Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism
Abstract
Major depression is the most common mental disorder and a leading cause of years lived with disability. In addition to the burden attributed to depressive symptoms and reduced daily life functioning, people with major depression are at increased risk of premature mortality, particularly due to cardiovascular diseases. Several studies point to a bi-directional relation between major depression and cardiovascular diseases, thereby indicating that both diseases may share common pathophysiological pathways. These include lifestyle factors (e.g. physical activity, smoking behavior), dysfunctions of endocrine systems (e.g. hypothalamus-pituitary adrenal axis), and a dysbalance of pro- and anti-inflammatory factors. Furthermore, recent research point to the role of epigenomic and proteomic factors, that are reviewed here with a particular focus on the mitochondrial energy metabolism.
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Raised levels of inflammation (because of factors such as pro-inflammatory cytokines) have been associated with depression.
“The findings show that raised levels of inflammation (because of factors such as pro-inflammatory cytokines) have been associated with depression [60,161,174,175,178].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [60]
Cites
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698 · see citing works
Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30118-4 · Cited by 5,255 · cited 2× · see citing works
“Lack of emotional support/social networks, low socioeconomic status and childhood adversities, which may be inter-correlated, can also increase the hazard ratio for depression and cardiovascular diseases (Hughes et al., 2017; Swartz et al., 2017; Walker et al., 2015).”
Derrien, T., Johnson, R., Bussotti, G., Andrea Tanzer, A., Djebali, S., Tilgner, H., Guernec, G., Martin, D., Merkel, A., Knowles, D. G., et al. (2012) · Genome Research · doi:10.1101/gr.132159.111 · Cited by 5,017 · see citing works
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,112 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045 · see citing works
Walker, E. R., McGee, R. E., & Druss, B. G. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2502 · Cited by 2,976 · see citing works
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531 · see citing works
Gakidou, E., Afshin, A., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulle, A. M., Abera, S. F., Aboyans, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32366-8 · Cited by 2,406 · see citing works
Hay, S. I., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32130-x · Cited by 2,083 · see citing works
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
The International Consortium for Blood Pressure Genome-Wide Association Studies (2011) · Nature · doi:10.1038/nature10405 · Cited by 2,033 · see citing works
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874 · see citing works
MicroRNAs in Stress Signaling and Human Disease
Mendell, J. T., & Olson, E. N. (2012) · Cell · doi:10.1016/j.cell.2012.02.005 · Cited by 1,673 · see citing works
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works
Stringhini, S., Carmeli, C., Jokela, M., Avendaño, M., Muennig, P., Guida, F., Ricceri, F., d'Errico, A., Barros, H., Bochud, M., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32380-7 · Cited by 1,319 · see citing works
(2006) · Europe PMC (PubMed Central) · Cited by 1,299 · see citing works
Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000019 · Cited by 1,208 · cited 2× · see citing works
“, 2009), so that WHO and the American Heart Association consider depression as a major risk factor for coronary heart disease, similar to hyperlipidemia, diabetes, hypertension, and smoking (Lichtman et al., 2014; Chaddha et al., 2016).”
Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution
Cheng, J., Kapranov, P., Drenkow, J., Dike, S., Brubaker, S., Patel, S. A., Long, J. C., Stern, D., Tammana, H., Helt, G. A., et al. (2005) · Science · doi:10.1126/science.1108625 · Cited by 1,175 · see citing works
Waddington, C. H. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr184 · Cited by 1,082 · see citing works
Correll, C. U., Detraux, J., De Lepeleire, J., & De Hert, M. (2015) · World Psychiatry · doi:10.1002/wps.20204 · Cited by 820 · see citing works
Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance
Saad, M. J. A., Santos, A., & Prada, P. O. (2016) · Physiology · doi:10.1152/physiol.00041.2015 · Cited by 818 · see citing works
Epigenetics: Definition, Mechanisms and Clinical Perspective
Dupont, C., Armant, D. R., & Brenner, C. A. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1237423 · Cited by 805 · see citing works
Wang, H., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Abraha, H. N., Abu-Raddad, L. J., Abu-Rmeileh, N. M. E., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31833-0 · Cited by 801 · see citing works
Inflammation: The Common Pathway of Stress-Related Diseases
Liu, Y.-Z., Wang, Y.-X., & Jiang, C.-L. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00316 · Cited by 800 · see citing works
Epidemiology and natural history of atrial fibrillation: clinical implications
Chugh, S. S., Blackshear, J. L., Shen, W.-K., Hammill, S. C., & Gersh, B. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01107-4 · Cited by 768 · see citing works
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases
Gluckman, P. D., Hanson, M. A., Buklijas, T., Low, F. M., & Beedle, A. S. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.102 · Cited by 627 · see citing works
Chen, Z., Venkat, P., Seyfried, D., Chopp, M., Yan, T., & Chen, J. (2017) · Circulation Research · doi:10.1161/circresaha.117.311170 · Cited by 565 · see citing works
Meijer, A., Conradi, H. J., Bos, E. H., Thombs, B. D., van Melle, J. P., & de Jonge, P. (2011) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.02.007 · Cited by 547 · see citing works
Johnston-Wilson, N. L., Sims, C. D., Hofmann, J.-P., Anderson, L., Shore, A. D., Torrey, E. F., Yolken, R. H., & the Stanley Neuropathology Consortium (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000696 · Cited by 531 · see citing works
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
AMPK: a metabolic gauge regulating whole-body energy homeostasis
Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 503 · see citing works
The complexity of miRNA-mediated repression
Wilczynska, A., & Bushell, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.112 · Cited by 496 · see citing works
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489 · see citing works
The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders
Smoller, J. W. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.266 · Cited by 479 · see citing works
Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.
