The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Neel, Benjamin G.; Gu, Haihua; Pao, Lily

doi:10.1016/s0968-0004(03)00091-4

Cited by 1,249Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingCytokine Signaling Pathways and Interactions

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Neel, Benjamin G., Gu, Haihua, Pao, Lily·2003·Trends in Biochemical Sciences

DOI 10.1016/s0968-0004(03)00091-4

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Abstract

Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly conserved subfamily of protein-tyrosine phosphatases, members of which are present in both vertebrates and invertebrates. The mechanism of regulation of Shps by ligand binding is now well understood. Much is also known about the normal signaling pathways regulated by each Shp and the consequences of Shp deficiency. Recent studies have identified mutations in human Shp2 as the cause of the inherited disorder Noonan syndrome. Shp2 mutations might also contribute to the pathogenesis of some leukemias. In addition, Shp2 might be a key virulence determinant for the important human pathogen Helicobacter pylori. Despite these efforts, however, the key targets of each Shp have remained elusive. Identifying these substrates remains a major challenge for future research.

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SHP2 is a non-receptor PTP encoded by PTPN11 gene.
“Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase (PTP) encoded by PTPN11 gene.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [259]
The PTPN11 gene and its Drosophila orthologue corkscrew (csw) encode the evolutionarily conserved protein tyrosine phosphatase SHP2.
“The PTPN11 gene, and its orthologue in fruit flies corkscrew (csw), encodes the evolutionarily conserved protein tyrosine phosphatase SHP2 (Freeman et al., 1992; Neel et al., 2003)”
From The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction (2009) · cites this paper as Neel et al., 2003
CSW is a key signaling relay in pathways in C. elegans, Drosophila, Xenopus and mammals.
“CSW is a key signaling relay in pathways in C. elegans, Drosophila, Xenopus and mammals (for review see, Neel et al., 2003).”
From The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction (2009) · cites this paper as Neel et al., 2003

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Authors: Neel, B. G., Gu, H., & Pao, L.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Neel, Benjamin G.
ORCID: Neel, Benjamin G.
Gu, Haihua
Pao, Lily
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2003-06
Volume: 28
Issue: 6
Pages: 284-293
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/s0968-0004(03)00091-4
OpenAlex: W2094548766
Cited by: 1,249
References: 98
Citations by year: 2026: 22 · 2025: 43 · 2024: 57 · 2023: 62 · 2022: 46 · 2021: 57 · 2020: 57 · 2019: 40 · 2018: 35 · 2017: 44 · 2016: 39 · 2015: 46 · 2014: 59 · 2013: 52 · 2012: 71
FWCI: 5.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: American Society of Hematology
National Institutes of Health
National Cancer Institute (R01-CA-49152, R01CA049152)
National Institute of Allergy and Infectious Diseases (R01AI051612, AI 51612)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK050693, DK-50693, P01-DK50654, P01DK050654)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords: protein tyrosine phosphatase, SHP2, Noonan syndrome, leukemia, phosphatase substrates, signal transduction
MeSH terms: Animals, Binding Sites, Humans, Leukemia, Mutation, Syndrome, Tyrosine, Signal Transduction, Protein Tyrosine Phosphatases, src Homology Domains, Intracellular Signaling Peptides and Proteins, Protein Tyrosine Phosphatase, Non-Receptor Type 11, SH2 Domain-Containing Protein Tyrosine Phosphatases

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The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

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About these checks