Natural history of chronic hepatitis B virus infection.
Abstract
Hepatitis B virus infection represents a major global health problem. Currently, there are more than 240 million chronically infected people worldwide. The development of chronic hepatitis B virus-mediated liver disease may lead to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma. Recently, the discovery of the viral entry receptor sodium taurocholate cotransporting polypeptide has facilitated new approaches for a better understanding of viral physiopathology. Hopefully, these novel insights may give rise to the development of more effective antiviral therapy concepts during the next years. In this review, we will discuss the natural history of hepatitis B virus infection including the viral biology, the clinical course of infection and the role of the immune response.
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Among adults, approximately half of newly acquired HBV infections are symptomatic, and approximately 1% of reported cases result in acute liver failure and death.
“Among adults, approximately half of newly acquired HBV infections are symptomatic, and approximately 1% of reported cases result in acute liver failure and death (1311).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1311]
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
- Authors
- Busch, K., & Thimme, R.
- Affiliations
- University Medical Center Freiburg (DE)
- Corresponding author
- Thimme, Robert
- ORCID
- Thimme, Robert
- Venue
- Medical Microbiology and Immunology
- Published
- 2014-12-25
- Volume
- 204
- Issue
- 1
- Pages
- 5-10
- ISSN
- 0044-3077 (ISSN-L)
- 0300-8584
- 1432-1831
- OpenAlex
- W2005144820
- Cited by
- 68
- References
- 88
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 3
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Medical Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- chronic hepatitis B, hepatitis B virus, natural history of infection, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, sodium taurocholate cotransporting polypeptide, viral entry receptor, viral pathogenesis, immune response, antiviral therapy
- MeSH terms
- Hepatitis B virus, Carcinoma, Hepatocellular, Humans, Liver Cirrhosis, Liver Neoplasms, Hepatitis B, Chronic
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