Huffman, J. C., Celano, C. M., Beach, S. R., Motiwala, S. R., & Januzzi, J. L. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/695925 · Cited by 445 · see citing works
MicroRNA in cardiovascular biology and disease
Wojciechowska, A., Osiak, A., & Kozar, K. (2017) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/62915 · Cited by 419 · see citing works
Depression and the Link with Cardiovascular Disease
Dhar, A. K., & Barton, D. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00033 · Cited by 404 · see citing works
microRNAs in Cardiovascular Diseases
Condorelli, G., Latronico, M. V. G., & Cavarretta, E. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.050 · Cited by 379 · see citing works
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works
A twin approach to unraveling epigenetics
Bell, J. T., & Spector, T. D. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.12.005 · Cited by 353 · see citing works
Amare, A. T., Schubert, K. O., Klingler‐Hoffmann, M., Cohen‐Woods, S., & Baune, B. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.261 · Cited by 346 · see citing works
The emerging role of Toll-like receptor 4 in myocardial inflammation
Yang, Y., Lv, J., Jiang, S., Ma, Z., Wang, D., Hu, W., Deng, C., Fan, C., Di, S., Sun, Y., et al. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.140 · Cited by 337 · see citing works
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337 · see citing works
Gardner, A., & Boles, R. G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.030 · Cited by 333 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works
Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318 · see citing works
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
Mitochondrial oxidative stress promotes atrial fibrillation
Xie, W., Santulli, G., Reiken, S. R., Yuan, Q., Osborne, B. W., Chen, B.-X., & Marks, A. R. (2015) · Scientific Reports · doi:10.1038/srep11427 · Cited by 303 · see citing works
Regional cerebral glucose utilization in patients with a range of severities of unipolar depression
Kimbrell, T. A., Ketter, T. A., George, M. S., Little, J. T., Benson, B. E., Willis, M. W., Herscovitch, P., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01216-1 · Cited by 300 · see citing works
The role of glucose transporters in brain disease: Diabetes and Alzheimer’s disease
Shah, K., DeSilva, S., & Abbruscato, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012629 · Cited by 288 · see citing works
Mitochondrial function in the brain links anxiety with social subordination
Hollis, F., van der Kooij, M. A., Zanoletti, O., Lozano, L., Cantó, C., & Sandi, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512653112 · Cited by 288 · see citing works
Beasley, C. L., Pennington, K., Behan, Á. T., Wait, R., Dunn, M. J., & Cotter, D. (2006) · PROTEOMICS · doi:10.1002/pmic.200500069 · Cited by 284 · see citing works
Long non-coding RNA and chromatin remodeling
Han, P., & Chang, C. (2015) · RNA Biology · doi:10.1080/15476286.2015.1063770 · Cited by 283 · see citing works
Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272 · see citing works
Region and cell-type resolved quantitative proteomic map of the human heart
Doll, S., Dreßen, M., Geyer, P. E., Itzhak, D. N., Braun, C., Doppler, S. A., Meier, F., Deutsch, M.-A., Lahm, H., Lange, R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01747-2 · Cited by 265 · see citing works
Microbiome, inflammation, epigenetic alterations, and mental diseases
Alam, R., Abdolmaleky, H. M., & Zhou, J. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32567 · Cited by 240 · see citing works
Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease
Halaris, A. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_28 · Cited by 233 · see citing works
Ito, K., Uchida, Y., Ohtsuki, S., Aizawa, S., Kawakami, H., Katsukura, Y., Kamiie, J., & Terasaki, T. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22487 · Cited by 231 · see citing works
Biological basis of suicide and suicidal behavior
Pandey, G. N. (2013) · Bipolar Disorders · doi:10.1111/bdi.12089 · Cited by 226 · see citing works
Epigenetic Regulation of Tumor Necrosis Factor Alpha
Sullivan, K. E., Reddy, A. B. M., Dietzmann, K., Suriano, A. R., Kocieda, V., Stewart, M., & Bhatia, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02429-06 · Cited by 224 · see citing works
Su, L., Cai, Y., Xu, Y., Dutt, A., Shi, S., & Bramon, E. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0321-9 · Cited by 223 · see citing works
Psychiatric Comorbidity in 36 Adults with Mitochondrial Cytopathies
Fattal, O., Link, J. N., Quinn, K. M., Cohen, B. H., & Franco, K. S. N. (2007) · CNS Spectrums · doi:10.1017/s1092852900015303 · Cited by 220 · see citing works
Ben‐Shachar, D., & Karry, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003676 · Cited by 215 · see citing works
Saxena, S., Brody, A. L., Ho, M. L., Alborzian, S., Ho, M. K., Maidment, K. M., Huang, S.-C., Wu, H.-M., Au, S. C., & Baxter, L. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01123-4 · Cited by 209 · see citing works
Gadad, B. S., Jha, M. K., Czysz, A., Furman, J. L., Mayes, T. L., Emslie, M. P., & Trivedi, M. H. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.07.001 · Cited by 205 · see citing works
Martins‐de‐Souza, D., Guest, P. C., Harris, L. W., Vanattou‐Saïfoudine, N., Webster, M. J., Rahmoune, H., & Bahn, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.13 · Cited by 202 · see citing works
Chromatin structure and epigenetics
Quina, A. S., Buschbeck, M., & Croce, L. D. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.016 · Cited by 201 · see citing works
Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.09.012 · Cited by 197 · see citing works
Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods
Khyzha, N., Alizada, A., Wilson, M. D., & Fish, J. E. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.004 · Cited by 193 · see citing works
Meder, B., Haas, J., Sedaghat‐Hamedani, F., Kayvanpour, E., Frese, K., Lai, A., Nietsch, R., Scheiner, C., Mester, S., Bordalo, D. M., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.027355 · Cited by 192 · see citing works
Dunn, R. T., Kimbrell, T. A., Ketter, T. A., Frye, M. A., Willis, M. W., Luckenbaugh, D. A., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01244-6 · Cited by 184 · see citing works
Swartz, J. R., Hariri, A. R., & Williamson, D. E. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.82 · Cited by 177 · see citing works
Microbial regulation of microRNA expression in the amygdala and prefrontal cortex
