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Cited by 87Race, Genetics, and SocietyGenetic Associations and EpidemiologyBlood Pressure and Hypertension Studies

Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans

Tang, Hua, Jorgenson, Eric, Gadde, Maya, Kardia, Sharon L. R., Rao, D. C., Zhu, Xiaofeng, Schork, Nicholas J., Hanis, Craig L. +1 more·2006·Human Genetics
DOI 10.1007/s00439-006-0175-4
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Abstract

Admixed populations such as African Americans and Hispanic Americans present both challenges and opportunities in genetic epidemiologic research. Because of variation in admixture levels among individuals, case-control association studies may be subject to stratification bias. On the other hand, admixed populations also present special opportunities both for examining the role of genetic and environmental factors for observed racial/ethnic differences, and for possibly mapping alleles that contribute to such differences. Here we examined the distribution and relationship of individual admixture (IA) estimates with BMI and three measures of blood pressure in two admixed populations in the NHLBI Family Blood Pressure Program (FBPP): African Americans and Mexican Americans. For the African Americans, we observed modest but significant differences in average African IA among four recruitment sites. We observed a slight excess of African IA among hypertensives compared to normotensives, and a positive (non-significant) regression of African IA on blood pressure in untreated participants. Within Mexican Americans, we found no difference in average IA between hypertensives and normotensives, but a positive (marginally significant) regression of African IA on diastolic blood pressure. We also observed a significant positive regression of Caucasian IA (and negative regression of Native American IA) on BMI. Our results are suggestive of genetic differences between Africans and non-Africans that influence blood pressure, but such effects are likely to be modest compared to environmental ones. Excess obesity among Native Americans compared to whites is not consistent with a simple genetic explanation.

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Crossref · 10.1007/s00439-006-0175-4

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  • The pattern of African genomic ancestry in Cape Verde is less skewed than in African Americans from FBPP, where African ancestry ranges 40.6% to 99.3% with median 89.5%.

    “in a randomly sampled African-American cohort from the Family Blood Pressure Study (FBPP) [21], African genomic ancestry ranges from 40.6% to 99.3%, with a median of 89.5%”

    From Genetic Architecture of Skin and Eye Color in an African-European Admixed Population (2013) · cites this paper as [21]

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Authors
Tang, H., Jorgenson, E., Gadde, M., Kardia, S. L. R., Rao, D. C., Zhu, X., Schork, N. J., Hanis, C. L., & Risch, N.
Affiliations
  • Fred Hutch Cancer Center (US)
  • University of California, San Francisco (US)
  • Stanford University (US)
  • University of Michigan (US)
  • Washington University in St. Louis (US)
  • Loyola University Medical Center (US)
  • University of California San Diego (US)
  • The University of Texas at Austin (US)
  • Kaiser Permanente (US)
Corresponding author
  • Tang, Hua
  • Risch, Neil
ORCID
Venue
Human Genetics
Publisher
Springer Science and Business Media LLC
Published
2006-05-05
Volume
119
Issue
6
Pages
624-633
ISSN
  • 0018-7348 (ISSN-L)
  • 0340-6717
  • 1432-1203
DOI
10.1007/s00439-006-0175-4
OpenAlex
W2023496421
Cited by
87
References
34
Citations by year
2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 9 · 2014: 2 · 2013: 7 · 2012: 9
FWCI
5.30
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Human Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute
  • National Institute of General Medical Sciences (R01GM073059)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
racial mixing, body mass index, blood pressure, hypertension, African Americans, Mexican Americans, obesity, Native Americans, genetic epidemiology
MeSH terms
Adult, Black or African American, Blood Pressure, Humans, Hypertension, Middle Aged, Body Mass Index, Mexican Americans

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