Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient

Prokisch, H.; Yarden, O.; Dieminger, M.; Tropschug, M.; Barthelmess, I. B.

doi:10.1007/s004380050551

Cited by 125Fungal and yeast genetics researchSignaling Pathways in DiseaseBacterial Genetics and Biotechnology

Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient

Prokisch, H., Yarden, O., Dieminger, M., Tropschug, M., Barthelmess, I. B.·1997·Molecular and General Genetics MGG

DOI 10.1007/s004380050551

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Abstract

The function of Neurospora crassa calcineurin was investigated in N. crassa strains transformed with a construct that provides for the inducible expression of antisense RNA for the catalytic subunit of calcineurin (cna-1). Induction of antisense RNA expression was associated with reduced levels of cna-1 mRNA and of immunodetectable CNA1 protein and decreased calcineurin enzyme activity, indicating that a conditional reduction of the target function had been achieved in antisense transformants with multiple construct integrations. Induction conditions caused growth arrest which indicated that the cna-1 gene is essential for growth of N. crassa. Growth arrest was preceded by an increase in hyphal branching, changes in hyphal morphology and concomitant loss of the distinctive tip-high Ca2+ gradient typical for growing wild-type hyphae. This demonstrates a novel and specific role for calcineurin in the precise regulation of apical growth, a common form of cellular proliferation. In vitro inhibition of N. crassa calcineurin by the complex of cyclosporin A (CsA) and cyclophilin20, and increased sensitivity of the induced transformants to the calcineurin-specific drugs CsA and FK506 imply that the drugs act in N. crassa, as in T-cells and Saccharomyces cerevisiae, by inactivating calcineurin. The finding that exposure of growing wild-type mycelium to these drugs leads to a phenotype very similar to that of the cna-1 antisense mutants is consistent with this idea.

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In N. crassa, calcineurin influences the tip high calcium gradient necessary for growing hyphal tip and normal vegetative growth.
“In the model filamentous fungi Neurospora crassa, calcineurin was shown to influence the tip high calcium gradient necessary for growing hyphal tip and normal vegetative growth (Kothe and Free, 1998; Prokisch et al., 1997).”
From Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis (2014) · cites this paper as Prokisch et al., 1997

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ORIGINAL PAPER
Prokisch, H., Yarden, O., Dieminger, M., Tropschug, M., & Barthelmess, I. B. (2015)
Calcineurin Subunit B Is Required for Normal Vegetative Growth inNeurospora crassa
Kothe, G. O., & Free, S. J. (1998) · Fungal Genetics and Biology · doi:10.1006/fgbi.1998.1037 · Cited by 68 · see citing works
Calcineurin Subunits A and B Interact to Regulate Growth and Asexual and Sexual Development in Neurospora crassa
Tamuli, R., Deka, R., & Borkovich, K. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151867 · Cited by 23 · see citing works
Dominant mutants of the calcineurin catalytic subunit (CNA-1) showed developmental defects, increased sensitivity to stress conditions, and CNA-1 interacts with CaM and CRZ-1 in Neurospora crassa
Kumar, A., Roy, A., Deshmukh, M. V., & Tamuli, R. (2019) · Archives of Microbiology · doi:10.1007/s00203-019-01768-z · Cited by 15 · see citing works
Protein phosphatase 2A is involved in hyphal growth of Neurospora crassa
Yatzkan, E., Szöőr, B., Fehér, Z., Dombrádi, V., & Yarden, O. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050844 · Cited by 44 · see citing works

Authors: Prokisch, H., Yarden, O., Dieminger, M., Tropschug, M., & Barthelmess, I. B.
Affiliations: Leibniz University Hannover (DE)
Hebrew University of Jerusalem (IL)
University of Freiburg (DE)
ORCID: Prokisch, H.
Yarden, O.
Venue: Molecular and General Genetics MGG
Publisher: Springer Science and Business Media LLC
Published: 1997-09
Volume: 256
Issue: 2
Pages: 104-114
ISSN: 0026-8925 (ISSN-L)
1432-1874
DOI: 10.1007/s004380050551
OpenAlex: W2049238469
Cited by: 125
References: 42
Citations by year: 2023: 2 · 2022: 1 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 5
FWCI: 2.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular and General Genetics MGG (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, Neurospora crassa, antisense RNA, hyphal growth, hyphal branching, hyphal morphology, cyclosporine, cyclophilin, FK506, calcineurin inhibitors, essential genes, mycelium
MeSH terms: Calcium, Cloning, Molecular, Immunosuppressive Agents, Neurospora crassa, Plasmids, Recombination, Genetic, RNA, Messenger, Transcription, Genetic, Transformation, Genetic, Gene Expression Regulation, Fungal, Gene Expression Regulation, Enzymologic, RNA, Antisense, Tacrolimus, Cyclosporine, Peptidylprolyl Isomerase, Calcineurin

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Impairment of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, morphology and maintenance of the apical Ca2+ gradient

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