Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases
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The effects of antidepressants on the gastrointestinal tract may contribute to their potential efficacy in functional dyspepsia and irritable bowel syndrome; buspirone, a prototype 5-HT1A agonist, enhances gastric accommodation and reduces postprandial symptoms in response to a challenge meal. Paroxetine, a selective serotonin reuptake inhibitor, accelerates small bowel but not colonic transit, and this property may not be relevant to improve gut function in functional gastrointestinal disorders. Venlafaxine, a prototype serotonin norepinephrine reuptake inhibitor, enhances gastric accommodation, increases colonic compliance and reduces sensations to distension; however, it is associated with adverse effects that reduce its applicability in treatment of functional gastrointestinal disorders. Tricyclic antidepressants reduce sensations in response to food, including nausea, and delay gastric emptying, especially in females. Buspirone appears efficacious in functional dyspepsia; amitriptyline was not efficacious in a large trial of children with functional gastrointestinal disorders. Clinical trials of antidepressants for treatment of irritable bowel syndrome are generally small. The recommendations of efficacy and number needed to treat from meta-analyses are suspect, and more prospective trials are needed in patients without diagnosed psychiatric diseases. Antidepressants appear to be more effective in the treatment of patients with anxiety or depression, but larger prospective trials assessing both clinical and pharmacodynamic effects on gut sensorimotor function are needed.
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Other potential pharmaceutical contributors such as antidepressants are used by 15-27% of HSD/hEDS patients.
“Other potential pharmaceutical contributors such as antidepressants, are used by 15–27% of HSD/hEDS patients.”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [74]
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- Authors
- Grover, M., & Camilleri, M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Camilleri, Michael
- Venue
- Journal of Gastroenterology
- Published
- 2012-12-20
- Volume
- 48
- Issue
- 2
- Pages
- 177-181
- ISSN
- 0944-1174 (ISSN-L)
- 1435-5922
- PMC
- PMC3698430
- OpenAlex
- W1976805265
- Cited by
- 65
- References
- 42
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- antidepressants, functional gastrointestinal disorders, functional dyspepsia, irritable bowel syndrome, serotonergic agents, 5-HT1A receptor agonist, buspirone, selective serotonin reuptake inhibitors, paroxetine, venlafaxine, tricyclic antidepressants, amitriptyline, gastric accommodation, gastric emptying, colonic transit, colonic compliance, postprandial symptoms, adverse effects
- MeSH terms
- Dyspepsia, Gastrointestinal Diseases, Humans, Meta-Analysis as Topic, Serotonin Agents, Gastrointestinal Tract, Irritable Bowel Syndrome
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