Cited by 65Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsGastroesophageal reflux and treatments

Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases

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Grover, Madhusudan, Camilleri, Michael·2013·Journal of Gastroenterology

Abstract

The effects of antidepressants on the gastrointestinal tract may contribute to their potential efficacy in functional dyspepsia and irritable bowel syndrome; buspirone, a prototype 5-HT1A agonist, enhances gastric accommodation and reduces postprandial symptoms in response to a challenge meal. Paroxetine, a selective serotonin reuptake inhibitor, accelerates small bowel but not colonic transit, and this property may not be relevant to improve gut function in functional gastrointestinal disorders. Venlafaxine, a prototype serotonin norepinephrine reuptake inhibitor, enhances gastric accommodation, increases colonic compliance and reduces sensations to distension; however, it is associated with adverse effects that reduce its applicability in treatment of functional gastrointestinal disorders. Tricyclic antidepressants reduce sensations in response to food, including nausea, and delay gastric emptying, especially in females. Buspirone appears efficacious in functional dyspepsia; amitriptyline was not efficacious in a large trial of children with functional gastrointestinal disorders. Clinical trials of antidepressants for treatment of irritable bowel syndrome are generally small. The recommendations of efficacy and number needed to treat from meta-analyses are suspect, and more prospective trials are needed in patients without diagnosed psychiatric diseases. Antidepressants appear to be more effective in the treatment of patients with anxiety or depression, but larger prospective trials assessing both clinical and pharmacodynamic effects on gut sensorimotor function are needed.

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  1. [38]Ford AC Talley NJ Schoenfeld PS Quigley EM Moayyedi P Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis Gut 2009 58 367 378 10.1136/gut.2008.163162 19001059 · DOI · Paper page
  2. [41]Friedrich M Grady SE Wall GC Effects of antidepressants in patients with irritable bowel syndrome and comorbid depression Clin Ther 2010 32 1221 1233 10.1016/j.clinthera.2010.07.002 20678672 · DOI

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Authors
Grover, M., & Camilleri, M.
Affiliations
Mayo Clinic (US)
Corresponding author
Camilleri, Michael
Venue
Journal of Gastroenterology
Published
2012-12-20
Volume
48
Issue
2
Pages
177-181
ISSN
  • 0944-1174 (ISSN-L)
  • 1435-5922
OpenAlex
W1976805265
Cited by
65
References
42
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 1
FWCI
0.61
Type
journal article
Language
en
Open access
Locations
  • Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
antidepressants, functional gastrointestinal disorders, functional dyspepsia, irritable bowel syndrome, serotonergic agents, 5-HT1A receptor agonist, buspirone, selective serotonin reuptake inhibitors, paroxetine, venlafaxine, tricyclic antidepressants, amitriptyline, gastric accommodation, gastric emptying, colonic transit, colonic compliance, postprandial symptoms, adverse effects
MeSH terms
Dyspepsia, Gastrointestinal Diseases, Humans, Meta-Analysis as Topic, Serotonin Agents, Gastrointestinal Tract, Irritable Bowel Syndrome

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