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Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala
Abstract
The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus with dense projections to the nucleus accumbens (NAc), dorsolateral region of the bed nucleus of the stria terminalis (BSTDL) and the lateral/capsular region of the central nucleus of the amygdala (CeL/CeC). Recent experimental evidence indicates that the PVT is involved in both appetitive and aversive behaviors. However, it is unknown if subgroups of neurons in the PVT innervate different subcortical targets or if the same neurons issue collaterals to multiple areas. To address this issue, we injected two different fluorescent retrograde tracers, cholera toxin subunit B conjugated to Alexa Fluor-488 or Alexa Fluor-594, into different pairs of the subcortical targets including different parts of the NAc (shell, core, dorsomedial shell, and ventromedial shell), BSTDL, and amygdala (basolateral amygdala and CeL/CeC). The results indicate a moderate to high level of collateralization of projections from neurons in the PVT to NAc, BSTDL, and CeL/CeC suggesting a potential importance of the PVT in simultaneously coordinating the activity of key regions of the brain involved in mediating emotional and motivational behaviors. We also observed a difference in the subcortical targets innervated by the anterior PVT (aPVT) and posterior PVT (pPVT) showing that more neurons in the aPVT innervate the dorsomedial part of the NAc shell, while more neurons in the pPVT innervate the ventromedial NAc shell, BSTDL, and CeL/CeC. This observation is suggestive of a potential functional difference between the aPVT and pPVT.
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“Given that the PVT projects to various reward-associated areas including the NAc, bed nucleus of the stria terminalis, and central amygdala through collateralized projections 10,14, mPFC->pPVT neurons are well-positioned to provide top-down control of brain networks.”
From A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice (2020) · cites this paper as [14]
Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,513 · cited 2×
“In contrast, the CeL and the BSTDL have been implicated in avoidance and defensive behaviors (Davis et al. 2010; LeDoux 2000) and pPVT projections to these areas may represent a means for the PVT to influence”
BackgroundResultPape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
Van der Werf, Y. D., Witter, M. P., & Groenewegen, H. J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00181-9 · Cited by 994
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action
Floresco, S. B. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115159 · Cited by 938
Amygdala inhibitory circuits and the control of fear memory
Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878
Pennartz, C. M. A., Groenewegen, H. J., & LOPESDASILVA, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90025-6 · Cited by 809
Berendse, H. W., & Groenewegen, H. J. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902990206 · Cited by 598
The specificity of the ‘nonspecific’ midline and intralaminar thalamic nuclei
Groenewegen, H. J., & Berendse, H. W. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90074-4 · Cited by 596
The thalamostriatal system: a highly specific network of the basal ganglia circuitry
Smith, Y., Raju, D. V., Paré, J., & Sidibé, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.004 · Cited by 595
The paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506
A temporal shift in the circuits mediating retrieval of fear memory
Do-Monte, F. H., Quiñones-Laracuente, K., & Quirk, G. J. (2015) · Nature · doi:10.1038/nature14030 · Cited by 491
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441
Efferent projections of the paraventricular thalamic nucleus in the rat
Moga, M. M., Weis, R. P., & Moore, R. Y. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590204 · Cited by 402
A thalamic input to the nucleus accumbens mediates opiate dependence
Zhu, Y., Wienecke, C. F. R., Nachtrab, G. T., & Chen, X. (2016) · Nature · doi:10.1038/nature16954 · Cited by 392
The nucleus accumbens as part of a basal ganglia action selection circuit
Nicola, S. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0510-4 · Cited by 383
Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior
Kirouac, G. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.005 · Cited by 357
Self-citationLuppi, P., Fort, P., & Jouvet, M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90131-t · Cited by 315
Organization of the basal ganglia: the importance of axonal collateralization
Parent, A., Sato, F., Wu, Y. N., Gauthier, J., Lévesque, M., & Parent, M. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00022-7 · Cited by 306
Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat
Vertes, R. P., & Hoover, W. B. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21679 · Cited by 296
Su, H., & Bentivoglio, M. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902970410 · Cited by 269
Li, S., & Kirouac, G. J. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21502 · Cited by 261
Self-citationReynolds, S. M., & Berridge, K. C. (2008) · Nature Neuroscience · doi:10.1038/nn2061 · Cited by 244
Choi, D. L., Davis, J. F., Fitzgerald, M. E., & Benoit, S. C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.002 · Cited by 239
Hsu, D. T., Kirouac, G. J., Zubieta, J.-K., & Bhatnagar, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00073 · Cited by 238
Self-citationOrexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats
Li, Y., Li, S., Wei, C., Wang, H., Sui, N., & Kirouac, G. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1948-y · Cited by 184
Self-citationHamlin, A. S., Clemens, K. J., Choi, E. A., & McNally, G. P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06623.x · Cited by 183
Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission
Monte, F. H. D., Minier-Toribio, A. M., Quiñones-Laracuente, K., Medina-Colón, E. M., & Quirk, G. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.036 · Cited by 175
Barson, J. R., Ho, H. T., & LEIBOWITZ, S. F. (2014) · Addiction Biology · doi:10.1111/adb.12139 · Cited by 134
Shinonaga, Y., Takada, M., & Mizuno, N. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90045-0 · Cited by 127
Hsu, D. T., & Price, J. L. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21934 · Cited by 127
Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior
Labouèbe, G., Boutrel, B., Tarussio, D., & Thorens, B. (2016) · Nature Neuroscience · doi:10.1038/nn.4331 · Cited by 125
Paraventricular Thalamus Balances Danger and Reward
Choi, E. A., & McNally, G. P. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3320-16.2017 · Cited by 120
Heydendael, W., Sharma, K., Iyer, V., Luz, S., Piel, D., Beck, S. G., & Bhatnagar, S. (2011) · Endocrinology · doi:10.1210/en.2011-1652 · Cited by 118
Chapter 4 The specificity of the nonspecific thalamus: The midline nuclei
Bentivoglio, M., Balercia, G., & Kruger, L. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63047-2 · Cited by 114
Chen, S., & Aston‐Jones, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00020-q · Cited by 113
James, M. H., Charnley, J. L., Jones, E., Levi, E. M., Yeoh, J. W., Flynn, J. R., Smith, D. W., & Dayas, C. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012980 · Cited by 110
A time-dependent role of midline thalamic nuclei in the retrieval of fear memory
Padilla-Coreano, N., Do-Monte, F. H., & Quirk, G. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.037 · Cited by 100
Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection
Neumann, P. A., Wang, Y., Yan, Y., Wang, Y., Ishikawa, M., Cui, R., Huang, Y. H., Sesack, S. R., Schlüter, O. M., & Dong, Y. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.52 · Cited by 96
Bubser, M., & Deutch, A. Y. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01373-5 · Cited by 90
Li, Y., Li, S., Wei, C., Wang, H., Sui, N., & Kirouac, G. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.12.016 · Cited by 83
Self-citationYoung, C. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00051-3 · Cited by 78
Stratford, T. R., & Wirtshafter, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.043 · Cited by 77
Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression
Li, Y., Dong, X., Li, S., & Kirouac, G. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00094 · Cited by 76
Self-citationOtake, K., & Nakamura, Y. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00062-1 · Cited by 73
Conte, W. L., Kamishina, H., & Reep, R. L. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0212-x · Cited by 65
Li, Y., Wang, H., Qi, K., Chen, X., Li, S., Sui, N., & Kirouac, G. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.10.006 · Cited by 65
Self-citationBrowning, J. R., Jansen, H. T., & Sorg, B. A. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.09.021 · Cited by 64
Matzeu, A., Weiss, F., & Martin‐Fardon, R. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.016 · Cited by 63
Matzeu, A., Kerr, T. M., Weiss, F., & Martin‐Fardon, R. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.235945 · Cited by 62
Unzai, T., Kuramoto, E., Kaneko, T., & Fujiyama, F. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv295 · Cited by 61
Li, Y., Li, S., Sui, N., & Kirouac, G. J. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.06.017 · Cited by 54
Self-citationBarson, J. R., Poon, K., Ho, H. T., Alam, M. I., Sanzalone, L., & LEIBOWITZ, S. F. (2015) · Addiction Biology · doi:10.1111/adb.12288 · Cited by 42
The Nigrostriatal Pathway: Axonal Collateralization and Compartmental Specificity
Prensa, L., Giménez‐Amaya, J. M., Parent, A., Bernácer, J., & Cebrián, C. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_4 · Cited by 34
Dong, X., Li, Y., & Kirouac, G. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00161 · Cited by 31
Self-citationBarson, J. R., & LEIBOWITZ, S. F. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.029 · Cited by 31
Reichard, R. A., Subramanian, S., Desta, M. T., Sura, T. A., Becker, M. L., Ghobadi, C. W., Parsley, K. P., & Zahm, D. S. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1321-y · Cited by 23
Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior
Reed, M. D., Hildebrand, D. G. C., Santangelo, G., Moffa, A., Pira, A. S., Rycyna, L., Radic, M., Price, K. E., Archbold, J., McConnell, K., et al. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.001 · Cited by 15
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Beauchaine, T. P., & Cicchetti, D. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000671 · Cited by 301
“For example, the nucleus accumbens (a ventral striatal structure) and the amygdala share inter-connections via the paraventricular nucleus and the stria terminalis (e.g., Dong, Li, & Kirouac, 2017).”
Dynamic salience processing in paraventricular thalamus gates associative learning
Zhu, Y., Nachtrab, G. T., Keyes, P. C., Allen, W. E., Luo, L., & Chen, X. (2018) · Science · doi:10.1126/science.aat0481 · Cited by 220
Thalamic subnetworks as units of function
Roy, D. S., Zhang, Y., Halassa, M. M., & Feng, G. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00996-1 · Cited by 177
Otis, J. M., Zhu, M., Namboodiri, V. M. K., Cook, C. A., Kosyk, O., Matan, A. M., Ying, R., Hashikawa, Y., Hashikawa, K., Trujillo‐Pisanty, I., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.018 · Cited by 195
“Signals from these input neurons may propagate to several downstream targets, as PVT neurons have bifurcating axon projections throughout the extended amygdala, including the NAc (Dong et al., 2017).”
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Metadata
- Authors
- Dong, X., Li, S., & Kirouac, G. J.
- Affiliations
- University of Manitoba (CA)
- Corresponding author
- Kirouac, Gilbert J.
- Venue
- Brain Structure and Function
- Published
- 2017-05-20
- Volume
- 222
- Issue
- 9
- Pages
- 3927-3943
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2616069238
- Cited by
- 143
- References
- 61
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 17 · 2023: 14 · 2022: 21 · 2021: 26 · 2020: 19 · 2019: 8 · 2018: 10 · 2017: 3
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute of Neurosciences, Mental Health and Addiction (MOP89758)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- paraventricular thalamus, collateral projections, nucleus accumbens, bed nucleus of the stria terminalis, central amygdala, subcortical projections, cholera toxin B subunit, retrograde tracing
- MeSH terms
- Animals, Brain Mapping, Cholera Toxin, Functional Laterality, Male, Neural Pathways, Nucleus Accumbens, Phosphopyruvate Hydratase, Septal Nuclei, Rats, Sprague-Dawley, Midline Thalamic Nuclei, Rats
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