Cancer-related fatigue: clinical practice versus practice guidelines
Open accessAbstract
PURPOSE: This study investigated adherence to treatment guidelines on cancer-related anaemia and fatigue (CRA/CRF) and factors influencing the choice of intervention. METHODS: In this prospective, observational study, 136 cancer patients being treated with chemotherapy in a large community hospital completed a questionnaire at consecutive outpatient visits assessing fatigue (the Functional Assessment of Chronic Illness Therapy-Fatigue) and fatigue-related counselling and advice received. Data on administration of chemotherapy and use of epoetin or blood transfusions were abstracted from the medical records. RESULTS: Fifty-three percent of patients with severe anaemia (Hb < 10 g/dl) and 6% of patients with less severe anaemia (Hb levels 10-12 g/dl) received treatment (epoetin and/or blood transfusions). Half of the patients with less severe anaemia reported clinically relevant levels of fatigue. More than 50% of all patients received fatigue-related counselling, primarily at the start of chemotherapy. Most counselling was directed at energy conservation. Fatigue was not associated significantly with the use of epoetin or blood transfusion. Patients receiving palliative treatment (17%), male patients (16%) and patients with a low Hb level (<6.2 g/dl, 38%) were treated significantly more often with epoetin. CONCLUSIONS: In daily clinical practice, guidelines concerning the use of epoetin or blood transfusion in severe CRA are adhered to in about half of the cases. In patients with less severe anaemia, the level of fatigue did not play a significant role in the use of epoetin. According to current guidelines, counselling on CRF should be directed primarily at activity enhancement. However, only a minority of patients receive such counselling.
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Only 14-27% of survivors received advice on management of fatigue, most directed at conserving energy (26-65%).
“Only 14-27% of survivors received advice on the management of fatigue, most of which was directed at conserving energy (26-65%) [27].”
From Empowerment in the treatment of fatigue in breast cancer patients (2021) · cites this paper as [27]
The Discussion reports that previous studies found 14–27% of cancer patients received fatigue treatment or advice; it does not describe that group as survivors. In this paper’s Results (Counselling for fatigue, Table 6), 26% of fatigued patients and 65% of non-fatigued patients received energy-conservation counselling, while 63% received fatigue counselling overall. The sentence combines figures from different groups as though they describe the same survivors. (LLM, conf=0.88)
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Cites
Why Don't Physicians Follow Clinical Practice Guidelines?: A Framework for Improvement
Cabana, M. D., Rand, C. S., Powe, N. R., Wu, A. W., Wilson, M. H., Abboud, P.-A. C., & Rubin, H. R. (1999) · JAMA · doi:10.1001/jama.282.15.1458 · Cited by 6,677 · see citing works
Exercise for the management of cancer-related fatigue in adults
Cramp, F., & Byron-Daniel, J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006145.pub3 · Cited by 1,096 · see citing works
Ludwig, H., Belle, S. V., Barrett-Lee, P. J., Birgegård, G., Bokemeyer, C., Gascón, P., Kosmidis, P., Krzakowski, M. J., Nortier, J. W. R., Olmi, P., et al. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.06.019 · Cited by 928 · see citing works
Cancer-related fatigue: the scale of the problem
Hofman, M., Ryan, J. L., Figueroa-Moseley, C. D., Jean-Pierre, P., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-4 · Cited by 895 · see citing works
(1997) · PubMed · Cited by 762 · see citing works
Stasi, R., Abriani, L., Beccaglia, P., Terzoli, E., & Amadori, S. (2003) · Cancer · doi:10.1002/cncr.11742 · Cited by 710 · see citing works
Cella, D. F. (1997) · PubMed · Cited by 683 · see citing works
Leyland-Jones, B. R., Семиглазов, В. Ф., Pawlicki, M., Pieńkowski, T., Tjulandin, S., Manikhas, G. M., Makhson, A., Roth, A., Dodwell, D. J., Baselga, J. M., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.150 · Cited by 661 · see citing works
Assessment and management of cancer-related fatigue in adults
Ahlberg, K., Ekman, T., Gaston‐Johansson, F., & Mock, V. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14186-4 · Cited by 545 · see citing works
Stone, P., Richardson, A., Ream, E., Smith, A. G., Kerr, D. J., & Kearney, N. (2000) · Annals of Oncology · doi:10.1023/a:1008318932641 · Cited by 438 · see citing works
Wright, J. R., Ung, Y., Julian, J. A., Pritchard, K. I., Whelan, T. J., Smith, C. D., Szechtman, B., Roa, W., Mulroy, L. A., Rudinskas, L. C., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.1514 · Cited by 427 · see citing works
Rizzo, J. D., Lichtin, A. E., Woolf, S. H., Seidenfeld, J., Bennett, C. L., Cella, D. F., Djulbegović, B., Goode, M. J., Jakubowski, A. A., Lee, S. J., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.177 · Cited by 417 · see citing works
Exercise for the management of cancer-related fatigue in adults
Cramp, F. L., & Daniel, J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006145.pub2 · Cited by 385 · see citing works
Rizzo, J. D., Somerfield, M. R., Hagerty, K. L., Seidenfeld, J., Bohlius, J., Bennett, C. L., Cella, D. F., Djulbegović, B., Goode, M. J., Jakubowski, A. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.3396 · Cited by 326 · see citing works
Cella, D. F., Kallich, J. D., McDermott, A. M., & Xu, X. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh235 · Cited by 246 · see citing works
Do Erythropoietin Receptors on Cancer Cells Explain Unexpected Clinical Findings?
