development in Ankle Dorsiflexors and Gait Function in Adults With Cerebral Palsy
Kirk, H., Geertsen, S. S., Lorentzen, J., Krarup, K. B., Bandholm, T., & Nielsen, J. B. (2016) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001376 · Cited by 40
Maximizing Hypertrophy: Possible Contribution of Stretching in the Interset Rest Period
Mohamad, N. I., Nosaka, K., & Cronin, J. B. (2010) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3181fe7164 · Cited by 41
Does foot mobility affect the outcome in the management of patellofemoral pain with foot orthoses versus hip exercises? A randomised clinical trial
Matthews, M., Rathleff, M. S., Claus, A. P., McPoil, T., Nee, R., Crossley, K. M., Kasza, J., & Vicenzino, B. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100935 · Cited by 38
Time Course of Strength and Power Recovery After Resistance Training With Different Movement Velocities
Ide, B. N., Leme, T. C., Lopes, C. R., Moreira, A., Dechechi, C. J., Sarraipa, M. F., da Mota, G. R., Brenzikofer, R., & de Macedo, D. V. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e7393f · Cited by 38
Strength training in addition to neuromuscular exercise and education in individuals with knee osteoarthritis—the effects on pain and sensitization
Holm, P. M., Petersen, K. K., Wernbom, M., Schrøder, H. M., Arendt‐Nielsen, L., & Skou, S. T. (2021) · European Journal of Pain · doi:10.1002/ejp.1796 · Cited by 37
Impairment-Based Rehabilitation Following Hip Arthroscopy: Postoperative Protocol for the HIP ARThroscopy International Randomized Controlled Trial
Heerey, J., Risberg, M. A., Magnus, J., Moksnes, H., Ødegaard, T. T., Crossley, K. M., & Kemp, J. L. (2018) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2018.8002 · Cited by 36
Neuromuscular Effects to 6 Weeks of Loaded Countermovement Jumping With Traditional and Daily Undulating Periodization
Ullrich, B., Pelzer, T., & Pfeiffer, M. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002290 · Cited by 36
Mechanical Load and Physiological Responses of Four Different Resistance Training Methods in Bench Press Exercise
Buitrago, S., Wirtz, N., Yue, Z., Kleinöder, H., & Mester, J. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318260ec77 · Cited by 35
Multiarticular Isokinetic High-Load Eccentric Training Induces Large Increases in Eccentric and Concentric Strength and Jumping Performance
Papadopoulos, C. G., Theodosiou, K., Bogdanis, G. C., Gkantiraga, E., Gissis, I., Sambanis, M., Souglis, A. G., & Sotiropoulos, A. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000456 · Cited by 35
Adherence to Commonly Prescribed, Home-Based Strength Training Exercises for the Lower Extremity Can Be Objectively Monitored Using the Bandcizer
Rathleff, M. S., Thorborg, K., Rode, L. A., McGirr, K., Sørensen, A. S., Bøgild, A., & Bandholm, T. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000675 · Cited by 34
Resistance training preserves high-intensity interval training induced improvements in skeletal muscle capillarization of healthy old men: a randomized controlled trial
Leuchtmann, A. B., Mueller, S. M., Aguayo, D., Petersen, J. A., Ligon‐Auer, M., Flück, M., Jung, H. H., & Toigo, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63490-x · Cited by 37
Self-citation
Effect of different resistance-training regimens on the WNT-signaling pathway
Leal, M. L., Lamas, L., Aoki, M. S., Ugrinowitsch, C., Carneiro‐Ramos, M. S., Tricoli, V., & Moriscot, A. S. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1874-7 · Cited by 35

Authors: Toigo, M., & Boutellier, U.
Affiliations: University of Zurich (CH)
Corresponding author: Toigo, Marco
Venue: European Journal of Applied Physiology
Publisher: Springer Science and Business Media LLC
Published: 2006-07-15
Volume: 97
Issue: 6
Pages: 643-663
ISSN: 0020-9376 (ISSN-L)
1439-6319
1439-6327
DOI: 10.1007/s00421-006-0238-1
OpenAlex: W1981567469
Cited by: 437
References: 229
Citations by year: 2026: 12 · 2025: 22 · 2024: 18 · 2023: 35 · 2022: 49 · 2021: 35 · 2020: 47 · 2019: 25 · 2018: 37 · 2017: 26 · 2016: 20 · 2015: 31 · 2014: 14 · 2013: 18 · 2012: 12
FWCI: 0.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
reroDoc Digital Library (submittedVersion)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
ETH Zürich Research Collection
Zurich Open Repository and Archive (University of Zurich)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: resistance training, skeletal muscle adaptation, exercise prescription, time under tension, muscular failure, range of motion
MeSH terms: Adaptation, Physiological, Animals, Humans, Models, Biological, Signal Transduction, Exercise, Muscle, Skeletal, Muscle Cells, Satellite Cells, Skeletal Muscle, Cell Enlargement

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New fundamental resistance exercise determinants of molecular and cellular muscle adaptations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks