Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures
Open accessAbstract
The mechanism of action of electroconvulsive seizures (ECS), one of the most effective treatments of major depression, may involve the regulation of gene expression. Chromatin remodeling at gene promoter regions is increasingly recognized as a key control point of gene expression and may, therefore, partly mediate acute and chronic effects of ECS on gene activity. Here, we assayed how posttranslational modifications of histones, a major form of chromatin remodeling, are altered at several gene promoters in rat hippocampus at 30 min, 2 hr, and 24 hr after acute or repeated ECS. We performed chromatin immunoprecipitation assays to measure levels of histone H3 and H4 acetylation and phosphoacetylation at the promoters of the c-fos, BDNF, and CREB (cAMP response element-binding protein) genes, the expression of which is altered by ECS. We found that, with few exceptions, levels of H4 acetylation correlated with mRNA levels for c-fos, BDNF, and CREB throughout the acute and chronic time course study, whereas acetylation and phosphoacetylation of H3 were detected more selectively. Our findings suggest that the chronic downregulation of c-fos transcription, observed in this study, may be achieved at the level of H4 acetylation, whereas chronic upregulation of BDNF transcription may be sustained via control of H3 acetylation, selectively at the BDNF P3 and P4 promoters. These data provide the first in vivo demonstration of the involvement of chromatin remodeling in ECS-induced regulation of gene expression in the brain and will help in understanding the mechanisms underlying the efficacy of ECS in the treatment of depression.
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In depression mice models, abnormal energy metabolism features have been documented, including abnormal glucose metabolism, elevated lactate levels, mitochondrial dysfunction, and abnormal ATP levels.
“In the depression mice model, features of abnormal energy metabolism have also been documented, including abnormal glucose metabolism, elevated lactate levels, mitochondrial dysfunction, and abnormal ATP levels [19–22].”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [21]
The Introduction and Discussion describe histone modifications and gene expression after electroconvulsive seizures in rat hippocampus, not energy metabolism in depression mouse models. Searches for glucose metabolism, lactate, mitochondrial dysfunction, ATP, and energy metabolism found no passage addressing those features. Page numbers were not available in our copy. (LLM, conf=0.77)
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Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Self-citationHistone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,778 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works
Self-citationThe cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Cellular Memory and the Histone Code
Turner, B. M. (2002) · Cell · doi:10.1016/s0092-8674(02)01080-2 · Cited by 1,142 · see citing works
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works
Cheung, P., Tanner, K. G., Cheung, W. L., Sassone‐Corsi, P., Denu, J. M., & Allis, C. D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80256-7 · Cited by 803 · see citing works
Regulation of transcription factors by neuronal activity
West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 604 · see citing works
Antidepressants and neuroplasticity
D'Sa, C. M., & Duman, R. S. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01203.x · Cited by 516 · see citing works
cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment
Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 507 · see citing works
Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497 · see citing works
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
Newton, S. S., Collier, E. F., Hunsberger, J. G., Adams, D., Terwilliger, R. Z., Selvanayagam, E., & Duman, R. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10841.2003 · Cited by 355 · see citing works
Chakrabarti, S. K., James, J. C., & Mirmira, R. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111857200 · Cited by 287 · see citing works
Dias, B. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00198-9 · Cited by 274 · see citing works
Huang, Y., Doherty, J., & Dingledine, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08422.2002 · Cited by 261 · see citing works
METSIS, M. L., Timmusk, T., Arenas, E., & Persson, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8802 · Cited by 248 · see citing works
Crosio, C., Heitz, E., Allis, C. D., Borrelli, E., & Sassone‐Corsi, P. (2003) · Journal of Cell Science · doi:10.1242/jcs.00804 · Cited by 242 · see citing works
Wells, J. M., & Farnham, P. (2002) · Methods · doi:10.1016/s1046-2023(02)00007-5 · Cited by 242 · see citing works
Thomson, S., Clayton, A. L., & Mahadevan, L. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00404-x · Cited by 192 · see citing works
MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation
Clayton, A. L., & Mahadevan, L. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00451-4 · Cited by 189 · see citing works
Hiroi, N., Marek, G. J., Brown, J. R., Ye, H., Saudou, F., Vaidya, V. A., Duman, R. S., Greenberg, M. E., & Nestler, E. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06952.1998 · Cited by 139 · see citing works
Self-citationWinston, S. M., Hayward, M. D., Nestler, E. J., & Duman, R. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04892.x · Cited by 119 · see citing works
Self-citationDissecting long-range transcriptional mechanisms by chromatin immunoprecipitation
Johnson, K. D., & Bresnick, E. H. (2002) · Methods · doi:10.1016/s1046-2023(02)00005-1 · Cited by 117 · see citing works
Chen, J., Zhang, Y., Kelz, M. B., Steffen, C., Ang, E. S., Zeng, L., & Nestler, E. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08965.2000 · Cited by 101 · see citing works
