Helicobacter pylori and gastric carcinogenesis

Global cancer statistics

Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works

Global Cancer Statistics, 2002

Parkin, D. M., Bray, F., Ferlay, J., & Pisani, P. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.74 · Cited by 18,573 · see citing works

Helicobacter pylori Infection and the Development of Gastric Cancer

Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., & Schlemper, R. J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa001999 · Cited by 4,466 · see citing works

Helicobacter pylori Infection and the Risk of Gastric Carcinoma

Parsonnet, J., FRIEDMAN, G. D., Vandersteen, D. P., Chang, Y., Vogelman∥, J. H., Orentreich∥, N., & Sibley, R. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110173251603 · Cited by 3,893 · see citing works

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

Correa, P. (1992) · PubMed · Cited by 3,149 · see citing works

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

Censini, S., Lange, C., Xiang, Z., Crabtree, J. E., GHIARA, P., Borodovsky, M. Y., Rappuoli, R., & Covacci, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14648 · Cited by 1,872 · see citing works

Helicobacter pyloriInfection and Gastric Carcinoma among Japanese Americans in Hawaii

Nomura, A. M. Y., Stemmermann, G. N., Chyou, P., Kato, I., Perez-Perez, G. I., & Blaser, M. J. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110173251604 · Cited by 1,761 · see citing works

E-cadherin germline mutations in familial gastric cancer

Guilford, P., Hopkins, J., Harraway, J. R., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A. C., & Reeve, A. E. (1998) · Nature · doi:10.1038/32918 · Cited by 1,653 · see citing works

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L., Peek, R. M., Chyou, P.-H., Stemmermann, G. N., & Nomura, A. M. Y. (1995) · PubMed · Cited by 1,608 · see citing works

Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China

Wong, B. C., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T., Feng, R. E., Lai, K. C., Hu, W. H. C., Yuen, S. T., Leung, S. Y., et al. (2004) · JAMA · doi:10.1001/jama.291.2.187 · Cited by 1,436 · see citing works

Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W. H., & Haas, R. (2000) · Science · doi:10.1126/science.287.5457.1497 · Cited by 1,286 · see citing works

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Neel, B. G., Gu, H., & Pao, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00091-4 · Cited by 1,249 · see citing works

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

Covacci, A., Censini, S., Bugnoli, M., Petracca, R., Burroni, D., Macchia, G., Massone, A., Papini, E., Xiang, Z., & Figura, N. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5791 · Cited by 1,248 · see citing works

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial

Fukase, K., Kato, M., Kikuchi, S., Inoue, K., Uemura, N., Okamoto, S., Terao, S., Amagai, K., Hayashi, S., & Asaka, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61159-9 · Cited by 1,242 · see citing works

Gastric Cancer Originating from Bone Marrow-Derived Cells

Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J. E., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., & Wang, T. C. (2004) · Science · doi:10.1126/science.1099513 · Cited by 1,167 · see citing works

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

Tartaglia, M., Niemeyer, C. M., Fragale, A., Song, X., Buechner, J., Jung, A., Hählen, K., Hasle, H., Licht, J. D., & Gelb, B. D. (2003) · Nature Genetics · doi:10.1038/ng1156 · Cited by 1,033 · see citing works

SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein

Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M., & Hatakeyama, M. (2002) · Science · doi:10.1126/science.1067147 · Cited by 1,028 · see citing works

Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.

Parsonnet, J., FRIEDMAN, G. D., Orentreich∥, N., & Vogelman, H. (1997) · Gut · doi:10.1136/gut.40.3.297 · Cited by 958 · see citing works

Identification of genes required for cytoplasmic localization in early C. elegans embryos

Kemphues, K. J., Priess, J. R., Morton, D. G., & Cheng, N. N. (1988) · Cell · doi:10.1016/s0092-8674(88)80024-2 · Cited by 859 · see citing works

Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori

Segal, E. D., Cha, J., Lo, J., Falkow, S., & Tompkins, L. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14559 · Cited by 769 · see citing works

Oncogenic mechanisms of the Helicobacter pylori CagA protein

Hatakeyama, M. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1433 · Cited by 756 · see citing works

Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003) · Science · doi:10.1126/science.1081919 · Cited by 739 · see citing works

Analyses of the cag pathogenicity island of Helicobacter pylori

Akopyants, N. S., Clifton, S. W., Kersulyte, D., Crabtree, J. E., Youree, B. E., Reece, C. A., Bukanov, N. O., Drazek, E. S., Roe, B. A., & Berg, D. E. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00770.x · Cited by 716 · see citing works

The PAR-aPKC system: lessons in polarity

Suzuki, A., & Ohno, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02898 · Cited by 695 · see citing works

Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production

Tummuru, M. K. R., Cover, T. L., & Blaser, M. J. (1993) · Infection and Immunity · doi:10.1128/iai.61.5.1799-1809.1993 · Cited by 649 · see citing works

Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status

Kuipers, E. J., Perez-Perez, G. I., Meuwissen, S. G. M., & Blaser, M. J. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.23.1777 · Cited by 595 · see citing works

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711183105 · Cited by 593 · see citing works

Colorectal cancer and genetic alterations in the Wnt pathway

Segditsas, S., & Tomlinson, I. (2006) · Oncogene · doi:10.1038/sj.onc.1210059 · Cited by 591 · see citing works

Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag -driven host cell translocation

Stein, M., Rappuoli, R., & Covacci, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1263 · Cited by 578 · see citing works

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Higashi, H., Tsutsumi, R., Fujita, A., Yamazaki, S., Asaka, M., Azuma, T., & Hatakeyama, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222375399 · Cited by 573 · see citing works

Meta-analysis of the relationship between cagA seropositivity and gastric cancer

Huang, J., Zheng, G. F., Sumanac, K., Irvine, E. J., & Hunt, R. H. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.033 · Cited by 548 · see citing works

NF-κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein

Brandt, S., Kwok, T., Hartig, R., König, W., & Backert, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409873102 · Cited by 535 · see citing works

Activating Mutations of the Noonan Syndrome-Associated <b> <i>SHP2/PTPN11</i> </b> Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

Bentires-Alj, M., Paez, J. G., David, F. S., Keilhack, H., Halmos, B., Naoki, K., Maris, J. M., Richardson, A., Bardelli, A., Sugarbaker, D. J., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1923 · Cited by 509 · see citing works

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata‐Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., et al. (2007) · Nature · doi:10.1038/nature05765 · Cited by 501 · see citing works

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

Matsumoto, Y. M., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I., Honjo, T., & Chiba, T. (2007) · Nature Medicine · doi:10.1038/nm1566 · Cited by 480 · see citing works

Activation of β-catenin by carcinogenic Helicobacter pylori

Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U. S., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L. S., Perez-Perez, G. I., Hatakeyama, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504927102 · Cited by 479 · see citing works

Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells

Asahi, M., Azuma, T., Ito, S., Ito, Y., Suto, H., Nagai, Y., Tsubokawa, M., Tohyama, Y., Maeda, S., Omata, M., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.4.593 · Cited by 474 · see citing works

Integrating the MAP kinase signal into the G1 phase cell cycle machinery

Roovers, K., & Assoian, R. K. (2000) · BioEssays · doi:10.1002/1521-1878(200009)22:9 · Cited by 469 · see citing works

Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R. M., Azuma, T., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210251 · Cited by 468 · see citing works

c‐Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs

Stein, M., Bagnoli, F., Halenbeck, R., Rappuoli, R., Fantl, W. J., & Covacci, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02781.x · Cited by 439 · see citing works

Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo

Selbach, M., Moese, S., Hauck, C. R., Meyer, T. F., & Backert, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100754200 · Cited by 414 · see citing works

Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus

Backert, S., Ziska, E., Brinkmann, V., Zimny‐Arndt, U., Fauconnier, A., Jungblut, P. R., Naumann, M., & Meyer, T. F. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00043.x · Cited by 403 · see citing works

Clinical Relevance of Helicobacter pylori cagA and vacA Gene Polymorphisms

Basso, D., Zambon, C., Letley, D. P., Stranges, A., Marchet, A., Rhead, J. L., Schiavon, S., Guariso, G., Ceroti, M., Nitti, D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.041 · Cited by 400 · see citing works

Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase

Tsutsumi, R., Higashi, H., Higuchi, M., Okada, M., & Hatakeyama, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208155200 · Cited by 281 · see citing works

Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation

Higashi, H., Nakaya, A., Tsutsumi, R., Yokoyama, K., Fujii, Y., Ishikawa, S., Higuchi, M., Takahashi, A., Kurashima, Y., Teishikata, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309964200 · Cited by 273 · see citing works

Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori

Argent, R. H., Kidd, M. S., Owen, R. J., Thomas, R. J., Limb, M. C., & Atherton, J. C. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.006 · Cited by 219 · see citing works

Activation of Abl by Helicobacter pylori: A Novel Kinase for CagA and Crucial Mediator of Host Cell Scattering

Tammer, I., Brandt, S., Hartig, R., König, W., & Backert, S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.050 · Cited by 219 · see citing works

Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA

Tsutsumi, R., Takahashi, A., Azuma, T., Higashi, H., & Hatakeyama, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.261-276.2006 · Cited by 204 · see citing works

Association between Diversity in the Src Homology 2 Domain–Containing Tyrosine Phosphatase Binding Site ofHelicobacter pyloriCagA Protein and Gastric Atrophy and Cancer

