Effects of high-intensity interval training on adipose tissue lipolysis, inflammation, and metabolomics in aged rats

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

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Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

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Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue

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Aging and adipose tissue: potential interventions for diabetes and regenerative medicine

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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

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Cycle and hormone changes during perimenopause

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Role of visceral adipose tissue in aging

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Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats

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Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure

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Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes

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Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community

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High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice

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The effect of high‐intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue

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High-intensity interval training improves insulin sensitivity in older individuals.

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The Muscle Metabolome Differs between Healthy and Frail Older Adults

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Effect of high-fat diets on body composition, lipid metabolism and insulin sensitivity, and the role of exercise on these parameters

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Potential roles of vitamin E in age-related changes in skeletal muscle health

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Beneficial alterations in body composition, physical performance, oxidative stress, inflammatory markers, and adipocytokines induced by long-term high-intensity interval training in an aged rat model

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Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

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Peroxisome Proliferator-Activated Receptor γ-Dependent Regulation of Lipolytic Nodes and Metabolic Flexibility

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Circadian Rhythms in Adipose Tissue Physiology

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Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen

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Association of Adipose Tissue Fatty Acids With Cardiovascular and All-Cause Mortality in Elderly Men

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Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis

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Effect of high-intensity interval training on body composition and inflammatory markers in obese postmenopausal women: a randomized controlled trial

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Aging-Associated Reductions in Lipolytic and Mitochondrial Proteins in Mouse Adipose Tissue Are Not Rescued by Metformin Treatment

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Exercise-Induced Alterations in Skeletal Muscle, Heart, Liver, and Serum Metabolome Identified by Non-Targeted Metabolomics Analysis

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Dose- and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes

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Steroidogenesis decline accompanied with reduced antioxidation and endoplasmic reticulum stress in mice testes during ageing

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Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet

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Metabolic effects of voluntary wheel running in young and old Syrian golden hamsters

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Physical Activity Producing Low, but Not Medium or Higher, Vertical Impacts Is Inversely Related to BMI in Older Adults: Findings From a Multicohort Study

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In obese mice, exercise training increases 11β-HSD1 expression, contributing to glucocorticoid activation and suppression of pulmonary inflammation

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Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats

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Metabolomics in Exercise and Sports: A Systematic Review

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Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease

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Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity

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High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

Chen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., & Zhang, J. (2023) · BMC Biology · doi:10.1186/s12915-023-01698-9 · Cited by 50 · see citing works

Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis

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Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss

Ahn, C., Ryan, B. J., Schleh, M. W., Varshney, P., Ludzki, A. C., Gillen, J. B., Pelt, D. W. V., Pitchford, L. M., Howton, S. M., Rode, T., et al. (2022) · The Journal of Physiology · doi:10.1113/jp282371 · Cited by 48 · see citing works

Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review

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The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway

Babaei, A., Nourshahi, M., Fani, M., Entezari, Z., Jameie, S. B., & Haghparast, A. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.006 · Cited by 37 · see citing works

Post-exercise Effects and Long-Term Training Adaptations of Hormone Sensitive Lipase Lipolysis Induced by High-Intensity Interval Training in Adipose Tissue of Mice

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Exercise workload: a key determinant of immune health – a narrative review

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Aerobic exercise and lipolysis: A review of the β-adrenergic signaling pathways in adipose tissue

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Comparison of visceral fat lipolysis adaptation to high-intensity interval training in obesity-prone and obesity-resistant rats

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Exercise increases bone mass by lactate/Gpr81 signaling pathway

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Immunological mechanisms of exercise therapy in dyslipidemia

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High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats

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The Role of Exercise Intensity on Fatty Liver in Rats

Gu, X., Ma, X., Mo, L., & Wang, Q. (2022) · The Chinese Journal of Physiology · doi:10.4103/0304-4920.365461 · Cited by 11 · see citing works

Aerobic interval training improves irisin and chemerin levels of both liver and visceral adipose tissues and circulating asprosin in rats with metabolic syndrome

Ahmadabadi, F., Nakhaei, H., Mogharnasi, M., & Huang, C. (2021) · Physiology International · doi:10.1556/2060.2021.00182 · Cited by 10 · see citing works

EFFECTS OF DIFFERENT TYPES OF ENVIRONMENTAL ENRICHMENT ON BEHAVIOUR, PERFORMANCE, WELFARE, CARCASS CHARACTERISTICS AND LIPID PROFILE OF BROILER CHICKENS

Elsayed, R. A., Mohammed, A. S., Abouelnaga, A., Abou-Ismail, U. A., Darwish, R. A., & Fouda, M. M. (2024) · Mansoura Veterinary Medical Journal · doi:10.35943/2682-2512.1225 · Cited by 11 · see citing works

Elucidating the primary mechanisms of high-intensity interval training for improved cardiac fitness in obesity

Bo, B., Guo, A., Kaila, S. J., Hao, Z., Zhang, H., Wei, J., & Yao, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1170324 · Cited by 8 · see citing works

