The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial
Open accessAbstract
PurposeOver half of all cancer patients receiving taxane-, platinum-, or vinca alkaloid-based chemotherapy experience chemotherapy-induced peripheral neuropathy (CIPN), which includes numbness, tingling, pain, cold sensitivity, and motor impairment in the hands and feet. CIPN is a dose-limiting toxicity, potentially increasing mortality. There are no FDA-approved drugs to treat CIPN, and behavioral interventions such as exercise are promising yet understudied. This secondary analysis of our nationwide phase III randomized controlled trial of exercise for fatigue examines (1) effects of exercise on CIPN symptoms, (2) factors that predict CIPN symptoms, and (3) factors that moderate effects of exercise on CIPN symptoms.MethodsCancer patients (N = 355, 56 ± 11 years, 93% female, 79% breast cancer) receiving taxane-, platinum-, or vinca alkaloid-based chemotherapy were randomized to chemotherapy or chemotherapy plus Exercise for Cancer Patients (EXCAP©®). EXCAP is a standardized, individualized, moderate-intensity, home-based, six-week progressive walking and resistance exercise program. Patients reported CIPN symptoms of numbness and tingling and hot/coldness in hands/feet (0–10 scales) pre- and post-intervention. We explored baseline neuropathy, sex, age, body mass index, cancer stage, and cancer type as possible factors associated with CIPN symptoms and exercise effectiveness.ResultsExercise reduced CIPN symptoms of hot/coldness in hands/feet (−0.46 units, p = 0.045) and numbness and tingling (− 0.42 units, p = 0.061) compared to the control. Exercise reduced CIPN symptoms more for patients who were older (p = 0.086), male (p = 0.028), or had breast cancer (p = 0.076).ConclusionsExercise appears to reduce CIPN symptoms in patients receiving taxane-, platinum-, or vinca alkaloid-based chemotherapy. Clinicians should consider prescribing exercise for these patients.Trial registrationClinical Trials.gov, # NCT00924651, http://www.clinicaltrials.gov.
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Cites
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
Costigan, M., Scholz, J., & Woolf, C. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135531 · Cited by 2,025
Reduced resting-state brain activity in the “default network” in normal aging
Damoiseaux, J. S., Beckmann, C. F., Arigita, E. J. S., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Rombouts, S. A. R. B. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm207 · Cited by 1,187 · cited 1×
“Specifically, normal aging impairs the function [36, 37] and structure [38, 39] of interoceptive brain circuitry, thus potentially making the brain more vulnerable to the effects of chemotherapy, thereby exacerbating symptoms of CIPN.”
BackgroundSelf-management: Enabling and empowering patients living with cancer as a chronic illness
McCorkle, R., Ercolano, E., Lazenby, M., Schulman-Green, D., Schilling, L. S., Lorig, K., & Wagner, E. H. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20093 · Cited by 950
Chemotherapy-induced peripheral neuropathy: a current review
Staff, N. P., Grisold, A., Grisold, W., & Windebank, A. J. (2017) · Annals of Neurology · doi:10.1002/ana.24951 · Cited by 908
Hui, D., Glitza, I., Chisholm, G., Yennu, S., & Bruera, E. (2013) · Cancer · doi:10.1002/cncr.27854 · Cited by 250
Interoceptive awareness declines with age
Khalsa, S. S., Rudrauf, D., & Tranel, D. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00859.x · Cited by 211
Tham, A., Jonsson, U., Andersson, G., Söderlund, A., Allard, P., & Bertilsson, G. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.06.013 · Cited by 104 · cited 1×
“However, duloxetine has not been shown to reduce numbness or completely eliminate CIPN pain [15], and it causes dry mouth, constipation, diarrhea, and dizziness [16].”
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Cited by
Loprinzi, C. L., Lacchetti, C., Bleeker, J., Cavaletti, G., Chauhan, C., Hertz, D. L., Kelley, M. R., Lavino, A., Lustberg, M. B., Paice, J. A., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01399 · Cited by 1,113
Breast cancer: pathogenesis and treatments
Xiong, X., Zheng, L.-W., Ding, Y., Chen, Y.-F., Cai, Y.-W., Wang, L.-P., Huang, L., Liu, C.-C., Shao, Z.-M., & Yu, K.-D. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02108-4 · Cited by 958
Cos, H., Li, D., Williams, G., Chininis, J., Dai, R., Zhang, J., Srivastava, R., Raper, L., Sanford, D., Hawkins, W., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/23595 · Cited by 63
Metadata
- Authors
- Kleckner, I. R., Kamen, C., Gewandter, J. S., Mohile, N. A., Heckler, C. E., Culakova, E., Fung, C., Janelsins, M. C., Asare, M., Lin, P.-J., Reddy, P. S., Giguere, J., Berenberg, J., Kesler, S. R., & Mustian, K. M.
- Venue
- Supportive Care in Cancer
- Published
- 2017-12-14
- Volume
- 26
- Issue
- 4
- Pages
- 1019-1028
- ISSN
- 0941-4355 (ISSN-L)
- 1433-7339
- OpenAlex
- W2774164535
- Cited by
- 309
- References
- 7
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Kleckner, I. R., Kamen, C., Gewandter, J. S., Mohile, N. A., Heckler, C. E., Culakova, E., Fung, C., Janelsins, M. C., Asare, M., Lin, P.-J., Reddy, P. S., Giguere, J., Berenberg, J., Kesler, S. R., & Mustian, K. M. (2018). Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial. Supportive Care in Cancer. https://doi.org/10.1007/s00520-017-4013-0
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