Henke, M., Mattern, D., PEPE, M. S., Bézay, C., Weißenberger, C., Werner, M., & Pajonk, F. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.2737 · Cited by 238 · see citing works
Putting Evidence Into Practice
Feight, D., Baney, T., Bruce, S. D., & McQuestion, M. (2011) · Clinical journal of oncology nursing · doi:10.1188/11.cjon.481-492 · Cited by 131 · see citing works
Cancer-Related Fatigue Clinical Practice Guidelines in Oncology
(2003) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2003.0029 · Cited by 115 · see citing works
Helde, G., Bovim, G., Bråthen, G., & Brodtkorb, E. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.06.008 · Cited by 103 · see citing works
Stone, P. C., Ream, E., Richardson, A., THOMAS, H., ANDREWS, P., Campbell, P., Dawson, T., Edwards, J., GOLDIE, T., Hammick, M. R., et al. (2003) · European Journal of Cancer Care · doi:10.1046/j.1365-2354.2003.00329.x · Cited by 83 · see citing works
Munch, T. N., Zhang, T., Willey, J. S., Palmer, J. L., & Bruera, E. D. (2005) · Journal of Palliative Medicine · doi:10.1089/jpm.2005.8.1144 · Cited by 54 · see citing works
Quality of life and clinical decisions in chemotherapy-induced anemia.
Cella, D. F. (2006) · PubMed · Cited by 30 · see citing works
Sigle, J. M., & Porzsolt, F. (1996) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(96)90067-5 · Cited by 26 · see citing works
Davis, K., Lai, J., Hahn, E. A., & Cella, D. F. (2007) · Supportive Care in Cancer · doi:10.1007/s00520-007-0317-9 · Cited by 17 · see citing works
Hilarius, D. L., Kloeg, P. H., Detmar, S. B., Muller, M. J., & Aaronson, N. K. (2006) · Patient Education and Counseling · doi:10.1016/j.pec.2006.06.002 · Cited by 16 · see citing works
Self-citationCommunicating about chemotherapy-induced anemia.
Davidson, B., Blum, D., Cella, D. F., Hamilton, H. E., Nail, L. M., & Waltzman, R. J. (2007) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer-related fatigue: a practical review
Campos, M. P., Hassan, B. J., Riechelmann, R. P., & del Giglio, A. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq458 · Cited by 222 · see citing works
Management of fatigue in patients with cancer – A practical overview
Koornstra, R. H. T., Peters, M. E. W. J., Donofrio, S. M., van den Borne, B., & de Jong, F. A. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2014.01.004 · Cited by 124 · see citing works
Chuang, T.-Y., Yeh, M., & Chung, Y. (2017) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2017.01.004 · Cited by 70 · see citing works
Cancer-related fatigue: a survey of health practitioner knowledge and practice
Pearson, E. J. M., Morris, M. E., & McKinstry, C. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2723-8 · Cited by 52 · see citing works
Self-management support for cancer-related fatigue: A systematic review
Agbejule, O. A., Hart, N. H., Ekberg, S., Crichton, M., & Chan, R. J. (2022) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2022.104206 · Cited by 48 · see citing works
Cancer related fatigue: implementing guidelines for optimal management
Pearson, E. J. M., Morris, M. E., & McKinstry, C. (2017) · BMC Health Services Research · doi:10.1186/s12913-017-2415-9 · Cited by 47 · see citing works
Pulewka, K., Strauss, B. M., Hochhaus, A., & Hilgendorf, I. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03419-z · Cited by 39 · see citing works
Junghaenel, D. U., Cohen, J., Schneider, S., Neerukonda, A. R., & Broderick, J. E. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2616-x · Cited by 40 · see citing works
Jones, G., Gollish, M., Trudel, G., Rutkowski, N. A., Brunet, J., & Lebel, S. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05676-7 · Cited by 38 · see citing works
The importance of self-care for fatigue amongst patients undergoing chemotherapy for primary cancer
Regan, P., & Hegarty, J. M. (2017) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2017.02.005 · Cited by 31 · see citing works
