Obesity in Patients with Craniopharyngioma: Assessment of Food Intake and Movement Counts Indicating Physical Activity
Abstract
Patients with childhood-onset craniopharyngioma (CP) often suffer from obesity. We evaluated two important etiological factors of obesity development, energy intake and physical activity. Energy intake was supposed to be high due to a disturbed hypothalamic regulation of appetite. We used a validated nutritional diary to determine the 1-wk food intake in 27 CP patients (12 with intrasellar tumors and 15 with hypothalamic tumors) and 1027 controls who were a representative sample of the 7- to 16-yr-old German population. In 2 accelerometry settings, we determined movement counts indicating physical activity. Nineteen CP patients were comparable to 26 controls for age and body mass index. One setting was a clinical one during weight reduction; the other was an out-patient setting. Daily energy intake was 1916 +/- 677 kcal (mean +/- SD) in intrasellar CP patients, 2075 +/- 877 kcal in hypothalamic CP patients, and 2476 +/- 815 kcal in non-CP controls. Patients suffering from CP showed fewer movement registrations [clinical setting, 228 vs. 298 cpm for obese controls (P = 0.01); out-patient setting, 228 vs. 282 cpm for controls (P = 0.08)]. Differences were most pronounced during leisure time (382 cpm in CP patients vs. 546 cpm in obese controls; P = 0.002; clinical setting). Our findings suggest that reduced physical activity, rather than increased energy intake, in CP patients is responsible for the obesity development noted in these subjects.
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Other patients with hypothalamic obesity will gain weight even in the absence of changes in eating.
“others will gain weight even in the absence of changes in eating”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [35]
Some patients with hypothalamic obesity will endorse hyperphagia.
“Although some patients with hypothalamic obesity will endorse hyperphagia”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [35]
Weight gain in the absence of changes in eating in hypothalamic obesity is attributable to a substantial decrease in metabolic rate.
“a phenomenon attributable to a substantial decrease in metabolic rate (35)”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [35]
Autonomic impairment may contribute to fatigue, exercise intolerance, and decreased voluntary physical activity in individuals with hypothalamic syndrome.
“Autonomic impairment may contribute to the fatigue, exercise intolerance, and decreased voluntary physical activity reported by many individuals with hypothalamic syndrome (35, 59, 60).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [35]
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Self-citationDiagnostics, treatment, and follow-up in craniopharyngioma
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Self-citationBariatric Surgery in Hypothalamic Obesity
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Childhood craniopharyngioma: treatment strategies and outcomes
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Obesity, Metabolic Syndrome and Disorders of Energy Balance
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Fasting Ghrelin Levels Are Not Elevated in Children with Hypothalamic Obesity
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Treatment of hypothalamic obesity in people with hypothalamic injury: new drugs are on the horizon
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- Authors
- Harz, K. J., Müller, H. L., Waldeck, E., Pudel, V., & Roth, C.
- Affiliations
- University Hospital Bonn (DE)
- Department of Pediatrics, Hospital of Oldenburg (H.L.M.), 26133 Oldenburg, Germany
- Berufsgenossenschaftliche Unfallklinik Murnau (DE)
- University of Göttingen (DE)
- ORCID
- Roth, Christian
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-11-01
- Volume
- 88
- Issue
- 11
- Pages
- 5227-5231
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1998361862
- Cited by
- 214
- References
- 25
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 11
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- craniopharyngioma, childhood obesity, energy intake, physical activity, hypothalamic tumors, intrasellar tumor, accelerometry, appetite regulation, weight loss
- MeSH terms
- Adolescent, Adult, Child, Craniopharyngioma, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Eating, Female, Humans, Male, Motor Activity, Movement, Obesity, Morbid, Pituitary Neoplasms, Retrospective Studies, Diet Records
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