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Molecular mechanisms underlying the activation of eNOS
Abstract
Endothelial cells situated at the interface between blood and the vessel wall play a crucial role in controlling vascular tone and homeostasis, particularly in determining the expression of pro- and anti-atherosclerotic genes. Many of these effects are mediated by changes in the generation and release of the vasodilator nitric oxide (NO) in response to hemodynamic stimuli exerted on the luminal surface of endothelial cells by the streaming blood (shear stress) and the cyclic strain of the vascular wall. The endothelial NO synthase (eNOS) is activated in response to fluid shear stress and numerous agonists via cellular events such as; increased intracellular Ca(2+), interaction with substrate and co-factors, as well as adaptor and regulatory proteins, protein phosphorylation, and through shuttling between distinct sub-cellular domains. Dysregulation of these processes leads to attenuated eNOS activity and reduced NO output which is a characteristic feature of numerous patho-physiological disorders such as diabetes and atherosclerosis. This review summarizes some of the recent findings relating to the molecular events regulating eNOS activity.
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“eNOS is constitutively expressed; a number of posttranslational modifications impact the ability of eNOS to produce NO, from changes in the NO production rates to, in some cases, the complete blockade of NO synthesis”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [296]
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“This kinase is activated in endothelial cells by several stimuli including angiotensin II, oxidative stress, and insulin”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [296]
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Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · cited 1×
“Thereafter, followed the demonstration of nitric oxide (NO) production by the endothelium and the physiological effectiveness of L-arginine analogs [86] and eventually the isolation of the first NO-generating enzyme or NO synthase (NOS) [13].”
BackgroundMassagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591
Self-citationIsolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D., Engelhardt, B., Cao, G., DeLisser, H. M., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,738
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652
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Research works printed but not linked: 2
- Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R (2001) Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 88:e68–e75
- Kou R, Prabhakar P, Michel T (2001) Phosphorylation of the endothelial isoform of nitric oxide synthase at serine 116: identification of a novel path for eNOS regulation by lysophosphatidic acid. Circulation 104:509
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Taguchi, K., Tano, I., Kaneko, N., Matsumoto, T., & Kobayashi, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110463 · Cited by 46
Ohashi, J., Sawada, A., Nakajima, S., Noda, K., Takaki, A., & Shimokawa, H. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0197 · Cited by 45
Xia, N., Weisenburger, S., Koch, E., Burkart, M., Reifenberg, G., Förstermann, U., & Li, H. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13703 · Cited by 44
Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation
Sobrino, A., Vallejo, S., Novella, S., Lázaro‐Franco, M., Mompeón, A., Bueno‐Betí, C., Walther, T., Sánchez‐Ferrer, C. F., Peiró, C., & Hermenegildo, C. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.01.012 · Cited by 45
Peluso, A. A., Bertelsen, J. B., Andersen, K., Mortensen, T. P., Hansen, P., Sumners, C., Bäder, M., Santos, R. A. S., & Steckelings, U. M. (2018) · Clinical Science · doi:10.1042/cs20171598 · Cited by 45
Association between dietary carotenoid intakes and hypertension in adults
Li, Z., Chen, J., & Zhang, D. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002200 · Cited by 44
Shimokawa, H. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.19-119 · Cited by 45
Giebe, S., Hofmann, A., Brux, M., Lowe, F., Breheny, D., Morawietz, H., & Brunßen, C. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102150 · Cited by 45
