Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 3

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction

Van Roessel, I. M. A. A., Van Schaik, J., Kleinlugtenbelt, L. B., van Duijn, S. N., Burghard, M., Takken, T., Tissing, W. J. E., Bekkering, W. P., van Santen, H. M.·2025·Supportive Care in Cancer
DOI 10.1007/s00520-025-09361-5
Open this paper in CoChat — free account

Abstract

Purpose: Survivors of a pediatric suprasellar tumor may suffer from hypothalamic-pituitary dysfunction (HD), which may result in hypothalamic obesity (HO). The first step in HO treatment is lifestyle intervention (e.g. exercise). Our aim was to assess physical activity (PA), health-related fitness (HRF) and physical performance (PP) in a cohort of children with a suprasellar tumor. Methods: Retrospective study on a national cohort including all children with a suprasellar tumor who were referred to the physiotherapy department 2018—2022. Data was collected on: PA defined as minutes of Moderate-to-Vigorous Physical Activity (MVPA) and number of steps per day, HRF defined as body composition, VO 2 peak percentage of predicted, mean power, and muscle strength, and PP based on the 10-m walk and run test, time up and down the stairs, and time to rise from the floor. Results: Seventy-three children (mean age 11.09, mean body mass index SDS 2.36) were evaluated. In total, 24.1% reached the guideline of ≥ 60 min MVPA per day. The VO 2 peak percentage of predicted was 71.0% [IQR 57.0 – 82.8] and in 58.3% mean power was ≤ -2 SDS. Muscle strength was not decreased (median of -0.5 SDS). PP was found to be better than the norm. Conclusion and key findings: PA and HRF are decreased in children with HD, however PP was not decreased. This implies that no PP restrictions are present to engage in PA and that a lifestyle coach can be involved to improve PA and HRF in these children.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00520-025-09361-5