Nonpharmacologic Approach to Fatigue in Patients With Cancer
Pachman, D. R., Price, K. A. R., & Carey, E. C. (2014) · The Cancer Journal · doi:10.1097/ppo.0000000000000064 · Cited by 26 · see citing works
Kuswanto, C. N., Sharp, J. L., Stafford, L., & Schofield, P. E. (2022) · Stress and Health · doi:10.1002/smi.3180 · Cited by 26 · see citing works
Translating Guidelines to Practice: A Training Session about Cancer-Related Fatigue
Jones, G., Rutkowski, N. A., Trudel, G., St-Gelais, C., Ladouceur, M., Brunet, J., & Lebel, S. (2020) · Current Oncology · doi:10.3747/co.27.5681 · Cited by 23 · see citing works
Jafari, H., Jannati, Y., Nesheli, H. M., & Hassanpour, S. (2017) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.199094 · Cited by 18 · see citing works
Wang, Y., Tian, L., Liu, X., Zhang, H., Tang, Y., Zhang, H., Nie, W., & Wang, L. (2023) · Cancers · doi:10.3390/cancers15245879 · Cited by 17 · see citing works
The effect of relaxation technique on fatigue levels after stem cell transplant
Hassanpour, S., Jafari, H., Jannati, Y., Charati, J. Y., & Bali, N. (2018) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/ijnmr.ijnmr_26_17 · Cited by 17 · see citing works
Tolotti, A., Bonetti, L., Pedrazzani, C., Bianchi, M., Moser, L., Pagnucci, N., Sari, D., & Valcarenghi, D. (2021) · BMC Nursing · doi:10.1186/s12912-021-00699-9 · Cited by 16 · see citing works
Menshadi, N., Bar‐Tal, Y., & Barnoy, S. (2013) · Oncology nursing forum · doi:10.1188/13.onf.133-138 · Cited by 14 · see citing works
Agbejule, O. A., Hart, N. H., Ekberg, S., & Chan, R. J. (2023) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01348-7 · Cited by 13 · see citing works
Standards for Palliative Care Delivery in Oncology Settings
Zafar, S. Y., Currow, D. C., Daugherty, C. K., & Abernethy, A. P. (2010) · The Cancer Journal · doi:10.1097/ppo.0b13e3181f289f7 · Cited by 13 · see citing works
Agbejule, O. A., Ekberg, S., Hart, N. H., & Chan, R. J. (2024) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2024.102726 · Cited by 12 · see citing works
Evaluation and management of fatigue in oncology: A multidimensional approach
Tazi, E. M., & Errihani, H. (2011) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.84528 · Cited by 10 · see citing works
Evaluation of Fatigue and Its Related Factors in Cancer Patients Undergoing Chemotherapy
Dehkordi, L. M., Kahangi, L. S., & Babashahi, M. (2018) · Journal of Health and Care · doi:10.29252/jhc.20.2.156 · Cited by 9 · see citing works
Staff Experience of Pain Management: An Improvement in Palliative Care
Unné, A., & Rosengren, K. (2013) · Pharmacy · doi:10.3390/pharmacy1020119 · Cited by 8 · see citing works
Kelelahan Pada Anak Dengan Leukemia Limfoblastik Akut Dalam Menjalani Kemoterapi Fase Induksi
Fernandes, A. (2020) · JURNAL KESEHATAN PERINTIS (Perintis s Health Journal) · doi:10.33653/jkp.v7i1.411 · Cited by 8 · see citing works
Tumoranämie im palliativen Kontext
Altinger, M., & Strasser, F. (2012) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-011-0047-y · Cited by 7 · see citing works
Nursing implications: symptom presentation and quality of life in rectal cancer patients
O’Gorman, C., Barry, A., Denieffe, S., Sasiadek, W., & Gooney, M. (2016) · Journal of Clinical Nursing · doi:10.1111/jocn.13234 · Cited by 6 · see citing works
Rutkowski, N. A., Jones, G., Brunet, J., & Lebel, S. (2024) · Current Oncology · doi:10.3390/curroncol31080325 · Cited by 5 · see citing works
Rad, M., Borzoee, F., Shahidsales, S., Tabarraie, Y., & Tabrizi, F. V. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 4 · see citing works
Khozimeh, F. S., Navidian, A., Sasanpour, P., & Kiani, F. (2019) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2019/792 · Cited by 4 · see citing works
CHEMOTHERAPY-INDUCED FATIGUE AMONG JORDANIAN CANCER PATIENTS: WHAT ARE THE CONTRIBUTING FACTORS?
