Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life
Open accessAbstract
UNLABELLED: Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants <1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants <1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. CONCLUSIONS: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HPeV is less well studied, but it has been suggested that with further data these infants may be able to be managed similarly to those who are positive for EV.
“HPeV is less well studied, but it has been suggested that with further data these infants may be able to be managed similarly to those who are positive for EV (16, 18).”
From Retrospective Evaluation of Infants Aged 1 to 60 Days with Residual Cerebrospinal Fluid (CSF) Tested Using the FilmArray Meningitis/Encephalitis (ME) Panel (2018) · cites this paper as [18]
The Introduction says neonatal HPeV clinical data are scarce, and the Abstract says identifying HPeV may prevent unnecessary treatment and prolonged hospitalization. The paper compares HPeV- and EV-positive infants, but neither passage suggests that, with further data, they could be managed similarly. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Benschop, K., Schinkel, J., Minnaar, R. P., Pajkrt, D., Spanjerberg, L., Kraakman, H. C., Berkhout, B., Zaaijer, H. L., Beld, M., & Wolthers, K. C. (2005) · Clinical Infectious Diseases · doi:10.1086/498905 · Cited by 261 · see citing works
Epidemiology and Clinical Associations of Human Parechovirus Respiratory Infections
Harvala, H., Robertson, I., McWilliam Leitch, E. C., Benschop, K., Wolthers, K. C., Templeton, K., & Simmonds, P. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01207-08 · Cited by 213 · see citing works
Khetsuriani, N., LaMonte, A., Oberste, M. S., & Pallansch, M. A. (2006) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000237798.07462.32 · Cited by 204 · see citing works
Human Parechovirus 3 and Neonatal Infections
Boivin, G., Abed, Y., & Boucher, F. D. (2005) · Emerging infectious diseases · doi:10.3201/eid1101.040606 · Cited by 199 · see citing works
Human parechoviruses: Biology, epidemiology and clinical significance
Harvala, H., & Peter Simmonds, K. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.03.009 · Cited by 197 · see citing works
Baumgarte, S., Luna, L. K. D. S., Grywna, K., Panning, M., Drexler, J. F., Karsten, C., Huppertz, H. I., & Drosten, C. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01468-07 · Cited by 133 · see citing works
Pediatric parechovirus infections
Esposito, S., Rahamat-Langendoen, J. C., Ascolese, B., Senatore, L., Castellazzi, L., & Niesters, H. G. M. (2014) · Journal of Clinical Virology · doi:10.1016/j.jcv.2014.03.003 · Cited by 121 · see citing works
Human Parechovirus 3 Causing Sepsis-like Illness in Children From Midwestern United States
Selvarangan, R., Nzabi, M., Selvaraju, S. B., Ketter, P., Carpenter, C., & Harrison, C. J. (2011) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181fbefc8 · Cited by 120 · see citing works
Sharp, J., Harrison, C. J., Puckett, K., Selvaraju, S. B., Penaranda, S., Nix, W. A., Oberste, M. S., & Selvarangan, R. (2013) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e318276b328 · Cited by 117 · see citing works
Harvala, H., McLeish, N., Kondracka, J., McIntyre, C. L., McWilliam Leitch, E. C., Templeton, K., & Simmonds, P. (2011) · Journal of Medical Virology · doi:10.1002/jmv.22023 · Cited by 112 · see citing works
Infant Deaths Associated with Human Parechovirus Infection in Wisconsin
SEDMAK, G. V., Nix, W. A., Jentzen, J. M., Haupt, T. E., Davis, J. P., Bhattacharyya, S., Pallansch, M. A., & Oberste, M. S. (2010) · Clinical Infectious Diseases · doi:10.1086/649863 · Cited by 103 · see citing works
Detection of enteroviral RNA and specific DNA of herpesviruses by multiplex genome amplification
Casas, I., Tenório, A., Echevarría, J. M., et al. (1997) · Journal of Virological Methods · doi:10.1016/s0166-0934(97)00035-9 · Cited by 98 · see citing works
Cabrerizo, M., Echevarría, J. E., González, I., de Miguel, T., & Trallero, G. (2008) · Journal of Medical Virology · doi:10.1002/jmv.21197 · Cited by 95 · see citing works
Self-citationHuman parechovirus infections, Lyon, France, 2008–10: Evidence for severe cases
Schuffenecker, I., Javouhey, É., Gillet, Y., Kugener, B., Billaud, G., Floret, D., Lina, B., & Morfin, F. (2012) · Journal of Clinical Virology · doi:10.1016/j.jcv.2012.04.016 · Cited by 85 · see citing works
Dermatologic Manifestations of Human Parechovirus Type 3 Infection in Neonates and Infants
Shoji, K., Komuro, H., Miyata, I., Miyairi, I., & Saitoh, A. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31827b1fd0 · Cited by 73 · see citing works
Human Parechovirus Infection, Denmark
Fischer, T. K., Midgley, S., Dalgaard, C., & Nielsen, A. C. Y. (2013) · Emerging infectious diseases · doi:10.3201/eid2001.130569 · Cited by 70 · see citing works
Harvala, H., Griffiths, M., Solomon, T., & Simmonds, P. (2014) · Journal of Infection · doi:10.1016/j.jinf.2014.02.017 · Cited by 69 · see citing works
Epidemiological survey of neonatal non‐polio enterovirus infection in the Netherlands
Verboon-Maciolek, M. A., Krediet, T. G., van Loon, A. M., Kaan, J. A., Galama, J. M. D., Gerards, L. J., & Fleer, A. (2001) · Journal of Medical Virology · doi:10.1002/jmv.2136 · Cited by 57 · see citing works
Piralla, A., Mariani, B., Stronati, M., Marone, P., & Baldanti, F. (2014) · Early Human Development · doi:10.1016/s0378-3782(14)70023-4 · Cited by 54 · see citing works
Human parechoviruses in infants with systemic infection
Piñeiro, L., Vicente, D. A., Montes, M., Dorronsoro, U. H., & Cilla, G. (2010) · Journal of Medical Virology · doi:10.1002/jmv.21878 · Cited by 47 · see citing works
Does SV40 infection contribute to the development of human cancers?
