Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats
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BACKGROUND: Two studies were conducted to evaluate and compare the efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 flea strain infesting cats. In both studies the treatment groups were comprised of non-treated controls, 6% w/v selamectin (Revolution®; Pfizer Animal Health) topical solution and 10% w/v imidacloprid + 1% w/v moxidectin (Advantage Multi® for Cats, Bayer Animal Health) topical solution. All cats were infested with 100 fleas on Days -2, 7, 14, 21, and 28. The difference in the studies was that in study #1 efficacy evaluations were conducted at 24 and 48 hours post-treatment or post-infestation, and in study #2 evaluations were conducted at 12 and 24 hours. RESULTS: In study #1 imidacloprid + moxidectin and the selamectin formulation provided 99.8% and 99.0% efficacy at 24 hours post-treatment. On day 28, the 24 hour efficacy of the selamectin formulation dropped to 87.1%, whereas the imidacloprid + moxidectin formulation provided 98.9% efficacy. At the 48 hour assessments following the 28 day infestations, efficacy of the imidacloprid + moxidectin and selamectin formulations was 96.8% and 98.3% respectively. In study # 2 the efficacy of the imidacloprid + moxidectin and selamectin formulations 12 hours after treatment was 100% and 69.4%, respectively. On day 28, efficacy of the imidacloprid + moxidectin and selamectin formulations 12 hours after infestation was 90.2% and 57.3%, respectively. In study #2 both formulations provided high levels of efficacy at the 24 hour post-infestation assessments, with selamectin and imidacloprid + moxidectin providing 95.3% and 97.5% efficacy, following infestations on day 28. CONCLUSIONS: At the 24 and 48 hour residual efficacy assessments, the imidacloprid + moxidectin and selamectin formulations were similarly highly efficacious. However, the imidacloprid + moxidectin formulation provided a significantly higher rate of flea kill against the KS1 flea strain infesting cats at every 12 hour post-infestation residual efficacy assessment. Both formulations should provide excellent flea control for an entire month on cats.
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Infestation is diagnosed only when the home is already contaminated with hundreds to thousands of flea life stages, potentially causing continuous re-infestations for the pet.
“This results in an infestation diagnosed only when the home is already contaminated with hundreds to thousands of flea life stages, potentially causing continuous re-infestations for the pet [102,145,146].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [146]
The KS1 cat flea strain has been maintained at Kansas State University, USA, since 1990 and has varying levels of resistance or reduced susceptibility to different compounds.
“Interestingly, several studies have evaluated parasiticides against the “KS1 cat flea strain”, which has been maintained at the Kansas State University, USA, since 1990 and has varying levels of resistance or reduced susceptibility to different compounds [146].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [146]
The susceptibility of the KS1 strain to different formulations at varying regimens is clear evidence of the efficacy of compounds presently marketed in controlling pulicosis for about an entire month.
“However, the susceptibility of this strain to different formulations at varying regimens (e.g. lufenuron, spinosad, imidacloprid + moxidectin, selamectin and others out of the scope of this review) is clear evidence of the efficacy of compounds presently marketed in controlling pulicosis for about an entire month [135,146,179,180].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [146]
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Fleas infesting pets in the era of emerging extra-intestinal nematodes
Traversa, D. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-59 · Cited by 53 · see citing works
- Authors
- Dryden, M. W., Payne, P. A., Smith, V., & Hostetler, J.
- Affiliations
- Kansas State University (US)
- Corresponding author
- Dryden, Michael W
- Venue
- Parasites & Vectors
- Published
- 2011-09-13
- Volume
- 4
- Issue
- 1
- Pages
- 174-174
- ISSN
- 1756-3305 (ISSN-L)
- PMC
- PMC3185275
- OpenAlex
- W2125279107
- Cited by
- 5
- References
- 19
- Citations by year
- 2017: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Parasites & Vectors (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Bayer Animal Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- flea control, Ctenocephalides felis, imidacloprid, moxidectin, selamectin, cats, treatment efficacy, pyrethroid insecticides, acaricides, flea infestation, product comparison, skin irritation, allergic contact dermatitis
- MeSH terms
- Neonicotinoids, Animals, Antiparasitic Agents, Cat Diseases, Cats, Drug Evaluation, Drug Therapy, Combination, Female, Imidazoles, Insecticides, Ivermectin, Male, Nitro Compounds, Random Allocation, Treatment Outcome, Macrolides, Ctenocephalides, Flea Infestations
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