Inflammatory markers and noncoding‐ RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle‐aged men with prediabetes

Nikseresht, M., Roshan, V. D., & Nasiri, K. (2024) · Physiological Reports · doi:10.14814/phy2.16146 · Cited by 6 · see citing works

Molecular mechanisms of exercise-induced improvements in Alzheimer’s disease: a focus on lipid homeostasis

Zhou, J., Zhang, X., Yin, S., Xue, S., He, Q., Chen, S., & Xue, X. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00537-5 · Cited by 5 · see citing works

High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats

Wang, X., Song, J., Xia, P., Lin, Q., Chen, A., Cheng, K., Kong, F., Shi, Y., & Li, X. (2023) · The Journal of Physiological Sciences · doi:10.1186/s12576-023-00866-4 · Cited by 4 · see citing works

Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys

Yuan, X.-K., Ni, P., Yan, Z.-H., Yu, Z., Wang, Z., Zhang, C., Li, F., & Yu, X. (2024) · Physiological Research · doi:10.33549/physiolres.935290 · Cited by 4 · see citing works

Age-related changes in adipose tissue metabolomics and inflammation, cardiolipin metabolism, and ferroptosis markers in female aged rat model

Wang, Z., Li, F., Ni, P., Sun, L., Zhang, C., Li, B., He, J., Yu, X., & Liu, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.06.027 · Cited by 4 · see citing works

Effectiveness of high-intensity interval training and high-protein diet on TNF-α protein level in colon tissue of obese male rats: The importance of diet modifying

Zaker, B. S. K., Saghebjoo, M., & Islami, F. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100403 · Cited by 3 · see citing works

Evaluation of the anti-arthritic properties of Litsea glutinosa (L.) C.B. Rob Bark: An integrated analysis utilizing in-silico, in-vitro, and in-vivo approaches, along with identification of major compounds

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The effectiveness of high-intensity interval training on body composition of rodent models of obesity: A systematic review and meta-analysis

Sordi, A. F., Silva, B. F., Furlan, J. P., de Moraes, S. M. F., Guariglia, D. A., & Peres, S. B. (2022) · Physiology International · doi:10.1556/2060.2022.00018 · Cited by 1 · see citing works

Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model

Abazari, O., Shakibaee, A., Shahriary, A., Arabzadeh, E., & Hofmeister, M. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02787-y · Cited by 1 · see citing works

Bewegungstherapie und Sport bei Fettstoffwechselstörungen

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Angular Gait Behavior and Muscle Collagen Remodeling in Rats of Different Ages and Diets Submitted to Intense Physical TrainingPreprint

Jimenes, D. R., Teixeira, N. R., de Oliveira, S. S. C., Rinaldi, W., Barbosa, C. P., & Deprá, P. P. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5147753

High-intensity interval training and glycine interventions ameliorate intestinal homeostasis via modulation of gut microbiota and metabolism in aged mice

He, J., Ni, P., Rong, X., Yu, Z., Li, B., Zhang, C., Zhang, Z., Wan, Q., Zhong, W., & Li, F. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250546

The Complexities of Metabolic Flexibility and Precision Approaches to Sustainable Weight Management

Theodorakis, N., Kreouzi, M., Pappas, A., Feretzakis, G., Sakagianni, A., Kalodanis, K., Αναστασίου, Α., Nikolaou, M., & Koumpouros, Y. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5787-3.ch005

Impact of high-intensity interval training on aging-related muscle atrophy: the role of semaphorin-3a in neuromuscular junction health

Dakhili, A. B., Amooei, M., Gharakhanlou, R., Rajabi, H., & Shamsi, M. M. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01471-1

Three-dimensional gait kinematics and muscle collagen remodeling in rats of different ages and diets subjected to high-intensity exercise

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Exercise Intensity Modulates the Human Plasma Secretome and Interorgan CommunicationPreprint

Olsen, L., Botella, J., Barrows, D., Romero, E., Baird, K., Katayama, M., Kilic, E., Peralta, C., Sanford, H., Farrell, L. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.22.683699

Additional file 1 of High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

Chen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.24165124

Additional file 2 of High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis

Chen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.24165127

Efeito do treinamento intervalado de alta intensidade sobre a área dos adipócitos em ratos alimentados com dieta hiperlipídica

Nakashima, H. H., Jimenes, D. R., do Vale, D. C. G., Wilxenski, A., Marosti, A. R., Berti, J. A., & Barbosa, C. P. (2025) · Cuadernos de Educación y Desarrollo · doi:10.55905/cuadv17n12-031

Cognitive and biochemical responses to continuous moderate and extensive interval exercise in randomized elderly male rats

Kandiş, S., Gençoğlu, C., Ilgın, R., Kirik, A. B. T., Yuksel, O., Ateş, M., Kızıldağ, S., & HARZADIN, N. U. (2026) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-026-01794-7

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High-Intensity Interval Training Remodels Adipose Tissue Inflammatory Signaling and Enhances Immunometabolic Health via microRNA RegulationPreprint

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