Hoban, A. E., Stilling, R. M., M. Moloney, G., Moloney, R. D., Shanahan, F., Dinan, T. G., Cryan, J. F., & Clarke, G. (2017) · Microbiome · doi:10.1186/s40168-017-0321-3 · Cited by 177 · see citing works
A Twin Study of Depression Symptoms, Hypertension, and Heart Disease in Middle-Aged Men
Scherrer, J. F., Xian, H., Bucholz, K. K., Eisen, S. A., Lyons, M. J., Goldberg, J. H., Tsuang, M. T., & True, W. R. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000077507.29863.cb · Cited by 175 · see citing works
The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
Zelinski, E. L., Deibel, S. H., & McDonald, R. J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.007 · Cited by 174 · see citing works
Genome-wide association study identifies three novel loci for type 2 diabetes
Hara, K., Fujita, H., Johnson, T. A., Yamauchi, T., Yasuda, K., Horikoshi, M., Chen, P., Hu, C., Ronald, C. W., Imamura, M., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt399 · Cited by 169 · see citing works
Toll-like receptors in the depressed and suicide brain
Pandey, G. N., Rizavi, H. S., Ren, X., Bhaumik, R., & Dwivedi, Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.021 · Cited by 164 · see citing works
Glucose transporters in healthy heart and in cardiac disease
Szablewski, L. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.083 · Cited by 160 · see citing works
Zuccoli, G. S., Saia-Cereda, V. M., Nascimento, J. M., & Martins-de-Souza, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00493 · Cited by 157 · see citing works
Zhu, Y. L., Stevens, R. G., Hoffman, A. E., Tjønneland, A. M., Vogel, U. B., Zheng, T., & Hansen, J. (2011) · Chronobiology International · doi:10.3109/07420528.2011.618896 · Cited by 155 · see citing works
CRY2 Is Associated with Depression
Lavebratt, C., Sjöholm, L. K., Soronen, P., Paunio, T., Vawter, M. P., Bunney, W. E., Adolfsson, R., Forsell, Y., Wu, J. C., Kelsoe, J. R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009407 · Cited by 155 · see citing works
A review of DNA methylation in depression
Chen, D., Meng, L., Pei, F., Zheng, Y., & Leng, J. (2017) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2017.05.022 · Cited by 154 · see citing works
The steroid receptor RNA activator is the first functional RNA encoding a protein
Chooniedass, S., Emberley, E. D., Hamedani, M. K., Troup, S., Wang, X., Czosnek, A., Hubé, F., Mutawe, M. M., Watson, P. H., & Leygue, E. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.104 · Cited by 151 · see citing works
Mental Depression and Cardiovascular Disease: A Multifaceted, Bidirectional Association
Lippi, G., Montagnana, M., Favaloro, E. J., & Franchini, M. (2009) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0029-1222611 · Cited by 149 · see citing works
Mental Health and Cardiovascular Disease
Chaddha, A., Robinson, E. A., Kline-Rogers, E. M., Alexandris-Souphis, T., & Rubenfire, M. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.05.018 · Cited by 148 · see citing works
Aavik, E., Lumivuori, H., Leppanen, O., Wirth, T., Häkkinen, S.-K., Bräsen, J. H., Beschorner, U., Zeller, T., Braspenning, M., Criekinge, W. V., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu437 · Cited by 147 · see citing works
Epigenetic regulation of BDNF expression according to antidepressant response
Lopez, J. P., Mamdani, F., Labonte, B., Beaulieu, M.-M., Yang, J. P., Berlim, M. T., Ernst, C., & Turecki, G. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.38 · Cited by 146 · see citing works
Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation
Pauwels, S., Ghosh, M., Duca, R. C., Bekaert, B., Freson, K., Huybrechts, I., Langie, S. A. S., Koppen, G., Devlieger, R., & Godderis, L. (2016) · Epigenetics · doi:10.1080/15592294.2016.1257450 · Cited by 142 · see citing works
Carrard, A., Salzmann, A., Malafosse, A., & Karege, F. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.018 · Cited by 138 · see citing works
Elevated PLA2 activity in schizophrenics and other psychiatric patients
Noponen, M., Sanfilipo, M. P., Samanich, K. M., Ryer, H. I., Ko, G. N., Angrist, B., Wolkin, A., Duncan, E., & Rotrosen, J. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90157-9 · Cited by 137 · see citing works
Inflammation, Heart Disease, and Depression
Halaris, A. E. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0400-5 · Cited by 135 · see citing works
Long Non-coding RNAs: Novel Targets for Nervous System Disease Diagnosis and Therapy
Qureshi, I., & Mehler, M. F. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0199-0 · Cited by 133 · see citing works
Genome-Wide DNA Methylation Scan in Major Depressive Disorder
Sabunciyan, S., Aryee, M. J., Irizarry, R. A., Rongione, M. A., Webster, M. J., Kaufmann, W. E., Murakami, P. N., Lessard, A., Yolken, R. H., Feinberg, A. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034451 · Cited by 132 · see citing works
The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System
Cholewa-Waclaw, J., Bird, A. P., von Schimmelmann, M. J., Schaefer, A., Yu, H., Song, H., Madabhushi, R., & Tsai, L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2492-16.2016 · Cited by 132 · see citing works
Stress habituation, body shape and cardiovascular mortality
Peters, A., & McEwen, B. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.001 · Cited by 129 · see citing works
Cottingham, C., & Wang, Q. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.011 · Cited by 124 · see citing works
Liu, Z., Li, X., Sun, N., Xu, Y. J., Meng, Y.-Q., Yang, C., Wang, Y., & Zhang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093388 · Cited by 121 · see citing works
Liu, J., Buisman-Pijlman, F., & Hutchinson, M. R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00309 · Cited by 119 · see citing works
Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Zhang, H., & Pavuluri, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.003 · Cited by 118 · see citing works
Translational Perspective on Epigenetics in Cardiovascular Disease
van der Harst, P., Windt, L. J. D., & Chambers, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.067 · Cited by 117 · see citing works
Szczepanska‐Sadowska, E. K., Cudnoch‐Jędrzejewska, A., Ufnal, M., & Żera, T. (2010) · PubMed · Cited by 116 · see citing works
Kondo, D. G., Sung, Y. H., Hellem, T., Fiedler, K. K., Shi, X., Jeong, E.-K., & Renshaw, P. F. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.010 · Cited by 116 · see citing works
Sarchiapone, M., Carli, V., Roy, A., Iacoviello, L., Cuomo, C., Latella, M. C., di Giannantonio, M., Janiri, L., de Gaetano, M., & Janal, M. N. (2008) · Neuropsychobiology · doi:10.1159/000142361 · Cited by 115 · see citing works
The selfish brain: Competition for energy resources