Musicki, B., Bivalacqua, T. J., Champion, H. C., & Burnett, A. L. “. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12391 · Cited by 44
Endothelial Gata5 transcription factor regulates blood pressure
Messaoudi, S., He, Y., Gutsol, A. A., Wight, A. E., Hébert, R., Vilmundarson, R. O., Makrigiannis, A. P., Chalmers, J. P., Hamet, P., Tremblay, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9835 · Cited by 44
Matsumoto, T., Watanabe, S., Kawamura, R., Taguchi, K., & Kobayashi, T. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1330-0 · Cited by 43
Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue
Xia, N., Förstermann, U., & Li, H. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13397 · Cited by 44
Subiabre, M., Silva, L., Villalobos-Labra, R., Toledo, F., Mario Paublo, M., López, M. A., Salsoso, R., Pardo, F., Leiva, A., & Sobrevía, L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.022 · Cited by 43
Salsoso, R., Guzmán‐Gutiérrez, E., Sáez, T., Bugueño, K., Ramírez, M. A., Farías, M., Pardo, F., Leiva, A., Sanhueza, C., Mate, A., et al. (2014) · Placenta · doi:10.1016/j.placenta.2014.12.007 · Cited by 42
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
Westermeier, F., Sáez, T., Arroyo, P., Toledo, F., Gutiérrez, J., Sanhueza, C., Pardo, F., Leiva, A., & Sobrevía, L. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2729 · Cited by 42
Zhang, X., Wang, B., Xiao, Y., Wang, C., & He, L. (2018) · The Analyst · doi:10.1039/c8an00905h · Cited by 42
Bed rest does not induce hypercoagulability
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Arishe, O. O., Ebeigbe, A. B., & Webb, R. C. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz158 · Cited by 43
Ribeiro, T. P., Barbeau, S., Baudrimont, I., Vacher, P., Freund‐Michel, V., Cardouat, G., Berger, P., Guibert, C., Ducret, T., & Quignard, J. (2022) · Cells · doi:10.3390/cells11152349 · Cited by 42
Montanaro, R., Vellecco, V., Torregrossa, R., Casillo, G. M., Manzo, O. L., Mitidieri, E., Bucci, M., Castaldo, S., Sorrentino, R., Whiteman, M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102657 · Cited by 40
Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction
Pardo, F., Silva, L., Sáez, T., Salsoso, R., Gutiérrez, J., Sanhueza, C., Leiva, A., & Sobrevía, L. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.57 · Cited by 40
Screening plant derived dietary phenolic compounds for bioactivity related to cardiovascular disease
Croft, K. D., Yamashita, Y., O’Donoghue, H., Shirasaya, D., Ward, N. C., & Ashida, H. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.12.002 · Cited by 43
Villalobos-Labra, R., Sáez, P. J., Subiabre, M., Silva, L., Toledo, F., Westermeier, F., Pardo, F., Farías, M., & Sobrevía, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.007 · Cited by 40
Liu, H., Mao, P., Wang, J., Wang, T., & Xie, C.-H. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.02.005 · Cited by 40
McCormick, M. E., Goel, R., Fulton, D. J., Oess, S., Newman, D. K., & Tzima, E. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.216200 · Cited by 39
Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis
Xu, H., Fang, B., Du, S., Wang, S., Li, Q., Jia, X., Bao, C., Ye, L., Sui, X., Qian, L., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138505 · Cited by 40
Maintenance of cellular tetrahydrobiopterin homeostasis
Kim, H.-L., & Park, Y. S. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.9.584 · Cited by 39
Chao, C., Lii, C., Ye, S.-Y., Li, C., Lu, C., Lin, A., Liu, K., & Chen, H. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5007165 · Cited by 41
Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo
Noguchi, K., Hamadate, N., Matsuzaki, T., Sakanashi, M., Nakasone, J., Uchida, T., Arakaki, K., Kubota, H., Ishiuchi, S., Masuzaki, H., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01089.2010 · Cited by 38
Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis
Mistry, R. K., & Brewer, A. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.025 · Cited by 37
The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells
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Jasemi, S. V., Khazaei, H., Aneva, I. Y., Farzaei, M. H., & Echeverría, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00145 · Cited by 37