Azuma, T., Yamazaki, S., Yamakawa, A., Ohtani, M., Muramatsu, A., Suto, H., Ito, Y., Dojo, M., Yamazaki, Y., Kuriyama, M., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/381782 · Cited by 186 · see citing works

Influence of EPIYA-Repeat Polymorphism on the Phosphorylation-Dependent Biological Activity of Helicobacter pylori CagA

Naito, M., Yamazaki, T., Tsutsumi, R., Higashi, H., Onoé, K., Yamazaki, S., Azuma, T., & Hatakeyama, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.038 · Cited by 185 · see citing works

Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

Poppe, M., Feller, S. M., Römer, G., & Weßler, S. (2006) · Oncogene · doi:10.1038/sj.onc.1210139 · Cited by 179 · see citing works

Helicobacter pylori cag-Type IV Secretion System Facilitates Corpus Colonization to Induce Precancerous Conditions in Mongolian Gerbils

Rieder, G., Merchant, J. L., & Haas, R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.064 · Cited by 177 · see citing works

Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

Yokoyama, K., Higashi, H., Ishikawa, S., Fujii, Y., Kondo, S., Kato, H., Azuma, T., Wada, A., Hirayama, T., Aburatani, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502529102 · Cited by 136 · see citing works

EPIYA Motif Is a Membrane-targeting Signal of Helicobacter pylori Virulence Factor CagA in Mammalian Cells

Higashi, H., Yokoyama, K., Fujii, Y., Ren, S., Yuasa, H., Saadat, I., Murata‐Kamiya, N., Azuma, T., & Hatakeyama, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503583200 · Cited by 126 · see citing works

Structural Basis and Functional Consequence of Helicobacter pylori CagA Multimerization in Cells

Ren, S., Higashi, H., Lu, H., Azuma, T., & Hatakeyama, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606172200 · Cited by 125 · see citing works

The CagA Protein ofHelicobacter pyloriIs Translocated into Epithelial Cells and Binds to SHP‐2 in Human Gastric Mucosa

Yamazaki, S., Yamakawa, A., Ito, Y., Ohtani, M., Higashi, H., Hatakeyama, M., & Azuma, T. (2003) · The Journal of Infectious Diseases · doi:10.1086/367807 · Cited by 112 · see citing works

Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity

Zeaiter, Z., Cohen, D., Müsch, A., Bagnoli, F., Covacci, A., & Stein, M. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01084.x · Cited by 90 · see citing works

Helicobacter pylori CagA—a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins

Hatakeyama, M. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(02)00085-0 · Cited by 83 · see citing works

Helicobacter pylori CagA protein activates serum response element–driven transcription independently of tyrosine phosphorylation

Hirata, Y., Maeda, S., Mitsuno, Y., Tateishi, K., Yanai, A., Akanuma, M., Yoshida, H., Kawabe, T., Shiratori, Y., & Omata, M. (2002) · Gastroenterology · doi:10.1053/gast.2002.37044 · Cited by 74 · see citing works

Deregulation of β‐catenin signal by Helicobacter pylori CagA requires the CagA‐multimerization sequence

Kurashima, Y., Murata‐Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., & Hatakeyama, M. (2007) · International Journal of Cancer · doi:10.1002/ijc.23190 · Cited by 72 · see citing works

CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model

Shibata, W., Hirata, Y., Maeda, S., Ogura, K., Ohmae, T., Yanai, A., Mitsuno, Y., Yamaji, Y., Okamoto, M., Yoshida, H., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2040 · Cited by 64 · see citing works

Conditional gene silencing utilizing the lac repressor reveals a role of SHP‐2 in cagA‐positive Helicobacter pylori pathogenicity

Higuchi, M., Tsutsumi, R., Higashi, H., & Hatakeyama, M. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03229.x · Cited by 61 · see citing works

Association between serum pepsinogens and polymorphismof PTPN11 encoding SHP‐2 among Helicobacter pylori seropositive Japanese

Goto, Y., Ando, T., Yamamoto, K., Tamakoshi, A., El-Omar, E. M., Goto, H., & Hamajima, N. (2005) · International Journal of Cancer · doi:10.1002/ijc.21338 · Cited by 50 · see citing works

Pathobiology of Helicobacter pylori–Induced Gastric Cancer

Amieva, M. R., & Peek, R. M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.004 · Cited by 907 · see citing works

Gastric Cancer

Correa, P. (2013) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2013.01.002 · Cited by 630 · see citing works

Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development

Watari, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i18.5461 · Cited by 321 · see citing works

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari, S., & Yamaoka, Y. (2019) · Toxins · doi:10.3390/toxins11110677 · Cited by 295 · see citing works

Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort Study

Kumar, S., Metz, D. C., Ellenberg, S. S., Kaplan, D. E., & Goldberg, D. S. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.019 · Cited by 287 · see citing works

Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified

Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works

Low Prevalence of Helicobacter pylori-negative Gastric Cancer among Japanese

Matsuo, T., Ito, M., Takata, S., Tanaka, S., Yoshihara, M., & Chayama, K. (2011) · Helicobacter · doi:10.1111/j.1523-5378.2011.00889.x · Cited by 249 · see citing works

A Global Overview of the Genetic and Functional Diversity in the Helicobacter pylori cag Pathogenicity Island

Olbermann, P., Josenhans, C., Moodley, Y., Uhr, M., Stamer, C., Vauterin, M., Suerbaum, S., Achtman, M., & Linz, B. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001069 · Cited by 235 · see citing works

Obesity and cancer pathogenesis

Berger, N. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12416 · Cited by 231 · see citing works

The Long‐term Impact of Helicobacter pylori Eradication on Gastric Histology: a Systematic Review and Meta‐analysis

Rokkas, T., Pistiolas, D., Sechopoulos, P., Robotis, I., & Margantinis, G. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00563.x · Cited by 230 · see citing works

Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy

Chew, V., Toh, H. C., & Abastado, J. (2012) · Journal of Oncology · doi:10.1155/2012/608406 · Cited by 217 · see citing works

Gastric cancer review

Carcas, L. (2014) · Journal of Carcinogenesis · doi:10.4103/1477-3163.146506 · Cited by 206 · see citing works

Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets

Dhanisha, S. S., Guruvayoorappan, C., Drishya, S., & Abeesh, P. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.006 · Cited by 194 · see citing works

DNA Damage Response and Immune Defense: Links and Mechanisms

Nakad, R., & Schumacher, B. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00147 · Cited by 193 · see citing works

Chronic atrophic gastritis: Natural history, diagnosis and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]

Lahner, E., Zagari, R. M., Zullo, A., Sabatino, A. D., Meggio, A., Cesaro, P., Lenti, M. V., Annibale, B., & Corazza, G. R. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.09.016 · Cited by 192 · see citing works

Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori : Genetic and Kinetic Characterization

Baker, L. M. S., Raudonikiene, A., Hoffman, P. S., & Poole, L. B. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1961-1973.2001 · Cited by 190 · see citing works

Meta‐analysis: esomeprazole or rabeprazole vs. first‐generation pump inhibitors in the treatment of H elicobacter pylori infection

McNicholl, A. G., Linares, P. M., Nyssen, O. P., Calvet, X., & Gisbert, J. P. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05211.x · Cited by 189 · see citing works

Helicobacter pylori Infection and Gastric Adenocarcinoma.

Correa, P., & Piazuelo, M. B. (2011) · PubMed · Cited by 184 · see citing works

Host pathogen interactions in Helicobacter pylori related gastric cancer

Chmiela, M., Karwowska, Z., Gonciarz, W., Allushi, B., & Stączek, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i9.1521 · Cited by 176 · see citing works

Patterns of gastric atrophy in intestinal type gastric carcinoma

El-Zimaity, H. M. T., Ota, H., Graham, D. Y., Akamatsu, T., & Katsuyama, T. (2002) · Cancer · doi:10.1002/cncr.10375 · Cited by 171 · see citing works

Virulence Factors of Helicobacter pylori: A Review

Röesler, B. M., Gonçalves, E. M. A. R., & Zeitune, J. M. R. (2014) · Clinical Medicine Insights Gastroenterology · doi:10.4137/cgast.s13760 · Cited by 163 · see citing works

Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow‐up multicenter study

Gonzalez, C. A., Sanz‐Anquela, J. M., Companioni, O., Bonet, C., Berdasco, M., López, C., Mendoza, J., Martín‐Arranz, M. D., Rey, E., Poves, E., et al. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13249 · Cited by 140 · see citing works

CpG island hypermethylation in progression of esophageal and gastric cancer

Sato, F., & Meltzer, S. J. (2005) · Cancer · doi:10.1002/cncr.21657 · Cited by 140 · see citing works

Helicobacter pylori -induced inflammation and epigenetic changes during gastric carcinogenesis

Valenzuela, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i45.12742 · Cited by 135 · see citing works

Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway

Maeda, M., Moro, H., & Ushijima, T. (2016) · Gastric Cancer · doi:10.1007/s10120-016-0650-0 · Cited by 131 · see citing works

Glycomic and Glycoproteomic Analysis of Serum from Patients with Stomach Cancer Reveals Potential Markers Arising from Host Defense Response Mechanisms

Bones, J., Byrne, J. C., O'Donoghue, N. M., McManus, C. A., Scaife, C., Boissin, H., Năstase, A., & Rudd, P. M. (2010) · Journal of Proteome Research · doi:10.1021/pr101036b · Cited by 130 · see citing works

Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs.