Peters, A. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21106 · Cited by 115 · see citing works
Singh-Taylor, A., Molet, J., Jiang, S., Korosi, A., Bolton, J. L., Noam, Y., Simeone, K., Cope, J., Chen, Y., Mortazavi, A., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.240 · Cited by 115 · see citing works
Mitochondrial respiration in blood platelets of depressive patients
Hroudová, J., Fišar, Z., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.05.005 · Cited by 108 · see citing works
Hroudová, J., & Fišar, Z. (2010) · PubMed · Cited by 106 · see citing works
Long noncoding RNAs in DNA methylation: new players stepping into the old game
Zhao, Y. F., Sun, H., & Wang, H. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0109-3 · Cited by 104 · see citing works
Kishi, T., Yoshimura, R., Fukuo, Y., Okochi, T., Matsunaga, S., Umene‐Nakano, W., Nakamura, J., Serretti, A., Correll, C. U., Kane, J. M., et al. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0337-4 · Cited by 101 · see citing works
van Rijn, M. J. E., Schut, A. F., Aulchenko, Y. S., Deinum, J., Sayed‐Tabatabaei, F. A., Yazdanpanah, M., Isaacs, A. J., Axenovich, T. I., Zorkoltseva, I. V., Zillikens, M. C., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e32801449fb · Cited by 101 · see citing works
Increased DNA methylation in the suicide brain
Haghighi, F., Xin, Y., Chanrion, B., O'Donnell, A. H., Ge, Y., Dwork, A. J., Arango, V., & Mann, J. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/jmann · Cited by 101 · see citing works
Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome
Li, J., Zhu, X., Yu, K., Jiang, H., Zhang, Y., Deng, S., Cheng, L., Liu, X., Zhong, J., Zhang, X., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.310324 · Cited by 101 · see citing works
Garaulet, M., Gómez-Abellán, P., Rubio-Sastre, P., Madrid, J. A., Saxena, R., & Scheer, F. A. J. L. (2015) · Metabolism · doi:10.1016/j.metabol.2015.08.003 · Cited by 100 · see citing works
Heritability: The family roots of obesity
Willyard, C. (2014) · Nature · doi:10.1038/508s58a · Cited by 97 · see citing works
The mitochondrial side of epigenetics
Castegna, A., Iacobazzi, V., & Infantino, V. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00096.2014 · Cited by 97 · see citing works
Epigenetic Modulation of BDNF Gene in Patients with Major Depressive Disorder
D’Addario, C., Dell’Osso, B. M., Galimberti, D., Palazzo, C., Benatti, B., Francesco, A. D., Scarpini, E. A., Altamura, A. C., & Maccarrone, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.009 · Cited by 96 · see citing works
Shao, W., Chen, J., Fan, S., Lei, Y., Xu, H., Zhou, J., Cheng, P.-F., Yang, Y., Rao, C.-L., Wu, B. C., et al. (2015) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2014.0164 · Cited by 93 · see citing works
Long Non-Coding RNAs in Cardiac Remodeling
Shen, S., Jiang, H., Bei, Y., Xiao, J., & Li, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471913 · Cited by 92 · see citing works
Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity
Almén, M. S., Nilsson, E., Jacobsson, J. A., Kalniņa, I., Kloviņš, J., Fredriksson, R., & Schiöth, H. B. (2014) · Gene · doi:10.1016/j.gene.2014.07.009 · Cited by 91 · see citing works
Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system
Weckmann, K., Deery, M. J., Howard, J. A., Feret, R., Asara, J. M., Dethloff, F., Filiou, M. D., Iannace, J., Labermaier, C., Maccarrone, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16183-x · Cited by 91 · see citing works
Major depression in adolescent children consecutively diagnosed with mitochondrial disorder
Koene, S., Kozicz, T., Rodenburg, R. J., Verhaak, C. M., de Vries, M. C., Wortmann, S. B., van den Heuvel, L. P., Smeitink, J. A. M., & Morava, É. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.06.023 · Cited by 89 · see citing works
Hung, C., Rivera, M., Craddock, N. J., Owen, M. J., Gill, M., Korszun, A., Maier, W., Mors, O. N., Preisig, M., Rice, J. P., et al. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.130419 · Cited by 86 · see citing works
Long noncoding RNAs in cardiovascular disease, diagnosis, and therapy
Haemmig, S., Simion, V., Yang, D., Deng, Y., & Feinberg, M. W. (2017) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000454 · Cited by 85 · see citing works
Epigenetic mechanisms in heart development and disease
Martinez, S., Gay, M. S., & Zhang, L.-B. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2014.12.018 · Cited by 84 · see citing works
Maternal separation is associated with DNA methylation and behavioural changes in adult rats
Anier, K., Malinovskaja, K., Pruus, K., Aonurm‐Helm, A., Zharkovsky, A., & Kalda, A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.07.012 · Cited by 82 · see citing works
Long Non-Coding RNA: Potential Diagnostic and Therapeutic Biomarker for Major Depressive Disorder
Cui, X., Sun, X., Niu, W., Kong, L., He, M., Zhong, A., Chen, S., Jiang, K., Zhang, L.-Y., & Cheng, Z. (2016) · Medical Science Monitor · doi:10.12659/msm.899372 · Cited by 82 · see citing works
microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors
Wang, S., Mu, R.-H., Li, C., Dong, S., Geng, D., Liu, Q., & Yi, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.024 · Cited by 80 · see citing works
MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression
Jiang, J.-J., Cm, L., Zhang, B., Wang, X.-W., Zhang, M., Saijilafu, Zhang, S.-R., Hall, P., Hu, Y.-W., & Zhou, F.-Q. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.239 · Cited by 79 · see citing works
Depressive behaviour in children diagnosed with a mitochondrial disorder
Morava, É., Gardeitchik, T., Kozicz, T., de Boer, L., Koene, S., de Vries, M. C., McFarland, R., Roobol, T. H., Rodenburg, R. J., & Verhaak, C. M. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.011 · Cited by 79 · see citing works
Azevedo, J. A., Carter, B. S., Meng, F., Turner, D. L., Dai, M., Schatzberg, A. F., Barchas, J. D., Jones, E. G., Bunney, W. E., Myers, R., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.012 · Cited by 79 · see citing works
Alural, B., Genç, Ş., & Haggarty, S. J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.010 · Cited by 74 · see citing works
Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies
Wu, Y., Ding, X., Sun, Y., Yang, H., Chen, J., Zhao, X. Y., Jiang, Y., Lv, X., & Wu, Z. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.06.015 · Cited by 72 · see citing works
State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
Higuchi, F., Uchida, S., Yamagata, H., Otsuki, K., Hobara, T., Abe, N., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.008 · Cited by 72 · see citing works