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 4 references

Research works printed but not linked: 35

  1. Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro Oncol 1(1):14–25
  2. Jagannathan J, Dumont AS, Jane JA Jr, Laws ER Jr (2005) Pediatric sellar tumors: diagnostic procedures and management. Neurosurg Focus 18(6A):E6
  3. Bartels U, Laperriere N, Bouffet E, Drake J (2012) Intracystic therapies for cystic craniopharyngioma in childhood. Front Endocrinol (Lausanne) 3:39 · DOI
  4. Müller HL (2014) Craniopharyngioma. Handb Clin Neurol 124:235–253 · DOI
  5. van Santen HM, van Schaik J, van Roessel I, Beckhaus J, Boekhoff S, Müller HL (2023) Diagnostic criteria for the hypothalamic syndrome in childhood. Eur J Endocrinol 188(2):lvad009 · DOI · Paper page
  6. van Iersel L, Brokke KE, Adan RAH, Bulthuis LCM, van den Akker ELT, van Santen HM (2019) Pathophysiology and Individualized Treatment of Hypothalamic Obesity Following Craniopharyngioma and Other Suprasellar Tumors: A Systematic Review. Endocr Rev 40(1):193–235 · DOI · Paper page
  7. Sterkenburg AS, Hoffmann A, Gebhardt U, Warmuth-Metz M, Daubenbüchel AM, Müller HL (2015) Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes. Neuro Oncol 17(7):1029–1038 · DOI · Paper page
  8. Meijneke RW, Schouten-van Meeteren AY, de Boer NY, van Zundert S, van Trotsenburg PA, Stoelinga F, van Santen HM (2015) Hypothalamic obesity after treatment for craniopharyngioma: the importance of the home environment. J Pediatr Endocrinol Metab 28(1):59–63
  9. Holmer H, Pozarek G, Wirfält E, Popovic V, Ekman B, Björk J, Erfurth E-M (2010) Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma. J Clin Endocrinol Metab 95(12):5395–5402 · DOI
  10. Muller HL (2011) Consequences of craniopharyngioma surgery in children. J Clin Endocrinol Metab 96(7):1981–1991 · DOI · Paper page
  11. Piguel X, Abraham P, Bouhours-Nouet N, Gatelais F, Dufresne S, Rouleau S, Coutant R (2012) Impaired aerobic exercise adaptation in children and adolescents with craniopharyngioma is associated with hypothalamic involvement. Eur J Endocrinol 166(2):215–222 · DOI
  12. Conklin HM, Ness KK, Ashford JM, Scoggins MA, Ogg RJ, Han Y et al (2019) Cognitive Performance, Aerobic Fitness, Motor Proficiency, and Brain Function Among Children Newly Diagnosed With Craniopharyngioma. J Int Neuropsychol Soc 25(4):413–425 · DOI · Paper page
  13. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320(7244):1240–1243 · DOI · Paper page
  14. Moussa G, Bassilious K, Mathews N (2021) A novel excel sheet conversion tool from Snellen fraction to LogMAR including “counting fingers”, “hand movement”, “light perception” and “no light perception” and focused review of literature of low visual acuity reference values. Acta Ophthalmol 99(6):E963–E965 · DOI · Paper page
  15. Nuijts MA, Stegeman I, van Seeters T, Borst MD, Bennebroek CAM, Buis DR et al (2022) Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor. Jama Ophthalmol 140(10):982–993 · doi:10.1001/jamaophthalmol.2022.3628
  16. Puyau MR, Adolph AL, Vohra FA, Zakeri I, Butte NF (2004) Prediction of activity energy expenditure using accelerometers in children. Med Sci Sport Exer 36(9):1625–1631
  17. Pfeiffer KA, McIver KL, Dowda M, Almeida MJ, Pate RR (2006) Validation and calibration of the Actical accelerometer in preschool children. Med Sci Sports Exerc 38(1):152–157 · DOI · Paper page
  18. Kelly LA, McMillan DG, Anderson A, Fippinger M, Fillerup G, Rider J (2013) Validity of actigraphs uniaxial and triaxial accelerometers for assessment of physical activity in adults in laboratory conditions. BMC Med Phys 13(1):5 · DOI · Paper page
  19. Colley RC, Janssen I, Tremblay MS (2012) Daily step target to measure adherence to physical activity guidelines in children. Med Sci Sports Exerc 44(5):977–982 · DOI · Paper page
  20. Shephard RJ (1995) Physical-Activity, Fitness, and Health - the Current Consensus. Quest 47(3):288–303 · doi:10.1080/00336297.1995.10484158
  21. Wells JC, Fewtrell MS (2006) Measuring body composition. Arch Dis Child 91(7):612–617 · DOI · Paper page
  22. Cleary J, Daniells S, Okely AD, Batterham M, Nicholls J (2008) Predictive validity of four bioelectrical impedance equations in determining percent fat mass in overweight and obese children. J Am Diet Assoc 108(1):136–139 · DOI
  23. McCarthy HD, Cole TJ, Fry T, Jebb SA, Prentice AM (2006) Body fat reference curves for children. Int J Obes (Lond) 30(4):598–602 · DOI · Paper page
  24. Van Brussel M, Bongers BC, Hulzebos EHJ, Burghard M, Takken T (2019) A Systematic Approach to Interpreting the Cardiopulmonary Exercise Test in Pediatrics. Pediatr Exerc Sci 31(2):194–203 · DOI
  25. Bongers BC, SI DEV, Helders PJ, T Takken (2013) The steep ramp test in healthy children and adolescents: reliability and validity. Med Sci Sports Exerc 45(2):366–71 · DOI
  26. Steenman K, Verschuren O, Rameckers E, Douma-van Riet D, Takken T (2016) Extended Reference Values for the Muscle Power Sprint Test in 6- to 18-Year-Old Children. Pediatr Phys Ther 28(1):78–84 · DOI
  27. Bongers BC, Werkman MS, Blokland D, Eijsermans MJ, Van der Torre P, Bartels B et al (2015) Validity of the Pediatric Running-Based Anaerobic Sprint Test to Determine Anaerobic Performance in Healthy Children. Pediatr Exerc Sci 27(2):268–276 · DOI
  28. Wind AE, Takken T, Helders PJM, Engelbert RHH (2010) Is grip strength a predictor for total muscle strength in healthy children, adolescents, and young adults? Eur J Pediatr 169(3):281–287 · DOI · Paper page
  29. Bohannon RW, Wang YC, Bubela D, Gershon RC (2017) Handgrip Strength: A Population-Based Study of Norms and Age Trajectories for 3-to 17-Year-Olds. Pediatr Phys Ther 29(2):118–123 · DOI
  30. Pereira AC, Ribeiro MG, Araujo APDC (2016) Timed motor function tests capacity in healthy children. Arch Dis Child 101(2):147–151 · doi:10.1136/archdischild-2014-307396
  31. Chrysagis N, Skordilis EK, Koutsouki D (2014) Validity and Clinical Utility of Functional Assessments in Children With Cerebral Palsy. Arch Phys Med Rehab 95(2):369–374 · doi:10.1016/j.apmr.2013.10.025
  32. Zaino CA, Marchese VG, Westcott SL (2004) Timed up and down stairs test: preliminary reliability and validity of a new measure of functional mobility. Pediatr Phys Ther 16(2):90–98 · DOI · Paper page
  33. Nevill AM, Duncan MJ, Sandercock G (2020) Modeling the dose-response rate/associations between VO2max and self-reported Physical Activity Questionnaire in children and adolescents. J Sport Health Sci 9(1):90–95 · doi:10.1016/j.jshs.2019.05.001
  34. Hills AP, Andersen LB, Byrne NM (2011) Physical activity and obesity in children. Brit J Sport Med 45(11):866–870 · DOI · Paper page
  35. Deforche B, Lefevre J, De Bourdeaudhuij I, Hills AP, Duquet W, Bouckaert J (2003) Physical fitness and physical activity in obese and nonobese Flemish youth. Obes Res 11(3):434–441 · DOI · Paper page

Cited by

See all 3

Metadata

Authors
Van Roessel, I. M. A. A., Van Schaik, J., Kleinlugtenbelt, L. B., van Duijn, S. N., Burghard, M., Takken, T., Tissing, W. J. E., Bekkering, W. P., & van Santen, H. M.
Venue
Supportive Care in Cancer
Publisher
Springer Science and Business Media LLC
Published
2025-03-18
Volume
33
Issue
4
ISSN
  • 0941-4355
  • 1433-7339
DOI
10.1007/s00520-025-09361-5
Cited by
3
References
4
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction. https://app.cochat.ai/papers/10.1007/s00520-025-09361-5
The paper
Van Roessel, I. M. A. A., Van Schaik, J., Kleinlugtenbelt, L. B., van Duijn, S. N., Burghard, M., Takken, T., Tissing, W. J. E., Bekkering, W. P., & van Santen, H. M. (2025). Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction. Supportive Care in Cancer. https://doi.org/10.1007/s00520-025-09361-5

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.