Cadamuro, A., Rossi, A. F. T., Maniezzo, N., & Silva, A. E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i6.1424 · Cited by 119 · see citing works

Molecular Pathways: Involvement of Helicobacter pylori–Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers

Ushijima, T., & Hattori, N. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2011 · Cited by 130 · see citing works

Helicobacter pylori research: historical insights and future directions

Fock, K. M., Graham, D. Y., & Malfertheiner, P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.96 · Cited by 123 · see citing works

Regulation of Gastric Carcinogenesis by Inflammatory Cytokines

Bockerstett, K. A., & DiPaolo, R. J. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.005 · Cited by 122 · see citing works

Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection

Park, S.-Y., Yoo, E. J., Cho, N., Kim, N., & Kang, G. H. (2009) · The Journal of Pathology · doi:10.1002/path.2596 · Cited by 118 · see citing works

A Review of the Genomics of Gastric Cancer

Hamilton, J. P., & Meltzer, S. J. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.01.019 · Cited by 116 · see citing works

Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence

Gonzalez, C. A., Sanz‐Anquela, J. M., Gisbert, J. P., & Correa, P. (2012) · International Journal of Cancer · doi:10.1002/ijc.28003 · Cited by 116 · see citing works

Gastritis and Carditis

Owen, D. A. (2003) · Modern Pathology · doi:10.1097/01.mp.0000062995.72390.14 · Cited by 114 · see citing works

Gastric Cancer in the Era of Precision Medicine

Liu, X., & Meltzer, S. J. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.003 · Cited by 114 · see citing works

The regulatory roles of phosphatases in cancer

Stebbing, J., Lit, L. C., Zhang, H., Darrington, R. S., Melaiu, O., Rudraraju, B., & Giamas, G. (2013) · Oncogene · doi:10.1038/onc.2013.80 · Cited by 112 · see citing works

miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer

Jiang, B., Li, Z., Zhang, W., Wang, H., Zhi, X., Feng, J., Chen, Z., Zhu, Y., Yang, L., Xu, H., et al. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0851-9 · Cited by 111 · see citing works

Gastric Cancer: An Infectious Disease

Piazuelo, M. B., Epplein, M., & Correa, P. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.010 · Cited by 108 · see citing works

The Role of Serum Pepsinogen and Gastrin Test for the Detection of Gastric Cancer in Korea

Kang, J. M., Kim, N., Yoo, J. Y., Park, Y. S., Lee, D. H., Kim, H. Y., Lee, H. S., Choe, G., Kim, J. S., Jung, H. C., et al. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00592.x · Cited by 104 · see citing works

Bile Acid Promotes Intestinal Metaplasia and Gastric Carcinogenesis

Tatsugami, M., Ito, M., Tanaka, S., Yoshihara, M., Matsui, H., Haruma, K., & Chayama, K. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0730 · Cited by 102 · see citing works

Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation

Tsang, Y. H., Lamb, A., Romero–Gallo, J., Huang, B., Ito, K., Peek, R. M., Ito, Y., & Chen, L. F. (2010) · Oncogene · doi:10.1038/onc.2010.304 · Cited by 100 · see citing works

A Comprehensive Sequence and Disease Correlation Analyses for the C-Terminal Region of CagA Protein of Helicobacter pylori

Xia, Y., Yamaoka, Y., Zhu, Q., Matha, I., & Gao, X. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007736 · Cited by 100 · see citing works

CagA-mediated pathogenesis of Helicobacter pylori

Tohidpour, A. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.005 · Cited by 100 · see citing works

The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa

Molina‐Castro, S., Tiffon, C., Giraud, J., Bœuf, H., Sifré, E., Giese, A., Belleannée, G., Lehours, P., Bessède, E., Mégraud, F., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.10.007 · Cited by 94 · see citing works

Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification

Wang, Y., Chu, F., Lin, J., Li, Y., Johnson, N. L., Zhang, J., Gai, C., Su, Z., Cheng, H.-J., Wang, L., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114399 · Cited by 94 · see citing works

Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells

Choi, Y. J., Kim, N., Chang, H. K., Lee, H. S., Park, S. M., Park, J. H., Shin, C. M., Kim, J. M., Kim, J. S., Lee, D. H., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv022 · Cited by 93 · see citing works

Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease

Bridge, D. R., & Merrell, D. S. (2013) · Gut Microbes · doi:10.4161/gmic.23797 · Cited by 92 · see citing works

Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer

Nishikawa, J., Iizasa, H., Yoshiyama, H., Shimokuri, K., Kobayashi, Y. O., Sasaki, S., Nakamura, M., Yanai, H., Sakai, K., Suehiro, Y., et al. (2018) · Cancers · doi:10.3390/cancers10060167 · Cited by 88 · see citing works

Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses

Asano, N., Imatani, A., Watanabe, T., Fushiya, J., Kondo, Y., Jin, X., Ara, N., Uno, K., Iijima, K., Koike, T., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2272 · Cited by 86 · see citing works

Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review

Ito, M., Takata, S., Tatsugami, M., Wada, Y., Imagawa, S., Matsumoto, Y., Takamura, A., Kitamura, S., Matsuo, T., Tanaka, S., et al. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0036-8 · Cited by 77 · see citing works

Helicobacter pylori cholesteryl glucosides interfere with host membrane phase and affect type IV secretion system function during infection in AGS cells

Wang, H., Cheng, W., Cheng, H., Lai, C., & Wang, W. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07910.x · Cited by 73 · see citing works

Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis

Bockerstett, K. A., Osaki, L. H., Petersen, C. P., Cai, C. W., Wong, C. F., Nguyen, T.-L. M., Ford, E. L., Hoft, D. F., Mills, J. C., Goldenring, J. R., et al. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.012 · Cited by 72 · see citing works

Deregulation of β‐catenin signal by Helicobacter pylori CagA requires the CagA‐multimerization sequence

Kurashima, Y., Murata‐Kamiya, N., Kikuchi, K., Higashi, H., Azuma, T., Kondo, S., & Hatakeyama, M. (2007) · International Journal of Cancer · doi:10.1002/ijc.23190 · Cited by 72 · see citing works

Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma

Lee, B. M., Jang, J. J., & Kim, H. S. (1998) · Cancer Letters · doi:10.1016/s0304-3835(97)00520-x · Cited by 69 · see citing works

Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis

Correa, P., & Piazuelo, M. B. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.1.21 · Cited by 68 · see citing works

Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8

Farnbacher, M., Jahns, T., Willrodt, D., Daniel, R., Haas, R., Goesmann, A., Kurtz, S., & Rieder, G. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-335 · Cited by 68 · see citing works

Microbiota in the stomach and application of probiotics to gastroduodenal diseases

Koga, Y. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i47.6702 · Cited by 67 · see citing works

Dysfunctional Gastric Emptying With Down-regulation of Muscle-Specific MicroRNAs in Helicobacter pylori-Infected Mice

Saito, Y., Suzuki, H., Tsugawa, H., Suzuki, S., Matsuzaki, J., Hirata, K., & Hibi∥, T. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.044 · Cited by 66 · see citing works

Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico

Román-Román, A., Martínez-Carrillo, D. N., Atrisco-Morales, J., Azúcar-Heziquio, J. C., Cuevas-Caballero, A. S., Castañón‐Sánchez, C. A., Reyes-Ríos, R., Betancourt-Linares, R., Reyes-Navarrete, S., Carmen, I. C.-D., et al. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0167-z · Cited by 62 · see citing works

Helicobacter pylori in Childhood: New Insights Into the Immunopathogenesis of Gastric Disease and Implications for Managing Infection in Children

Ernst, P. B., & Gold, B. D. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199905000-00005 · Cited by 60 · see citing works

Characteristics of gastric cancer according to H elicobacter pylori infection status

Kwak, H. A., Choi, I. J., Cho, S., Lee, J. Y., Kim, C. G., Kook, M., Ryu, K. W., & Kim, Y. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12605 · Cited by 58 · see citing works

Helicobacter pylori infection and lung cancer: a review of an emerging hypothesis

Deng, B., Li, Y., Zhang, Y., Bai, L., & Yang, P. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt114 · Cited by 57 · see citing works

Multiple Infections and Cancer: Implications in Epidemiology

Vedham, V., Divi, R. L., Starks, V. L., & Verma, M. (2013) · Technology in Cancer Research & Treatment · doi:10.7785/tcrt.2012.500366 · Cited by 56 · see citing works

Biopsy site for detecting Helicobacter pylori infection in patients with gastric cancer

Kim, C. G., Choi, I. J., Lee, J. Y., Cho, S., Nam, B., Kook, M., Hong, E. K., & Kim, Y. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05679.x · Cited by 55 · see citing works

Helicobacter pylori Protein–Specific Antibodies and Risk of Colorectal Cancer

Epplein, M., Pawlita, M., Michel, A., Peek, R. M., Cai, Q., & Blot, W. J. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0702 · Cited by 53 · see citing works

Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection

Rivas-Ortiz, C. I., López‐Vidal, Y., Arredondo‐Hernández, R., & Castillo-Rojas, G. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00047 · Cited by 53 · see citing works

Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation

Busada, J. T., Ramamoorthy, S., Cain, D. W., Xu, X., Cook, D. N., & Cidlowski, J. A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123233 · Cited by 53 · see citing works