Gottschalk, M. G., Wesseling, H., Guest, P. C., & Bahn, S. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu019 · Cited by 71 · see citing works
Martins‐de‐Souza, D., Guest, P. C., Vanattou‐Saïfoudine, N., Rahmoune, H., & Bahn, S. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0301-3 · Cited by 71 · see citing works
The Selfish Brain: Stress and Eating Behavior
Peters, A., Kubera, B., Hubold, C., & Langemann, D. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00074 · Cited by 70 · see citing works
Kleimann, A., Kotsiari, A., Sperling, W., Gröschl, M., Heberlein, A., Kahl, K. G., Hillemacher, T., Bleich, S., Kornhuber, J., & Frieling, H. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1336-6 · Cited by 70 · see citing works
Self-citationBDNFVal66met polymorphism: a potential bridge between depression and thrombosis
Amadio, P., Colombo, G. I., Tarantino, E., Gianellini, S., Ieraci, A., Brioschi, M., Banfi, C., Werba, J. P., Parolari, A., Lee, F. S., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv655 · Cited by 67 · see citing works
DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons
Oh, G., Wang, S.-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.016 · Cited by 66 · see citing works
Prevalence of diabetes and obesity in association with prematurity and growth restriction
Kopec, G. L., Shekhawat, P., & Mhanna, M. J. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s115890 · Cited by 66 · see citing works
Ignácio, Z. M., Réus, G. Z., Abelaira, H. M., & Quevedo, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.036 · Cited by 65 · see citing works
Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals
Rivera, M., Locke, A. E., Corre, T., Czamara, D., Wolf, C., Ching-López, A., Milaneschi, Y., Kloiber, S. M., Cohen‐Woods, S., Rucker, J., et al. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.116.183475 · Cited by 65 · see citing works
Weaver, I. C. G., Korgan, A. C., Lee, K., Wheeler, R. V., Hundert, A. S., & Goguen, D. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00041 · Cited by 64 · see citing works
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression
Lok, A., Bockting, C., Koeter, M. W. J., Snieder, H., Assies, J., Mocking, R. J. T., Vinkers, C. H., Kahn, R. S., Boks, M. P., & Schene, A. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.60 · Cited by 63 · see citing works
Connectivity between mitochondrial functions and psychiatric disorders
Hroudová, J., & Fišar, Z. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02178.x · Cited by 62 · see citing works
Novakovic, B., Gordon, L., Robinson, W. P., Desoyé, G., & Saffery, R. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.006 · Cited by 61 · see citing works
Bingham, A. J., Ooi, L., Kozera, Ł., White, E., & Wood, I. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00269-07 · Cited by 57 · see citing works
Yang, Q., Bailey, L. B., Clarke, R., Flanders, W. D., Liu, T., Yesupriya, A., Khoury, M. J., & Friedman, J. M. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.022384 · Cited by 57 · see citing works
State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
Higuchi, F. (2013) · Medical Entomology and Zoology · Cited by 57 · see citing works
DNA methylation in imprinted genes IGF2 and GNASXL is associated with prenatal maternal stress
Vangeel, E. B., Izzi, B., Hompes, T., Vansteelandt, K., Lambrechts, D., Freson, K., & Claes, S. J. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12249 · Cited by 56 · see citing works
MicroRNAs Regulating Reactive Oxygen Species in Cardiovascular Diseases
Gong, Y.-Y., Luo, J., Wang, L., & Huang, Y. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7328 · Cited by 55 · see citing works
Wesseling, H., Gottschalk, M. G., & Bahn, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu015 · Cited by 54 · see citing works
Scaini, G., Maggi, D. D., De-Nês, B. T., Gonçalves, C. L., Ferreira, G. K., Teodorak, B. P., Bez, G. D., Ferreira, G. C., Schuck, P. F., Quevedo, J., et al. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00548.x · Cited by 53 · see citing works
Beta‐1‐adrenergic receptor gene in major depression: Influence on antidepressant treatment response
Zill, P., Baghai, T. C., Engel, R. R., Zwanzger, P., Schüle, C., Minov, C., Behrens, S., Ronald Bottlender, A., Jäger, M., Rupprecht, R., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20017 · Cited by 52 · see citing works
Association between toll-like receptor 4 expression and symptoms of major depressive disorder
Hung, Y.-Y., Wu, M., Huang, T., Huang, K.-W., & Huang, G. Y.-L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s88430 · Cited by 51 · see citing works
CRY2 Genetic Variants Associate with Dysthymia
Kovanen, L., Kaunisto, M. A., Donner, K. M., Saarikoski, S. T., & Partonen, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071450 · Cited by 51 · see citing works
Murphy, G. M., Sarginson, J. E., Ryan, H. S., O’Hara, R., Schatzberg, A. F., & Lazzeroni, L. C. (2013) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328360b175 · Cited by 50 · see citing works
liu, Z., Guo, H., Cao, X., Cheng, C., Yang, C., Xu, C., Zhang, A., Sun, N., Li, X., & Zhang, K. (2014) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2014.05.010 · Cited by 50 · see citing works
Bot, M., Milaneschi, Y., Penninx, B. W. J. H., & Drent, M. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.028 · Cited by 50 · see citing works
Grotenfelt, N. E., Wasenius, N., Rönö, K., Laivuori, H. M., Stach‐Lempinen, B., Orho‐Melander, M., Schulz, C., Kautiainen, H., Koivusalo, S. B., & Eriksson, J. G. (2016) · Diabetologia · doi:10.1007/s00125-016-3989-1 · Cited by 50 · see citing works
Lopez, J. P., Pereira, F., Richard-Devantoy, S., Berlim, M., Chachamovich, E., Fiori, L. M., Niola, P., Turecki, G., & Jollant, F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.9 · Cited by 50 · see citing works
Chen, H., Orozco, L. D., Wang, J., Rau, C. D., Rubbi, L., Ren, S. V., Wang, Y., Pellegrini, M. A., Lusis, A. J., & Vondriska, T. M. (2016) · Circulation Research · doi:10.1161/circresaha.115.305298 · Cited by 48 · see citing works
Reduced brain leptin in patients with major depressive disorder and in suicide victims
Eikelis, N., Esler, M., Barton, D., Dawood, T., Wiesner, G., & Lambert, G. W. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001862 · Cited by 47 · see citing works
Rusconi, F., Ceriotti, P., Miragoli, M., Carullo, P., Salvarani, N., Rocchetti, M., Pasquale, E. D., Rossi, S., Tessari, M. M., Caprari, S., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.021347 · Cited by 47 · see citing works
MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research.