Self-citationActivity-Induced Expression of Common Reference Genes in Individual CNS Neurons
Chen, J., Гарриевич, С. Д., Beck, H., Maréchal, D., Wiestler, O. D., & Becker, A. J. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780300 · Cited by 77 · see citing works
Flagged first, then by citations
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Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Self-citationBelmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
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Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
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Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
Self-citationFlavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works
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Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767 · see citing works
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Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works
Self-citationGreer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661 · see citing works
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Meaney, M. J., & Szyf, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.006 · Cited by 658 · see citing works
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Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
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Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
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Pandey, S. C., Sakharkar, A. J., Tang, L., & Zhang, H. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.019 · Cited by 191 · see citing works
Yang, Y. J., Baltus, A. E., Mathew, R. S., Murphy, E. A., Evrony, G. D., Gonzalez, D. M., Wang, E. P., Marshall-Walker, C. A., Barry, B. J., Murn, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.043 · Cited by 176 · see citing works
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Self-citationSakharkar, A. J., Vetreno, R. P., Zhang, H., Kokare, D. M., Crews, F. T., & Pandey, S. C. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1196-y · Cited by 122 · see citing works
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Self-citationDuclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103 · see citing works
Shen, H.-Y., Kalda, A., Yu, L., Ferrara, J., Zhu, J., & Chen, J.-F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.019 · Cited by 91 · see citing works
Bartlett, A. A., Singh, R., & Hunter, R. G. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_8 · Cited by 91 · see citing works
Lubin, F. D., Ren, Y., Xu, X., & Anderson, A. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04863.x · Cited by 75 · see citing works
Kleimann, A., Kotsiari, A., Sperling, W., Gröschl, M., Heberlein, A., Kahl, K. G., Hillemacher, T., Bleich, S., Kornhuber, J., & Frieling, H. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1336-6 · Cited by 70 · see citing works
Stress, epigenetic control of gene expression and memory formation
Trollope, A. F., Gutièrrez-Mecinas, M., Mifsud, K. R., Collins, A., Saunderson, E. A., & Reul, J. M. H. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.03.022 · Cited by 69 · see citing works
Neurophysiological mechanisms of electroconvulsive therapy for depression
Kato, N. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.01.014 · Cited by 65 · see citing works
Arey, R. N., Enwright, J. F., Spencer, S. M., Falcon, E., Ozburn, A. R., Ghose, S., Tamminga, C., & McClung, C. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.12 · Cited by 62 · see citing works
Liu, D., Qiu, H.-M., Fei, H.-Z., Hu, X.-Y., Xia, H.-J., Wang, L.-J., Qin, L.-J., Jiang, X.-H., & Zhou, Q.-X. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213513987 · Cited by 49 · see citing works
Maurel, O. M., Torrisi, S. A., Barbagallo, C., Purrello, M., Salomone, S., Drago, F., Ragusa, M., & Leggio, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105157 · Cited by 44 · see citing works
The importance of epigenetics in diagnostics and treatment of major depressive disorder
Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030167 · Cited by 37 · see citing works
APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
Mechanisms of HIV transcriptional regulation by drugs of abuse
Tyagi, M., Bukrinsky, M., & L. Simon, G. (2016) · Current HIV Research · doi:10.2174/1570162x14666160324124736 · Cited by 42 · see citing works
Zhao, Y., Xing, B., Dang, Y.-H., Qu, C.-L., Zhu, F., & Yan, C.-X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052698 · Cited by 36 · see citing works
Montel Hayes, R., Mason, C. E., & Miller, J. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671122 · Cited by 5 · see citing works
- Authors
- Tsankova, N. M., Kumar, A., & Nestler, E. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-06-16
- Volume
- 24
- Issue
- 24
- Pages
- 5603-5610
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6729334
- OpenAlex
- W2062740397
- Cited by
- 447
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 15 · 2023: 13 · 2022: 5 · 2021: 18 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 16 · 2016: 24 · 2015: 30 · 2014: 38 · 2013: 30 · 2012: 27
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- electroconvulsive seizures, histone modifications, chromatin remodeling, promoter, hippocampus, histone H3 acetylation, histone H4 acetylation, c-fos, brain-derived neurotrophic factor, CREB, gene expression regulation, major depressive disorder
- MeSH terms
- Acetylation, Animals, Chromatin, Electroshock, Hippocampus, Histones, Male, Promoter Regions, Genetic, Protein Processing, Post-Translational, RNA, Messenger, Time Factors, Polymerase Chain Reaction, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Immunoprecipitation, Rats
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