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Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial

Talha, Ahmed, Abdelbaki, Tamer, Farouk, Ayman, Hasouna, Ehab, Azzam, Eman, Shehata, Gihan·2020·Surgical Endoscopy
DOI 10.1007/s00464-019-07323-7
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Abstract

Background Rapid weight loss is associated with a high incidence of cholelithiasis. Objectives To identify the incidence of gallstone formation after weight loss surgery and to detect the efficacy of 6 months regimen of prophylactic Ursodeoxycholic acid (UDCA). Methods RCT included a total of 1530 morbid obese patients who were subjected to either laparoscopic one anastomosis gastric bypass (OAGB), sleeve gastrectomy (SG), or greater curve plication (GCP). Patients with previous or concomitant cholecystectomy and missed follow-up were excluded, leaving 1432 patients to analyze. They were randomly allocated into two groups receiving either UDCA or placebo with a minimum follow-up of one year for assessment of cholelithiasis and weight loss. Results The overall incidence of cholelithiasis after surgery was 9.7%. There was a significant decrease in the incidence of gallstone formation from 22% in placebo to 6.5% in treated group with UDCA. The mean percentage of excess weight loss (%EWL) was significantly higher in those who develop gallstones than others. Of those developing gallstones, there was 64.7 % with SG versus 28.1% and 7.2% in OAGB and GCP, respectively, which is statistically significant. NNT to prevent cholelithiasis is six, AR% is 70.4%, and RR is 3.4%. Conclusions Cholelithiasis after SG and OAGB was higher than GCP. %EWL was rapid and higher in OAGB and SG contributing to the higher rate of symptomatic cholelithiasis and could be predictive for post-bariatric chol…