Narahari, A., Hussain, M., & Sreeram, V. (2017) · PubMed Central · Cited by 47 · see citing works
Tu, K.-Y., Wu, M., Chen, Y., Lin, P., Wang, H., Wu, C.-K., & Tseng, P. (2016) · Medicine · doi:10.1097/md.0000000000002411 · Cited by 46 · see citing works
Human hypertension, sympathetic activity and the selfish brain
Hart, E. C. (2016) · Experimental Physiology · doi:10.1113/ep085775 · Cited by 46 · see citing works
Kahl, K. G., Georgi, K., Bleich, S., Muschler, M., Hillemacher, T., Hilfiker-Kleinert, D., Schweiger, U., Ding, X., Kotsiari, A., & Frieling, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.002 · Cited by 44 · see citing works
microRNA-124: a putative therapeutic target and biomarker for major depression
Dwivedi, Y. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1328501 · Cited by 44 · see citing works
do Carmo, J. M., da Silva, A. A., Ebaady, S. E., Sessums, P. O., Abraham, R. S., Elmquist, J. K., Lowell, B. B., & Hall, J. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00131.2014 · Cited by 43 · see citing works
Ngai, Y. F., Sulistyoningrum, D. C., O'Neill, R., Innis, S. M., Weinberg, J., & Devlin, A. M. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00075.2015 · Cited by 42 · see citing works
Long noncoding RNA variations in cardiometabolic diseases
Dechamethakun, S., & Muramatsu, M. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.70 · Cited by 42 · see citing works
Jurkowska, R. Z., & Jeltsch, A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-43624-1_1 · Cited by 42 · see citing works
Soldatov, N. M. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150507093258 · Cited by 41 · see citing works
Melanocortin neurons: Multiple routes to regulation of metabolism
Shen, W.-J., Yao, T. S., Kong, X., Williams, K. W., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.007 · Cited by 41 · see citing works
Kim, J., Stewart, R. J., Kang, H., Bae, K., Kim, S., Shin, I., Hong, Y. J., Ahn, Y., Jeong, M. H., & Yoon, J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.013 · Cited by 39 · see citing works
Mao, Y., Fu, A., Hoffman, A. E., Jacobs, D., Jin, M., Chen, K., & Zhu, Y. L. (2015) · Tumor Biology · doi:10.1007/s13277-014-2989-3 · Cited by 37 · see citing works
Ni, X., Liao, Y., Li, L., Zhang, X., & Wu, Z. (2018) · Journal of Integrative Neuroscience · doi:10.31083/jin-170052 · Cited by 37 · see citing works
Ad, N., Schneider, A., Халиулин, И. Г., Borman, J. B., & Schwalb, H. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.03.058 · Cited by 36 · see citing works
Single nucleotide polymorphisms and mRNA expression for melatonin MT2 receptor in depression
Gałecka, E., Szemraj, J., Florkowski, A., Gałecki, P., Bieńkiewicz, M., Karbownik‐Lewińska, M., & Lewiñski, A. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.01.021 · Cited by 35 · see citing works
Gao, K., Wang, J., Li, L., Zhai, Y., Ren, Y., You, H., Wang, B., Wu, X., Li, J., Liu, Z., et al. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13030260 · Cited by 35 · see citing works
Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes
Grüters‐Kieslich, A., Reyes, M., Sharma, A., Demirci, C., DeClue, T. J., Lankes, E., Tiosano, D., Schnabel, D., & Jüppner, H. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00395 · Cited by 35 · see citing works
Kloiber, S. M., Ripke, S., Kohli, M. A., Reppermund, S., Salyakina, D., Uher, R., McGuffin, P., Perlis, R. H., Hamilton, S. P., Pütz, B., et al. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.08.010 · Cited by 34 · see citing works
lep Expression and Its Role in Obesity and Type-2 Diabetes
Qadir, M. I., & Ahmed, Z. (2017) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2017019386 · Cited by 34 · see citing works
DNA Methylation in Major Depressive Disorder
Pishva, E., Rutten, B. P. F., & van den Hove, D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_10 · Cited by 34 · see citing works
Rezeli, M., Végvári, Á., Donnarumma, F., Gidlöf, O., Smith, J. G., Erlinge, D., & Marko-Varga, G. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.05.016 · Cited by 33 · see citing works
Stelzhammer, V., Alsaif, M., Chan, M. K., Rahmoune, H., Steeb, H., Guest, P. C., & Bahn, S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.022 · Cited by 33 · see citing works
Zhang, X., Ai, X., Nakayama, H., Chen, B., Harris, D., Tang, M., Xie, Y., Szeto, C., Li, Y., Li, Y., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0523-4 · Cited by 33 · see citing works
Platelet 5-HT1A receptor correlates with major depressive disorder in drug-free patients
Zhang, Z., Wang, D., Man, S. C., Ng, R., McAlonan, G. M., Wong, H. K., Wong, W., Lee, J., & Tan, Q. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.004 · Cited by 31 · see citing works
Zheng, C., Man, C. D., Cobelli, C., Groop, L., Zhao, H., Bale, A. E., Shaw, M. M., Duran, E. J., Pierpont, B. M., Caprio, S., et al. (2015) · Obesity · doi:10.1002/oby.21030 · Cited by 30 · see citing works
Davidson, K. W., & Korin, M. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77.s3.04 · Cited by 29 · see citing works
PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder
Kovanen, L., Donner, K. M., Kaunisto, M. A., & Partonen, T. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.034 · Cited by 29 · see citing works
Role of NRSF/REST in the Regulation of Cardiac Gene Expression and Function
Kuwahara, K. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1210 · Cited by 28 · see citing works
Genetic association of adrenergic receptor alpha 2A with obesity and type 2 diabetes