Shah, K. V. (2000) · Reviews in Medical Virology · doi:10.1002/(sici)1099-1654(200001/02)10:1 · Cited by 44 · see citing works
Human parechovirus type 3 central nervous system infections in Israeli infants
Ghanem‐Zoubi, N., Shiner, M., Shulman, L. M., Sofer, D., Wolf, D. G., Marva, E., Kra-Oz, Z., Shachor‐Meyouhas, Y., Averbuch, D., Fellner, A., et al. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.06.001 · Cited by 37 · see citing works
Ahmad, S., Dalwai, A., & Al‐Nakib, W. (2013) · Journal of Medical Virology · doi:10.1002/jmv.23604 · Cited by 25 · see citing works
Cabrerizo, M., Calvo, C., Rabella, N., Muñoz‐Almagro, C., del Amo, E., Pérez-Ruiz, M., Sanbonmatsu‐Gámez, S., Moreno‐Docón, A., Otero, A., & Trallero, G. (2014) · Journal of Virological Methods · doi:10.1016/j.jviromet.2014.08.008 · Cited by 21 · see citing works
Self-citationSelva, L., Martínez-Planas, A., García‐García, J. J., Casadevall, R., Cubells, C. L., & Muñoz‐Almagro, C. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1364-1 · Cited by 11 · see citing works
Self-citationSepsis and Meningitis Caused by Pasteurella Multocida and Echovirus 9 in a Neonate
Aguado, I., Calvo, C., Wilhelmi, I., et al. (2014) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000504 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Epidemiology and Immune Pathogenesis of Viral Sepsis
Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351 · see citing works
Blaschke, A. J., Holmberg, K. M., Daly, J. A., Leber, A. L., Dien Bard, J., Korgenski, E. K., Bourzac, K. M., & Kanack, K. J. (2018) · Journal of clinical microbiology · doi:10.1128/jcm.00277-18 · Cited by 57 · see citing works
Enteroviral infections in the first three months of life
Sandoni, M., Ciardo, L., Tamburini, C., Boncompagni, A., Rossi, C., Guidotti, I., Garetti, E., Lugli, L., Iughetti, L., & Berardi, A. (2022) · Pathogens · doi:10.3390/pathogens11010060 · Cited by 34 · see citing works
de Ceano-Vivas, M., García, M. L., Velázquez, A., Martín del Valle, F., Menasalvas, A., Cilla, A., Epalza, C., Romero, M. P., Cabrerizo, M., & Calvo, C. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.719119 · Cited by 22 · see citing works
Self-citation
- Authors
- *And the study group of “Enterovirus and parechovirus infections in children under 3 years-old, S. P.-0., Cabrerizo, M., Trallero, G., Pena, M. J., Cilla, A., Megias, G., Muñoz-Almagro, C., Del Amo, E., Roda, D., Mensalvas, A. I., Moreno-Docón, A., García-Costa, J., Rabella, N., Omeñaca, M., Romero, M. P., Sanbonmatsu-Gámez, S., Pérez-Ruiz, M., Santos-Muñoz, M. J., & Calvo, C.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Hospital Universitario de Burgos (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital Universitario Severo Ochoa (ES)
- Corresponding author
- Calvo, Cristina
- Venue
- European Journal of Pediatrics
- Published
- 2015-05-16
- Volume
- 174
- Issue
- 11
- Pages
- 1511-1516
- ISSN
- 0340-6199 (ISSN-L)
- 1432-1076
- PMC
- PMC4623089
- OpenAlex
- W1517484573
- Cited by
- 60
- References
- 26
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 10
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Pediatrics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS)) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
- Keywords
- human parechovirus, enterovirus, viral prevalence, fever without source, sepsis, encephalitis, pleocytosis, meningitis, cerebrospinal fluid, viral genotyping
- MeSH terms
- Enterovirus Infections, Enterovirus, Female, Genotype, Humans, Infant, Newborn, Male, Picornaviridae Infections, Prospective Studies, Spain, Viremia, Prevalence, Encephalitis, Viral, Parechovirus, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
