Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples
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Previous research has shown associations between brain structure and resting state high-frequency heart rate variability (HF HRV). Age affects both brain structure and HF HRV. Therefore, we sought to examine the relationship between brain structure and HF HRV as a function of age. Data from two independent studies were used for the present analysis. Study 1 included 19 older adults (10 males, age range 62-78 years) and 19 younger adults (12 males, age range 19-37). Study 2 included 23 older adults (12 males; age range 55-75) and 27 younger adults (17 males; age range 18-34). The root-mean-square of successive R-R-interval differences (RMSSD) from ECG recordings was used as time-domain measure of HF HRV. MRI scans were performed on a 3.0-T Siemens Magnetom Trio scanner. Cortical reconstruction and volumetric segmentation were performed with the Freesurfer image analysis suite, including 12 regions as regions of interests (ROI). Zero-order and partial correlations were used to assess the correlation of RMSSD with cortical thickness in selected ROIs. Lateral orbitofrontal cortex (OFC) cortical thickness was significantly associated with RMSSD. Further, both studies, in line with previous research, showed correlations between RMSSD and anterior cingulate cortex (ACC) cortical thickness. Meta-analysis on adjusted correlation coefficients from individual studies confirmed an association of RMSSD with the left rostral ACC and the left lateral OFC. Future longitudinal studies are necessary to trace individual trajectories in the association of HRV and brain structure across aging.
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Decreased parasympathetic activity with age may partially account for the finding that only low low-frequency heart rate variability is associated with depression in older adults.
“Decreased parasympathetic activity with age appears to result in decreased HRV in the general (primarily non-depressed) older adult population176,177, which may partially account for this finding.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [176]
Decreased parasympathetic activity with age appears to result in decreased heart rate variability in the general older adult population.
“Decreased parasympathetic activity with age appears to result in decreased HRV in the general (primarily non-depressed) older adult population176,177, which may partially account for this finding.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [176]
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Brain structure and parasympathetic function during rest and stress in young adult women
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Self-citation
- Authors
- Yoo, H. J., Thayer, J. F., Greening, S., Lee, T.-H., Ponzio, A., Min, J., Sakaki, M., Nga, L., Mather, M., & Koenig, J.
- Affiliations
- University of Southern California (US)
- The Ohio State University (US)
- Louisiana State University (US)
- University of North Carolina at Chapel Hill (US)
- University of Reading (GB)
- Heidelberg University (DE)
- Corresponding author
- Mather, Mara
- ORCID
- Venue
- Brain Structure and Function
- Published
- 2017-09-18
- Volume
- 223
- Issue
- 2
- Pages
- 727-737
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC5828882
- OpenAlex
- W2754503389
- Cited by
- 94
- References
- 55
- Citations by year
- 2026: 10 · 2025: 3 · 2024: 9 · 2023: 17 · 2022: 9 · 2021: 14 · 2020: 16 · 2019: 7 · 2018: 7 · 2017: 2
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- National Institute on Aging (R01AG025340)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- heart rate variability, resting state, brain structure, cortical thickness, aging, older adults, lateral orbitofrontal cortex, anterior cingulate cortex, RMSSD, autonomic nervous system
- MeSH terms
- Adult, Aged, Aging, Brain, Electrocardiography, Female, Heart Rate, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Rest, Young Adult
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