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  1. Sunyer FX (1996) A review of long-term studies evaluating the efficacy in weight loss ameliorating disorders associated with obesity. Clin Ther 18:1006–1035 · DOI
  2. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292(14):1724–1737 · DOI · Paper page
  3. De Maria EJ (2007) Bariatric surgery for morbid obesity. N Engl J Med 356(21):2176–2183 · DOI
  4. Holst JJ, Madsbad S, Bojsen-Møller KN, Svane MS, Jørgensen NB, Carsten D et al (2018) Mechanisms in bariatric surgery: gut hormones, diabetes resolution, and weight loss. Surg Obes Relat Dis 14:708–714 · DOI
  5. Dimitriadis GK, Randeva MS, Miras AD (2017) Potential hormone mechanisms of bariatric surgery. Curr Obes Rep 6:253–265 · DOI
  6. Brody F (2004) Minimally invasive surgery for morbid obesity. Clevel Clin J Med 71(4):289–298 · DOI
  7. Shiffman ML, Sugerman HJ, Kellum JM, Moore EW (1992) Changes in gallbladder bile composition following gallstone formation and weight reduction. Gastroenterology 103:214–221 · DOI · Paper page
  8. Boerlage TCC, Haal S, de Brauw LM, Acherman YIZ, Bruin S, Van de Laar AW et al (2017) Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial). BMC Gastroenterol 17(1):164. https://doi.org/10.1186/s12876-017-0674-x · DOI · Paper page
  9. Deitel M, Petrov I (1987) Incidence of symptomatic gallstones after bariatric operations. Surg Gynecol Obstet 164:549–552
  10. International Federation for the Surgery of Obesity (1997) Statement on patient selection for bariatric surgery. Obes Surg 7:41 · DOI
  11. Mason EE (2002) Gallbladder management in obesity surgery. Obes Surg 12(2):222–229 · DOI
  12. Wattchow DA, Hall JC, Whiting MJ, Bradley B, Iannos J, Watts JM (1983) Prevalence and treatment of gallstones after gastric bypass surgery for morbid obesity. Br Med J Clin Res 286:763 · DOI
  13. Angrisani L, Lorenzo M, De Palma G, Sivero L, Catanzano C, Tesauro B et al (1995) Laparoscopic cholecystectomy in obese patients compared with nonobese patients. Surg Laparosc Endosc 5:197–201
  14. Festi D, Colecchia A, Larocca A, Villanova N, Mazzella G, Petroni ML et al (2000) Review: low caloric intake and gall-bladder motor function. Aliment Pharmacol Ther 14(2):51–53 · DOI · Paper page
  15. Everhart JE (1993) Contributions of obesity and weight loss to gallstone disease. Ann Intern Med 119:1029–1035 · DOI · Paper page
  16. Shiffman ML, Shamburek RD, Schwartz CC, Sugerman HJ, Kellum JM, Moore EW (1993) Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology 105:1200–1208 · DOI · Paper page
  17. Shiffman ML, Sugerman HJ, Kellum JH, Brewer WH, Moore EW (1993) Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord 17:153–158
  18. Dittrick GW, Thompson JS, Campos D, Bremers D, Sudan D (2005) Gallbladder pathology in morbid obesity. Obes Surg 15(2):238–242 · DOI
  19. Tucker ON, Fajnwaks P, Szomstein S, Rosenthal RJ (2008) Is concomitant cholecystectomy necessary in obese patients undergoing laparoscopic gastric bypass surgery? Surg Endosc 22(11):2450–2454 · DOI
  20. Portenier DD, Grant JP, Blackwood HS, Pryor A, McMahon RL, DeMaria E (2007) Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis 3(4):476–479 · DOI
  21. Papasavas PK, Gagné DJ, Ceppa FA, Caushaj PF (2006) Routine gallbladder screening not necessary in patients undergoing laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis 2(1):41–46 · DOI
  22. Villegas L, Schneider B, Provost D, Chang C, Scott D, Sims T et al (2004) Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg 14(2):206–211 · DOI
  23. Ryia MH, Abd-Allah HS, Khadrawy OH, Moussa GI (2014) Predictors of gallstone formation in morbidly obese patients after bariatric surgery: a retrospective observational study. Surg Sci 5:1–5 · DOI
  24. Oliveira CIB, Chaim EA, Silva BB (2003) Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg 13(4):625–628 · DOI
  25. Yang H, Peterson GM, Roth MP, Schoenfield LJ, Marks JW (1992) Risk factors for gallstones formation during rapid loss of weight. Dig Dis Sci 37(6):912–918 · DOI · Paper page
  26. Uy MC, Talingdan-Te MC, Espinosa WZ, Daez ML, Ong JP (2008) Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg 18(12):1532–1538 · DOI · Paper page
  27. Wudel LJ, Wright JK, Debelak JP, Allos TM, Shyr Y, Chapman WC (2002) Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study. J Surg Res 102(1):50–56 · DOI · Paper page
  28. Sugerman HJ, Brewer WH, Shiffman ML, Brolin RE, Fobi MA, Linner JH (1995) A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg 169:91–96 (Discussion 96–97) · DOI · Paper page
  29. Li VK, Pulido N, Fajnwaks P, Szomstein S, Rosenthal R, Duartez P (2009) Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc 23(7):1640–1644 · DOI · Paper page
  30. Cirillo DJ, Wallace RB, Rodabough RJ, Greenland P, LaCroix AZ, Limacher MC (2005) Effect of estrogen therapy on gallbladder disease. JAMA 293:330–339 · DOI
  31. Schmidt JH, Hocking MP, Rout WR, Woodward ER (1988) The case for prophylactic cholecystectomy concomitant with gastric restriction for morbid obesity. Am Surg 54:269–272
  32. Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW (1991) Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroentrol 86(8):1000–1005
  33. Miller K, Höller E, Hell E (2002) Restrictive procedures in the treatment of morbid obesity: vertical banded gastroplasty vs. adjustable gastric banding. Zentralbl Chir 127:1038–1043 · DOI
  34. Jonas E, Marsk R, Rasmussen F, Freedman J (2010) Incidence of postoperative gallstone disease after antiobesity surgery: population-based study from Sweden. Surg Obes Relat Dis 6:54–58 · DOI

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Metadata

Authors
Talha, A., Abdelbaki, T., Farouk, A., Hasouna, E., Azzam, E., & Shehata, G.
ORCID
Talha, Ahmed
Venue
Surgical Endoscopy
Publisher
Springer Science and Business Media LLC
Published
2019-12-19
Volume
34
Issue
12
Pages
5331-5337
ISSN
  • 0930-2794
  • 1432-2218
DOI
10.1007/s00464-019-07323-7
Cited by
56
References
1
Language
en
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CoChat. (2026). Citation check: Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial. https://app.cochat.ai/papers/10.1007/s00464-019-07323-7
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Talha, A., Abdelbaki, T., Farouk, A., Hasouna, E., Azzam, E., & Shehata, G. (2020). Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial. Surgical Endoscopy. https://doi.org/10.1007/s00464-019-07323-7