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Cited by 60Chronic Obstructive Pulmonary Disease (COPD) ResearchCardiovascular and exercise physiologyRespiratory Support and Mechanisms

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

Laveneziana, Pierantonio, Palange, Paolo, Ora, Josuel, Martolini, Dario, O’Donnell, Denis E.·2009·European Journal of Applied Physiology
DOI 10.1007/s00421-009-1169-4
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Abstract

Respiratory mechanical abnormalities in patients with chronic obstructive pulmonary disease (COPD) may impair cardiodynamic responses and convective oxygen delivery during exercise, resulting in slower ventilatory, pulmonary gas exchange (PGE), and heart rate (HR) kinetics compared with normal. We reasoned that bronchodilators and the attendant reduction of operating lung volumes should accelerate ventilatory, PGE, and HR kinetics in the transition from rest to high-intensity exercise. Twelve clinically stable COPD patients undertook constant-work rate cycle testing at 75% of each individual's maximum work capacity after receiving either combined nebulized bronchodilators (BD) or placebo (PL), randomly. Mean response time (MRT) and amplitude of slow component for oxygen uptake (V'O(2)), carbon dioxide production (V'CO(2)), ventilation (V'(E)), and HR together with operating dynamic end-expiratory lung volume (EELV) were measured. Resting and exercise EELV decreased significantly by 0.38 L after BD compared with PL. After BD, V'O(2), V'CO(2), V'(E), and HR MRT accelerated (p < 0.05) by an average of 12, 22, 27, and 22 s, respectively (i.e., 15, 18, 22 and 27%, respectively). The slow component for V'O(2) declined by an average of 55 ml/min compared with PL. Speeded MRT for V'O(2) correlated with indices of reduced lung hyperinflation, such as resting EELV (r = -0.64, p = 0.025) and EELV at isotime (r = -0.77, p = 0.0032). The results confirm an important interaction between abnormal dynamic respiratory mechanics and indices of cardio-circulatory function in the rest-to-exercise transition in COPD patients.

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  • Studies that have unloaded the respiratory muscles of hyperinflated patients with bronchodilators or heliox resulted in an improvement in indices of limb muscle fractional oxygen extraction.

    “Indeed, studies that have unloaded the respiratory muscles of hyperinflated patients with bronchodilators or heliox resulted in an improvement in indices of limb muscle fractional oxygen extraction.75,76”

    From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [76]

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Authors
Laveneziana, P., Palange, P., Ora, J., Martolini, D., & O’Donnell, D. E.
Affiliations
  • Queen's University (CA)
  • Sapienza University of Rome (IT)
Corresponding author
O’Donnell, Denis E.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2009-08-27
Volume
107
Issue
6
Pages
633-643
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-009-1169-4
OpenAlex
W2150599441
Cited by
60
References
52
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 8
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords
chronic obstructive pulmonary disease, bronchodilators, high-intensity exercise, heart rate kinetics, end-expiratory lung volume, lung hyperinflation, respiratory mechanics
MeSH terms
Aged, Bronchodilator Agents, Canada, Female, Heart Rate, Humans, Italy, Male, Middle Aged, Pulmonary Gas Exchange, Pulmonary Ventilation, Exercise, Respiratory Mechanics, Pulmonary Disease, Chronic Obstructive

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