BDNF serum levels and promoter methylation of BDNF exon I, IV and VI in depressed patients receiving electroconvulsive therapy
Abstract
We examined potential changes in brain-derived neurotrophic factor (BDNF) serum levels and promoter methylation of the BDNF gene in 11 patients with treatment-resistant major depressive disorder during a series of electroconvulsive therapy (ECT). Blood samples were taken before, 1 and 24 h after ECT treatment sessions 1, 4, 7 and 10. Patients remitting under ECT had significantly lower mean promoter methylation rates, especially concerning the exon I promoter, compared to non-remitters (both p < 0.002). These findings may point to a depression subtype in which ECT is particularly beneficial.
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In depression, studies report low peripheral BDNF levels and higher promoter methylation, while antidepressants and electroconvulsive therapy (ECT) increase BDNF expression and reverse methylation.
“In depression, studies report low peripheral BDNF levels and higher promoter methylation, while antidepressants and electroconvulsive therapy (ECT) increase BDNF expression and reverse methylation”
From The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry (2025) · cites this paper as [64]
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- Authors
- Kleimann, A., Kotsiari, A., Sperling, W., Gröschl, M., Heberlein, A., Kahl, K. G., Hillemacher, T., Bleich, S., Kornhuber, J., & Frieling, H.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Kleimann, Alexandra
- Venue
- Journal of Neural Transmission
- Published
- 2014-11-12
- Volume
- 122
- Issue
- 6
- Pages
- 925-928
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W1989863639
- Cited by
- 70
- References
- 11
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 3
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medizinischen Hochschule Hannover
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- brain-derived neurotrophic factor, electroconvulsive therapy, depression remission, depression subtypes, epigenetic regulation
- MeSH terms
- Major Depressive Disorder, Depressive Disorder, Major, Electroconvulsive Therapy, Exons, Female, Humans, Male, Middle Aged, Promoter Regions, Genetic, Prospective Studies, Treatment Outcome, DNA Methylation, Brain-Derived Neurotrophic Factor, Depressive Disorder, Treatment-Resistant
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