Autoimmune Gastritis and Gastric Microbiota

Conti, L., Annibale, B., & Lahner, E. (2020) · Microorganisms · doi:10.3390/microorganisms8111827 · Cited by 52 · see citing works

Unifying Themes in Microbial Associations with Animal and Plant Hosts Described Using the Gene Ontology

Torto-Alalibo, T. A., Collmer, C. W., Giglio, M. G., Lindeberg, M., Meng, S., Chibucos, M. C., Tseng, T., Lomax, J., Biehl, B. S., Ireland, A., et al. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-10 · Cited by 51 · see citing works

High-Salt Diet Exacerbates H. pylori Infection and Increases Gastric Cancer Risks

Balendra, V., Amoroso, C., Galassi, B., Esposto, J., Bareggi, C., Luu, J. H., Scaramella, L., & Ghidini, M. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13091325 · Cited by 51 · see citing works

Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer

Hou, R., Cao, B., Zhong-dong, C., Li, Y., Ning, T., Xu, C., Xu, C., & Chen, Z. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9705-1 · Cited by 51 · see citing works

Role of Helicobacter pylori in Gastric Carcinogenesis: The Origin of Gastric Cancers and Heterotopic Proliferative Glands in Mongolian Gerbils

Tatematsu, M., Tsukamoto, T., & Mizoshita, T. (2005) · Helicobacter · doi:10.1111/j.1523-5378.2005.00305.x · Cited by 51 · see citing works

Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations

Katoh, H., & Ishikawa, S. (2021) · Journal of Human Genetics · doi:10.1038/s10038-021-00960-8 · Cited by 50 · see citing works

Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages

Du, S.-Y., Wang, H., Cheng, H., Chen, S.-D., Wang, L. H.-C., & Wang, W. (2014) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2014.05.011 · Cited by 49 · see citing works

Helicobacter pyloriand the molecular pathogenesis of intestinal-type gastric carcinoma

Hanada, K., & Graham, D. Y. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.911092 · Cited by 49 · see citing works

Development of gastric adenocarcinoma in Mongolian gerbils after long‐term infection with Helicobacter pylori

Zheng, Q., Chen, X. Y., SHI, Y., & Shu Dong, X. I. A. O. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03469.x · Cited by 49 · see citing works

Characterization of Streptococcus salivarius as New Probiotics Derived From Human Breast Milk and Their Potential on Proliferative Inhibition of Liver and Breast Cancer Cells and Antioxidant Activity

Srikham, K., Daengprok, W., Niamsup, P., & Thirabunyanon, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.797445 · Cited by 48 · see citing works

Effect of Eradication of Helicobacter pylori on the Histology and Cellular Phenotype of Gastric Intestinal Metaplasia

Watari, J., Das, K. K., Amenta, P. S., Tanabe, H., Tanaka, A., Geng, X., Lin, J. J., Kohgo, Y., & Das, K. M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.12.044 · Cited by 48 · see citing works

Reactive Nitrogen Species Mediate DNA Damage in Helicobacter pylori‐Infected Gastric Mucosa

Katsurahara, M., Kobayashi, Y., Iwasa, M., Ma, N., Inoue, H., Fujita, N., Tanaka, K., Horiki, N., Gabazza, E. C., & Takei, Y. (2009) · Helicobacter · doi:10.1111/j.1523-5378.2009.00719.x · Cited by 45 · see citing works

Clinicopathologic characteristics and prognosis of synchronous multifocal gastric carcinomas

Otsuji, E., Kuriu, Y., Ichikawa, D., Okamoto, K. K., Hagiwara, A., & Yamagishi, H. (2005) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2004.03.013 · Cited by 45 · see citing works

Detailed clinicopathological characteristics and possible lymphomagenesis of type II intestinal enteropathy-associated T-cell lymphoma in Japan

Kikuma, K., Yamada, K., Nakamura, S., Ogami, A., Nimura, S., Hirahashi, M., Yonemasu, H., Urabe, S., Naito, S., Matsuki, Y., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2013.10.038 · Cited by 43 · see citing works

The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology

Hitzler, I., Kohler, E., Engler, D. B., Sayi‐Yazgan, A., & Mueller, A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00142 · Cited by 42 · see citing works

Diversity ofHelicobacter pylorigenotypes in Iranian patients with different gastroduodenal disorders

Vaziri, F. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i34.5685 · Cited by 42 · see citing works

Deconstructing host-pathogen interactions inDrosophila

Bier, E., & Guichard, A. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.000406 · Cited by 42 · see citing works

The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area

Zhou, L., San Ren, L. I. N., Ding, S. G., HUANG, X. B., ZHANG, L., Ling Mei, M. E. N. G., Rong Li, C. U. I., & Jin, Z. H. U. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00204.x · Cited by 42 · see citing works

Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin

Liu, Y. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i21.2674 · Cited by 41 · see citing works

The EPIYA-ABCC motif pattern in CagA of Helicobacter pyloriis associated with peptic ulcer and gastric cancer in Mexican population

Beltrán‐Anaya, F. O., Poblete, T. M., Román-Román, A., Reyes-Navarrete, S., Sampedro-Reyes, J. D., Peralta-Zaragoza, Ó., Rodríguez, M. Á., Moral-Hernández, Ó. D., Illades‐Aguiar, B., & Fernández‐Tilapa, G. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0223-9 · Cited by 40 · see citing works

Helicobacter pylori bacteria alter the p53 stress response via Erk-HDM2 pathway

Bhardwaj, V., Noto, J. M., Wei, J., Andl, C. D., El-Rifai, W. M., Peek, R. M., & Zaika, A. I. (2015) · Oncotarget · doi:10.18632/oncotarget.2828 · Cited by 40 · see citing works

Inhibition of ADP Ribosylation Prevents and Cures Helicobacter -Induced Gastric Preneoplasia

Toller, I. M., Altmeyer, M., Kohler, E., Hottiger, M. O., & Mueller, A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0528 · Cited by 39 · see citing works

Clinical relevance of cagL gene and virulence genotypes with disease outcomes in a Helicobacter pylori infected population from Iran

Yadegar, A., Mobarez, A. M., Alebouyeh, M., Mirzaei, T., Kwok, T., & Zali, M. R. (2014) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-014-1673-5 · Cited by 38 · see citing works

Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseases

Yadegar, A., Mobarez, A. M., & Zali, M. R. (2019) · Cancer Medicine · doi:10.1002/cam4.1941 · Cited by 38 · see citing works

Clinicopathologic Implications of Genetic Instability in Intestinal-Type Gastric Cancer and Intestinal Metaplasia as a Precancerous Lesion

Zaky, A. H., Watari, J., Tanabe, H., Sato, R., Moriichi, K., Tanaka, A., Maemoto, A., Fujiya, M., Ashida, T., & Kohgo, Y. (2008) · American Journal of Clinical Pathology · doi:10.1309/dflelpgpnv5lk6b1 · Cited by 38 · see citing works

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis

Wizenty, J., Müllerke, S., Kolesnichenko, M., Heuberger, J., Lin, M., Fischer, A., Mollenkopf, H., Berger, H., Tacke, F., & Sigal, M. J. (2022) · The EMBO Journal · doi:10.15252/embj.2021109996 · Cited by 37 · see citing works

Status of kinases in Epstein-Barr virus and Helicobacter pylori Coinfection in gastric Cancer cells

Sonkar, C., Verma, T., Chatterji, D., Jain, A. K., & Jha, H. C. (2020) · BMC Cancer · doi:10.1186/s12885-020-07377-0 · Cited by 37 · see citing works

Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis

Raza, Y., Khan, A., Farooqui, A., Mubarak, M., Facista, A., Akhtar, S. S., Khan, S., Kazi, J. I., Bernstein, C., & Kazmi, S. U. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9762-1 · Cited by 37 · see citing works

MGMTandMLH1methylation inHelicobacter pylori-infected children and adults

Alvarez, M. C. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i20.3043 · Cited by 36 · see citing works

Chronic CagA‐positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell‐like properties in gastric mucosal epithelial cells

Li, L., Wei, H., Yi, J., Xie, B., Chen, J., Zhou, C., Wang, L., & Yang, Y. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29031 · Cited by 36 · see citing works

Effect of polymorphisms in the 3′ untranslated region (3′‐UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan

Tahara, T., Shibata, T., Nakamura, M., Yamashita, H., Yoshioka, D., Hirata, I., & Arisawa, T. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20554 · Cited by 36 · see citing works

Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase

Shibayama, K., Takeuchi, H., Wachino, J., Mori, S., & Arakawa, Y. (2011) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2011.00333.x · Cited by 35 · see citing works

Oncogenic mechanism of Helicobacter pylori

Hatakeyama, M. (2008) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.31.132 · Cited by 5 · see citing works

The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells

Hatakeyama, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85563-1.00005-8 · Cited by 2 · see citing works

Helicobacter pylori Oncoprotein CagA and gastric cancer

Hatakeyama, M. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv462

The Role of Helicobacter pylori CagA in Gastric Carcinogenesis

Hatakeyama, M. (2006) · International Journal of Hematology · doi:10.1532/ijh97.06166 · Cited by 62 · see citing works

[H. pylori oncoprotein CagA and gastric cancer].

Hatakeyama, M. (2012) · PubMed · Cited by 4 · see citing works