Protein Tyrosine Phosphatase SHP2 Mediates Chronic Insulin-Induced Endothelial Inflammation
Giri, H., Muthuramu, I., Dhar, M., Rathnakumar, K., Ram, U., & Dixit, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.239251 · Cited by 37
Li, H., Förstermann, U., Xia, N., Kuntić, M., Münzel, T. F., & Daiber, A. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.009 · Cited by 38
Buie, J. N. J., & Oates, J. C. (2014) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000284 · Cited by 36
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Gaynullina, D. K., Lubomirov, L. T., Sofronova, S. I., Kalenchuk, V. U., GLOE, T. R., Pfitzer, G., Tarasova, O. S., & Schubert, R. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt138 · Cited by 36
Yang, D., Xie, P., & Liu, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042076 · Cited by 36
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Dent, M. R., DeMartino, A. W., Tejero, J., & Gladwin, M. T. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.1c01048 · Cited by 35
Mackay, C., Floen, M., Leo, M. D., Hasan, R., Garrud, T. A. C., Fernández‐Peña, C., Singh, P., Malik, K. U., & Jaggar, J. H. (2022) · eLife · doi:10.7554/elife.74765 · Cited by 38
Loot, A. E., Pierson, I., Syzonenko, T., Elgheznawy, A., Randriamboavonjy, V., Živković, A., Stark, H., & Fleming, I. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31828d0fa3 · Cited by 35
Self-citationSubiabre, M., Villalobos-Labra, R., Silva, L., Fuentes, G., Toledo, F., & Sobrevía, L. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.021 · Cited by 36
Involvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity
Cabalín, C., Villalobos-Labra, R., Toledo, F., & Sobrevía, L. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.01.001 · Cited by 35
Regulation of pancreatic β-cell survival by nitric oxide
Bedoya, F. J., Salguero‐Aranda, C., Cahuana, G. M., Tapia‐Limonchi, R., Soria, B., & Tejedo, J. R. (2012) · Islets · doi:10.4161/isl.19822 · Cited by 35
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Zhernov, Y. V., Simanduyev, M. Y., Zaostrovtseva, O. K., Semeniako, E. E., Kolykhalova, K. I., Fadeeva, I. A., Kashutina, M. I., Vysochanskaya, S. O., Belova, E., Shcherbakov, D. V., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010809 · Cited by 37
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Fels, J., & Kusche‐Vihrog, K. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7327 · Cited by 34
Gaynullina, D. K., Schubert, R., & Tarasova, O. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061421 · Cited by 34
Suriyo, T., Watcharasit, P., Thiantanawat, A., & Satayavivad, J. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2011.12.017 · Cited by 34
Chen, M., Yi, B., Zhu, N., Wei, X., Zhang, G., Huang, S., & Sun, J. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv250 · Cited by 34
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Lenasi, H. (2011) · InTech eBooks · doi:10.5772/27067 · Cited by 34
Wu, Q. J., Dong, J., Bai, X., Jiang, Y., Li, J., Fan, S., Cheng, Y., & Jiang, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174974 · Cited by 35
Charoensin, S., Eroğlu, E., Opelt, M., Bischof, H., Madreiter‐Sokolowski, C. T., Kirsch, A., Depaoli, M. R., Frank, S., Schrammel, A., Mayer, B., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.049 · Cited by 33
Kaczara, P., Proniewski, B., Lovejoy, C. E. J., Kuś, K., Motterlini, R., Abramov, A. Y., & Chłopicki, S. (2018) · FEBS Journal · doi:10.1111/febs.14411 · Cited by 33
Korkmaz, Y., Lang, H., Beikler, T., Cho, B., Behrends, S., Bloch, W., Addicks, K., & Raab, W. H.-M. (2011) · Journal of Dental Research · doi:10.1177/0022034510390808 · Cited by 33
(-)-Epicatechin-induced calcium independent eNOS activation: roles of HSP90 and AKT
Ramírez‐Sánchez, I., Aguilar, H., Ceballos, G. M., & Villarreal, F. J. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1405-9 · Cited by 33
Blood Brothers: Hemodynamics and Cell–Matrix Interactions in Endothelial Function
Yurdagul, A., & Orr, A. W. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6525 · Cited by 32
CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells
Gaete, P. S., Lillo, M. A., Puebla, M., Poblete, I. M., & Figueroa, X. F. (2019) · Scientific Reports · doi:10.1038/s41598-019-44333-w · Cited by 32
