A structured, nurse-led intervention program improves quality of life in patients with epilepsy: A randomized, controlled trial
Abstract
We tested the hypothesis that structured epilepsy nursing improves quality of life (QOL). One hundred fourteen adult patients with uncontrolled epilepsy were randomly assigned to either an intervention group or a control group. The intervention group was offered an interactive, 1-day group education program followed by extended nurse follow-up and counseling. The nurse was present at as many outpatient consultations as possible and performed repeated consultations by telephone. All patients completed the QOLIE-89 before randomization and after 2 years. QOL was significantly improved from inclusion to completion of study in the intervention group (P=0.019), mainly in the subitems for Health Discouragement (P=0.01), Medication Effects (P=0.035), and Physical Role Limitations (P=0.05). To our knowledge, this is the first study to demonstrate a significant effect of a structured nurse-led intervention program in QOL of patients with epilepsy.
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Two studies investigated mixed interventions for adolescents and adults.
“2 studies investigated mixed interventions for adolescents and adults, 49,50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
One combined intervention combined an epilepsy education group session covering epilepsy knowledge and nurse-led personalized counseling with the primary goal of enhancing QoL.
“One combined an epilepsy education group session covering epilepsy knowledge and nurse-led personalized counseling with the primary goal of enhancing QoL. 49”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
The remaining 7 studies (29%) employed a usual care (UC)/treatment as usual (TAU) control group.
“The remaining 7 studies (29%) employed a usual care (UC)/treatment as usual (TAU) control group. 26,27,31,41,44,48 -50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
Four interventions (17%) combined group therapy with individual sessions.
“and 4 interventions (17%) combined group therapy with individual sessions. 34,35,49,50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
A rating of low ROB was confirmed based on document review of registered protocols provided by the authors for 9 studies (37%).
“A rating of low ROB was confirmed based on document review of registered protocols provided by the authors for 9 studies (37%). 32,36,40,42,44 -46,49,50”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
The risk of infidelity to the intervention protocol was considered to be relatively low whenever the therapist delivering the intervention coincided with the developer of the intervention protocol (n = 6, 25%).
“Furthermore, the risk of infidelity to the intervention protocol was considered to be relatively low whenever the therapist delivering the intervention coincided with the developer of the intervention protocol (n = 6, 25%) 25 -27,34,46,48,49”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
The meta-analysis comprised data from 9 studies (37%) with a total of 468 participants.
“Consequently, the meta-analysis comprised data from 9 studies (37%) 26 -30,33,36,46,49,50 with a total of 468 participants (see studies highlighted in gray in Table 1).”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
Eight studies (33%) were rated as low risk for attrition bias as there was only a small number of missing data, which were balanced across the groups with justifiable reasons.
“Eight studies (33%) 27,29,36,38,39,44,48,49 were rated as low risk as there was only a small number of missing data, which were balanced across the groups with justifiable reasons.”
From Cochrane systematic review and meta-analysis of the impact of psychological treatments for people with epilepsy on health-related quality of life (2018) · cites this paper as [49]
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Effects of Drug Compliance on Quality of Life in Patients with Epilepsy
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The Impact of The Coronavirus Disease 2019 Outbreak on The Quality of Life of Patients with Epilepsy
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Epilepsy and Psychiatric Comorbidities: New Approaches and Perspectives
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- Authors
- Helde, G., Bovim, G., Bråthen, G., & Brodtkorb, E.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Helde, Grethe
- Venue
- Epilepsy & Behavior
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 7
- Issue
- 3
- Pages
- 451-457
- ISSN
- 1525-5050 (ISSN-L)
- OpenAlex
- W2066932667
- Cited by
- 103
- References
- 34
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 4 · 2012: 3
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsy & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Health Professions › Pharmacy › Nursing care and research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- epilepsy, quality of life, nurse-led intervention, nursing care, group education program, telephone follow-up, uncontrolled epilepsy, QOLIE-89, adverse drug reactions, physical role limitation
- MeSH terms
- Adolescent, Adult, Aged, Epilepsy, Female, Humans, Male, Middle Aged, Nurses, Outpatients, Patient Education as Topic, Quality of Life, Treatment Outcome
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