Progranulin as a candidate biomarker for therapeutic trial in patients with ALS and FTLD

El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis

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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

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The Determinants of Quality of Life of Nursing Home Residents with Young-Onset Dementia and the Differences between Dementia Subtypes

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

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A harmonized classification system for FTLD-TDP pathology

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Conversion of Proepithelin to Epithelins

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Flow rate of cerebrospinal fluid (CSF) — A concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases

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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

Damme, P. V., Hoecke, A. V., Lambrechts, D., Vanacker, P., Bogaert, E., Swieten, J. C. V., Carmeliet, P., Bosch, L. V. D., & Robberecht, W. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712039 · Cited by 421 · see citing works

Protein size and cerebrospinal fluid composition

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Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

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Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

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The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene

Mackenzie, I. R., Baker, M., Pickering-Brown, S. M., Hsiung, G. R., Lindholm, C., Dwosh, E., Gass, J. M., Cannon, A. D., Rademakers, R., Hutton, M., et al. (2006) · Brain · doi:10.1093/brain/awl271 · Cited by 294 · see citing works

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia

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Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo.

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Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

Feneberg, E., Steinacker, P., Lehnert, S., Schneider, A., Walther, P., Thal, D. R., Linsenmeier, M., Ludolph, A. C., & Otto, M. (2014) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2014.905606 · Cited by 156 · see citing works

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

Cenik, B., Sephton, C. F., Dewey, C. M., Xian, X., Wei, S., Yu, K., Niu, W., Coppola, G., Coughlin, S. E., Lee, S. E., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193433 · Cited by 148 · see citing works

Membrane protein expression and production: effects of polyhistidine tag length and position

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Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

Capell, A., Liebscher, S., Fellerer, K., Brouwers, N., Willem, M., Lammich, S., Gijselinck, I., Bittner, T., Carlson, A. M., Sasse, F., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5757-10.2011 · Cited by 132 · see citing works

Progranulin protein levels are differently regulated in plasma and CSF

Nicholson, A. M., Finch, N. A., Thomas, C. S., Wojtas, A., Rutherford, N. J., Mielke, M. M., Roberts, R. O., Boeve, B. F., Knopman, D. S., Petersen, R. C., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000445 · Cited by 86 · see citing works

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration

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Summary of cerebrospinal fluid routine parameters in neurodegenerative diseases

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Increased caspase activation and decreased TDP‐43 solubility in progranulin knockout cortical cultures

Kleinberger, G., Wils, H., Ponsaerts, P., Joris, G., Timmermans, J., Broeckhoven, C. V., & Kumar‐Singh, S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06961.x · Cited by 68 · see citing works

Inflammatory molecules in Frontotemporal Dementia: Cerebrospinal fluid signature of progranulin mutation carriers

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Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

Vercellino, M., Grifoni, S., Romagnolo, A., Masera, S., Mattioda, A., Trebini, C., Chiavazza, C., Caligiana, L., Capello, E., Mancardi, G., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511406164 · Cited by 57 · see citing works

Progranulin and TDP-43: Mechanistic Links and Future Directions

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Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD

Ungurs, M. J., Sinden, N., & Stockley, R. A. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00221.2013 · Cited by 42 · see citing works

Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation

Alberici, A., Archetti, S., Pilotto, A., Premi, E., Cosseddu, M., Bianchetti, A., Semeraro, F., Salvetti, M., Muiesan, M. L., Padovani, A., et al. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1683-y · Cited by 33 · see citing works

Defining Elastic Fiber Interactions by Molecular Fishing

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Erythropoietin in Cerebrospinal Fluid: Age-related Reference Values and Relevance in Neurological Disease

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Kinetics of protein agglomeration. A nephelometric method for the determination of total protein in biological samples

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Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists

Minami, S., Shen, V., Le, D., Krabbe, G., Asgarov, R., Perez-Celajes, L., Lee, C., Li, J., Donnelly‐Roberts, D. L., & Gan, L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.016 · Cited by 14 · see citing works

Imaging and fluid biomarkers in frontotemporal dementia

Meeter, L. H., Kaat, L. D., Rohrer, J. D., & van Swieten, J. C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.75 · Cited by 210 · see citing works

Fluid biomarkers in frontotemporal dementia: past, present and future

Swift, I. J., Sogorb-Esteve, A., Heller, C., Synofzik, M., Otto, M., Graff, C., Galimberti, D., Todd, E., Heslegrave, A. J., van der Ende, E. L., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-323520 · Cited by 122 · see citing works

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

Suárez‐Calvet, M., Capell, A., Araque Caballero, M. Á., Morenas‐Rodríguez, E., Fellerer, K., Franzmeier, N., Kleinberger, G., Eren, E., Deming, Y., Piccio, L., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809712 · Cited by 109 · see citing works

Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

Meeter, L. H. H., Patzke, H., Loewen, G., Dopper, E. G. P., Pijnenburg, Y. A. L., van Minkelen, R., & van Swieten, J. C. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000447738 · Cited by 87 · see citing works

Biomarkers for diseases with TDP-43 pathology

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An 8‐week, open‐label, dose‐finding study of nimodipine for the treatment of progranulin insufficiency from <i>GRN</i> gene mutations

Sha, S. J., Miller, Z. A., Min, S., Zhou, Y., Brown, J., Mitic, L. L., Karydas, A., Koestler, M., Tsai, R., Corbetta‐Rastelli, C., et al. (2017) · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions · doi:10.1016/j.trci.2017.08.002 · Cited by 36 · see citing works

Blood biomarkers in frontotemporal dementia: Review and meta-analysis

Ntymenou, S., Tsantzali, I., Kalamatianos, T., Voumvourakis, K. I., Kapaki, E., Tsivgoulis, G., Stranjalis, G., & Paraskevas, G. P. (2021) · Brain Sciences · doi:10.3390/brainsci11020244 · Cited by 31 · see citing works

The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials

Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works

Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers

Katisko, K., Solje, E., Koivisto, A. M., Krüger, J., Kinnunen, T. T., Hartikainen, P. H., Helisalmi, S., Korhonen, V. E., Herukka, S., Haapasalo, A., et al. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.05.011 · Cited by 20 · see citing works

Amyotrophic Lateral Sclerosis with Frontotemporal Dementia in the Presence of C9orf72 Repeat Expansion-A Case Report.

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[ 18 F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion

Bevan-Jones, W. R., Cope, T., Jones, S. P., Passamonti, L., Hong, Y. T., Fryer, T. D., Arnold, R. J., Coles, J., Aigbirhio, F. A., Patterson, K. E., et al. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.631 · Cited by 23 · see citing works

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

Junttila, A., Kuvaja, M., Hartikainen, P. H., Siloaho, M., Helisalmi, S., Moilanen, V., Kiviharju, A., Jansson, L., Tienari, P. J., Remes, A. M., et al. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000444788 · Cited by 55 · see citing works

TMEM106B is a Genetic Modifier of Frontotemporal Lobar Degeneration with C9orf72 Hexanucleotide Repeat Expansions (I5-1.008)

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