Evaluation of the efficacy of an imidacloprid 10% / moxidectin 1% spot-on against Otodectes cynotis in cats
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Advocate is highly effective in the treatment of feline otocariosis.
“As key examples, this formulation has shown to be highly effective in the treatment of feline otocariosis (Fourie et al. 2003)”
From Efficacy and safety of imidacloprid 10 %/moxidectin 1 % spot-on formulation in the treatment of feline infection by Capillaria aerophila (2012) · cites this paper as Fourie et al. 2003
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Bradbury, C. A., & Lappin, M. R. (2010) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.236.8.869 · Cited by 70 · see citing works
“Moxidectin is an avermectin that can prevent infestation of cats with Dirofilaria immitis and protect against adult, immature, and L4 larval stages of hookworms and roundworms as well as control Otodectes cynotis.(19,20) The objective of the study reported here was to determine whether monthly topical administration o…”
BackgroundReichard, M. V., Thomas, J. E., Arther, R. G., Hostetler, J. A., Raetzel, K. L., Meinkoth, J. H., & Little, S. E. (2013) · Parasitology Research · doi:10.1007/s00436-013-3277-7 · Cited by 56 · see citing works
“2007), Otodectes cynotis (Fourie et al. 2003; Davis et al. 2007; Farkas et al. 2007) and Toxocara cati (Reinemeyer and Charles 2003) in cats.”
Mites and Lice: Biology and Control
Arther, R. G. (2009) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2009.06.009 · Cited by 37 · see citing works
Fourie, L. J., Heine, J., & Horak, I. (2006) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.2006.tb13117.x · Cited by 35 · see citing works
Self-citationTraversa, D., Di Cesare, A., Di Giulio, E., Castagna, G., Schaper, R., Braun, G., Lohr, B., Pampurini, F., Milillo, P., & Strube, K. (2012) · Parasitology Research · doi:10.1007/s00436-012-3025-4 · Cited by 33 · see citing works
Becskei, C., Reinemeyer, C. R., King, V. L., et al. (2017) · Veterinary Parasitology · doi:10.1016/j.vetpar.2017.02.029 · Cited by 31 · see citing works
Taenzler, J., de Vos, C., Roepke, R. K. A., et al. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-3167-z · Cited by 31 · see citing works
Yang, C. W., & Huang, H. (2016) · Veterinary Dermatology · doi:10.1111/vde.12340 · Cited by 24 · see citing works
Farkas, R., Germann, T., & Szeidemann, Z. (2007) · Parasitology Research · doi:10.1007/s00436-007-0609-5 · Cited by 23 · see citing works
“Three independent laboratory and one field studies have been conducted in cats naturally infested with Otodectes cynotis to evaluate the efficacy of imidacloprid/moxidectin (Fourie et al. 2003).”
BackgroundA systematic review of moxidectin as a treatment for parasitic infections in mammalian species
Schraven, A. L., Stannard, H. J., & Old, J. M. (2021) · Parasitology Research · doi:10.1007/s00436-021-07092-0 · Cited by 19 · see citing works
Arther, R. G., Davis, W. L., Jacobsen, J. A., et al. (2015) · Veterinary Parasitology · doi:10.1016/j.vetpar.2015.02.022 · Cited by 19 · see citing works
Sueur, C. L., Bour, S., & Schaper, R. (2011) · Parasitology Research · doi:10.1007/s00436-011-2411-7 · Cited by 18 · see citing works
“2 and 3) (Davis et al. 2007; Farkas et al. 2007; Fourie et al. 2003) with one or two spot-on treatments at 4-week intervals.”
BackgroundInfluentialArther, R. G., Atkins, C., Ciszewski, D. K., Davis, W. L., Ensley, S. M., & Settje, T. L. (2005) · Parasitology Research · doi:10.1007/s00436-005-1447-y · Cited by 14 · see citing works
“A topically applied formulation containing 10% w/v imidacloprid+1% w/v moxidectin (Advocate®/Advantage multi®) has been developed for monthly application to kittens and cats for the prevention of feline heartworm (HW) disease caused by Dirofilaria immitis; and for the treatment and control of flea infestations, ear mi…”
MethodTielemans, E., Prullage, J., Otsuki, T., et al. (2021) · Parasite · doi:10.1051/parasite/2021022 · Cited by 14 · see citing works
Nunn-Brooks, L., Robin, M., Ravitz, L. B., et al. (2011) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2011.03.003 · Cited by 13 · see citing works
Bourguignon, E., Diegues, L., Sell, T. G. R., et al. (2013) · InTech eBooks · doi:10.5772/53660 · Cited by 13 · see citing works
“1 mg/kg, two ap‐ plications with two weeks interval) is effective for Otodectis cynotis infestation in cats [157].”
