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Cited by 204Probiotics and Fermented FoodsExercise and Physiological ResponsesThermoregulation and physiological responses

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

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Shing, Cecilia M., Peake, Jonathan M., Lim, Chin Leong, Briskey, David, Walsh, Neil P., Fortes, Matthew B., Ahuja, Kiran D. K., Vitetta, Luis·2014·European Journal of Applied Physiology
DOI 10.1007/s00421-013-2748-y
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Abstract

Purpose This study aimed to investigate the effects of multi-strain probiotics supplementation on gastrointestinal permeability, systemic markers of inflammation and running performance when exercising in the heat.Methods Ten male runners were randomized to 4 weeks of daily supplementation with a probiotics capsule (45 billion CFU of Lactobacillus, Bifidobacterium and Streptococcus strains) or placebo, separated by a washout period (double-blind, cross-over trial). After each treatment, the runners exercised to fatigue at 80% of their ventilatory threshold at 35 °C and 40% humidity. To assess gastrointestinal permeability, runners ingested lactulose and rhamnose before exercise and post-exercise urine was collected to measure sugar concentrations. Venous blood samples were collected before, immediately after and 1 h after exercise, and core temperature was monitored during exercise.Results Probiotics supplementation significantly increased run time to fatigue (min:s 37:44 ± 2:42 versus 33:00 ± 2:27; P = 0.03, d = 0.54). Average core temperature during exercise was similar between trials (probiotic 38.1 ± 0.2 °C, placebo 38.1 ± 0.1 °C; P = 0.77, d = 0.13). Serum lipopolysaccharide concentration increased post-exercise (P < 0.001), while there was a moderate to large reduction in pre-exercise (d = 0.70) and post-exercise (d = 1.24) concentration following probiotics supplementation. Plasma concentrations of IL-6, IL-10 and IL-1ra increased after exercise (P < 0.01), but there was no significant difference between trials (P > 0.05). There was a small to moderate reduction (d = 0.35) in urine lactulose:rhamnose and a small reduction (d = 0.25) in symptoms of gastrointestinal discomfort following probiotics supplementation (both P = 0.25).Conclusion Four weeks of supplementation with a multi-strain probiotic increased running time to fatigue in the heat. Further studies are required to elucidate the exact mechanisms for this performance benefit.

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  1. Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381

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Metadata

Authors
Shing, C. M., Peake, J. M., Lim, C. L., Briskey, D., Walsh, N. P., Fortes, M. B., Ahuja, K. D. K., & Vitetta, L.
Affiliations
  • University of Tasmania (AU)
  • Queensland University of Technology (AU)
  • National University of Singapore (SG)
  • The University of Queensland (AU)
  • Bangor University (GB)
Corresponding author
Shing, Cecilia M.
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2013-10-23
Volume
114
Issue
1
Pages
93-103
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-013-2748-y
OpenAlex
W1601403942
Cited by
204
References
45
Citations by year
2026: 14 · 2025: 18 · 2024: 22 · 2023: 17 · 2022: 27 · 2021: 19 · 2020: 23 · 2019: 20 · 2018: 20 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 5
FWCI
6.45
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Faculty of Health; Institute of Health and Biomedical Innovation
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Keywords
multi-strain probiotics, gastrointestinal permeability, exercise in the heat, running performance, systemic inflammation, lipopolysaccharide, interleukins, core body temperature, gastrointestinal discomfort, Lactobacillus, Bifidobacterium, Streptococcus
MeSH terms
Adult, Double-Blind Method, Hot Temperature, Humans, Inflammation, Intestinal Absorption, Male, Running, Cytokines, Exercise Tolerance, Cross-Over Studies, Probiotics, Gastrointestinal Tract

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