Långberg, E., Ahmed, M. S., Efendić, S., Gu, H. F., & Östenson, C. (2013) · Obesity · doi:10.1002/oby.20162 · Cited by 28 · see citing works
Guay, S., Légaré, C., Brisson, D., Mathieu, P., Bossé, Y., Gaudet, D., & Bouchard, L. (2016) · Epigenomics · doi:10.2217/epi.15.120 · Cited by 27 · see citing works
Petkevičienė, J., Klumbienė, J., Šimonytė, S., Čeponienė, I., Jurėnienė, K., Kriaučionienė, V., Raskilienė, A., Smalinskienė, A., & Lesauskaitė, V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109974 · Cited by 26 · see citing works
Mosher, Melton, P. E., Stapleton, Schanfield, & Crawford, C. (2016) · Human Biology · doi:10.13110/humanbiology.88.2.0121 · Cited by 26 · see citing works
Ma, J., Wang, L., Yang, Y., Qiao, Z., Fang, D., Qiu, X., Yang, X., Zhu, X., He, J., Pan, H., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170994 · Cited by 26 · see citing works
LC-MS-MS quantitative analysis reveals the association between FTO and DNA methylation
Zhu, Y., Zhou, G., Yu, X., Xu, Q., Wang, K., Xie, D., Yang, Q., & Wang, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175849 · Cited by 26 · see citing works
Flagged first, then by citations
3 of the 234 references couldn’t be matched to a known paper.
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Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482 · see citing works
Sharifi‐Rad, J., Rodrigues, C. F., Sharopov, F. S., Docea, A. O., Karaça, A. C., Sharifi‐Rad, M., Kahveci, D., Gülseren, G., Şenol, E., Demircan, E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072326 · Cited by 295 · see citing works
Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review
Wu, J., Luo, Y., Deng, D., Su, S., Li, S., Li, X., Hu, Y., Wang, P., & Meng, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14725 · Cited by 125 · see citing works
Psychological factors and risk of atrial fibrillation: A meta-analysis and systematic review
Wu, H., Li, C., Li, B., Zheng, T., Feng, K., & Wu, Y. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.05.048 · Cited by 59 · see citing works
Srivastava, A., Yadav, T. C., Khera, H. K., Mishra, P., Raghuwanshi, N., Pruthi, V., & Prasad, R. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102614 · Cited by 53 · see citing works
Murri, M. B., Folesani, F., Zerbinati, L., Nanni, M. G., Ounalli, H., Caruso, R., & Grassi, L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155545 · Cited by 47 · see citing works
Schnabel, R. B., Hasenfuß, G., Buchmann, S. J., Kahl, K. G., Aeschbacher, S., Osswald, S., & Angermann, C. E. (2021) · Herz · doi:10.1007/s00059-021-05022-5 · Cited by 46 · see citing works
Ge, C., Wang, S., Wu, X., & Lei, L. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102313 · Cited by 42 · see citing works
Biology of cyclooxygenase-2: An application in depression therapeutics
He, Y., Han, Y., Liao, X., Zou, M., & Wang, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1037588 · Cited by 35 · see citing works
Liu, X., Liu, H.-L., Zhao, D., Wei, F., Wang, Y., Lv, M., Chen, S.-J., Li, S., & Qin, X. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114123 · Cited by 27 · see citing works
Leukocyte telomere length is reduced in patients with major depressive disorder
Pisanu, C., Tsermpini, E. E., Σκώκου, Μ., Kordou, Z., Gourzis, P., Assimakopoulos, K., Congiu, D., Meloni, A., Balasopoulos, D., Patrinos, G. P., et al. (2019) · Drug Development Research · doi:10.1002/ddr.21612 · Cited by 25 · see citing works
Pang, F., Yang, Y., Huang, S., Yang, Z., Zhu, Z., Liao, D., Guo, X., Zhou, M., Li, Y., & Tang, C. (2023) · Brain Sciences · doi:10.3390/brainsci13030436 · Cited by 25 · see citing works
Zhou, Y.-F., Feng, L., Liu, X., Xue, T., Wang, L.-S., Zhang, M., Wang, Z., Chen, S., & Chang, Q. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116751 · Cited by 20 · see citing works
Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders
Omori, N. E., Malys, M. K., Woo, G. H., & Mansor, L. S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1142682 · Cited by 18 · see citing works
Krivosova, M., Gondáš, E., Murín, R., Dohál, M., Ondrejka, I., Tonhajzerová, I., Hutka, P., Ferencová, N., Višňovcová, Z., Hrtánek, I., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12040813 · Cited by 17 · see citing works
Zhang, Y., Zhai, Y., Niu, B., Liu, X., Zhang, X., Wu, S., & Zhu, C. (2022) · Psychopathology · doi:10.1159/000524228 · Cited by 16 · see citing works
Modulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases
Dănilă, M. D., Piollet, M., Aburel, O.-M., Angoulvant, D., Gabillard-Lefort, C., Chadet, S., Roger, S., Muntean, D. M., & Ivanés, F. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173060 · Cited by 16 · see citing works
The association between depressive mood and ischemic heart disease: a twin study
Wium‐Andersen, M. K., Wium‐Andersen, I. K., Jørgensen, M. B., McGue, M. K., Jørgensen, T. S. H., Christensen, K., & Osler, M. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13072 · Cited by 14 · see citing works
Depression and Cardiovascular Disease in Women
Rivera, M. A. M., Rivera, I. R., Ávila, W. S., Marques-Santos, C., Costa, F. A., Ferro, C. R. C., & Fernandes, J. M. G. (2022) · International Journal of Cardiovascular Sciences · doi:10.36660/ijcs.20200416 · Cited by 13 · see citing works
Deng, Y., Li, W., & Zhang, B. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030405 · Cited by 12 · see citing works
Han, Y., Jia, Y., Tian, J., Zhou, S., Chen, A., & Luo, X. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237377 · Cited by 13 · see citing works