Abu, O. K., Yaser, S., Khattab, M., Faisal, A. B., Laila, S., & Nehaya, A. D. (2014) · Middle East journal of cancer · Cited by 4 · see citing works
Li, S., Gao, Y., Lin, Y., Wu, W., Fang, Q., Ni, X., Zhou, Y., Hong, M., Zhang, R., & Lou, Y. (2022) · Journal of Clinical Nursing · doi:10.1111/jocn.16272 · Cited by 3 · see citing works
Nonpharmacological Interventions in the Treatment of Cancer-Related Fatigue
Lü, L., Dai, H., Jomeen, J., Puts, M. T. E., & Tian, L. (2024) · Clinical Cancer Investigation Journal · doi:10.51847/jujcxoohhg · Cited by 3 · see citing works
Unné, A., & Rosengren, K. (2014) · Pharmacy · doi:10.3390/pharmacy2030205 · Cited by 3 · see citing works
Fatigue in Early Stage among Jordanian Patients with Cancer Receiving Chemotherapy
Obead, K. A., Yaser, S., & Khattab, M. (2014) · Middle East Journal of Nursing · doi:10.5742/men.2014.92469 · Cited by 3 · see citing works
Empowerment in the treatment of fatigue in breast cancer patients
Era, D. P., Sitorus, R., & Afiyanti, Y. (2021) · Russian Open Medical Journal · doi:10.15275/rusomj.2021.0411
“Only 14-27% of survivors received advice on the management of fatigue, most of which was directed at conserving energy (26-65%) [27].”
BackgroundO’Gorman, C. (2014) · SETU Waterford Libraries - Open Access Repository
Bowman, R. E. (2013) · ePublications at Regis University (Regis University)
Nursing Management of Fatigue in Cancer Patients: Mixed Methods StudyPreprint
Tolotti, A., Bonetti, L., Pedrazzani, C., Bianchi, M., Moser, L., Pagnucci, N., Sari, D., & Valcarenghi, D. (2021) · Research Square · doi:10.21203/rs.3.rs-257672/v1
Era, D. P., Sitorus, R., Afiyanti, Y., & Eryando, T. (2022) · Indonesian Journal of Multidisciplinary Science · doi:10.55324/ijoms.v2i3.292
Versorgungssituation: Herausforderungen und Lösungsmöglichkeiten
Horneber, M., Weis, J., & Otto, S. (2023) · Springer eBooks · doi:10.1007/978-3-662-64615-1_5
Utami, K. C., & Puspita, L. M. (2023) · Coping Community of Publishing in Nursing · doi:10.24843/coping.2023.v11.i03.p13
Tolotti, A., Bonetti, L., Pedrazzani, C., Bianchi, M., Moser, L., Pagnucci, N., Sari, D., & Valcarenghi, D. (2021) · Figshare · doi:10.6084/m9.figshare.16696308
- Authors
- Hilarius, D. L., Kloeg, P. H., van der Wall, E., Komen, M., Gundy, C. M., & Aaronson, N. K.
- Affiliations
- Rode Kruis Ziekenhuis (NL)
- Medisch Centrum Alkmaar (NL)
- The Netherlands Cancer Institute (NL)
- Corresponding author
- Aaronson, Neil K.
- Venue
- Supportive Care in Cancer
- Published
- 2010-03-19
- Volume
- 19
- Issue
- 4
- Pages
- 531-538
- ISSN
- 0941-4355 (ISSN-L)
- 1433-7339
- PMC
- PMC3061212
- OpenAlex
- W1983173150
- Cited by
- 43
- References
- 26
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Supportive Care in Cancer (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- cancer-related fatigue, cancer-related anemia, epoetin, blood transfusion, guideline adherence, chemotherapy-induced anemia, energy conservation, palliative care, hemoglobin levels
- MeSH terms
- Adult, Aged, Aged, 80 and over, Anemia, Antineoplastic Agents, Blood Transfusion, Erythropoietin, Fatigue, Female, Hospitals, Community, Humans, Male, Middle Aged, Neoplasms, Palliative Care, Patient Education as Topic, Prospective Studies, Severity of Illness Index, Sex Factors, Practice Guidelines as Topic, Guideline Adherence
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