The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala
Abstract
The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus with dense projections to the nucleus accumbens (NAc), dorsolateral region of the bed nucleus of the stria terminalis (BSTDL) and the lateral/capsular region of the central nucleus of the amygdala (CeL/CeC). Recent experimental evidence indicates that the PVT is involved in both appetitive and aversive behaviors. However, it is unknown if subgroups of neurons in the PVT innervate different subcortical targets or if the same neurons issue collaterals to multiple areas. To address this issue, we injected two different fluorescent retrograde tracers, cholera toxin subunit B conjugated to Alexa Fluor-488 or Alexa Fluor-594, into different pairs of the subcortical targets including different parts of the NAc (shell, core, dorsomedial shell, and ventromedial shell), BSTDL, and amygdala (basolateral amygdala and CeL/CeC). The results indicate a moderate to high level of collateralization of projections from neurons in the PVT to NAc, BSTDL, and CeL/CeC suggesting a potential importance of the PVT in simultaneously coordinating the activity of key regions of the brain involved in mediating emotional and motivational behaviors. We also observed a difference in the subcortical targets innervated by the anterior PVT (aPVT) and posterior PVT (pPVT) showing that more neurons in the aPVT innervate the dorsomedial part of the NAc shell, while more neurons in the pPVT innervate the ventromedial NAc shell, BSTDL, and CeL/CeC. This observation is suggestive of a potential functional difference between the aPVT and pPVT.
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“Given that the PVT projects to various reward-associated areas including the NAc, bed nucleus of the stria terminalis, and central amygdala through collateralized projections 10,14, mPFC->pPVT neurons are well-positioned to provide top-down control of brain networks.”
From A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice (2020) · cites this paper as [14]
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“In contrast, the CeL and the BSTDL have been implicated in avoidance and defensive behaviors (Davis et al. 2010; LeDoux 2000) and pPVT projections to these areas may represent a means for the PVT to influence”
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Emotion Dysregulation and Emerging Psychopathology: A Transdiagnostic, Transdisciplinary Perspective
Beauchaine, T. P., & Cicchetti, D. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000671 · Cited by 301
“For example, the nucleus accumbens (a ventral striatal structure) and the amygdala share inter-connections via the paraventricular nucleus and the stria terminalis (e.g., Dong, Li, & Kirouac, 2017).”
Dynamic salience processing in paraventricular thalamus gates associative learning
Zhu, Y., Nachtrab, G. T., Keyes, P. C., Allen, W. E., Luo, L., & Chen, X. (2018) · Science · doi:10.1126/science.aat0481 · Cited by 220
Thalamic subnetworks as units of function
Roy, D. S., Zhang, Y., Halassa, M. M., & Feng, G. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00996-1 · Cited by 177
Otis, J. M., Zhu, M., Namboodiri, V. M. K., Cook, C. A., Kosyk, O., Matan, A. M., Ying, R., Hashikawa, Y., Hashikawa, K., Trujillo‐Pisanty, I., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.018 · Cited by 195
“Signals from these input neurons may propagate to several downstream targets, as PVT neurons have bifurcating axon projections throughout the extended amygdala, including the NAc (Dong et al., 2017).”
BackgroundThe physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Metadata
- Authors
- Dong, X., Li, S., & Kirouac, G. J.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Kirouac, Gilbert J.
- Venue
- Brain Structure and Function
- Published
- 2017-05-20
- Volume
- 222
- Issue
- 9
- Pages
- 3927-3943
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2616069238
- Cited by
- 143
- References
- 61
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 17 · 2023: 14 · 2022: 21 · 2021: 26 · 2020: 19 · 2019: 8 · 2018: 10 · 2017: 3
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute of Neurosciences, Mental Health and Addiction (MOP89758)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- paraventricular thalamus, collateral projections, nucleus accumbens, bed nucleus of the stria terminalis, central amygdala, subcortical projections, cholera toxin B subunit, retrograde tracing
- MeSH terms
- Animals, Brain Mapping, Cholera Toxin, Functional Laterality, Male, Neural Pathways, Nucleus Accumbens, Phosphopyruvate Hydratase, Septal Nuclei, Rats, Sprague-Dawley, Midline Thalamic Nuclei, Rats
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