Association between apolipoprotein E genotype and cancer susceptibility: a meta-analysis
Open accessAbstract
Background Apolipoprotein E (ApoE), a protein primarily involved in lipoprotein metabolism, occurs in three isoforms (E2, E3 and E4). Studies evaluating the association between APOE genotype and incidence of malignancies have given inconclusive results. Objective The objective of the present study was to analyze the association between APOE genotype and incidence of cancer by a meta-analysis. Methods We conducted a literature search in the electronic databases for studies with information on APOE genotype in malignancies. Sixteen studies (14 case-control and 2 cohort; 77,970 controls and 12,010 cases) were included for the present meta-analysis. Pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated assuming a random-effect model for all the genotypes and alleles. Subgroup analyses based on study design, ethnicity of populations, site of cancer and source of controls were performed as a post hoc measure. Appropriate tests to detect heterogeneity, publication bias and sensitivity were done at all stages. The review protocol is registered with the PROSPERO database vide registration number CRD42013006496. Results The pooled effect measure for the comparisons did not reveal an association in primary analyses. In the subgroup analyses, we observed a negative association between APOE4+ genotypes and overall risk of cancer in the cohort study subgroup (pooled OR 0.86; 95 % CI 0.82-0.91; p < 0.00001; I (2) = 0 %). Sensitivity analyses did not alter the overall pooled effect measure, and there were no evidences to suggest a publication bias. Conclusion Overall, the present meta-analysis did not show any association between APOE alleles and genotypes with incidence of cancer in general.
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The potential association between APOE genotype and cancer outcome has remained inconclusive.
“The potential association between APOE genotype and cancer outcome has remained inconclusive10,11.”
From Common germline variants of the human APOE gene modulate melanoma progression and survival (2020) · cites this paper as [11]
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- Authors
- Anand, R., Prakash, S. S., Veeramanikandan, R., & Kirubakaran, R.
- Affiliations
- Christian Medical College, Vellore (IN)
- Corresponding author
- Anand, R.
- Venue
- Journal of Cancer Research and Clinical Oncology
- Published
- 2014-04-05
- Volume
- 140
- Issue
- 7
- Pages
- 1075-1085
- ISSN
- 0084-5353 (ISSN-L)
- 0171-5216
- 1432-1335
- PMC
- PMC11823783
- OpenAlex
- W2131505642
- Cited by
- 18
- References
- 58
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Cancer Research and Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- apolipoprotein E, APOE genotype, APOE ε4, cancer susceptibility, cancer incidence, genetic polymorphism, lipoprotein metabolism, genetic risk factors
- MeSH terms
- Apolipoproteins E, Genotype, Humans, Neoplasms, Risk Factors, Cohort Studies, Case-Control Studies, Genetic Predisposition to Disease, Genetic Association Studies
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