Van, T. V., Watari, E., Taketani, Y., Kitamura, T., Shiota, A., Tanaka, T., Tanimura, A., Harada, N., Nakaya, Y., Yamamoto, H., et al. (2012) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-96 · Cited by 32
Baraúna, V. G., Mantuan, P. R., Magalhães, F. D. C., Campos, L. C. G., & Krieger, J. E. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.108 · Cited by 31
Devika, N. T., & Ali, B. M. J. (2013) · Molecular BioSystems · doi:10.1039/c3mb70258h · Cited by 31
Cocks, M. S., & Wagenmakers, A. J. M. (2015) · The Journal of Physiology · doi:10.1113/jp270329 · Cited by 37
Mechanosensory entities and functionality of endothelial cells
Mierke, C. T. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1446452 · Cited by 36
Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase
Bignon, E., Rizza, S., Filomeni, G., & Papaleo, E. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.03.011 · Cited by 30
Gete, Y. G., Koblan, L. W., Mao, X., Trappio, M., Mahadik, B. P., Fisher, J. P., Liu, D. R., & Cao, K. (2021) · Aging Cell · doi:10.1111/acel.13388 · Cited by 29
Cho, D., Park, J., Lee, E. J., Won, K., Lee, S., Kim, Y.-H., Hwang, S., Kwon, K. J., Shin, C. Y., Song, K., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.043 · Cited by 31
Braga, V. A., Couto, G., Lazzarin, M. C., Rossoni, L., & Medeiros, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125388 · Cited by 33
Attanzio, A., Frazzitta, A., Cilla, A., Livrea, M. A., Tesoriere, L., & Allegra, M. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000186 · Cited by 29
Nakayama, A., Albarrán-Juárez, J., Liang, G., Roquid, K. A., Iring, A., Tonack, S., Chen, M., Müller, O. J., Weinstein, L. S., & Offermanns, S. (2020) · JCI Insight · doi:10.1172/jci.insight.140485 · Cited by 29
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Park, J. Y., Choi, Y. W., Yun, J. W., Bae, J. U., Seo, K. W., Lee, S. J., Park, S. Y., & Kim, C. D. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.06.002 · Cited by 29
Waldbauer, K., Seiringer, G., Nguyen, D. L., Winkler, J., Blaschke, M., McKinnon, R., Urban, E., Ladurner, A., Dirsch, V. M., Zehl, M., et al. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05061 · Cited by 29
Assersen, K. B., Sumners, C., & Steckelings, U. M. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.02.095 · Cited by 28
Ladurner, A., Atanasov, A. G., Heiß, E. H., Baumgartner, L., Schwaiger, S., Rollinger, J. M., Stuppner, H., & Dirsch, V. M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.029 · Cited by 28
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
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Hohmann, N., Xia, N., Steinkamp-Fenske, K., Förstermann, U., & Li, H. (2016) · Molecules · doi:10.3390/molecules21080973 · Cited by 27
Böger, R. H., & Hannemann, J. (2020) · Pulmonary Circulation · doi:10.1177/2045894020918850 · Cited by 27
Troidl, K., Hammerschick, T., Albarrán-Juárez, J., Jung, G., Schierling, W., Tonack, S., Krüger, M., Matuschke, B., Troidl, C., Schaper, W. K. A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.313316 · Cited by 24
Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis
Henderson, J. M., Weber, C., & Santovito, D. (2021) · Cells · doi:10.3390/cells10030625 · Cited by 27
van Langen, J., Fransen, P. F., Hove, C. E. V., Schrijvers, D. M., Martinet, W., Meyer, G. R. Y. D., & Bult, H. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.09.016 · Cited by 26
Predescu, S. A., Knezevic, I. I., Bardita, C., Neamu, R. F., Brovcovych, V., & Predescu, D. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075846 · Cited by 26
ChengHua, H., Qi, J., Gao, S., Li, C., Ma, Y., Wang, J., Bai, Y., & Zheng, X. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.05.007 · Cited by 26
Cruz, E. F., Cerezo, A. B., Cantos‐Villar, E., Richard, T., Troncoso, A. M., & García-Parrilla, M. C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00282 · Cited by 26
Cellular microdomains for nitric oxide signaling in endothelium and red blood cells
Leo, F., Hutzler, B., Ruddiman, C. A., Isakson, B. E., & Cortese-Krott, M. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.002 · Cited by 28
Xu, M., Xu, J.-J., Kang, L., Liu, Z., Su, M.-M., Zhao, W., Wang, Z.-H., Sun, L., Xiao, J., Evans, P. C., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01317-5 · Cited by 25