Schmahl, G., Mehlhorn, H., Harder, A., Klimpel, S., & Krieger, K. J. (2007) · Parasitology Research · doi:10.1007/s00436-007-0615-7 · Cited by 12 · see citing works
“Both products are suggested formonthly use to control flea andmite infestations, to kill intestinal nematodes and to prevent infection with feline and canine heartworms (Dirofilaria immitis) (Arther et al. 1997, Fourie et al. 2003, Hellmann et al. 2003, von Samson-Himmelstjerna et al. 2003).”
BackgroundVenco, L., Mortarino, M., Carro, C., Genchi, M., Pampurini, F., & Genchi, C. (2008) · Veterinary Parasitology · doi:10.1016/j.vetpar.2008.02.020 · Cited by 9 · see citing works
Ahn, A.-J., Oh, D.-S., Ahn, K.-S., et al. (2013) · Korean Journal of Parasitology · doi:10.3347/kjp.2013.51.1.125 · Cited by 6 · see citing works
“1 ml/kg body weight resulted in a treatment success rate of 80%, as assessed 50 days after treatment in cats [15].”
BackgroundQureshi, T., Everett, W. R., & Palma, K. G. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-1020-1 · Cited by 6 · see citing works
“The combination of imidacloprid and moxidectin (Advantage Multi®, Advocate®) is used for prevention of heartworm disease [16] and for treatment of fleas, intestinal nematodes [17], sarcoptic mange [18], demodex mange [19] and ear mites [20].”
MethodLeone, F., & Han, H. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-29836-4_19 · Cited by 5 · see citing works
Bowman, D. D. (2007) · doi:10.1002/9780470344552.ch18 · Cited by 4 · see citing works
Lefkaditis, M., & Koukeri, S. E. (2008) · Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Veterinary Medicine · doi:10.15835/buasvmcn-vm:64:1-2:2469 · Cited by 3 · see citing works
Weese, J. S., Peregrine, A. S., Anderson, M., & Fulford, M. B. (2010) · Wiley eBooks · doi:10.1002/9780470958957.ch1 · Cited by 6 · see citing works
Arther, R. G., Atkins, C. E., Ciszewski, D. K., Davis, W. L., & Settje, T. L. (2007) · Parasitology Research · doi:10.1007/s00436-007-0613-9 · Cited by 1 · see citing works
“…to kittens and cats for the prevention of feline heartworm disease caused byDirofilaria immitis; and for the treatment and control of flea infestations, ear mites and intestinal nematodes (Arther et al. 2003, Fourie et al. 2003, Reinemeyer and Charles 2003, Samson-Himmelstjerna et al. 2003).”
BackgroundAkashi, K., Nakamura, Y., Iyori, K., et al. (2019) · The Japanese Journal of Veterinary Dermatology · doi:10.2736/jjvd.25.217
Bowman, D. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-54396-5.00011-8
Leone, F., & Han, H. S. (2023) · Springer eBooks · doi:10.1007/978-3-662-65907-6_19
(2000) · Time to knit · doi:10.1016/s1283-0828(05)42128-6
The most effective systemic treatment in cats with otodectic mange: A critically appraised topic.
Burnouf, T., & Guaguère, É. (2025) · PubMed
Tishyn, O. L., Yuskiv, I. D., Muzyka, V. P., et al. (2025) · Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology · doi:10.36359/scivp.2025-26-2.34
- Authors
- Fourie, L. J., Kok, D. J., & Heine, J.
- Affiliations
- University of the Free State (ZA)
- Clinvet (ZA)
- Bayer (Germany) (DE)
- Corresponding author
- Fourie, L. J.
- Venue
- Parasitology Research
- Published
- 2003-07-01
- Volume
- 90
- Issue
- 0
- Pages
- S112-S113
- ISSN
- 0044-3255 (ISSN-L)
- 0932-0113
- 1432-1955
- OpenAlex
- W1995039761
- Cited by
- 31
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Parasitology Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Otodectes cynotis, ear mites, imidacloprid, moxidectin, spot-on formulation, topical acaricide, cats, treatment efficacy, cure rate
- MeSH terms
- Neonicotinoids, Animals, Cat Diseases, Cats, Drug Therapy, Combination, Imidazoles, Insecticides, Mite Infestations, Nitro Compounds, Treatment Outcome, Macrolides
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