The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Serum diamine oxidase activity as a diagnostic test for histamine intolerance
Abstract
Background Histamine intolerance (HIT) is characterized by an imbalance between histamine intake and the capacity for histamine degradation. The main enzyme for metabolizing ingested histamine is diamine oxidase (DAO). Determining DAO activity in serum may be useful in diagnosing HIT.Methods Over a period of 3.5 years we recruited 316 subjects with clinically suspected HIT and 55 healthy controls. Serum DAO activity was measured with a quantitative enzyme immunoassay. Twenty patients with highly reduced DAO activity went on a histamine-free diet for 6-12 months. Afterwards, their DAO activity was determined again.Results We found that DAO activity was significantly lower in patients than in healthy control subjects (P < 0.0001). Furthermore, 54 patients had highly reduced serum DAO activity (< 40 HDU/ml). Their main symptoms involved the skin, gastrointestinal tract, respiratory system, and eyes. In all the 20 patients with highly reduced DAO activity, the main clinical symptoms typical of histamine intolerance disappeared after they adopted a histamine-free diet. Furthermore, the serum DAO activity values measured increased significantly (P < 0.0001).Conclusions Our results suggest that determining DAO activity in serum is a useful tool in diagnosing HIT. Furthermore, our results showed the benefit of a histamine-free diet because after the diet the majority of symptoms disappeared and the serum DAO activity significantly increased.
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The current diagnosis of HIT primarily relies on clinical evaluation.
“It is important to emphasise that, currently, the diagnosis of HIT still relies primarily on clinical evaluation.”
From Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance (2023) · cites this paper as [12]
There is limited knowledge about low DAO levels in healthy adults who do not present any HIT-related symptoms or signs.
“There is also limited knowledge about low DAO levels in healthy adults who do not present any HIT-related symptoms or signs [ 1 , 12 ].”
From Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance (2023) · cites this paper as [12]
Citations
Cites
Histamine and histamine intolerance
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No correlation between wine intolerance and histamine content of wine
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Histamine intolerance: a metabolic disease?
Schwelberger, H. G. (2009) · Inflammation Research · doi:10.1007/s00011-009-0134-3 · Cited by 47
Determination of Diamine Oxidase Activity in Normal Human Blood Serum
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Histamine intolerance: Overestimated or underestimated?
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Diaminoxidase keine diagnostische Hilfe bei Histaminintoleranz
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Histaminintoleranz imitiert Anorexia nervosa
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Research works printed but not linked: 1
- Jarisch R. Histamin-Intoleranz [Histamine intolerance]. Aerztemagazin. 2004;8:1–4.
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Histamine Intolerance: The Current State of the Art
Comas-Basté, O., Sánchez-Pérez, S., Veciana-Nogués, M. T., Latorre-Moratalla, M., & Vidal-Carou, M. D. C. (2020) · Biomolecules · doi:10.3390/biom10081181 · Cited by 246
Cucca, V., Ramirez, G. A., Pignatti, P., Asperti, C., Russo, M., Della-Torre, E., Breda, D., Burastero, S. E., Dagna, L., & Yacoub, M.-R. (2022) · Nutrients · doi:10.3390/nu14071513 · Cited by 41
Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance
Arih, K., Đorđević, N., Košnik, M., & Rijavec, M. (2023) · Nutrients · doi:10.3390/nu15194246 · Cited by 20
Self-citation
Metadata
- Authors
- Mušič, E., Korošec, P., Šilar, M., Adamič, K., Košnik, M., & Rijavec, M.
- Affiliations
- University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
- Corresponding author
- Rijavec, Matija
- Venue
- Wiener klinische Wochenschrift
- Published
- 2013-04-12
- Volume
- 125
- Issue
- 9-10
- Pages
- 239-243
- ISSN
- 0043-5325 (ISSN-L)
- 1613-7671
- OpenAlex
- W1595142782
- Cited by
- 84
- References
- 15
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 3 · 2023: 14 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Wiener klinische Wochenschrift (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- histamine intolerance, diamine oxidase, histamine metabolism, diagnostic biomarkers, enzyme immunoassay
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Female, Food Hypersensitivity, Amine Oxidase (Copper-Containing), Histamine, Humans, Male, Middle Aged, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Prevalence, Slovenia, Risk Assessment, Young Adult
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