Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging
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Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 kcal/day lower than expected on the basis of weight loss, indicating sustained metabolic adaptation over 2 years. This metabolic adaptation was accompanied by significantly reduced thyroid axis activity and reactive oxygen species (F2-isoprostane) production. Findings from this 2-year CR trial in healthy, non-obese humans provide new evidence of persistent metabolic slowing accompanied by reduced oxidative stress, which supports the rate of living and oxidative damage theories of mammalian aging.
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Environmental factors such as fewer calories, good sleep, less stress, good relationships, no smoking, and low alcohol drinking can delay aging.
“It was shown that less calories [469], good sleep [470], less stress [471], good relationships [472], no smoke and low alcohol drinking are environmental factors capable of delaying aging, while genetic factors play a role for in 25% to 30% of life expectancy [473].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [469]
Dietary restriction in humans reduces oxidative stress.
“Dietary restriction in humans was shown to reduce oxidative stress [297]”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [297]
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Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
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Calorie Restriction and Aging in Humans
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Self-citationRegulators of health and lifespan extension in genetically diverse mice on dietary restriction
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
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Modeling transcriptomic age using knowledge-primed artificial neural networks
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Senolytic treatment rescues blunted muscle hypertrophy in old mice
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Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
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Recent advances in understanding the mechanisms determining longevity
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- Authors
- Redman, L. M., Smith, S. R., Burton, J. H., Martin, C. K., Il'yasova, D., & Ravussin, E.
- Affiliations
- Pennington Biomedical Research Center (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Redman, Leanne M.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 27
- Issue
- 4
- Pages
- 805-815.e4
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5886711
- OpenAlex
- W2792782460
- Cited by
- 472
- References
- 80
- Citations by year
- 2026: 37 · 2025: 41 · 2024: 41 · 2023: 54 · 2022: 61 · 2021: 78 · 2020: 69 · 2019: 62 · 2018: 29
- FWCI
- 23.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 AG029914, U01 AG020478, P30DK072476)
- Louisiana Clinical and Translational Science Center (U54 GM104940)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, energy expenditure, metabolic adaptation, rate of living theory, oxidative stress, reactive oxygen species, F2-isoprostanes, hypothalamic-pituitary-thyroid axis, sleep energy expenditure, weight loss, lifespan extension, healthspan
- MeSH terms
- Adult, Aging, Energy Metabolism, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Weight Loss, Body Mass Index, Oxidative Stress, Caloric Restriction
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