Chronic hepatitis C virus infection and depression
Abstract
Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observed in patients with chronic hepatitis B virus infection or the general population. HCV seems to play a direct and indirect role in the development of depression. Impaired quality of life and increasing health care costs have been reported for patients with HCV infection with depression. Treatment-induced HCV clearance has been associated with improvement of depression and quality of life.
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Depression and anxiety symptoms are known to be prevalent in patients with hepatitis C virus.
“DEP and ANX symptoms are known to be prevalent in patients with HCV, [16]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [16]
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- Authors
- Adinolfi, L. E., Nevola, R., Rinaldi, L., Romano, C., & Giordano, M.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Adinolfi, Luigi Elio
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 21
- Issue
- 3
- Pages
- 517-534
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2608662514
- Cited by
- 59
- References
- 140
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- hepatitis C virus, chronic hepatitis C, depression, neuropsychiatric symptoms, extrahepatic manifestations, quality of life, health care costs, antiviral therapy, HCV clearance, depression prevalence
- MeSH terms
- Antidepressive Agents, Antiviral Agents, Central Nervous System, Depression, Humans, Quality of Life, Prevalence, Hepacivirus, Hepatitis C, Chronic
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