Ishida, K., Matsumoto, T., Taguchi, K., Kamata, K., & Kobayashi, T. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1088-9 · Cited by 25
Arias-Durán, L., Estrada-Soto, S. E., Hernández-Morales, M., Millán‐Pacheco, C., Navarrete‐Vázquez, G., Villalobos‐Molina, R., Ibarra-Barajas, M., & Almanza-Pérez, J. C. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113948 · Cited by 25
Nitric oxide synthase and its function in animal reproduction: an update
Zhang, W., Chen, S. J., Guo, L., Zhang, Z., bin Zhang, J., Wang, X. M., Meng, X. B., Zhang, M., Zhang, K., Chen, L., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1288669 · Cited by 28
Shi, P., Liu, S., Xia, X., Qian, J., Jing, H., Yuan, J., Zhao, H., Wang, F., Wang, Y., Wang, X., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153039 · Cited by 24
Woolf, E. K., Lee, S. Y., Ghanem, N., Vazquez, A. R., & Johnson, S. A. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.09.007 · Cited by 24
Tanano, I., Nagaoka, T., Omae, T., Ishibazawa, A., Kamiya, T., Ono, S., & Yoshida, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10115 · Cited by 24
CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats
Xu, X., Tu, L., Wang, L., Fang, X., & Wang, D. W. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-114 · Cited by 24
Kovačević, I., Müller, M. J., Kojonazarov, B. K., Ehrke, A., Randriamboavonjy, V., Kohlstedt, K., Hindemith, T., SCHERMULY, R. T., Fleming, I., Hoffmeister, M., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.306187 · Cited by 26
Self-citationZhang, Y., Chen, J., Li, F., Li, D., Xiong, Q., Lin, Y., Zhang, D., Wang, X., Yang, P., & Rui, Y. (2012) · Stroke · doi:10.1161/strokeaha.112.657908 · Cited by 24
Drummond, P. D. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139012850.004 · Cited by 22
Warboys, C. M., Chen, N., Zhang, Q., Shaifta, Y., Vanderslott, G., Passacquale, G., Hu, Y., Xu, Q., Ward, J. P. T., & Ferro, A. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu173 · Cited by 23
Wild, J., Soehnlein, O., Dietel, B., Urschel, K., Garlichs, C. D., & Cicha, I. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-11-0908 · Cited by 23
Re, A., Aiello, A., Nanni, S., Grasselli, A., Benvenuti, V., Pantisano, V., Strigari, L., Colussi, C., Ciccone, S., Mazzetti, A. P., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1024 · Cited by 23
Bouzinova, E. V., Hangaard, L., Staehr, C., Mazur, A., Ferreira, A., Chibalin, A., Sandow, S. L., Xie, Z. J., Aalkjær, C., & Matchkov, V. V. (2018) · Acta Physiologica · doi:10.1111/apha.13059 · Cited by 23
The Roles of AMPK in Revascularization
Chen, M.-H., & Fu, Q.-M. (2020) · Cardiology Research and Practice · doi:10.1155/2020/4028635 · Cited by 22
Ceconi, C., Guardigli, G., Rizzo, P., Francolini, G., & Ferrari, R. (2011) · European Heart Journal Supplements · doi:10.1093/eurheartj/sur014 · Cited by 22
Metadata
- Authors
- Fleming, I.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Fleming, Ingrid
- ORCID
- Fleming, Ingrid
- Venue
- Pflügers Archiv - European Journal of Physiology
- Published
- 2009-12-13
- Volume
- 459
- Issue
- 6
- Pages
- 793-806
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- OpenAlex
- W2000165700
- Cited by
- 437
- References
- 125
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 22 · 2023: 20 · 2022: 20 · 2021: 27 · 2020: 33 · 2019: 32 · 2018: 29 · 2017: 31 · 2016: 32 · 2015: 32 · 2014: 35 · 2013: 23 · 2012: 44
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endothelial nitric oxide synthase, eNOS activation, nitric oxide, endothelial cells, fluid shear stress, cyclic strain, intracellular calcium, protein phosphorylation, adaptor proteins, atherosclerosis, diabetes mellitus, vascular tone, hemodynamics
- MeSH terms
- Soluble Guanylyl Cyclase, Amino Acid Sequence, Biopterins, Calmodulin, Enzyme Activation, Guanylate Cyclase, Humans, Nitric Oxide, Phosphorylation, Protein Kinases, Signal Transduction, Receptors, Cytoplasmic and Nuclear, HSP90 Heat-Shock Proteins, Platelet Endothelial Cell Adhesion Molecule-1, Dynamins, Adaptor Proteins, Signal Transducing, Caveolin 1, Nitric Oxide Synthase Type III, Protein Tyrosine Phosphatase, Non-Receptor Type 11
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