Clinical serum metabolomics study on fluoxetine hydrochloride for depression
Shen, D., Zhao, H., Gao, S., Li, Y., Cheng, Q., Bi, C., Zhou, Z., Li, Y., & Chunquan, Y. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135585 · Cited by 13 · see citing works
Tuncer, M., & Öskay, Ü. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad065 · Cited by 12 · see citing works
Liou, Y., Chen, M.-H., Hsu, J.-W., Huang, K.-L., Huang, P.-H., & Bai, Y.-M. (2021) · Scientific Reports · doi:10.1038/s41598-021-97853-9 · Cited by 10 · see citing works
Pinocembrin Decreases Atrial Fibrillation Susceptibility in a Rodent Model of Depression
Ran, Q., Chen, X., Zhang, C., Wan, W., Ye, T., Sun, Y., Zhao, X., Shi, S., Yang, B., & Zhao, Q. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.766477 · Cited by 9 · see citing works
Bhuvaneshwar, K., & Gusev, Y. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae098 · Cited by 8 · see citing works
Peripheral Endothelial Dysfunction Is Associated With Incident Major Depressive Disorder
Sara, J. D. S., Rajai, N., Breitinger, S. A., Medina‐Inojosa, B. J., Lerman, L. O., López-Jiménez, F. A., & Lerman, A. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.036812 · Cited by 7 · see citing works
Perez, N. B., Vorderstrasse, A. A., Yu, G., Melkus, G. D., Wright, F., Ginsberg, S. D., Crusto, C. A., Sun, Y. V., & Taylor, J. Y. (2022) · Epigenetics Insights · doi:10.1177/25168657221109781 · Cited by 7 · see citing works
Pate, B. S., Smiley, C. E., Harrington, E. N., Bielicki, H., Davis, J. M., Reagan, L. P., Grillo, C. A., & Wood, S. K. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103175 · Cited by 7 · see citing works
DNA methylation studies of depression with onset in the peripartum: A critical systematic review
Braun, S. E., Lapato, D. M., Brown, R., Lancaster, E. E., York, T. P., Amstadter, A. B., & Kinser, P. A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.005 · Cited by 7 · see citing works
Mond, L., de Zwaan, M., Safieddine, B., Kahl, K. G., Stahmeyer, J. T., & Epping, J. (2025) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2025.112066 · Cited by 4 · see citing works
Elsaka, O. (2025) · APIK Journal of Internal Medicine · doi:10.4103/ajim.ajim_46_24 · Cited by 2 · see citing works
Su, Y., Lin, S., She, L., Xiong, J., Ding, Y., Zhang, Y., & Chen, Y. (2025) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/cjgh/6632867 · Cited by 2 · see citing works
Kahl, K. G., Stapel, B., Heitland, I., Lamadé, E. K., Pedraz-Petrozzi, B., & Deuschle, M. (2026) · Der Nervenarzt · doi:10.1007/s00115-025-01932-5 · Cited by 2 · see citing works
Versorgung von Herzinsuffizienzpatienten – eine interdisziplinäre Herausforderung
Störk, S., Angermann, C., Bauersachs, J. K., & Frantz, S. (2021) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/a-1235-0422 · Cited by 2 · see citing works
Leite, M. E. (2001) · Cadernos de Campo Revista de Ciências Sociais · Cited by 2 · see citing works
Depresión, ansiedad e ira en adultos que sufrieron ataque al miocardio: un estudio de caso-control
García-Batista, Z. E., Guerra-Peña, K., Vindel, A. C., Herrera-Martínez, S. X., Flores-Kanter, P. E., & Medrano, L. A. (2019) · Revista de Psicología · doi:10.18800/psico.202001.009 · Cited by 2 · see citing works
Martyushev-Poklad, A. V., Yankevich, D. S., Savitskaya, N. G., & Petrova, M. V. (2022) · Clinical nutrition and metabolism · doi:10.17816/clinutr110996 · Cited by 1 · see citing works
Yadav, A. P., Lata, S., Awasthi, A., Katiyar, P., Shukla, P., Vishwakarma, A., & Singh, S. K. (2025) · Journal of Intellectual Disability - Diagnosis and Treatment · doi:10.6000/2292-2598.2025.13.02.3 · Cited by 1 · see citing works
Bioinformatics in Mental Health: Deriving Knowledge from Molecular and Cellular Data
Bhuvaneshwar, K., & Gusev, Y. (2021) · Health informatics · doi:10.1007/978-3-030-70558-9_11 · Cited by 1 · see citing works
Dysfunction of circulating endothelial progenitor cells in major depressive disorder
Liou, Y., Chen, M., Hsu, J.-W., Huang, K., Huang, P., & Bai, Y. (2024) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.49 · Cited by 1 · see citing works
Shriya, A. S. K., Pawar, V. B., & Paul, A. A. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998305019240702095537 · Cited by 1 · see citing works
Kapfhammer, H. (2023) · Springer eBooks · doi:10.1007/978-3-662-68309-5_4
Sara, J., Breitinger, S. A., Lilach, O., Lerman, A., Rajai, N., & Medina‐Inojosa, B. J. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.045020
Venko, K., & Žerovnik, E. (2026) · Biomolecules · doi:10.3390/biom16091286
Souri, H., Koopaei, M., Garavand, A., & Souri, F. (2026) · Current Cardiology Reports · doi:10.1007/s11886-026-02442-9
- Authors
- Kahl, K. G., Stapel, B., & Frieling, H.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Kahl, Kai G.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 89
- Pages
- 146-157
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2892142660
- Cited by
- 47
- References
- 234
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 6
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, cardiovascular disease, epigenomics, proteomics, energy metabolism, mitochondrial metabolism, bidirectional relationship, hypothalamic-pituitary-adrenal axis, inflammation, premature mortality, lifestyle factors
- MeSH terms
- Animals, Cardiovascular Diseases, Major Depressive Disorder, Depressive Disorder, Major, Energy Metabolism, Humans, Proteomics, Epigenesis, Genetic, Epigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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