High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
Open accessAbstract
Background: The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of the protein. Methods: C57B/L6 mice were divided into 3 groups: the control group, HIIT group, and dichloroacetate injection + HIIT group (DCA + HIIT). The HIIT and DCA + HIIT groups underwent 8 weeks of HIIT treatment, and the DCA + HIIT group was injected DCA before HIIT treatment. The expression of lipid metabolism-related genes was determined. Protein lactylation in subcutaneous adipose tissue was identified and analyzed using 4D label-free lactylation quantitative proteomics and bioinformatics analyses. The fatty acid synthase (FASN) lactylation and activity was determined. Results: HIIT had a significant effect on fat loss; this effect was weakened when lactate production was inhibited. HIIT significantly upregulated the protein lactylation while lactate inhibition downregulated in iWAT. FASN had the most modification sites. Lactate treatment increased FASN lactylation levels, inhibited FASN activity, and reduced palmitate and triglyceride synthesis in 3T3-L1 cells. Conclusions: This investigation revealed that lactate produced by HIIT increased protein pan-lactylation levels in iWAT. FASN lactylation inhibited de novo lipogenesis, which may be an important mechanism in HIIT-induced fat loss.
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Enhanced sensitivity to lipolytic hormones, increased browning thermogenesis, and lactylation of fatty acid synthase are involved in the post-exercise fat loss process associated with HIT.
“Enhanced sensitivity to lipolytic hormones [26], increased browning thermogenesis [31] and lactylation of fatty acid synthase [32] have been demonstrated to be involved in the post-exercise fat loss process associated with HIT.”
HIT facilitates the browning of adipose tissue and inhibits fat synthesis via lactate.
“However, HIT has been demonstrated to facilitate the browning of adipose tissue [53] and inhibit fat synthesis via lactate [32].”
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- Authors
- Chen, X., Huang, W., Zhang, J., Li, Y., Xing, Z., Guo, L., Jiang, H., & Zhang, J.
- Affiliations
- Beijing Normal University (CN)
- Capital Medical University (CN)
- Corresponding author
- Zhang, Jing
- Venue
- BMC Biology
- Published
- 2023-09-19
- Volume
- 21
- Issue
- 1
- Pages
- 196-196
- ISSN
- 1741-7007 (ISSN-L)
- PMC
- PMC10510295
- OpenAlex
- W4386857367
- Cited by
- 50
- References
- 37
- Citations by year
- 2026: 22 · 2025: 19 · 2024: 9
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31871207)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- high-intensity interval training, lactylation, fatty acid synthase, lactate, de novo lipogenesis, lipogenesis, subcutaneous adipose tissue, dichloroacetate, fat loss, 3T3-L1 adipocytes, triglyceride synthesis
- MeSH terms
- High-Intensity Interval Training, Animals, Lipids, Lactic Acid, Lipogenesis, Mice, Fatty Acid Synthase, Type I, Fatty Acid Synthases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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